성·재생산 건강과 권리에 대한 국제적 정책 추세와 한국에 주는 함의

김새롬 ( Kim¸ Saerom ) 한국보건사회연구원 2021 국제사회보장리뷰 Vol.18 No.-

성·재생산 건강과 권리는 임신·출산·양육과 돌봄을 담당하는 여성의 몸에 대한 인구통제정책 비판을 통해 발견된다. 1995년 베이징 세계여성대회 이후 주류화된 인권 규범이다. 유럽연합을 비롯한 국제사회에서 성·재생산 건강에 대한 국가 전략과 정책이 수립되고 있다. 미국에서는 바이든 정부 집권 이후 국제금지규정이 철폐되고 인구주택총조사에 성적 지향과 젠더 정체성 문항이 포함되는 등 성·재생산 건강과 권리에 대해 보다 진보적인 정책이 추진되고 있다. 한국에서는 제4차 저출산고령사회 기본계획에서 최초로 성·재생산권 보장이 공식 정책 목표로 포함되었지만, 이를 추진하기 위한 기반은 부족한 상태다. 국가 중심의 인구통제와 재생산하는 몸을 도구화한다는 비판과 불신을 벗어나 사람 중심적 대응을 위해 성·재생산 건강과 권리라는 규범적·실용적 관점을 채택한 정책을 설계해 나가야 한다.

Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer.

Kim, Jung Ho,Hwang, You-Jin,Han, Sang Hoon,Lee, Young Eun,Kim, Saerom,Kim, Yoon Jae,Cho, Jae Hee,Kwon, Kwang An,Kim, Ju Hyun,Kim, Se-Hee WJG Press 2015 WORLD JOURNAL OF GASTROENTEROLOGY Vol.21 No.34

<P>To elucidate the effects of dexamethasone on hypoxia-induced epithelial-to-mesenchymal transition (EMT) in colon cancer.</P>

Alginate/bacterial cellulose nanocomposite beads prepared using <i>Gluconacetobacter xylinus</i> and their application in lipase immobilization

Kim, Ji Hyun,Park, Saerom,Kim, Hyungsup,Kim, Hyung Joo,Yang, Yung-Hun,Kim, Yong Hwan,Jung, Sang-Kyu,Kan, Eunsung,Lee, Sang Hyun Elsevier 2017 Carbohydrate polymers Vol.157 No.-

<P><B>Abstract</B></P> <P>Alginate/bacterial cellulose nanocomposite beads, with well-controlled size and regular spherical shapes, were prepared in a simple manner by entrapping <I>Gluconacetobacter xylinus</I> in barium alginate hydrogel beads, followed by cultivation of the entrapped cells in culture media with a low sodium ion concentration. The entire surface of the alginate hydrogel beads containing the cells was covered with cellulose fibers (∼30nm) after 36h of cultivation. The cellulose crystallinity index of the alginate/bacterial cellulose beads was 0.7, which was slightly lower than that of bacterial cellulose prepared by cultivating dispersed cells. The water vapor sorption capacity of the alginate/bacterial cellulose beads increased significantly from 0.07 to 38.00 (g/g dry bead) as cultivation time increased. These results clearly indicate that alginate/bacterial cellulose beads have a much higher surface area, crystallinity, and water-holding capacity than alginate beads. The immobilization of lipase on the surface of the nanocomposite beads was also investigated as a potential application of this system. The activity and specific activity of lipase immobilized on alginate/bacterial cellulose beads were 2.6- and 3.8-fold higher, respectively, than that of lipase immobilized on cellulose beads. The alginate/bacterial cellulose nanocomposite beads prepared in this study have several potential applications in the biocatalytic, biomedical, and pharmaceutical fields because of their biocompatibility, biodegradability, high crystallinity, and large surface area.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Alginate/bacterial cellulose (BC) beads with well-controlled size and shape were prepared. </LI> <LI> Alginate/BC beads showed high surface area, high crystallinity, and high water-holding capacity. </LI> <LI> Alginate/BC beads were more favorable than alginate beads for lipase immobilization. </LI> <LI> Alginate/BC beads have many potential applications in biocatalytic, biomedical, and pharmaceutical fields. </LI> </UL> </P>

Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal Study

Kim Jung-Ah,Bang Hae In,Shin Jeong Won,Park Yoonhye,Kim Saerom,Kim Mi-Young,Jang Eui Young,Shin Woo Yong,Kim Jieun,Park Rojin,Choi Tae Youn 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.6

Following the original severe acute respiratory syndrome coronavirus 2 strain (Wuhan-Hu-1) in December 2019, the Delta variant in May 2021 and the Omicron variant in December 2021 were classified as variants of concern. The pandemic has been ongoing for more than two years, and the three-dose vaccination rate has reached approximately 50% in Korea. We analyzed anti-S antibodies (Abs) and neutralizing Abs (NAbs) in 32 healthcare workers at a university hospital, focusing on the first to third doses of ChAdOx1-ChAdOx1-BNT162b2, which is the most common vaccination regimen in Korea. Antibodies were analyzed at eight time points according to the vaccine regimen. The first to third doses of ChAdOx1-ChAdOx1-BNT162b2 produced high Ab concentrations; NAb concentrations after the third dose were predicted to remain high for a longer period than those after the first and second doses. The effectiveness of a second dose of ChAdOx1 in the real world was demonstrated by analyzing samples collected during an outbreak that occurred in the study period, 4–5 months after the second dose. The relative risk ratio was 88.0%, and the efficacy of the second ChAdOx1 dose was 12.0% (P<0.05). Therefore, maintaining appropriate Ab concentrations through regular vaccination will help protect against coronavirus disease-19.

한국 전공의들의 근무환경, 건강, 인식된 환자안전: 2014 전공의 근무환경조사

김새롬 ( Kim Saerom ),김승섭 ( Kim Seung-sup ),김자영 ( Kim Ja Young ) 한국보건사회연구원 2015 保健社會硏究 Vol.35 No.2

본 연구는 한국 전공의들의 근무환경과 건강, 환자안전 관련 현황을 파악하기 위한 단면조사연구이다. 2014년 전공의 11,564명을 대상으로 설문조사를 실시하였으며, 인턴 359명과 25개 전문과목의 레지던트 1,386명의 자료를 분석하였다. 기술분석을 통해 전공의들의 인구사회학적 특성과 근무환경과 건강상태, 환자안전 관련변수의 분포를 확인하였으며 간접표준화를 통해 전공의들의 건강상태를 전일제 일반근로자집단과 비교 하고 표준화유병비를 제시하였다. 분석 결과 전공의들은 주 평균 93시간을 근무하고 있었다. 지난 3개월간 인턴 중 13.1%, 61.5%, 10.2%가, 지난 12개월간 레지던트 중 11.4%, 44.4%, 6.0%가 각각 직장 내 신체적 폭력, 욕설 등 언어폭력, 성희롱 및 원치 않는 성적 관심을 경험한 것으로 나타났다. 또한 전공의들은 전일제 일반근로자집단과 비교하였을 때 유의하게 높은 수준의 근골격계 증상과 우울증상, 그리고 자살생각을 보고하였다. 환자안전과 관련하여 지난 3개월 동안 인턴 13.8%와 레지던트 8.7%가 의료과실을, 인턴 89.3%와 레지던트 68.6%가 주의집중실패를 경험한 것으로 밝혀졌다. 한국 전공의들의 근무환경과 건강, 그리고 이와 관련된 환자안전에 대해 보다 심층적인 연구와 대안의 모색이 필요하다. We conducted a nationwide survey in 2014 to understand working conditions, health and perceived patient safety among medical interns/ residents in South Korea. The survey included 359 interns and 1,386 residents from 25 medical specialties. On average, interns/residents worked 93 hours per week. The prevalence of physical, verbal, sexual violence in the preceding 3 months of interns was 13.1%, 61.5%, and 10.2% while that of residents in the preceding 12 months was 11.4%, 44.4%, and 6.0%, respectively. Regarding health conditions, interns and residents reported significantly higher prevalence of all physical (e.g., musculoskeletal pain) and mental health problems (e.g., depressive symptoms) compared to full-time waged workers. Over the preceding 3 months, the prevalence of medical error and attentional failure was 13.8% and 89.3% among interns, while the figures for residents were 8.7% and 68.6%. This is the first nationwide survey about Korean medical interns/residents. Future studies are required to investigate how the work environment is related to health conditions of interns/residents, and patient safety outcomes in South Korea.

The Prevalence of and Factors Associated with Influenza Vaccination in Patients with Asthma in Korea

( Sang Hyuk Kim ),( Sungmin Zo ),( Hwasik Jung ),( Saerom Kim ),( Ho Joo Yoon ),( Jang Won Sohn ),( Tae-hyung Kim ),( Sang-heon Kim ),( Ji-yong Moon ),( Dong Won Park ),( Tai Sun Park ),( Hye Yun Park 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Patients with asthma are at high risk of hospitalization and death from influenza infection, which Results in an additional burden on the medical system. However, despite the crucial role of influenza vaccination in preventing influenza infection and its complication, detailed epidemiologic data regarding influenza vaccination among patients with asthma is lacking. This study aimed to investigate the rate of influenza vaccination and factors associated with the vaccination in patients with asthma using nationally representative survey data. Methods Among 72,843 participants of the Korea National Health and Nutrition Examination Survey between 2010 and 2019, 760 patients with self-reported physician-diagnosed asthma were included in this study. The outcome was the influenza vaccination rate assessed by questionnaire. Logistic regression analysis was performed to evaluate factors associated with not being vaccinated in patients with asthma. Results The overall influenza vaccination rate was 63.7% in patients with asthma and there was no significant change in the vaccination rate (range 58.7%-70.0%) during the study period. In multivariable logistic regression analysis, younger age (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 1.07-1.16, p < 0.001), lower income (aOR 2.76, 95% CI 0.77-3.80, p = 0.040), and the presence of respiratory symptoms (aOR 2.56, 95% CI 1.22-5.36, p = 0.012) were associated with the increased odds of being unvaccinated for influenza. Conclusion The vaccination rate in patients with asthma was stable, ranging from approximately 60% to 70% between 2010 and 2019 in Korea. As patients with younger age, lower income, or respiratory symptoms might be non-adherent to influenza vaccination, more attention is needed in these patients to increase the influenza vaccination rate. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, Information and Communications Technologies (MSIT) (NRF-2020R1F1A1070468 and NRF-2021M3E5D1A01015176).

Bacterial cellulose–carbon nanotube composite as a biocompatible electrode for the direct electron transfer of glucose oxidase

Kim, Young‐,Hoo,Park, Saerom,Won, Keehoon,Kim, Hyung Joo,Lee, Sang Hyun John Wiley Sons, Ltd 2013 Journal of chemical technology and biotechnology Vol.88 No.6

<P><B>Abstract</B></P><P><B>Background</B></P><P><B>Bacterial cellulose (BC)‐based materials have many potential applications in the biomedical field because of their inherent biocompatibility. Carbon nanotubes (CNTs) have been used as electrode materials owing to their high electrical conductivity. In this study, BC‐CNT composite electrodes were prepared simply by directly filtering CNTs through BC hydrogel and vacuum drying the BC hydrogel containing the CNTs. Glucose oxidase (GOx) was immobilized on BC‐CNT composite electrodes.</B></P><P><B>Results</B></P><P><B>Cyclic voltammograms revealed that the BC‐CNT‐GOx electrodes had a pair of well‐defined peaks. The formal redox potential peak was –496 mV (vs. Ag/AgCl), which agreed well with that of FAD/FADH<SUB>2</SUB>. This result clearly indicates that direct electron transfer occurred between GOx and the BC‐CNT composite electrode. In addition, the GOx immobilized on the electrode retained its catalytic ability to oxidize glucose.</B></P><P><B>Conclusion</B></P><P><B>Conductive BC‐CNT composite films form a good biocompatible electrode for the direct electron transfer of glucose oxidase. They have many potential applications in the biomedical field such as biosensors, biofuel cells, and bioelectronic devices. © 2012 Society of Chemical Industry</B></P>

Poor People and Poor Health: Examining the Mediating Effect of Unmet Healthcare Needs in Korea

Kim, Youngsoo,Kim, Saerom,Jeong, Seungmin,Cho, Sang Guen,Hwang, Seung-sik The Korean Society for Preventive Medicine 2019 Journal of Preventive Medicine and Public Health Vol.52 No.1

Objectives: The purpose of this study was to estimate the mediating effect of subjective unmet healthcare needs on poor health. The mediating effect of unmet needs on health outcomes was estimated. Methods: Cross-sectional research method was used to analyze Korea Health Panel data from 2011 to 2015, investigating the mediating effect for each annual dataset and lagged dependent variables. Results: The magnitude of the effect of low income on poor health and the mediating effect of unmet needs were estimated using age, sex, education level, employment status, healthcare insurance status, disability, and chronic disease as control variables and self-rated health as the dependent variable. The mediating effect of unmet needs due to financial reasons was between 14.7% to 32.9% of the total marginal effect, and 7.2% to 18.7% in lagged model. Conclusions: The fixed-effect logit model demonstrated that the existence of unmet needs raised the likelihood of poor self-rated health. However, only a small proportion of the effects of low income on health was mediated by unmet needs, and the results varied annually. Further studies are necessary to search for ways to explain the varying results in the Korea Health Panel data, as well as to consider a time series analysis of the mediating effect. The results of this study present the clear implication that even though it is crucial to address the unmet needs, but it is not enough to tackle the income related health inequalities.

Outcomes of Intravenous Tigecycline-containing Multidrug Regimens for Mycobacterium Abscessus Subspecies Abscessus Pulmonary Disease

( Saerom Kim ),( Hojoong Kim ),( O Jung Kwon ),( Byung Woo Jhun ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Mycobacterium abscessus subspecies abscessus-pulmonary disease (M. abscessus-PD) is difficult to treat due to its resistance to conventional antibiotics. This study was performed to evaluate the microbiological response to tigecycline-containing regimens versus the conventional regimen without tigecycline. Methods We reviewed 61 consecutive patients with M. abscessus-PD receiving a multidrug regimen with or without intravenous tigecycline in the initial phase at Samsung Medical Center between April 2013 and August 2020. All patients with M. abscessus-PD were treated with conventional agents, including amikacin (intravenous or inhaled), imipenem/cefoxitin, macrolide, clofazimine, linezolid, or rifabutin, while the tigecycline group also received tigecycline for 2 or 4 weeks during the initial phase. Results The study population had a median age of 59 years and 79% were female. Fifty-four (89%) patients had nodular bronchiectatic disease, and the most common underlying condition was a previous history of tuberculosis (54%). Of these patients, 25 (41%) received 2 or 4 weeks of intravenous tigecycline, and the remaining 36 (59%) were treated with multidrug regimens without tigecycline. Acid-fast bacilli culture negativity rate at 1 month after treatment was significantly higher in the tigecycline group than the non-tigecycline group (88% [22/25] vs. 51% [18/36], respectively, p = 0.007). However, the culture conversion rate at 12 months after treatment was not different between the two groups (16% [4/25] vs. 27% [10/36], respectively, p = 0.509). Acquired resistance to macrolide at 6 months after treatment occurred in one and three patients in the tigecycline group and non-tigecycline group, respectively (p = 0.929). Conclusions Short-term intravenous tigecycline therapy during the initial phase may improve early microbiological response in patients with M. abscessus-PD. However, the short-term use of tigecycline did not improve the long-term culture conversion rate of M. abscessus-PD. Therefore, further studies on the efficacy of prolonged intravenous tigecycline-containing regimens are needed.

Economic and environmental sustainability and public perceptions of rooftop farm versus extensive garden

Kim, Euna,Jung, Jihyeun,Hapsari, Gita,Kang, Seju,Kim, Kibeum,Yoon, Saerom,Lee, Miran,Han, Mooyoung,Choi, Yongju,Choe, Jong Kwon Elsevier 2018 Building and environment Vol.146 No.-

<P><B>Abstract</B></P> <P>Green roofs have become popular in urban areas as a solution to restore green space in cities and mitigate urban problems. In this study, the economic and environmental sustainability of using green roofs for rooftop agriculture (i.e., roof farms) is evaluated and compared with that of using green roofs as extensive gardens of flowers and non-edible plants with low maintenance (i.e., roof gardens) based on these two green roofs that were installed and operated for over five years in a university building in Seoul, Korea. The life cycle cost analysis results show that the total cost of the roof garden is 38.9% lower than the flat roof whereas the total cost of the roof farm is 68.3% higher than the roof garden. The environmental impacts of both the roof garden and farm were 2.4–35 times as high as those of the flat roof. The need to frequently replenish the lightweight soil over its lifetime was the main contributor to both the economic cost and environmental impacts of the roof farm, suggesting a need to develop cost-effective and environmentally benign lightweight soil materials. A survey was also conducted to investigate public preferences and perceptions of these two green roof options. Over 80% of the respondents expressed the necessity for green roofs in urban areas, and 79.3% preferred roof gardens over farms. Our results show that roof farms have several merits in urban areas, especially social benefits, but future research should focus on improving their economic and environmental sustainability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Use of green roofs as rooftop farm versus extensive garden is evaluated. </LI> <LI> The life cycle cost of roof garden is lower than flat roof, but roof farm was higher. </LI> <LI> Lightweight soil is the main economic and environmental contributor of roof farm. </LI> <LI> A survey study showed that 79.3% of respondents preferred roof gardens over farms. </LI> <LI> Economic and environmental sustainability of roof farms should be further improved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>