Approach for visualizing research trends

Sang-Jun Yea,Chul Kim 한국콘텐츠학회 2014 International Journal of Contents Vol.10 No.1

Research Trends Analysis through Journals on Traditional Korean Medicine

Yea Sang-Jun,Seong Bo-Seok,Kim Chul 한국콘텐츠학회 2014 한국콘텐츠학회 ICCC 논문집 Vol.- No.-

Effect of Grafted Myofibrillar Protein on Physicochemical Properties of Enhanced Whole Cooked Ham

Yea-Ji Kim,Tae-Kyung Kim,Hyun-Jung Yun,Jake Kim,Ji Yoon Cha,Jun Young Ahn,Jae Hoon Lee,Yun-Sang Choi 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Effects of the Cultural and Environmental Differences between Smart Farming and Practical Farming on the Growth of Pot-mum

Yea Lim Kim,Sang Kun Park 한국화훼학회 2020 한국화훼학회 정기총회 및 학술발표회 자료집 Vol.28 No.1

The Effects of International Entrepreneurial Orientation and Entrepreneurial Activities on SMEs’ Export Performance

Sung-Joon Yoo,Hag-Min Kim,Yea-Rim Lee 한국무역학회 2019 Journal of Korea trade Vol.23 No.7

Purpose - Without question, globalization has presented different opportunities to entrepreneurs seeking to expand their companies in foreign markets. The aim of this study is to examine the relationship between entrepreneurial orientation, entrepreneurial activity, information internalization, and product differentiation in export oriented firms. As such, entrepreneurial activities are divided into exploitative and exploratory opportunities. These opportunities are crucial in improving firms’ performance. Design/methodology - A structural questionnaire was developed using 21 factors/indicators from previous researches. The subjects of this study were recruited using convenience sampling in export SMEs in the Seoul Metropolitan Area. Data were collected through visits or e-mails from the export managers, executives, and CEOs of export SMEs in advance. 321 questionnaires were collected over a period of one month. 316 questionnaires were used in the final analysis. Findings - First, International Entrepreneurial-orientation (IE) has a positive effect on the exploration and exploitation of business opportunities. Second, the exploration and exploitation of business opportunities have a positive impact on information internalization. Third, information internalization has a significant effect on product differentiation and plays a mediating role in seeking opportunities, utilizing opportunities, and differentiating products. Originality/value - This study contributes to the development of academic discussions by explaining existing research gaps. First, there is currently a lack of research focusing precisely on the product differentiation capability of SMEs in manufacturing field in terms of IE. To bridge these gaps, we examined the entrepreneurial factors impact on product differentiation and tries to expand the discussion about the internationalization of SMEs, which were mainly focused on IT companies, and manufacturing companies. Second, there is no intuitive explanation regarding international entrepreneurial activity in terms of exploration and exploitation within existing. In this study, international entrepreneurship activities were classified in terms of exploration and exploitation.

[P323] A case of vulvar intraepithelial neoplasia in a patient with kidney transplantation

( Yea Son Lee ),( Min Sung Kim ),( Bong Seok Shin ),( Chan Ho Na ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Vulvar intraepithelial neoplasia(VIN) is a high-grade intraepithelialsquamous lesion and precursor of invasive squamouscell carcinoma. Theclassification distinguished twotypes of VIN: usual type (human papillomavirus(HPV)-related)and differentiated type (not HPV-related). There is a close relationship with other genital and extragenital premalignant and malignant condition, immunosuppression, and lichen sclerosus.A 44-year-old woman presented with a 1-month history of painful multiple various sized eyrthematous hyperkeratotic maculopapules and plaques with oozing on vulva.On past history, there was a kidney transplantation10 years ago and she had taken antihypertensive and immunosuppressive medications. Histopathological examination revealedbasal layer involvement, enlarged nuclei, hyperchromatic, pleomorphic, andincreased numbers of mitotic figures. The pap smear and ultrasonography were within normal limit. HPV typing was positive with 6 and 11. Topical 5% imiquimod cream was initiated. After 1 week, she refused to use the treatment due to burning sensation.Later on, treatment with cryotherapy was appliedevery 2 week, resulting in the resolution of most lesions. Herein, we report a case of vulvar intraepithelial neoplasia in a patient with kidney transplantation successfully treated with cryotherapy.

Genetic Variations and Haplotypes of UDP-glucuronosyltransferase 1A Locus in a Korean Population

Yea, Sung Su,Lee, Sang Seop,Kim, Woo-Young,Liu, Kwang-Hyeon,Kim, Hyojin,Shon, Ji-Hong,Cha, In-June,Shin, Jae-Gook Lippincott Williams Wilkins, Inc. 2008 Therapeutic drug monitoring Vol.30 No.1

Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important mechanisms for host defense against xenobiotics and endobiotics. Although genetic polymorphisms of several UGT1A isoforms have been reported separately, the haplotypes in all functional exons have not been identified, and little information is available regarding single nucleotide polymorphisms in Koreans. We analyzed genetic polymorphisms in all functional exons of the UGT1A locus by direct sequencing of genomic DNA from 50 healthy Korean subjects, and their haplotypes were inferred from genotype data using an expectation-maximization algorithm. We identified 67 polymorphisms, including three novel single nucleotide polymorphisms, 233C>T in UGT1A1 (T78M), 292C>T in 1A4 (Q98Stop), and 701T>C in 1A7 (I234T). Two amino acid substitutions, 1A4 Q98Stop and 1A7 I234T, were each associated with a decrease of enzymatic activity, whereas UGT1A1 T78M had no significant influence on catalytic function. The frequencies of the known variants in Koreans differed significantly from those reported in other ethnic groups. Haplotype analysis was performed within the polymorphisms in each UGT1A isoform as well as across the isoforms. Based on strong linkage disequilibrium within UGT1A7, between 1A5 and 1A4, and within 1A3, the complex was divided into three blocks, Block 7, Block 5/4, and Block 3. The haplotypes for each block were subsequently determined, revealing a profile that differed from those of other ethnic groups. These results suggest that genetic polymorphisms of the UGT1A locus differ between Koreans and other ethnic populations. Such differences should be considered in pharmacogenetic studies.

Mapping Korean Medicinal Material Concepts to UMLS

Kim, Jin-Hyun,Jang, Hyun-Chul,Kim, Sang-Kyun,Kim, Chul,Yea, Sang-Jun,Jeon, Byoung-Uk,Song, Mi-Young The Society of Korean Medicine 2011 대한한의학회지 Vol.32 No.6

Objectives: This pilot study was carried out with the purpose of suggesting a methodology on mapping and registering Korean medicinal material concepts at 2011AB of the UMLS. Methods: 411 medicinal material concepts were mapped to biomedical terminology within the metathesaurus of the UMLS. Based on the forms of listing on the UMLS and thesauri information, the medicinal material concepts were classified into three groups and mapped. Results: 76 concepts in Group 1 which English CUIs have Chinese AUIs were mapped considering scientific names and Chinese strings. 259 concepts in Group 2 that have CUIs in the form of 'botanical name/Chinese pinyin' were mapped with the information of Korean and Chinese Pharmacopoeias. Groups 3, 76 concepts of English names in the Korean Pharmacopoeia are matched considering their botanic names and used parts. Conclusion: This study suggested a methodology to map Korean medicinal material concepts to international standard terminology, which will help ensure interoperability and compatibility between traditional medicine terminology and the UMLS.

Effects of Tested Pack Containing Plant Extracts on Elasticity and Size of Women’s Breasts

Yea Hun Choi(최예훈),Min-Kyung Park(박민경),Yong Gyun Kim(김용균),Sang Mong Lee(이상몽),Hong Joo Son(손홍주),Hyean Cheal Park(박현철),Sun Tae Kim(김선태),In Soo Choi(최인수),Keun Ki Kim(김근기) 한국생명과학회 2012 생명과학회지 Vol.22 No.3

본 연구는 콩과식물과 허브식물 및 국내 자생식물체들로부터 estrogen 생성과 대사에 활성을 나타내는 물질을 발굴하기 위하여, 12종의 식물체로부터 식물 유래의 isoflavone류를 포함한 2차대사산물을 용매로 추출하여 지방세포의 지방합성과 축적에 활성을 조사하였다. 활성을 보이는 Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens 5종의 식물체 용매추출물을 전체중량의 3% 되게 첨가하여 천연 팩을 제조하였으며 임상실험을 통하여 가슴의 탄력과 크기변화에 미치는 영향을 조사하였다. C. lanceolata 추출물을 25 μg/ml 농도로 처리한 곳에서 3T3-L1의 세포성장을 control과 비교했을 때 130% 이상 증가시켰으며, 지방의 축적은 S. repens H2O 추출물을 처리한 곳에서 190% 정도 지방축적량이 많았으며, C. lanceolata와 P. bambusoides EtOH 추출물을 처리한 곳에서도 각각 145%와 154% 활성이 높게 나타났다. 지방합성을 촉진하는 식물체추출물들을 첨가하여 천연 팩을 제조하였으며, 제조한 팩으로 더마프로에 가슴크기 변화와 탄력에 미치는 영향 등의 임상실험을 의뢰하였다. 임상 실험 결과, 가슴둘레, 탄력, 볼륨이 모두 유의적으로 향상되는 것을 확인할 수 있었고. 효능에 관한 설문평가 결과, 사용효과 항목에서 80% 이상의 긍정적으로 답하였으며, 사용 후 2주간 효과에 대해 65%이상이 긍정적인 응답을 하였다. 사용성 설문평가 결과 또한 피험자의 90%이상이 긍정적으로 평가하였다. 피부 안전성 평가에서는 피험자 6명이 사용 중 가려움을 호소하였으나, 그 증상이 미약하여 사용에는 문제가 없었으며, 1명은 사용 3일 후 홍반이 관찰되었으나 5일 후 소멸되었고, 그 외의 다른 이상반응은 관찰되지 않아 인체에 대한 부작용의 문제는 없었다. 이상의 연구 결과, Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens의 추출물을 혼합하여 첨가한 겔타입의 팩 제조물은 여성의 가슴크기 향상과 탄력유지에 유효하다는 사실을 세포수준의 실험과 임상실험에서 그 효과를 확인 할 수 있었다. In this study, we purified the extracts from the seeds and the roots of various plant species, including Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens, and then investigated the effects of these extracts on cell growth and fat accumulation in adipocytes. We found that the extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens more effectively increased the cell growth, as well as promoting the fat accumulation in adipocytes to a greater extent, than other extracts in vitro. Therefore, we made breast packs containing these effective extracts, and then investigated whether they were effective in enhancing the elasticity and volume of women’s breasts. The measurements of breast elasticity and size revealed that the breast packs efficiently increased the elasticity and size of women’s breasts. Furthermore, evaluation of the questionnaires related to usage of the breast packs indicated great satisfaction in terms of the lift, firmness, and elasticity of breasts. In conclusion, extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens leading to cell growth and fat accumulation in adipocytes can effectively contribute to improving the elasticity and size of women’s breasts.

The Design of Integrated Service Model for Traditional Korean Medical Statistics

Sang-Jun Yea,Chul Kim,Hyun-Chul Jang,Sang-Kyun Kim,Jin-Hyun Kim,Mi-Young Song 한국콘텐츠학회 2011 한국콘텐츠학회 ICCC 논문집 Vol.- No.-