牛黃淸心元의 長期投與가 血中 水銀 濃度와 血球 및 肝, 腎機能에 미치는 影響

金東雄 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

牛黃淸心元은 韓醫學의 代表的인 救急藥으로 卒中風 및 各種 精神神經系疾患에 活用되고 있는 處方이다. 牛黃, 朱砂를 비롯한 30種의 藥物의 複合處方으로 되어 있으며 樓成藥物中에는 朱砂, 雄黃, 金 等 金屬性藥物이 들어 있어 使用시 恒常 重金屬에 의한 副作用이 念慮된다. 특히 朱砂 黃化水銀(HgS)을 主成分(86.2%)으로 하는 天然鑛石으로서 黃化水銀은 無機水銀에 該當된다. 現在 많은 中風患者가 朱砂가 包含된 牛黃淸心元을 服用 하고 있어 이로 인한 副作用을 살펴보고자 朱砂가 包含된 牛黃淸心元을 長期間 投藥하였던 卒中風 患者들을 對象으로 血中 水銀 濃度 및 肝機能, 賢機能, 尿中의 變化을 觀察하여 人體에 對한 毒性 與否를 살펴보았다. 硏究方法으로 投藥前後의 血中 水銀 濃度와 血中의 白血球,血色素,血小板數値와 血淸 AST(Aspatate aminotransferase)와 ALT (Alanine aminotransferase), BUN (Blood urea nitrogen)과 Creatinine, 尿糖과 尿蛋白을 測定하여 投藥後 人體에 미치는 影響을 觀察 하였다. The purpose of this dinical study is to confirm the side effect of Woohwangchungsimwon in the inpatients with acute stroke. The subjects of this study were 13 inpatients in Intemal Medicine department, Wonkwang University Hospital of Oriental Medicine from June, 1994 to february, 1997. They were confirmatively diagnosed as stroke by Brain CT or MRI. Woohwangchungsinwon was administrated and the results were follows. 1. Woowhangchungsinwon 21.08±2.99 pellets was averagely given per oral in hospital. Initial serum Mercury concentration level was 1.34±0.51 ㎍/㎗, and then follow up level was 2.10±1.14 ㎍/㎗, but it was within normal limit. 2. Initial serum ALP, AST, ALT, BUN, Creatinine were 7.35±1.76 KUA, 26.54±5.06U/L, 13.32±2.49 ㎎/㎗, 1.13 ±0.15 m㎎/㎗, then follow up levels were 6.16±1.39 KAU, 20.30±4.17 U/L, 29.46±5.81 U/L, 14.46±5.81 ㎎/㎗, 1.03 ± 0.23 ㎎/㎗, but they were not valuable. According to the above mentioned results, Woohwangchungsinwon should not induce the acute mercury intoxication.

한의학적 응급치료를 받은 급성기 뇌경색환자의 혈압변화에 대한 임상적 고찰

金東雄 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

뇌혈관 질환은 심혈관질환과 악성종양과 더불어 주요한 사망원인으로서 뇌혈관 질환을 발생시키는 요인 중 고혈압은 주된 위험인자이며 많은 급성 뇌졸중환자에서 고혈압을 관찰할수 있다. 따라서 고혈압의 치료는 뇌혈관 질환을 예방할 수 있는 효과적인 방법이나 뇌졸중 발생후 고혈압의 치료는 아직 논란의 여지가 있으며 특히 뇌경색에 있어서는 초기의 과도한 혈압 강하가 뇌혈류의회복에 도움이 되지 않는다는 것이 밝혀졌다. 한의학에서 뇌혈관질환 즉 中風은 本虛表實하고 上盛下虛한 증상으로,급성기에는 本虛의 증상이 있으나 表寶의 증상이 위주가 되고 病程의 변화가 급격하므로 治表하는 것이 원칙으로 調氣,順氣,割痰,疏風,滋陰시키는 治法이 응용된다. 본 연구는 원광한의대 전주 한방병원에 입원치료 하였던 급성 뇌경색 환자들중 WHO 기준에 의하여 고혈압으로 진단된 53명(남:55 명,여 28명,평균연령 65.77세)의 환자들을 대상으로 한의학적인 응급치료를 하며 4주간 혈압의 변화를 관찰하였다. 결과:입원후 24시간 안정후의 혈압은 평균 수축기 150.18± 10.46mmHg,이완기 94.77± 4.89mmHg였으며 이후 일주일간씩의 수축기 및 이완기의 혈압 평균은 1주 수축기 135.90±13.25mmHg 이완기 85.28±7.19mmHg,2주 수축기 134.17±11.07mmHg 이완기 84.85±6.37mmHg, 3주 수축기 133.47±10.nmmHg 이완기 84.44±6.89mmHg,4주 수축기 135.25 ± 12.44mmHg 이완기 85.01 ±7.10mmHg으로서 입원후 24시간 안정후의 혈압과 비교하여 수축기와 이완기 혈압 모두에서 유의한 (P<O.05)저하를 보였으나 2주이후의 혈압의 저하는 유의하지 않았으나(P>0.05) 정상 범위내의 혈압으로 하강하였다. 이상의 결과로 한의학적 응급치료를 시행하는 뇌경색 초기의 환자는 과도한 혈압의 강하를 위한 치료는 1주일이상 환자의 혈압을 면밀히 관찰한후 시행되어 져야 할것으로 사료되었다. Cerebrovascular diaease is the third leading cause of mortality following coronary heart disease and malignancies. Cerebrovascular disease is a common cause of morbidity and mortality, espedally in the elderly. Hypertension is one of the most important cerebrovascular risk factors. Hypertension is seen in 80% of acute stroke patients. Treatment of hypertension is effective in the primary prevention of stroke. By increasing the number of treated hypertensive patients and by increasing the effectiveness of treatment it is possible to achieve a decline of the cerebrovascular mortality. But the dinical significance of post-stroke hypertension is uncertain and its management is a contentious issue. In 53 patients from the Won Kwang Oriental hospitals with acute cerebral infarction(25 men; 28 woman; median age, 65.77 years) , we prospectively studied BP changes between admission and 4 weeks. In this study patients receiving no antihypertensive medication after stroke and they were treated with oriental medical emergency care include herb medicine and acupuncture. RESULTS: Systolic and diastolic BP at admission is 150.18±10.46mmHg and 94.77±4.89mmHg. Systolic and diastolic BP fell by 14.28 mm Hg (95% confidence interval [Cl]) and 8.49 mm Hg (95% CI) respectively, in the first week but no further thereafter. CONCLUSIONS: We have demonstrated a marked fall in systolic and diastolic BP levels during the first 7 days in cerebral infarction patients who were treated with oriental medical emergency care, with little change thereafter. This study suggest that antihypertensive medication should be avoided in patients with acute cerebral infarction unless vital organs are compromised, the diastolic BP rises to 130 mm Hg or greater, or the patient has hypertensive encephalopathy.

韓國 大學生의 大學生活 適應에 關한 硏究 : 第二部 成大生의 大學生活 適應 Part II : Scholastic Adjustment of SKK Students

韓東一,吳圓哲,金榮敦,韓德雄 성균관대학교 학생생활연구소 1976 學生指導硏究 Vol.3 No.1

Spherical Harmonics 전개방법에 의한 간단한 이원자 분자의 쌍극자 모멘트의 계산

오세웅,김동희 木浦大學校基礎科學硏究所 1988 基礎科學硏究誌 Vol.6 No.-

The dipole moments for LiH, BH, NH, BF, and LiF molecules are calculated using the expansion method for spherical harmonics. The calculated numerical values of dipole moments for these molecules are agreement with the previous results. The orientation of dipole moments follows as ??, and ??.

당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

최우정,김동웅,신선호,이언정,최진영,신학수,조권일,이광석 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the "Deficiency in Origin and Excess in Superficiality(本虛表實)“points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.

새로운 세정 Bath Type 의 제안 및 유동현상해석에 따른 타당성 평가

함승주,강운용,김동주 호서대학교반도체제조장비국산화 연구센터 2000 반도체 장비기술 논문집 Vol.2000 No.-

기존의 bath가 가지고 있는 문제점을 해결하기 위해 tapered manifold의 유체배출 흐름 특성을 살펴보고 가시화 기법을 이용하여 2면 overflow방식의 bath 내부 flow pattern을 살펴보았다. 그 결과 4면 overflow 방식에 비해 균일한 흐름이 얻어졌으며 치우침현상도 개선된 형태를 보여주었다. 또한 bath 내에 rod를 장착하는 rod upflow 방식이 제안하여 이에 대한 simulation을 수행하였다. 이 경우에 있어서 중요한 공정변수로는 bath 내 rod와 rod 간의 간격, inlet의 너비, rod와 bath와의 간격 등이다. 먼저 inlet 이 4곳인 겨우2-D simulation 결과 벽면쪽 inlet 에서만 흐름이 있는 경우 bath 내에서 균일한 흐름을 얻을 수가 있었다. 이를 바탕으로 하여 2-D simulation 에서 안쪽의 rod로 인해 보였던 와류 (vortex) 현상을 개선하고자 inlet이 2곳인 경우 3-D simulation을 수행하였으나 큰 소용돌기가 생겼고 flow pattern이 균일하지 못했다. 이에 inlet 이 균일하지 못했다. 이에 inlet 이 4곳인 새로운 bath를 제안하여 simulation 을 수행한 결과 벽면쪽 inlet 에서 도입유량이 60 ℓ이고, rod와 rod 사이의 거리는 2mm, rod의 지름이 10mm, inlet의 너비는 1mm, bath와 rod 사이의 간격이 2mm인 경우에 wafer가 위치한 곳에서 large size vortex로 인해 전체적으로 균일한 흐름이 얻어 졌다.

增損五積丸(碑積方)이 사람의 各種 癌細胞株의 成長沮碍에 미치는 效果

李竝求,元秦喜,文錫哉,金東雄,元京淑,文九 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

chemosensitivity test of Geungsonojukwhan-Bijukbang was performed on the three different human cancer cell lines originated from liver, cervix and colon tissue, namely Hep 3B, Hela and HCT-15, which have similar doubling times. Semiautomated sulforhodamine B(SRB) assay appears to offer an valuable tool for chemosensitivity of unknown compounds, since it is a simple, valid and inexpensive method of assessing drug monitoring for large samples in a short time. The results obtained in this study were as follows 1. Good correlations were shown from the results of SRB assay and those of clogenetic assay. 2. As a result of exposure to Geungsonojukwhan, the proliferation of Hela cell and Hep 3B cell was slightly decreased in Geungsonojukwhan-Bijukbang(GIP), Geungsonojukwhan-Pejukbang(LUP) and Geungsonojukwhan-Sinjukbang(RTP). 3. As a result of exposure to Geungsonojukwhan, GIP showed better anticancer effect to HCT-15 cell lines than those of LUP and RTP. 4. The extract of Geungsonojukwhan-Bijukbang in 40℃ were more effective in cytotoxic response than those in 100℃. 5. The research showed that the higher concentration the more effective in the inhibition of proliferation of the cancer cell lines, however, the cytotoxic effect of Geungsonojukwhan-Bijukbang in the concentration of 1.60mg/㎖ and 3.20mg/㎖ showed the most effective inhibition rate according to the increase of concentration.

Changes in Blood Lipid Profile and Hepatic Enzyme Levels after Oriental Medical Treatment to Metabolic Syndrome Patients with Abnormal Liver Function

Kim, Dong-Woung The Physiological Society of Korean Medicine and T 2008 동의생리병리학회지 Vol.22 No.6

Among patients who are receiving treatments at an oriental medical hospital for various symptoms and diseases, patients whose main disease is accompanied by metabolic syndrome with abnormal liver function. This research was performed in order to observe the progression of changes in the liver function and serum lipid profile after the oriental medical treatments to patients who have been receiving oriental medical treatment for various other diseases and have been diagnosed as having metabolic syndrome at their first visit to the hospital based on NCEP ATP III diagnosis criteria and WHO Asia Pacific region criteria. Total number of subject patients were 39cases(mean age:55.58${\pm}$2.09 years) which had 20 male and 19 female. For the references for hepatic enzyme levels and blood lipid profile were measured in before treatment and four times after treatments(every 2.31${\pm}$06.17 weeks). Serum AST was 48.86${\pm}$7.46 IU/L before oriental medical treatment. After the treatment, 40.63${\pm}$4.69, 43.12${\pm}$5.46, 37.82${\pm}$4.52 IU/L were measured where although the level decreased to the normal level compared to pre-treatment, the value was not significant statistically(P>0.05). ALT was 66.26${\pm}$11.01 IU/L before oriental medical treatment. After the treatment 62.10${\pm}$8.20, 61.10${\pm}$8.76, 43.79${\pm}$5.68 were measured where although the level decreased, abnormally high level was maintained. The last result was significant statistically(P<0.05) compared to pre-treatment. ALP was 193.06${\pm}$14.20 IU/L before oriental medical treatment. After the treatment, 176.80${\pm}$6.48, 177.46${\pm}$11.81, 162.41${\pm}$9.06 where although compared to pre-treatment the last result was significant statistically(P<0.05), the change was within the normal range. ${\gamma}$-GGT was 87.83${\pm}$12.59 IU/L before oriental medical treatment. After the treatment, progressively near normal level was achieved with 118.73${\pm}$46.45, 85.03${\pm}$17.12, 70.64${\pm}$10.93 and the last result was statistically significant compared to pre-treatment (P<0.05). Blood triglyceride was 217.63${\pm}$32.18 mg/dL before oriental medical treatment. After treatment 215.09${\pm}$22.18, 189.93${\pm}$22.44, 191.22${\pm}$18.51 where abnormal values continued even after treatment although results was not statistically significant compared to pre-treatment(P>0.05). Total-cholesterol was 197.28${\pm}$9.24 mg/dL before oriental medical treatment, after treatment 201.55${\pm}$11.13, 186.87${\pm}$8.77 and 186.68${\pm}$7.61 were measured that results were not statistically significant compared to pre-treatment(P>0.05). HDL-cholesterol was 41.88${\pm}$2.38 mg/dL before oriental medical treatment, after treatment 48.75${\pm}$4.22, 44.10${\pm}$1.91, 48.00${\pm}$2.06 the results were not statistically significant compared to pre-treatment(P>0.05). LDL-cholesterol was 111.66${\pm}$13.08 mg/dL before oriental medical treatment, after treatment 109.94${\pm}$10.18, 101.79${\pm}$8.63, 104.00${\pm}$6.98 the results were not statistically significant compared to pre-treatment(P>0.05). With such results, even if common oriental medical treatments were given to metabolic syndrome patients with abnormal liver function, the liver function was confirmed not to be aggravated, and the concentration of lipids in the blood was confirmed not to be affected in most patients.

Pseudoaneurysm of the Inferior Thyroid Artery Presenting as a Thyroid Nodule

Kim, Hua Sun,Kim, Jinna,Kim, Eung Yeop,Lee, Seung-Koo,Kim, Dong Ik,Chung, Woung Youn Mary Ann Liebert 2009 Thyroid Vol.19 No.1

<P>A 63-year-old woman complained of a growing neck mass. Sonography revealed a solid and cystic mass in the right thyroid lobe. Color Doppler study and computed tomography revealed anechoic cystic portions within the thyroid nodule to be a pseudoaneurysm arising from the right inferior thyroid artery. The only identifiable risk factor was a past thyroid needle biopsy performed approximately 5 years previously according to the patient's recollection. Right lobectomy was performed and the pseudoaneurysm was treated without complication.</P>