직장 Dieulafoy 병변으로 다량의 혈변을 보인 1 예

김태영;이상헌;김지현;배영환;정은주;김승만;지삼룡;설상영 인제대학교 2011 仁濟醫學 Vol.32 No.-

Dieulafoy’s lesion is very rare cause of gastrointestinal bleeding, Deiulafoy’s lesion is exposure of non ulcerative, abnormally large tortuous, thick- walled artery in the muscularis mucosa through a small submucosal defect. It is usullay found on stomach antrum and lesser curvature side of the proximal body, and possibly found on any sites throughout whole gastrointestinal tract, but rarely on rectum. The principal of treating Dieulafoy’s lesion was the surgical resection of lesion, but recently remarkable advances in endoscopic technique make endoscopic approach more popular. We report a case of rectal Dieulafoy’s lesion successfully treated with endoscopic hemoclipping in an elderly female patient.

Preparation of new natural silk non-woven fabrics by using adhesion characteristics of sericin and their characterization

Lee, Ji Hye,Bae, Yeon Su,Kim, Su Jin,Song, Dae Woong,Park, Young Hwan,Bae, Do Gyu,Choi, Jin Hyun,Um, In Chul ELSEVIER 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.106 No.-

<P><B>Abstract</B></P> <P>Electro-spun regenerated silk webs have been extensively studied for biomedical applications because of the simplicity of their fabrication methods However, the productivity of the electro-spinning process is low for web fabrication and the mechanical properties of the electro-spun silk web are not satisfactory, which restricts its commercialization. In this study, a new silk non-woven fabric was successfully fabricated by wetting and hot press treatments using the excellent binding characteristic of sericin. The effects of the press temperature and residual sericin content on the preparation, structure, and properties of the silk non-woven fabric were examined. A press temperature of 200°C was optimum for obtaining non-woven fabrics with best mechanical properties, without yellowing. The silk non-woven fabric could not be fabricated without sericin, and a minimum of 8% sericin was required to fabricate it. As the sericin content was increased, the strength and Young’s modulus of the silk non-woven fabric increased, while the tensile elongation remained constant. Regardless of the press temperature and sericin content, all the silk non-woven fabrics showed good cell viability, comparable to that of the tissue culture plate (TCP) used as a control until 4days, which however decreased compared to that of TCP after 7days.</P>

Fe-0.7%C-2.3%Si강의 미세조직과 기계적 성질에 미치는 잔류 오스테나이트 변태 거동

손제영 ( Je Young Son ),권도영 ( Do Young Kwon ),김지훈 ( Ji Hun Kim ),김원배 ( Won Bae Kim ),예병준 ( Byung Joon Ye ) 한국주조공학회 2012 한국주조공학회지 Vol.32 No.3

This steel has been synthesized integrating concepts from Austempering Ductile Cast Iron (ADI) technology. While ADI has excellent mechanical and physical properties, the Young`s modules of ADI is approximately 20% lower than steel. In addition, the presence of graphite nodules in ADI can be sites of crack initiation, where fracture takes place at graphite matrix interface. Because of this limitations of ADI, there has been a growing interest in austempered steels as structural materials in resent years. In this investigation, a new steel with microstructure composed of ferrite and austenite and with simultaneous high tensile strength (1,150MPa) and high ductility (33%) was developed. The goal of this investigation is to obtain a better understanding of deformation and transformation behaviour in high carbon retained austenite(γHC) and over-saturated ferrite(α) during the plastic deformation. A detailed study of the microstructure of this steel was carried out by means of X-ray diffraction (XRD) and electron back scattering diffraction (EBSD) technic. In this way it was shown that BCC phase (BCC) took up the larger part of the nominal strain whereas the a part of retained austenite responded to the mechanincal load by partial martensite transformation, and misorientation change in the retained austenite after plastic strain could be attributed to the large elongation.

갑상선암의 임상적 고찰

배진선,설지영 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Thyriod carrinoma is rare, representing approximately 1% of all malignancies but account for 90% of all endocrine malignancies. Thyroid carcinoma has a wide spectrum of biologic activity varying from nearly innocuous to very lethal malignancies. The primary treatment for thyroid carcinoma is surgical excision. But the extent of resection, indications for regional lymph node dissection, and the postoperative follow up of patients are the most controversial aspects of management. To formulate a valid rationale for the diagnosis and treatment of the thyroid cancer, a retrospective study of the thyroid cancer treated at the Department of Surgery, Chungnam National University Hospital from January, 1986 to October, 1991 was conducted. The results were as follows ; 1)By the pathological classification, the papillary carcinoma was the most common type and its incidence was 81.1% 2)Female was predminated over male by the ratio of 6.5:1 and most common age incidence was noted from fourth decade to sixth decade, that was 68.9%. 3)The most common duration of illness between the appearance of the symptoms and the treatment was 3 months, which was 31.1%. 4)The most common symptom was the palpable mass at the anterior portion of the neck. 5)Most cases of the thyroid cancer were appeared as cold nodule in the ^99m Tc-Thyroid scan, which was 98.9% in incidence. 6)The right lobe(50%)was the more common site of the thyroid cancer in comparison to the left lobe(28.9%). 7)The incidence of thyroid cancer located in the gland without extrathyroidal extension was 48.9%, and that of the metastasis to the cervical lymph nodes was 34.4% 8)The common surgical procedures of the thyriod cancer were lobectomy which incidence was 51.1%, total thyroidectomy 15.6%, near-total thyroidectomy 10.0% and lobectomy with isthmusectomy 5.6% in order respecitively. And the neck dissection was performed in 16 cases(17.7%) 9) The most common postoperative complications were transient hypoparathyroidism(11.1%), and followed by transient unilateral recurrent laryngeal nerve paralysis(10.0%), hematoma(5.6%). bilateral recurrent laryngeal nerve paralysis and permanent hypoparathyroidism.

직접치수복조재에 따른 비글견 치수의 조직반응에 대한 연구

배지현,김영균,윤필영,조병훈,최용훈 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.1

본 연구에서는 인위적으로 노출시킨 비글견의 치수조직을 기존의 수산화칼슘제재와 MTA, 접착성 레진, 광중합형 수산화칼슘제재를 사용하여 직접치수복조한 후 각 재료에 따른 치수의 반응을 광학현미경 하에서 조직학적으로 관찰하여 비교분석하였다. 2마리 비글견의 36개 치아를 이용하여, 실험적으로 치수를 노출시키고 노출된 치수에 치수복조재를 적용한 후 와동은 복합레진으로 충전하여 직접치수복조술을 시행하였다: (1) Mineral Trioxide Aggregate (MTA: ProRoot MTA, Dentsply, Tulsa, USA), (2) Clearfil SE Bond (Dentin adhesive system: Kuraray, Osaka, Japan), (3) Ultra-Blend (Photopolymerized Calcium hydroxide: Ultradent, South Jordan, USA), (4) Dycal (Quick setting Calcium hydroxide: LD Caulk Co., Milford, USA). 희생전 90일, 30일, 7일 전에 각 복조재별로 3개씩의 와동을 충전하였고 비글견을 희생시키고 조직시편을 제작하였다. 시편을 H&E 염색 후 광학 현미경으로 치수염증반응과 경조직 형성 정도를 관찰하였다. MTA 군은 초기에는 경조직 형성이 관찰되지 않고 치수조직의 위축과 부분괴사가 관찰되었으나 시간이 지나면서 경조직 형성이 관찰되었다. Clearfil SE Bond군은 초기에 염증세포의 침윤과 치수세포의 괴사를 관찰할 수 있었고 시간이 지날수록 치수 세포의 괴사가 더욱 진행한 양상을 보였다. Ultra-blend 군과 Dycal 군은 MTA 군과 비슷하게 초기에는 경조직 형성을 보이지 않고 중등도의 염증반응이 관찰되었으며 시간이 지나면서 경조직 형성이 관찰되었다. MTA, 수산화칼슘제재와 광중합 수산화칼슘제재는 초기의 치수염증반응 이후 조상아세포층, 상아질교 형성을 보여 직접치수복조재로 적당하였으며, 접착성 레진은 심한 염증반응과 치수 조직의 괴사 양상을 보여 직접치수복조재로 부적당하다는 결론을 얻을 수 있었다. The purpose of this study was to evaluate the pulp tissue reaction to direct pulp capping of mechanically exposed beagle dogs' pulp with several capping materials. A total of 36 teeth of 2 healthy beagle dongs were used. The mechanically exposed pulps were capped with one of the followings: (1) Mineral Trioxide Aggregate (MTA: ProRoot MTA. Dentsply, Tulsa, USA), (2) Clearfil SE Bond (Dentin adhesive system: Kuraray, Osaka, Japan), (3) Ultra-Blend (Photo-polymerized Calcium hydroxide: Ultradent, South Jordan, USA), (4) Dycal (Quick setting Calcium hydroxide: LD Caulk Co., Milford, USA) at 7, 30, and 90 days before sacrificing. The cavities were restored with Z350 flowable composite resin (3M ESPE, St. Paul. MN, USA). After the beagle dogs were sacrificed, the extracted teeth were fixed, decalcified, prepared for histological examination and stained with HE stain. The pulpal tissue responses to direct pulp capping materials were assessed. In MTA calcium hydroxide, and photo-polymerized calcium hydroxide groups, initial mild inflammatory cell infiltration, newly formed odontoblast-like cell layer and hard tissue bridge formation were observed. Compared with dentin adhesive system, these materials were biocompatible and good for pulp tissue regeneration. In dentin adhesive system group, severe inflammatory cell infiltration, pulp tissue degeneration and pulp tissue necrosis were observed. It seemed evident that application of dentin adhesive system in direct pulp capping of beagle dog teeth cannot lead to acceptable repair of the pulp tissue with dentine bridge formation.

C6 glia 세포에서 유도성 Nitric Oxide Synthase 유전자 발현조절에 관한 연구

배진영,허강민,배소현,박지선,이충재,이재흔,석정호 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

To investigate transcriptional regulation of iNOS gene by LPS and cytokines, the production of NO, expression of iNOS mRNA and protein, binding activity of nuclear factor-kappa B(NF-kB), and promoter activity of iNOS gene were examined in rat C6 glial cells. LPS, interferon-gamma(IFN-γ), and tumor necrosis factor-alpha (TNF-α) stimulated the production of NO, which was increased synergistically by co-treatment. By the treatment of LPS, iNOS mRNA expression was initiated at 1 h, markedly increased by 3 h, and decreased gradually afterward. iNOS mRNA expression was markedly enhanced by mixture of LPS, IFN-γ and TNF-α. iNOS protein synthesis was increased by the treatment of mixture LPS and cytokine mixture. Treatment of LPS stimulated NF-kB activation, and the activation reached to the maximum level at 30 min, and the treatment of mixture of LPS and cytokines increased the activation. To determine the effect of NF-kB binding activity on iNOS promoter activation, CAT assay was performed. iNOS promoter activity was increased by the treatment with LPS for 5.5 h, and further increased by the combined treatment with LPS and cytokines. These results suggest that NF-kB activation by LPS and cytokines may play a significant role in the induction of the iNOS gene.

소아에서의 선천성 상완동맥 동맥류 : Case report and review of the literatures

배진선,설지영,김경헌,이영 大韓脈管外科學會 1995 大韓脈管外科學會誌 Vol.11 No.2

학교 지역문화교육을 위한 지역협의체 구성에 관한 연구

김영순,임지혜,배현주 한국문화교육학회 2011 문화예술교육연구 Vol.6 No.2

The aim of this study was to search conditions activating the regional consortium for regional culture education in schools. Results of this study are follows: the regional consortium consists of parents of students, communities, schools, school boards, public institutes, and NGO groups. The consortium contribute the educational support and development for student activities in schools. Furthermore the consortium make an offer to coordinate and facilitate the delivery of information, resources, and services to students, educators, employers, and the community. Therefore, the consortium might be best described as "matchmakers" that help ensure that our customers are able to easily connect with providers of the services they need. The consortium will be made up of a network of service providers from across its region that all collaborate in helping to connect the local education and school communities. 본 연구에서는 지역 사회의 인적·물적 자산을 활용한 문화적 체험활동 교육이 활성화되고 정착되기 위한 방안으로 학교와 지역사회가 밀접한 관계를 형성할 수 있는 지역협의체를 구성하는 안을 제시하였다. 이를 위해 지역문화교육에 필요한 지역협의체에 대한 문헌연구를 수행하였고, 이와 유사한 실제 사례를 찾아 관련 전문가를 대상으로 한 심층인터뷰 결과를 정리하고 시사점을 도출하였다. 연구결과, 지역협의체는 지역특수성, 전문성, 개방성, 공공성, 지속성의 기본원칙을 전제로 하여 교육행정기관, 지자체 행정기관, 민간 및 공공기관, 학교 등의 협력을 통해 구성될 수 있다. 또한 지역에서의 문화적 체험활동의 효율적인 운영을 지원하기 위해 1) 지역사회 내 교육기부 협력기관을 모색 및 발굴·연계, 2) 지역의 교육 인프라 접근성 향상, 3) 지역의 문화 교육 자원 간 네트워크 확장, 4) 지역 내 긍정적인 담론 형성을 위한 홍보 및 인식 개선, 5) 지역문화교육 프로그램 수행 과정의 성찰 등의 역할을 수행해야 한다. 지역협의체를 통한 학교와 지역교육자원의 연계 방안은 교육자원의 유형과 교육운영 주체에 따라 분류될 수 있었고, 강동구청과 대구광역시교육청의 예를 통해 지역문화교육 지원의 구체적인 사례를 살펴볼 수 있었다. 이와 같이 본 연구에서 제안한 지역협의체의 구성은 지역문화교육의 활성화를 위한 초석을 마련해 줄 것이라고 기대해 본다.

소아의 장중첩증에 대한 임상적 고찰

배진선,설진영 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

lntussusception is a common cause of intestinal obstruction in the infants and most often observed in babies between 8 and 12 months of age. A clinical analysis was made in 69 children with intussusception who has been treated during 5 years and 11 months from January 1985 through November 1990 in the Department of Surgery, Chungnam National University Hospital. The results were as follows: 1. The sex ratio of male to female was 2:1. 2. As to the age distribution, 82.6% of all patients was occured during 1st year of life, and 60.8% of all was between the third and ninth month. 3. As to the clinical manifestations, vomiting was most frequent(79.7%), followed by abdominal pain(71.0%), bloody-mucus stool(66.7%) and palpable abdominal mass (50.7%) in order of frequency. 4. Overall success rate of reduction by barium enema was 71.0%, and it was decreased with the passage of time, i.e. 90% within 12 hours. 89% within 24 hours, 80% within 48 hours, and 25% later than 72 hours. 5. Body temperature or WBC count was not determinants about the management or outcome of intussusception. 6. Laparotomy was undertaken in 29% of all cases, in whom 70% was managed by manual reduction and resection was performed in 30% of cases. 7. As to the anatomical types in operation group, ileoileal type was most frequent, followed by ileocecal, ileocolic and ileoileocolic type. 8. The complications were present in four cases(5.8%) and there was no death.

담낭염 및 담석의 임상적 연구

배진선,길기선,설지영,김제룡 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

A retrospective clinical analysis was performed on 152 patients with cholelithiasis who were admitted and treated surgically at the Department of Surgery of Chungnam National University Hospital from January 1995 through December 1996. The results were as follows. 1. The peak incidence of cholelithiasis was 6th decade (27.6%), followed by 7th decade, and the ratio of male to female was 1:1.3. 2. The duration of symptoms was within 1 month in 44.7% of patients. 3. The most common symptom and sign were RUQ abdominal pain (89.5%) and RUQ abdominal tenderness (58.6%). 4. The positive laboratory findings were eleveated ALT (42.8%), elevated AST (38.2%) and leukocytosis (38.8%). 5. The major associated conditions in cholelithiasis were cholecystitis (59.7%), cholangitis (15. 1%) and pancreatitis (9.2%). 6. The location of stones was most prevalent in the gallbladder (86.1%), followed by in the common bile duct (26.9%), and in the intrahepatic duct (12.5%). 7. The most common operative procedure was cholecystectomy (63.2%), followed by cholecystectomy and T-tube drainage (15.8%). 8. Bile was cultured in 44 cases, and the most frequent microorganism was E. coli (40.9%). 9. The postoperative complication rate was 34 of 152 (22.4%), among which residual stone and wound infection were most frequent. 10. The operative mortality was 0.7% and the cause of death was sepsis.