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A phosphodiesterase-5 inhibitor as a potential therapeutic effector following mild ischemic stroke
Juhyeon Kang,Yeon Hee Yu,Kahyun Lee,Gangho Kim,Jaehyeon Park,Kyounguk Lee,Hansol Lee,Whiin Lee,Seungwon Choi,Dae-Young Yoo,In Koo Hwang,Dae-Kyoon Park,Kyung-Ho Park,Man-Ryul Lee,Jae-Sang Oh,Duk-Soo Ki 대한체질인류학회 2018 대한체질인류학회 학술대회 연제 초록 Vol.61 No.-
Yeonjae Lee,Ryan Kang,Jenna Kwon,Kyuhee Jo,Jungbin Im,Sangwook Jung,DongHyun Lee,Juhyeon Lee,Jeong-Sang Lee 한국인터넷방송통신학회 2018 Journal of Advanced Smart Convergence Vol.7 No.2
Celiac disease (CD) is an immune-mediated enteropathy of small intestine diagnosed in both childhood and adulthood. CD is caused by gluten, which produces gliadorphin during its digestion. The enzyme dipeptidyl peptidase-4 (DPP4) breaks gliadorphin down nevertheless the last tripeptide remains and eventually inhibits DPP4, thus slowing down its process. Therefore, the idea is to produce an additional DPP4 enzyme which is crucial. Consequently, the functional DPP4 gene was cloned into pCDNA3 intermediate (FLAG+DPP4) vector and finally a recombinant plasmid pSB1C3 (Andersons promoters+ FLAG+DPP4) was constructed using synthetic biology. Normally, a DPP4 inhibitor is used as a cure for diabetes. Another important concern was overexpression of DPP4, which might lead to diabetes, accordingly the work was also performed for the regulation of the DPP4 gene expression. In this regard, three types of Anderson promoters (strong, moderate and weak) were utilized to study the control overexpression. This is the first report of idealistic trial for control the exogenous DPP4 gene-expression by molecular biologic tools.
Juhyeon Lee*,Chan Sub Park*,Jeong Hun Oh,In-Chul Park,Min-Ki Seong,Woo Chul Noh,Hyun-Ah Kim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.1
Purpose: Whether administering chemotherapy followed by tamoxifen plus a gonadotropin-releasing hormone (GnRH) agonist to treat patients with lower-risk hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer provides a greater benefit than administering tamoxifen plus GnRH agonist alone remains unclear. This study aimed to compare the outcomes of propensity score-matched (PSM) patients who underwent these 2 types of treatment plans. Methods: This retrospective study included patients treated at our institution between 2009 and 2019. Eligible patients had HR-positive, HER2-negative, invasive breast cancer who had undergone surgery. There were 579 patients with HR-positive, HER2-negative breast cancer who were treated with a GnRH agonist and tamoxifen; patients with pathologic N2 and those who received neoadjuvant chemotherapy were excluded. After 1:1 PSM of patients who underwent GnRH agonist treatment and tamoxifen with versus without chemotherapy, 122 patients from these 2 groups were analyzed. Survival rates were calculated using the Kaplan-Meier method and compared via the log-rank test. Results: After PSM, there were no significant differences in several baseline characteristics between the 2 groups. After a median follow-up of 62.8 months, the patients in both groups demonstrated similar outcomes with no significant difference in disease-free survival (P = 0.596). Conclusion: Patients derived no significant survival benefit from undergoing a chemotherapy regimen before receiving tamoxifen and GnRH agonist therapy compared to forgoing such chemotherapy.
Juhyeon Lee,Eung-Ho Cho,Sang Bum Kim,Ryounggo Kim 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4
Backgrounds/Aims: Intrahepatic recurrence is frequent result after hepatectomy for hepatocellular carcinoma (HCC). We analyzed the clinical results of patients who had the intrahepatic recurrences of HCC after curative surgical resections. Methods: From January 2009 to December 2016, 320 patients underwent curative surgical resection for HCC in department of Surgery, Korea Cancer Center Hospital. After surgical resection, 155 patients had suffered HCC recurrence during follow-up period. Among them, 122 patients had only intrahepatic recurrence initially, who were included in this retrospective study. We analyzed about the period of the recurrence after surgery, treatment methods for the recurred tumors, and poor prognostic factors for survival after intrahepatic recurrences. Results: Among the 122 patients, 83 patients had recurrence within 24 months after surgery. Thirty-eight patients underwent curative treatment for the recurred tumors (re-resection in 18, radiofrequency ablation in 20 patients). Non-curative treatments were performed in 77 patients (TACE in 68 patients, radiotherapy in 9 patients) and conservative management in 7 patients. Five-year survival rate of patients who underwent curative treatment is 86.4% (p≤0.001). Five-year survival rate of non-curative treatment is 55.7% (p≤0.001), conservative management is 0% (p=0.021). Among the clinical factors, non-curative treatment for recurred tumor, AFP level at the time of recurrence, size of recurred tumor were independent poor prognostic factors for survival after intrahepatic recurrences (p<0.001). Conclusions: For the patients who had intrahepatic recurrent HCC after surgery, aggressive local treatment can improve the prognosis in selective cases. Further study is necessary to validate this retrospective investigation.
Adaptive Spectrum Hole Prediction Scheme in Cognitive Radio Networks
Juhyeon Lee,Hyung-Kun Park 한국정보통신학회 2014 2016 INTERNATIONAL CONFERENCE Vol.6 No.1
Channel prediction is a useful method to provide efficient spectrum allocation in Cognitive Radio networks because it can predict future usage of channels and reduce interference to Primary Users. Generally, channel prediction is made by channel statistical parameters that are determined by past channel sensing information. However, if these statistical parameters change fast, the prediction performance can be degraded because determining the channel parameters requires a substantial period of time. In this paper, we propose an adaptive prediction scheme to improve the accuracy of the prediction in fast changing channel environment. We define the prediction error and adjust the prediction lengths by using the prediction error.
WiMAX 시스템에서 QoS에 기반한 Multi-Class 스케줄러
이주현(Juhyeon Lee),박형근(Hyung-Kun Park) 대한전기학회 2010 전기학회논문지 Vol.59 No.4
Mobile WiMAX system provides various classes of traffic such as real-time and non-realtime services. These services have different QoS requirements and the QoS aware scheduling has been an important issue. Although many of scheduling algorithms for various services in OFDMA system have been proposed, it is needed to be modified to be applied to Mobile WiMAX system. Since Mobile WiMAX supports five kinds of service classes, it is important to take QoS characteristics of each class into consideration. In this paper, we propose an efficient packet scheduling algorithm to support QoS of each class. Proposed scheme selects a service class first considering QoS Characteristics of each class and choose an appropriate user in the selected class. Simulation results show that the proposed algorithm has better performance than the other algorithm.
이주현(Juhyeon Lee),박형근(Hyung-Kun Park) 대한전기학회 2012 전기학회논문지 Vol.61 No.4
In Cognitive Radio network, spectrum selection scheme is one of a important part to manage idle spectrums efficiently. However, in CR networks, they have to adopt time-varying channel availability to minimize the interference to primary users (PU), and be able to manage spectrum resources efficiently. In this paper, we proposed a modified PF scheduler which can be appropriate to schedule downlink CR users and channels, by considering the fairness and the throughput as well as the primary user characteristics of each channel.