動作導演

賈磊磊(Jia Lei Lei) 중국문화연구학회 2004 중국문화연구 Vol.0 No.3

BRCA1 Reversion Mutation Confers Resistance to Olaparib and Camrelizumab in a Patient with Breast Cancer Liver Metastasis

Jia-Ni Pan,Lei Lei,Wei-Wu Ye,Xiao-Jia Wang,Wen-Ming Cao 한국유방암학회 2021 Journal of breast cancer Vol.24 No.5

Reversion mutations are associated with clinical resistance to poly(ADP-ribose) polymerase inhibitors (PARPi). Here, we describe the detection of a BRCA1 reversion mutation in a 39-year-old woman with metastatic breast cancer harboring a heterozygous germline BRCA1 exons 7–8 deletion who received PARPi olaparib combined with immune checkpoint inhibitor camrelizumab as third-line therapy. During progression from the olaparib and camrelizumab combination therapy, we identified via genomic sequencing a novel 7-base pair somatic deletion in BRCA1 (c.617_623delACAAATC). Sequence analyses indicated that this mutation realigned the reading frame of BRCA1, which potentially led to the reversal of its normal function and conferred resistance to PARPi.

Theoretical Analysis of Laser-Locked Spectroscopy Employing a Confocal Fabry-Perot Cavity

Lei Dong,Li Linfeng,suotang Jia,wangbao Yin,weiguang ma,Zhang Lei 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I

A theoretical analysis of laser-locked enhanced absorption spectroscopy employing a confocal Fary-Perot cavity (CFPC) is presented. The signal-to-noise ratio and the minimum detectable absorbance, which are limited by either the shot noise or the amplitude noise due to the loose laser lock loop, are also discussed in detail. The results show that the effective absorption path length of a CFPC configuration is the same as that of the conventional nonconfocal Fary-Perot cavity configuration, with the CFPC configuration being more convenient to align without deliberate mode matching. Thus, the CFPC configuration should greatly simplify the complications of conventional laser-locked spectroscopy.

Ag2Se Modified TiO2 Heterojunction with Enhanced Visible-Light Photocatalytic Performance

Lei Zhu,Jia-Yao Tang,Jia-Yi Fan,Chen-Sun,Won-Chun Oh 한국재료학회 2021 한국재료학회지 Vol.31 No.12

To build a highly active photocatalytic system with high efficiency and low cast of TiO2, we report a facile hydrothermal technique to synthesize Ag2Se-nanoparticle-modified TiO2 composites. The physical characteristics of these samples are analyzed by X-ray diffraction, scanning electron microscopy with energy dispersive X-ray analysis, transmission electron microscopy and BET analysis. The XRD and TEM results show us that TiO2 is coupled with small sized Ag2Se nanoplate, which has an average grain size of about 30 nm in diameter. The agglomeration of Ag2Se nanoparticles is improved by the hydrothermal process, with dispersion improvement of the Ag2Se@TiO2 nanocomposite. Texbrite BA-L is selected as a simulated dye to study the photodegradation behavior of as-prepared samples under visible light radiation. A significant enhancement of about two times the photodegradation rate is observed for the Ag2Se@TiO2 nanocomposite compared with the control sample P25 and as-prepared TiO2. Long-term stability of Ag2Se@TiO2 is observed via ten iterations of recycling experiments under visible light irradiation.

Melatonin Attenuates Noise Stress-induced Gastrointestinal Motility Disorder and Gastric Stress Ulcer: Role of Gastrointestinal Hormones and Oxidative Stress in Rats

( Lei Zhang ),( Ji T Gong ),( Hu Q Zhang ),( Quan H Song ),( Guang H Xu ),( Lei Cai ),( Xiao D Tang ),( Hai F Zhang ),( Fang E Liu ),( Zhan S Jia ),( Hong W Zhang ) 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.2

Background/Aims There are increasing evidences for gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. Methods Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. Results The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and malondialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). Conclusions Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and gastrointestinal hormones. (J Neurogastroenterol Motil 2015;21:189-199)

Wave propagation of graphene platelets reinforced metal foams circular plates

Lei-Lei Gan,Jia-Qin Xu,Gui-Lin She 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.5

Based on first-order shear deformation theory, a wave propagation model of graphene platelets reinforced metal foams (GPLRMFs) circular plates is built in this paper. The expressions of phase-/group- velocities and wave number are obtained by using Laplace integral transformation and Hankel integral transformation. The effects of GPLs pattern, foams distribution, GPLs weight fraction and foam coefficient on the phase and group velocity of GPLRMFs circular plates are discussed in detail. It can be inferred that GPLs distribution have great impacts on the wave propagation problems, and Porosity- I type distribution has the largest phase velocity and group velocity, followed by Porosity-III, and finally Porosity-II; With the increase of the GPLs weight fraction, the phase- and group- velocities for the GPLRMFs circular plate will be increased; With the increase of the foam coefficient, the phase- and group- velocities for the GPLRMFs circular plate will be decreased.

Microwave Assisted Synthesis of Graphene-Bi2MoO6 Nanocomposite as Sono-Photocatalyst

Jia-Yao Tang,Lei Zhu,Jia-Yi Fan,Chen-Sun,Won-Chun Oh 한국재료학회 2022 한국재료학회지 Vol.32 No.1

In this investigation, Bi2MoO6 deposited graphene nanocomposite (BMG) was synthesized using a simple microwave assisted hydrothermal synthesis method. The synthesized BMG nanocomposite was characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy with energy dispersive X-ray analysis, and photocurrent analysis. The study revealed that the catalysts prepared have high crystalline nature, enhanced light responsive property, high catalytic activity, and good stability. XRD results of BMG composite exhibit a koechlinite phase of Bi2MoO6. The surface property is shown by SEM and TEM, which confirmed a homogenous composition in the bulk particles of Bi2MoO6 and nanosheets of graphene. The catalytic behavior was investigated by the decomposition of Rhodamine B as a standard dye. The results exhibit excellent yields of product derivatives at mild conditions under ultrasonic/visible light-medium. Approximately 1.6-times-enhanced sono-photocatalytic activity was observed by introduction of Bi2MoO6 on graphene nanosheet compared with control sample P25 during 50 min test.

Hot deformation behavior of CNTs/Al-Li composite prepared by powder metallurgy

Jia Lei,Liu Yang,Xing Zhiguo,He Gengchao,Lu Zhenlin,Zhou Yongxin 한국탄소학회 2022 Carbon Letters Vol.32 No.5

CNTs/Al-Li composite was first prepared by hot-pressed sintering from Al-Li alloy powder and CNTs solution, and then the hot compression tests were performed on MMS-100 thermal simulator at strain rate range of 0.01– 10 s−1, deformation temperature range of 350–500 °C, and total deformation amount of 60%. True stress–strain curves were plotted, and constitutive equation as well as hot processing maps were successfully confirmed based on Arrhenius constitutive model and Prasad instability criterion. Results show that CNTs/Al-Li composite have a very poor hot deformation ability and narrow processing region, which is strain rate range of 0.1–1 s−1 and deformation temperature range of 360–400 °C. Hot extrusion experiment was carried out and the processing parameters were selected according to the established hot processing map, and an improvement on strength and a good balance between strength and plasticity can be obtained, which is about 650 MPa for tensile strength and 9% for elongation.

p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid

Liu, Jia,Wu, Ning,Ma, Lei-Na,Zhong, Jia-Teng,Liu, Ge,Zheng, Lan-Hong,Lin, Xiu-Kun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, it is still unclear that what molecular signaling is responsible for this effect. In this study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the molecular mechanisms underlying OA anti-tumor activity. We found that activation of MAPK pathways, including p-38 MAPK, JNK and ERK, was triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. Activation was accompanied by cleavage of caspases and PARP as well as cytochrome C release. SB203580 (p38 MAPK inhibitor), but not SP600125 (JNK inhibitor) and U0126 (ERK inhibitor), rescued the pro-apoptotic effect of OA on A549 and BXPC-3 cells. OA induced p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibited Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event was indispensable for p38 MAPK-dependent apoptosis in cancer cells. In vivo, p38 MAPK knockdown A549 tumors proved resistant to the growth-inhibitory effect of OA. Collectively, we elucidated that activation of ROS/ASK1/p38 MAPK pathways is responsible for the apoptosis stimulated by OA in cancer cells. Our finding can contribute to a better understanding of molecular mechanisms underlying the antitumor activity of nutritional components.

A Multiscale Analysis Method for Predicting the Transverse Mechanical Properties of Unidirectional Fibre-reinforced Composites

Wenbin Jia,Lei Fang,Zhi Chen,Kai Zhao,Hongmei Huang,Lei Pan 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6

Mechanical property prediction methods for composites are very important as theoretical tools for engineeringstructural design. To more accurately capture the transverse mechanical properties of composites, a multiscale analysismethod is developed in this paper. The multiscale analysis method includes three scales: (1) At the microscale, a microscopiccohesive model based on atomic potential energy is established for the interface; (2) At the mesoscale, a unit cell model isestablished for the fibre, matrix and interface; and (3) At the macroscale, the homogenization method, failure criteria anddamage degradation models are used for predicting the transverse mechanical properties. Subsequently, the transversemechanical properties and the damage evolution process are simulated with the multiscale analysis method. A comparisonbetween the simulations and experiments shows that the maximum error of the predicted transverse modulus and transversestrength is -4.45 % and -12.05 %, respectively. Finally, the effects of the interfacial strength on the macroscopic transversemechanical properties and the damage onset are analysed. The following conclusions are drawn from the simulation results:(1) The interfacial strength has a more significant effect on the transverse strength and ultimate strain than on the transversemodulus; (2) Decreasing the interfacial strength has a greater effect on the transverse modulus, strength and ultimate strainthan increasing the interfacial strength; and (3) The interfacial strength can change the damage onset.