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Woo, Jongmin,Han, Dohyun,Wang, Joseph Injae,Park, Joonho,Kim, Hyunsoo,Kim, Youngsoo American Chemical Society 2017 Journal of proteome research Vol.16 No.9
<P>The development of systematic proteomic quantification techniques in systems biology research has enabled one to perform an in-depth analysis of cellular systems. We have developed a systematic proteomic approach that encompasses the spectrum from global to targeted analysis on a single platform. We have applied this technique to an activated microglia cell system to examine changes in the intracellular and extracellular proteomes. Microglia become activated when their homeostatic microenvironment is disrupted. There are varying degrees of microglial activation, and we chose to focus on the proinflammatory reactive state that is induced by exposure to such stimuli as lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Using an improved shotgun proteomics approach, we identified 5497 proteins in the whole-cell proteome and 4938 proteins in the secretome that were associated with the activation of BV2 mouse microglia by LPS or IFN-gamma. Of the differentially expressed proteins in stimulated microglia, we classified pathways that were related to immune-inflammatory responses and metabolism. Our label-free parallel reaction monitoring (PRM) approach made it possible to comprehensively measure the hyper-multiplex quantitative value of each protein by high resolution mass spectrometry. Over 450 peptides that corresponded to pathway proteins and direct or indirect interactors via the STRING database were quantified by label-free PRM in a single run. Moreover, we performed a longitudinal quantification of secreted proteins during microglial activation, in which neurotoxic molecules that mediate neuronal cell loss in the brain are released. These data suggest that latent pathways that are associated with neurodegenerative diseases can be discovered by constructing and analyzing a pathway network model of proteins. Furthermore, this systematic quantification platform has tremendous potential for applications in large-scale targeted analyses. The proteomics data for discovery and label-free PRM analysis have been deposited to the ProteomeXchange Consortium with identifiers <PXDO06558> and <PXDO06556>, respectively.</P>
Woo, Hyeonseok,Kim, Jongmin,Cho, Sangeun,Jo, Yongcheol,Roh, Cheong Hyun,Lee, Jun Ho,Seo, Yong Gon,Kim, Hyungsang,Im, Hyunsik,Hahn, Cheol-Koo Elsevier 2018 Superlattices and microstructures Vol.120 No.-
<P><B>Abstract</B></P> <P>An effective method for high-quality molecular beam epitaxy growth of InGaN/GaN multiple quantum wells is demonstrated by inserting an ultrathin low temperature GaN (LT-GaN) interlayer between InGaN well and conventional high temperature GaN (HT-GaN) barrier layers. The LT-GaN interlayer is fabricated using metal migration enhanced epitaxy at the same growth temperature for InGaN. A smooth LT-GaN surface with a low defect density is obtained and indium decomposition is not observed. Large emission blueshift is significantly suppressed and narrow linewidth photoluminescence emission is achieved. The improved optical properties of the InGaN/GaN MQWs with LT-GaN interlayers are due to reduced compositional fluctuation and improved interface roughness.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High quality epi-GaN is grown at a low temperature (590 °C) using metal migration enhanced MBE epitaxy. </LI> <LI> Surface roughness and defect density of low-temperature GaN are considerably improved. </LI> <LI> InGaN/GaN QWs with low-temperature epi-GaN insertion show significantly suppressed indium decomposition and single PL peak. </LI> </UL> </P>
Development of an accurate operational definition for asthma using decision tree model
( Woo Ho Ban ),( Chin Kook Rhee ),( Jongmin Lee ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Analysis of the National Health Insurance data has been actively carried out for the purpose of academic research and establishing scientific evidences for health care service policy in asthma. However, there has been a limitation for the accuracy of the data extracted through conventional operational definition. Aim : To establish an operational definition that predicts asthma more accurately. Methods: From Jan 2017 to Jan 2018, we extracted patients with asthma using the conventional operational definition in Seoul St. Mary’s Hospital and St. Paul’s Hospital at the Catholic University of Korea. Total 4,235 patients were extracted. Among these, 10% of patients were randomly sampled. And we excluded patients younger than 19 years of age and patients who didn’t visit pulmonology and allergy clinic. We developed a tree-based decision model using prescribed drugs to define asthma. Results: Total 353 patients were enrolled in this study. One hundred fifty nine (43.3%) patients were not eligible for asthma. Of these, 85 (24.1%) patients were chronic obstructive pulmonary disease, followed by bronchitis (n=21, 5.9%), bronchiolitis obliterans (n=20, 5.7%), solid malignancy (n=11, 3.1%), bronchiectasis (n=10, 2.8%) and others (n=12, 3.4%). By a tree-based decision model, overall accuracy was 85.2 %, sensitivity and specificity were 85.5 % and 84.8 %. Conclusions : The conventional operational definition of asthma has limitation to extract true asthma patients in real world. Therefore, it is necessary to establish an accurate standardized operational definition of asthma. This research was supported by a grant of the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI18C0522).
Effect of heating on electrical transport in AlGaN/GaN Schottky barrier diodes on Si substrate
Woo, Hyeonseok,Jo, Yongcheol,Kim, Jongmin,Roh, Cheonghyun,Lee, Junho,Kim, H.,Im, H.,Hahn, Cheol-koo,Park, Jungho Elsevier 2014 CURRENT APPLIED PHYSICS Vol.14 No.1
Thermal properties of the AlGaN/GaN Schottky barrier diodes were investigated, using a pulsed-IV measurement technique. The thermally degraded mobility in the DC-bias configuration was restored, when the pulse-bias voltages were applied. It was observed that heat generation was minimized, using a pulse width of 500 ns and pulse period of 10 ms. For the SBDs consisting of 5 mu m of anode-cathode distance, on-resistance measured by the pulse-IV and DC-IV were 1.6 and 6.2 Omega-mm, respectively. We also demonstrated the device-width dependence of the thermal properties of the SBDs. We found that the performance of the power devices can be greatly influenced by the heat generation. (C) 2013 Elsevier B.V. All rights reserved.
( Jongmin Lee ),( Chang Dong Yeo ),( Sang Haak Lee ),( Jin Woo Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: A high proportion of patients in whom neutropenia had been complicated by pneumonia during neutropenia recovery are related to an increased risk of acute lung injury (ALI) and detrimental outcomes. The aim of the present study is to investigate whether neutrophil elastase (NE) inhibition is effective in murine LPS-induced ALI during neutropenia recovery and whether NE inhibition suppresses the activation of Mer signaling pathway. Methods: Cyclophosphamide was given to mice to induce neutropenia. Mice were administrated by intratracheal instillation of LPS seven days after cyclophosphamide administration. Sivelestat, neutrophuil elastase inhibitor, was given by intraperitoneal injection once daily starting on day 0 and continuing until mice were sacrificed on day 5 (preventive group). In addition, sivelestat was given after, instead of before, LPS administration on day 2 (therapeutic group). Results: Sivelestat attenuated the lung edema and histopathological change of LPS-induced lung injury. The accumulation of neutrophils and the concentrations of TNF-a, IL-6 and MPO in BAL fiuids were effectively inhibited by sivelestat. The gene expression of Mer tyrosine kinase was increased by sivelestat treatment. Conclusions: Sivelestat significantly attenuated LPS induced ALI during neutropenia recovery. These findings suggest NE inhibition could be a promising target alleviating lung infiammation without increasing susceptibility to infection in ALI/ARDS during neutropenia recovery.
Evaluation of Long-term Performance of Metal Seal Through Accelerated Test
Woo-seok Choi,Jongmin Lim,Yun-young Yang,Sang Soon Cho 한국방사성폐기물학회 2020 방사성폐기물학회지 Vol.18 No.2(E)
사용후핵연료를 저장하는 볼트체결 저장용기의 격납경계를 형성하는 주된 구성요소는 금속 밀봉재이다. 이러한 금속 밀봉 재는 열과 방사선에 의해 그 성질이 저하된다. 또한, 금속 밀봉재가 강한 열에 장기간 노출되면 크리프 현상이 발생한다. 이러한 크리프는 밀봉시스템에 응력 이완을 가져와서, 결국 밀봉재의 건전성을 해치게 된다. 이러한 응력 이완은 금속 밀봉재의 밀봉성능 저하로 이어지며, 저하의 정도에 따라 저장용기의 누설을 야기할 수 있다. 또한, 볼트 체결력의 감소도 밀봉성능 저하에 영향을 미친다. 본 논문에서는 금속 밀봉재의 격납건전성과 볼트체결력 감소를 평가하기 위해 수행한 가속화 시 험의 결과에 대하여 기술한다. 전 시험기간 동안 각 시편에서의 누설률, 볼트 변형률, 금속 밀봉재 주변 온도를 계측하여 분석하였고, 금속 밀봉재는 저장기간 50년 동안 격납건전성을 유지함을 입증하였다. 또한, 가속화 시험의 타당성에 대해서 기술하였다. Metal seals are the main components that establish the containment boundary in bolted casks, which store spent nuclear fuel. These seals are degraded by heat and radiation. In addition, creep occurs when the seals are exposed to intense heat for an extended period. This creep results in the stress relaxation of the seals, which consequently impairs the seal integrity. The stress relaxation can reduce the sealing performance of the metal seal, which can further cause leakage in the storage cask. Moreover, the reduction of bolt tension leads to sealing performance degradation. In this study, the results of high-temperature-accelerated tests were obtained to evaluate the containment integrity of metal seals and the decrease in bolt tension. During the tests, the leakage rate, bolt strain, and ambient temperature of the metal seals were measured and analyzed. The metal seals were found to maintain containment integrity for 50 years of storage. The validity of the acceleration test was also investigated.
Drop-casted Polyaniline Thin Films on Flexible Substrates for Supercapacitor Applications
Jongmin Kim,J. Sohn,조용철,Hyeon Seok Woo,Jaeseok Han,조상은,INAMDARAKBAR IBRAHIM,김형상,임현식 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.9
The PANI (polyaniline) thin films are synthesized on flexible ITO/PET (indium tin oxide/polyethylene terephthalate) substrates by using the drop-casting method. The amount of thePANI for the drop casting varies from 0.04 to 0.16 g. The morphology of the drop-casted PANI filmsshows a porous vermicular shape. The electrochemical supercapacitor properties of the PANI filmsare examined in a 0.5-M LiClO4 + PC electrolyte. The PANI films with 0.08 g of PANI show highercurrent density and considerably higher specific capacitance and capacity retention, compared withother PANI films. The highest specific capacitance of the films with 0.08 g of PANI is found to be120 F/g, and the capacity retention is found to be as high as 70.51% after 100 charge-dischargecycles.
Woo, Hyeonseok,Kim, Jongmin,Cho, Sangeun,Jo, Yongcheol,Roh, Cheong Hyun,Kim, Hyungsang,Hahn, Cheol-Koo,Im, Hyunsik The Korean Vacuum Society 2017 Applied Science and Convergence Technology Vol.26 No.3
An InGaN/GaN multiple quantum well (MQW) structure is grown on a GaN/sapphire template using a plasma-assisted molecular beam epitaxy (PA-MBE). The fluctuation of the quantum well thickness formed from roughly-grown InGaN layer results in a disordered photoluminescence (PL) spectrum. The surface morphologies of the InGaN layers with various In compositions are investigated by reflection high energy electron diffraction (RHEED) and atomic force microscopy (AFM). A blurred InGaN/GaN hetero-interface and the non-uniform QW size is confirmed by high resolution transmission electron microscopy (HR-TEM). Inhomogeneity of the quantum confinement results in a degradation of the quantum efficiency even though the InGaN layer has a uniform In composition.