http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
[PA-0008] Assembly and Analysis of the Complete mitogenome of Silybum marianum
Jeongwoo Lee(Jeongwoo Lee),Yedomon Ange Bovys Zoclanclounon(Yedomon Ange Bovys Zoclanclounon ),Hwajin Jung(Hwajin Jung),Taeho Lee(Taeho Lee),Jeonggu Kim(Jeonggu Kim),Guhwang Park(Guhwang Park),Keunpyo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Kim, Eunjin,Kang, Jeongwoo,Cho, Minchul,Lee, Sojung,Seo, Eunhee,Choi, Heesook,Kim, Yumi,Kim, Junghee,Kang, Kum Yong,Kim, Kwang Pyo,Han, Jaeyong,Sheen, Yhunyhong,Yum, Young Na,Park, Sue-Nie,Yoon, Do-Yo D. A. Spandidos 2009 MOLECULAR MEDICINE REPORTS Vol.2 No.1
<P>The E6 and E7 oncoproteins of human papilloma virus (HPV) type 16 have been known to cooperatively induce the immortalization and transformation of primary keratinocytes. We established an E7 transgenic mouse model to screen HPV-related biomakers using the omics approach. The methods used to identify HPV-modulated factors were genomics analysis by microarray using the Affymetrix 430 2.0 array to screen E7-modulated genes, and proteomics analysis using nano-LC-ESI-MS/MS to screen E7-modulated proteins with the lung tissue of E7 transgenic mice. According to omics data, cyclin B1, cyclin E2, topoisomerase IIα, calnexin, activated leukocyte cell adhesion molecule CD166, actinin α1, diaphorase 1, gelsolin, platelet glycoprotein, and annexin A2 and A4 were up-regulated in the E7-Tg mice, while proteoglycan 4, sarcolipin, titin, vimentin, drep 1, troponin and cofilin-1 were down-regulated. We further confirmed the significance of differences between the expression levels of the selected factors in E7-Tg and non-Tg mice by real-time PCR. Genes related to cancer cell adhesion, cell cycle and migration, proliferation and apoptosis, as well as to the intermediate filament network and to endoplasmic reticulum proteins, were selected. Taken together, the results suggest that the E7 oncogene modulates the expression levels of cell cycle-related (cyclin B1, cyclin E2) and cell adhesion- and migration-related (actinin α1, CD166) factors, which may play important roles in cellular transformation in cancer. In addition, the solubilization of the rigid intermediate filament network by specific proteolysis mediated via up-regulating gelsolin and down-regulating cofilin-1, as well as increased levels of endoplasmic reticulum protein calnexin with chaperone functions, might also be involved in E7-lung epithelial cells.</P>
Correlation between balance and thickness of abdominal and quadriceps muscles
Seok-hyun Kim,Jae-hong Kim,Jeongwoo Jeon,Jiheon Hong,Jaeho Yu,Jinseop Kim,Seong-Gil Kim,Dongyeop Lee 한국융합학회 2023 미래기술융합논문지 Vol.2 No.2
본 연구는 서 있는 자세에서 측정된 정적균형과 근육두께(배근육, 넙다리네갈래근)의 상관관계를 확인하였 다. 29명의 건강한 성인 29명이 본 연구에 참여하였으며, 근육두께와 정적균형을 측정하였다. 넙다리곧은근의 근 육 두께는 정적균형체중분포지수와 유의한 상관관계를 나타냈다. 그러나 다른 근육과의 유의한 관계는 발견되지 않았다. 본 연구는 건강한 20대 남성만을 대상으로 하였으며, 그 결과를 다른 연령대에 일반화할 수 없었다. 본 연구의 한계점으로는 근력과 시각이 측정되지 않아 연구의 정확성을 표현하고 결과를 일반화하기에는 무리가 있어 보인다. 향후 연구에서는 대단위의 피험자 수를 대상으로 근력을 추가적으로 측정하여 연구를 진행할 필요가 있다. This study compares the correlation between muscle thickness (abdominal, quadriceps muscle) and how the muscle thickness affects the static balance when the static balance is measured in a standing position. The subjects of study were to select 29 subjects to find out what relationship muscle thickness had on the static balance when measuring muscle thickness and static balance. rectus femoris muscle thickness showed a significant correlation in statically balanced weight distribution index. In this study, only healthy men in their twenties were selected, and the results could not be generalized to other age groups. As a limitation of this study, muscle strength and peripheral vision were not measured, so it seems difficult to express the accuracy of the study and generalize the results. In future studies, the number of subjects and muscle strength should be measured to proceed with the study.
Improved neutral shift method for fault tolerant operation of three phase MLCI
Kim, Jeongwoo,Cho, Younghoon The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.1
In a three-phase multilevel cascaded inverter (MLCI), when a failed module is bypassed, the number of modules in each phase becomes unbalanced. Under this condition, a method to obtain a balanced three-phase output is to move the neutral point of the MLCI. The neutral-point shift (NS) method has attracted a great deal of attention since the output of the inverter has a relatively low harmonic distortion when compared to other fault-tolerant operation methods. To move the neutral point, an offset voltage of the fundamental frequency component is injected. If the injected offset voltage exceeds the available range of the offset voltage, overmodulation occurs. Then, the output of the inverter is distorted. In this paper, the overmodulation regions of the NS method are analyzed for the fault-tolerant operation in the three-phase MLCI. In addition, a modified NS method is proposed to compensate for the overmodulation region. Both simulation and experimental results in a two-by-three MLCI demonstrate the performance of the proposed method.
Kim, Young-Eun,Lee, Minji,Gu, Hyejung,Kim, Jeongwoo,Jeong, Seongju,Yeo, Sujin,Lee, You Jeong,Im, Sin-Hyeog,Sung, Young-Chul,Kim, Hak Jae,Weissman, Irving L.,Ahn, G-One The Company of Biologists Ltd 2018 Disease models & mechanisms Vol.11 No.7
<P><B>ABSTRACT</B></P><P>Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypoxia-inducible factor (HIF), a transcription factor activated under hypoxic conditions in myeloid cells, in the progression of IBD. To do this, we utilized myeloid-specific knockout (KO) mice targeting HIF pathways, created by a Cre-loxP system with human MRP8 (hMRP8), an intracellular calcium-binding protein, as the myeloid promoter. By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (<I>Vhl</I>) KO mice, in which HIF-1α and HIF-2α are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice. These parameters were restored to, if not better than, the WT levels when we examined hMRP8 <I>Hif-1a</I> KO mice upon 5% DSS feeding. hMRP8 <I>Hif-2a</I> KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice. Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 <I>Hif-1a</I> KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1α in myeloid cells is dispensable for tumorigenesis. Collectively, our results suggest that HIF-1α activation in myeloid cells critically regulates IBD progression.</P>
Kim, Jeongwoo,Jhi, Seung-Hoon,Wu, Ruqian American Chemical Society 2016 NANO LETTERS Vol.16 No.10
<P>The tailoring, of topological surface states in topological insulators is essential for device applications and for exploring new topological phase. Here, we propose a practical way to induce the quantum anomalous Hall phase and unusual metal-insulator transitions in Cr-doped Bi2Se3 films based on the model Hamiltonian and first-principles calculations. Using the combination of in-plane and plane-normal components of the spin, along with external electric fields, we demonstrate that the topological state and band structures of topological insulating films exhibit rich features such as the shift of Dirge cones and the opening of nontrivial band gaps. We also show that: the in-plane magnetization leads to significant suppression,of inter-TSS scattering in Cr-doped Bi2Se3. Our work provides new strategies to obtain the desired electronic structures for the device, complementary to the-efforts of an extensive material search.</P>