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Junho Hyun,Jae Yeong Cho,Jong-Chan Youn,Darae Kim,Dong-Hyuk Cho,Sang Min Park,Mi-Hyang Jung,Hyun-Jai Cho,Seong-Mi Park,Jin-Oh Choi,Wook-Jin Chung,Byung-Su Yoo,Seok-Min Kang 대한심장학회 2023 Korean Circulation Journal Vol.53 No.7
The Korean Society of Heart Failure (KSHF) Guidelines provide evidence-based recommendations based on Korean and international data to guide adequate diagnosis and management of heart failure (HF). Since introduction of 2017 edition of the guidelines, management of advanced HF has considerably improved, especially with advances in mechanical circulatory support and devices. The current guidelines addressed these improvements. In addition, we have included recently updated evidence-based recommendations regarding acute HF in these guidelines. In summary, Part IV of the KSHF Guidelines covers the appropriate diagnosis and optimized management of advanced and acute HF.
Alpha-gal IgE measurement in red meat allergy patients using bovine thyroglobulin and cetuximab
( Dong Hyun Kim ),( Kyung Hee Park ),( Da Woon Sim ),( Young Joo Kim ),( Junho Kim ),( Jong Sun Lee ),( Hee Jae Han ),( Hye Jung Park ),( Jae-hyun Lee ),( Jung-won Park ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Introduction: Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate epitope in red meat allergy (RMA). Alpha gal sensitized RMA patients suffered from delayed hypersensitivity reactions after red meat consumption. Detection of α-Gal -sIgE is important for diagnosis of RMA. Bovine thyroglobulin and cetuximab shared antigenic epitope with α-Gal. Objective: In this study, we aimed to detect α-Gal-sIgE using bovine thyroglobulin and cetuximab for differential diagnosis of α-Gal allergy patients. Methods: Two patients with suspected symptoms of red meat allergy (RMA) were enrolled. Sera of the patients were collected with written informed consents. For comparison, beef and pork sensitized patients without allergic symptom were also enrolled (FP, false positive group). Sera of 2 negative control (NC) patients were also compared. We measured IgE antibodies against beef, pork, bovine thyroglobulin, and cetuximab in their sera by ImmunoCAP method. BTG and cetuximab were biotylated and coated on streptavidine ImmunoCAP. Specific IgE ≥ 0.35 kUA/L was considered as positive. Results: Two RMA patients experienced urticaria after 3 hours of red meat consumption. They were sensitized to beef and pork. FP patients did not experienced allergic reaction with red meat. However, sIgE to beef and pork were elevated. NC patients were not sensitized to beef or pork. Thyroglubulin-specific IgE was detected in four patients without NC group. Cetuximab-specific IgE was detected in only RMA group. However, FP group did not have cetuximab-specific IgE. sIgE against cetuximab were increased only in 2 RMA patient’s sera. Both thyroglubulin and cetuximab-specific IgE showed 100% of sensitivity. Regard with specificity, Cetuximab-sIgE (100%) was higher than thyroglobulin (50%). Conclusions: All subjects who had a delayed hypersensitivity reaction to red meat, IgE antibodies against bovine thyroglobulin and cetuximab were detected. The antibodies were specific for galactose-α 1,3 galactose (α-Gal). ImmunoCAP tests of bovine thyroglobulin and cetuximab are useful for red meat allergy.
Reliability-based structural design framework against accidental loads – ship collision
Koh, Hyun-Moo,Lim, Jeong-Hyun,Kim, Hyunjoong,Yi, Jiwoon,Park, Wonsuk,Song, Junho Taylor Francis 2017 STRUCTURE AND INFRASTRUCTURE ENGINEERING Vol.13 No.1
<P>As civil infrastructures become highly complex and interconnected, accidental events such as fire, explosion, dropped objects and collision tend to occur more frequently, and are causing critical structural damage and socio-economic costs. Therefore, accidental loads should be considered appropriately during the structural design. To achieve this goal, the paper presents a reliability-based structural design framework against accidental loads. The proposed framework employs a scenario-based simulation in which the occurrence of an accidental load event and the resulting structural loads are modelled probabilistically. The probabilistic distribution of accidental loads is then determined based on the occurrence probabilities of identified scenarios and the conditional probability of structural loads given each accident scenario. In order to estimate the structural responses under accidental loads, an appropriate type of structural analysis is carried out for the given limit states of the structural resistance at the critical sections. The proposed framework is illustrated by an example of a cable-stayed bridge whose piers are under ship collision risk. To consider the dynamic amplification of bridge response caused by ship-bridge collision, time history analysis is performed for the equivalent static ship collision loads. The paper also identifies research needs and challenges in applying the proposed framework to other accidental loads.</P>
Choe, Junho,Ryu, Incheol,Park, Ok Hyun,Park, Joori,Cho, Hana,Yoo, Jin Seon,Chi, Sung Wook,Kim, Min Kyung,Song, Hyun Kyu,Kim, Yoon Ki National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.43
<P>It has long been considered that intron-containing (spliced) mRNAs are translationally more active than intronless mRNAs (identical mRNA not produced by splicing). The splicing-dependent translational enhancement is mediated, in part, by the exon junction complex (EJC). Nonetheless, the molecular mechanism by which each EJC component contributes to the translational enhancement remains unclear. Here, we demonstrate the previously unappreciated role of eukaryotic translation initiation factor 4AIII (eIF4AIII), a component of EJC, in the translation of mRNAs bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein 80 (CBP80) and CBP20. eIF4AIII is recruited to the 5'-end of mRNAs bound by the CBC by direct interaction with the CBC-dependent translation initiation factor (CTIF); this recruitment of eIF4AIII is independent of the presence of introns (deposited EJCs after splicing). Polysome fractionation, tethering experiments, and in vitro reconstitution experiments using recombinant proteins show that eIF4AIII promotes efficient unwinding of secondary structures in 5'UTR, and consequently enhances CBC-dependent translation in vivo and in vitro. Therefore, our data provide evidence that eIF4AIII is a specific translation initiation factor for CBC-dependent translation.</P>