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On the Estimation of Heritability with Family-Based and Population-Based Samples
Kim, Youngdoe,Lee, Young,Lee, Sungyoung,Kim, Nam Hee,Lim, Jeongmin,Kim, Young Jin,Oh, Ji Hee,Min, Haesook,Lee, Meehee,Seo, Hyeon-Jeong,Lee, So-Hyun,Sung, Joohon,Cho, Nam H.,Kim, Bong-Jo,Han, Bok-Ghee Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples. Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population- and family-based samples. In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24. Furthermore, we found differences in how heritability is estimated—in particular the amount of variance attributable to common environment in twins can be substantial—which indicates heritability estimates should be interpreted with caution.</P>
Kim, Tae Heon,Kim, Yu Kyung,Kwon, Youngdo,Heo, Jin Hyung,Kang, Haeyoun,Kim, Gwangil,An, Hee Jung Blackwell Publishing Ltd 2010 Histopathology Vol.57 No.5
<P>Kim T H, Kim Y K, Kwon Y, Heo J H, Kang H, Kim G & An H J(2010) <I>Histopathology</I><B>57</B>, 734–743 <B>Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours</B></P><P>Aims: </P><P>The pathological and clinical significance of aberrant miRNA expression in ovarian tumours has yet to be adequately documented. The aim of this study was to assess the differences in miRNA expression of human ovarian tumours according to histological subtype, and to determine whether miRNAs are potential diagnostic and prognostic markers in ovarian cancers.</P><P>Method and results: </P><P>The miRNA expression profiles of 103 human ovarian tumours were evaluated. Via a bead-based miRNA microarray, five aberrant miRNAs were selected which were expressed differentially in malignant serous tumours from borderline and benign ovarian tumours, including miRNA (miR)-519a, miR-18b (up-regulation) and miR-153, miR-511 and miR-485-5p (down-regulation). We conducted quantitative real-time reverse transcription–polymerase chain reaction (qRT–PCR) in order to confirm that these miRNAs are differentially expressed in different histological subtypes of ovarian tumours, and compared the expression profiles of these miRNAs between different clinical subsets. The expression of these miRNAs was correlated with clinicopathological parameters. miR-519a, miR-153 and miR-485-5p were differentially expressed in four major histotypes of ovarian cancers (<I>P </I>< 0.05), which suggests that they might be of potential importance as diagnostic biomarkers. Down-regulation of miR-153 and miR-485-5p was correlated significantly with FIGO grade 3 (<I>P </I>< 0.05). Down-regulation of miR-153 and up-regulation of miR-519a were correlated significantly with advanced clinical stage (<I>P </I>< 0.05). The results of Kaplan–Meier survival analysis indicated that the higher expression of miR-519a in late stage serous carcinoma was associated significantly with poor progression-free survival (<I>P </I>= 0.0058).</P><P>Conclusions: </P><P>A significant correlation was detected between the deregulation of specific types of miRNAs, such as miR-519a, miR-153 and miR-485-5p, and clinical variables as well as histological subtypes in ovarian cancers. Hence, these miRNAs may perform functions as diagnostic or prognostic biomarkers.</P>
Kim Hyeongyeong,Kim Youngdoe,Kang Jiho 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3
We aimed to evaluate the safety and effectiveness of darunavir (DRV) in the treatment of human immunodeficiency virus-1 (HIV-1) infection in Korea. From October 29, 2010, 225 eligible patients with HIV-1 infection receiving DRV were enrolled. DRV was administered with other antiretroviral agents, and followed for 24 weeks. The primary objective was safety evaluation, and effectiveness was assessed by viral load and CD4 T cell counts after 12 weeks and 24 weeks. Adverse drug reactions occurred in 18 patients (9.2%); diarrhea was the most common. Viral load was controlled (<400 copies/mL) in 90.9% of patients. CD4 T cell counts were increased 45.0/mm3 significantly at Week 12 (P = 0.0002), and 70.5/mm3 at Week 24 (P <0.0001). DRV safety and effectiveness was consistent with previous studies.
Scalable synthesis of the C14–C23 fragment of Eribulin and Halichondrin B
Kim U Bin,Samala Srinivas,Kim Namhyeon,Bogonda Ganganna,Lago‐Santomé Hugo,Jeong Youngdo,Kim Jin,Jung Jaehun,Jeon Sung‐Hyun,Lee Seung Jong,신현석 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.12
A novel, scalable approach to the C14–C23 fragment of eribulin mesylate is disclosed. Key 2,3-Wittig rearrangement is strategically effected via [Rh] mediated decomposition of 1,2,3-triazole intermediate to derive the 2,5-trans-tetrahydrofuran motif, enabling multi-kilogram access to the desired C14–C23 fragment.
Jinkwon Kim,Junsik Mun,Youngdo Kim,Bongju Kim,Jeong Rae Kim,Lingfei Wang,Miyoung Kim,Changyoung Kim,Jason W. A. Robinson,Yoshiteru Maeno,Tae Won Noh 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Ruddlesden-Popper (RP) phase oxides (An+1BnO3n+1, n = 1, 2, ...) have been spotlighted with versatile physical properties such as high-temperature superconductivity, colossal magnetoresistance. These emergent phenomena provide a platform for novel oxide-based electronic devices including spintronics application. However, high-quality RP-phase thin film growth has been disturbed by extended structural defects, such as out-of-phase boundaries (OPBs). OPB is a translational boundary between neighboring unit cells, shifted in a specific crystallographic direction. For instance, if RP-phase thin films grown on ABO₃ perovskite substrates, the structural mismatch between film and substrates induces a crystallographic shift in the c-axis direction, thus OPBs form at the film-substrate interface. Since OPB formation hampers the physical properties of RP-phase thin films, the suppression of the structural defects is highly required to carry out the high-performance RP-phase based functional devices. In this study, we suppressed OPB suppression in RP-phase oxide thin films by atomic-scale interface engineering. As model systems, the unconventional superconductor Sr₂RuO₄ (bulk Tc ~ 1.5 K) and La2-xSrxCuO₄ (bulk Tc ~ 39 K) thin films were employed. Despite the structural similarities between films and substrates, Sr2RuO4 and La2-xSrxCuO₄ films exhibited huge OPB formations. By controlling the atomic-scale interface engineering, the OPBs were significantly suppressed in the film structure. Notably, these OPB-free Sr₂RuO₄ and La2-xSrxCuO₄ thin films exhibited highly enhanced superconductivity than the film with huge OPB formation. Our study suggests a comprehensive method to suppress OPB formation in RP thin films, enabling superconducting spintronics devices based on the unconventional superconductivity.
Jinkwon Kim,Youngdo Kim,Junsik Mun,Jeong Rae Kim,Miyoung Kim,Changyoung Kim,Tae Won Noh 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1
Over the past decades, Ruddlesden-Popper (RP) phase oxides (A<sub>n+1</sub>B<sub>n</sub>O<sub>3n+1</sub>, n = 1, 2, ...) have been spotlighted with advantageous physical properties such as high-temperature superconductivity, giant magnetoresistance. <sup>[1-2]</sup> These emergent phenomena provide a platform for novel oxide-based electronic devices including spintronics application. However, high-quality RP-phase thin film growth has been disturbed by extended structural defects, so-called out-of-phase boundaries (OPBs).<sup>[3]</sup> OPB is a translational boundary between neighboring unit cells, shifted in a specific crystallographic direction. For instance, if RP-phase thin films grown on ABO<sub>3</sub> perovskite substrates, the structural mismatch between film and substrates induces a crystallographic shift in the c-axis direction, thus OPBs form at the film-substrate interface. Since OPB formation hampers the physical properties of RP-phase thin films, the suppression of the structural defects is highly required to carry out the high-performance RP-phase based functional devices.<sup>[4-5]</sup> In this study, we suppressed OPB suppression in RP-phase oxide thin films by using single-terminated LaSrAlO4 substrate (n = 1 RP phase, a = b= 3.756 Å and c =12.636 Å). As a model system, the high-T<sub>c</sub> cup rates superconductor La<sub>1.85</sub>Sr<sub>0.15</sub>CuO4 thin film (n = 1 RP phase, a = b= 3.777 Å and c =13.226 Å) was employed. Despite the structural similarities between films and substrates, the La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films exhibited huge OPB formations when deposited on mixed-terminated LaSrAlO4 substrate. In contrast, when the La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films were deposited on single-terminated LaSrAlO4 substrates, the OPBs were significantly suppressed in the film structure. Notably, these OPB-free La<sub>2-x</sub>Sr<sub>x</sub>CuO<sub>4</sub> films exhibited highly enhanced superconductivity (T<sub>c</sub><sup>zero</sup> ~ 30 K) than the film with huge OPB formation (T<sub>c</sub><sup>zero</sup> ~ 5 K) under the same thickness (~ 6.5 nm). Our study suggests a comprehensive method to suppress OPB formation in RP thin films, enabling superconducting spintronics devices based on RP-phase high-T<sub>c</sub> superconductors.[5-6]
김영직 ( Youngjik Kim ),양영도 ( Youngdo Yang ),박소진 ( Sojin Park ),임대재 ( Daejae Yim ),김아련 ( Aryeon Kim ),이상준 ( Sangjun Lee ),신지훈 ( Jihoon Shin ),김영운 ( Youngwun Kim ) 한국폐기물자원순환학회(구 한국폐기물학회) 2018 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2018 No.-
핫멜트 접착제는 열가소성 수지를 기초로 하여 수지 단독, 또는 점착부여제, 왁스 등과 혼합한 100% 고체로써 가열 용융에 의해 접착되기 때문에 접착의 가역성, 단시간 접착, 무공해의 장점을 가져 널리 사용되고 있다. 대표적인 핫멜트 접착제의 조성은 에틸린 바이닐아세테이트(EVA, ethylene vinylacetate)계가 대부분이며, 폴리에스테르, 열가소성 에폭시, 폴리아미드, 폴리우레탄 등이 사용되고 있다. 본 연구에서는 폐식물유 기반 모노머인 다이머산 메틸에스테르(dimer acid methyl ester, DAME)를 활용하여 다양한 바이오 또는 석유계 기반 di-acid와 diol 단량체와 축합중합법을 이용하여 높은 분자량을 가지는 폴리에스테르를 합성하였다. 모노머의 조성을 변화하며 합성한 폴리에스테르를 DAME 함량에 따른 특성을 분석하였다. <sup>1</sup>H, <sup>1</sup>3C NMR, SEC분석을 통해 구조와 분자량을 확인하였으며, 공중합체의 열적거동을 DSC, TGA를 통하여 분석하였다. 인장강도시험을 통하여 기계적 특성을 분석하였다.
적외선 가연성가스 센서의 입출력 특성 및 캘리브레이션 연구
김승모(Seungmo Kim),박규태(Gyoutae Park),김병덕(Byuongduk Kim),조영도(Youngdo Jo),김희식(Hiesik Kim) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.11
In this paper, we conducted a study of the calibration to grasp the input and output characteristics of the two types of gas sensors to be used in a flammable gas detector. In fact, when developing gas detectors, there are many difficulties, which the specifications listed in the sensor and the measured data values are not matched each other. It is necessary validation and calibration of specifications when sensors are used practically. In this study, the output voltages were measured by inputs of 8 kinds of standard gases into the two types of infrared gas sensor. The linear regression function derived by using least square estimation to represent the output voltages. When inverting the derived linear regression function and actually measuring its approximation equation, errors occur due to pressure of gas injection, temperature, humidity and nonlinearity of circuits. In order to reduce these errors and optimize responses of sensor"s inputs and outputs, we adjusted the slope and offset of the designed equation. Also, it is confirmed through experiment that the output according to the input is linear other than before.