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KIM, Bongtae,AHN, Kyoung Kyu,HA, Yooncheol,LEE, Yong Hoon,KIM, Duyeol,LIM, Jeong Han,KIM, Sung-Hoon,KIM, Mi-Young,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.5
<P>The relationship between tumor necrosis factor (TNF)-α level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-α was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-α concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (<I>P</I><0.05) and steady thereafter. Mean rectal temperatures were above 40°C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-α in BAL fluids from pigs experimentally infected with SIV (<I>r</I><SUB>s</SUB>=0.9754, <I>P</I><0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF- α (<I>r</I><SUB>s</SUB>=0.9949, <I>P</I><0.001). The results suggest that the expression of TNF-α protein plays an important role in induction of pulmonary lesion and clinical sign such as fever in SIV infection.</P>
KIM, Bongtae,LEE, Kichan,HAN, Kiwon,KIM, Duyeol,HA, Yooncheol,KIM, Chung Hyun,OH, Yeonsu,KANG, Ikjae,LEE, Jeehoon,CHAE, Chanhee Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.9
<P>The aim of this study was to develop <I>in situ</I> hybridization for detection of <I>Mycoplasma hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from pigs with polyserositis. <I>M. hyorhinis</I> was isolated from the spleen (2 pigs) and pericardium (1 pig). <I>M. hyorhinis</I> DNA was detected 16 out of 20 pigs with polyserositis. <I>In situ</I> hybridization produced a distinct positive signal for the <I>M. hyorhinis</I> p37 gene in inflammatory cells in the polyserositis. <I>In situ</I> hybridization developed in the present study present diagnostic tools capable of detection of <I>M. hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from the naturally infected pigs.</P>
Han Sungpil,Choi Hee Youn,Kim Yo Han,Choi SeungChan,Kim Seokuee,Nam Ji Yeon,Kim Bongtae,Song Geun Seog,Lim Hyeong-Seok,Bae Kyun-Seop 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively control nocturnal acid breakthrough. To evaluate the pharmacodynamics of tegoprazan versus dexlansoprazole regarding nocturnal acid breakthrough in healthy subjects. Methods: In a randomized, open-label, single-dose, balanced incomplete block crossover study, 24 healthy male volunteers were enrolled and randomized to receive oral tegoprazan (50, 100, or 200 mg) or dexlansoprazole (60 mg) during each of two administration periods, separated by a 7- to 10-day washout period. Blood samples were collected for pharmacokinetic parameter analysis; gastric monitoring was performed for pharmacodynamic parameter evaluation. Results: All 24 subjects completed the study. Average maximum plasma concentration, area under the plasma concentration–time curve, and mean time with gastric pH >4 and pH >6 for tegoprazan demonstrated dose-dependent incremental increases. All the tegoprazan groups reached mean pH ≥4 within 2 hours, whereas the dexlansoprazole group required 7 hours after drug administration. Based on pharmacodynamic parameters up to 12 hours after evening dosing, 50, 100, and 200 mg of tegoprazan presented a stronger acid-suppressive effect than 60 mg of dexlansoprazole. Moreover, the dexlansoprazole group presented a comparable acid-suppressive effect with the tegoprazan groups 12 hours after dosing. Conclusions: All the tegoprazan groups demonstrated a significantly faster onset of gastric pH increase and longer holding times above pH >4 and pH >6 up to 12 hours after evening dosing than the dexlansoprazole group.
Moo-Young Song,Sang-Koo Park,Chang Seok Kim,Tae Hyoung Yoo,Bongtae Kim,Min-Soo Kim,김용성,Won Jae Kwag,Byung-Kyu Lee,백광희 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1
In order to develop an anti-human TNF-α mAb, mice were imunized with recombinant human TNF-α. A murine mAb, TSK114, which showed the highest bind-ing activity for human TNF-α was selected and characterized. TSK114 specifically bound to human TNF-α without cross-reactivity with the homologous α and human TNF-β. TSK114 was found to be of IgG1 isotype with κ light chain. The nucleotide se-quences of the variable regions of TSK114 heavy and light chains were determined and analyzed for the us-age of gene families for the variable (V), diversity (D), and joining (J) segments. Kinetic analysis of TSK114 binding to human TNF-α by surface plasmon reso-nance technique revealed a binding affinity (KDpM, which is about 1,000- and 100-fold higher than those of clinically relevant infliximab (Remicade) and adalimumab (Humira) mAbs, respectively. TSK114 neutralized human TNF-α-mediated cytotoxicity in proportion to the concentration, exhibiting about 4-fold greater eficiency than those of infliximab and adalimumab in WEHI 164 cells used as an in vitro model system. These results suggest that TSK114 has the po-α-neutr-alizing antibody with picomolar affinity.
Seo, Hyeon-Seok,Han, Bongtae,Kim, Youn-Jea American Scientific Publishers 2012 Journal of nanoscience and nanotechnology Vol.12 No.6
<P>A new type of electrokinetic micromixer with a ring-type channel is introduced for fast mixing. The proposed mixer takes two fluids from different inlets and combines them in a ring-type mixing chamber. The fluids enter two different inlets (inner radius: 25 microm and outer radius: 50 microm), respectively. The total channel length is 500 microm, and four microelectrodes are positioned on the outer wall of the mixing chamber. The electric potentials on the four microelectrodes are sinusoidal with time, having various maximum values of voltage, zeta potential and frequency. Also, in order to compare the mixing performance with different obstacle configurations, we performed a numerical analysis using a commercial code, COMSOL. The concentration of the dissolved substances in the working fluid and the flow and electric fields in the channel were investigated and the results were graphically depicted for various flow and electric conditions.</P>
이경희,윤장우,류원,김봉태,Lee, Kyounghee,Yoon, Changwoo,Ryu, Won,Kim, Bongtae 대한임베디드공학회 2008 대한임베디드공학회논문지 Vol.3 No.4
The convergence of broadcasting and telecommunication services is being accelerated by broadband networks, digital broadcasting and Web2.0. This paper describes the definition and service characteristics of IPTV as a representative of broadcasting and telecommunication convergence services. Especially, the changes of infrastructure and technology for IPTV2.0 are addressed in terms of the service features of mobility, intelligence and participation. IPTV2.0 shall be characterized by the open IPTV service based on Web2.0 and the mobile IPTV service over the heterogeneous networks employing various wireless/wired access technologies. The IP Multimedia Subsystem (IMS) and Service Delivery Platform (SDP) technologies are increasingly considered to support the personalization and openness. The mobility management technology is being evolved to provide QoS-guaranteed mobile communication services to users at anytime and anywhere. IPTV2.0 services and platforms are also anticipated to be core components to achieve knowledge-based ubiquitous society. IPTV2.0 contents are required to be integrated with the enhanced metadata to efficiently support search, selection, convergence and delivery of the contents. Moreover, those contents shall be enhanced to provide the scalable services which is adaptable to the network status and user preferences. Therefore, the networking technologies for IPTV2.0 should tightly cooperate with application services and adaptive contents. Those technologies will be developed to construct the ubiquitous content service platform considering the evolution of networks and various converged services.