다양한 비스테로이드성 소염진통제의 쥐 피부 투과

김민정,도희정,조원제,용철순,최한곤,이치호,김대덕 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

Rat skin permeation of various nonsteroidal antiinflammatory drugs (NSAIDs) was investigated in vitro using Franz diffusion cell at 37℃. The effect of various skin permeation enhancers was also observed as a preliminary study of developing transdermal delivery systems of NSAIDs. Lipophilicity of NSAIDs was determined from the partition coefficient (log P) in 1-octanol/water and 1-octanol/IPB mutual-saturated solutions. The solubility was determined in water, isotonic phosphate buffer (IPB), and propylene glycol (PG) at 37℃. The rat skin permeation rate of acetaminophen, piroxicam, and aceclofenac was almost negligible, although they were saturated in PG. Addition of 1 % permeation enhancer increased the permeation rate of ketoprofen, ketorolac, and diclofenac. However, the skin permeation rate of ibuprofen did not increase with the addition of various enhancers. Among the permeation enhancers tested, oleic acid was the most effective for various NSAIDs. Based on the daily dose, lipophilicity, and the skin permeation rate achieved in this study, ketoprofen and ketorolac seem to be the most promising drug candidates for transdermal delivery systems, especially when formulated with unsaturated fatty acids, such as oleic acid.

Memory 소자 응용을 위한 BST(Ba_xSr_1-_xTiO_3) 강유전체 박막과 전극과의 계면특성

정민재,조정희,홍석민,김호건,김옥경 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

BaxSr1-xTiO3 powders were prepared by changing stoichiometry of Ba and Sr. After they were calcined and sintered at 1,200℃ and 1,300℃ respectively, BST sputtering targets were made in 3inch mould. For MIM structure capacitors. Pt-based structures such as Pt/TiN/SiO2/Si, Pt/Ti/Si3N4/Si, Pt/SiO2/Si, Ru/SiO2/Si and Ru/Si3N4/Si were used for bottom electrodes, and subsequently, the BaxSrl-xTiO3 thin films were sputtered on them. After the analysis of their structures by XRD, Al was evaporated on the BST films for MIM capacitor. We found that the structures of the films showed good crystallinity above 550℃ from the results of XRD measurements. The largest dielectric constant of films was obtained with 0.7mol% of Ba. The electric properties of the capacitors were very good with Pt/TiN/SiO2/Si electrodes.

국내 발전소별 바텀애시를 잔골재 대체재로 사용한 모르터의 특성에 대한 실험적 연구

송민섭,장재봉,조봉석,김재환,김용로,김무한 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

With the advance in industrial development and modern living comfort, the demand for electricity throughout the country is ever increasing. Also the annual consumption of coal by coal-fired power plants is increasing. The amount of ash produced in 2000 is estimated to be about 4.5 million tons. The disposal of this huge amount of ash introduces serious environmental problems. Fly ash among the ash produced is used in building industries as a substitute to cement in concrete and the concrete thus produced is said to be lighter and stronger. But bottom ash among the ash produced is not used because of its poor properties. But encouraging the use of bottom ash as a construction material is a sensible method of utilization as it avoids the problems and costs associated with disposal and provides an alternative aggregate source. This study is aimed at using bottom ash as an alternative fine aggregate source to provide a solution to disposal and insufficient fine aggregate for the production of concrete. So properties of bottom ash produced in power plants were estimated due to the difference of bottom ash produced in each plant. And mortar strength was estimated as basic data to use bottom ash in building industries.

임플란트 매식시 수직골 높이에 따른 응력분석

김민호,강재석,계기성 조선대학교 구강생물학연구소 2002 口腔生物學硏究 Vol.26 No.2

The purpose of this study was to compare the distributing pattern of stress on the finite element models with the different vertical bone level of implant fixture. The two kinds of finite element models were designed according to vertical bone level around fixture (4.0㎜ x 11.5㎜). The cemented crowns for mandibular first and second molars were made. Three- dimensional finite element model was created with the components of the implant and surrounding bone. Vertical loads were applied with force of 200N distributed within 0.5㎜ radius circle from the center of central fossa and distance 2mm and 4mm apart from the center of central fossa. Von-Mises stresses were recorded and compared in the supporting bone, fixtures, abutment screws, and crown. The results were as following: 1. In vertical loading at the center circle of central fossa on model 1 and 2, the difference from vertical bone in implant placement did not affect the stress Pattern on all components of implant except for crown. 2. With offset distance increasing and the bone level of implant decreasing, the concentration of stress occurred in the buccal side of long crown, around the buccal crestal bone, and on the fixture- abutment interface As a conclusion, the research showed a tendency to increase the stress on the supporting bone, fixture and screw under the offset loads when the vertical level of bone around fixture was different. Since the same vertical bone bed has more benefits than the different bone bed around fixtures, it is important to prepare a same vertical level of bone bed for the success of implants under occlusal loads.

TMS320C6711을 이용한 Digital X-ray 신호처리 시스템 개발

정민수,이재균,강문호,이채욱 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.1

기존의 의료용 X선 영상장치에 있어서 TV 방식은 형광증배관에 나타나는 잡음과 TV자체의 잡음으로 인하여 비교적 잡음이 많이 발생한다. 그리고 interlace 주사로 인한 화면 떨림 현상이 발생하여 카메라 해상도가 저하되어 모니터에 나타나는 전체적인 화면의 화질이 그다지 선명하지 않다. 본 논문에서는 NTSC 방식의 잡음 문제를 해결하기 위해, X-ray에 의해 투시된 X-ray 형광증배의 아날로그 화면은 A/D converter를 이용하여 디지털 신호를 만든다. 또한 interlace 방식의 화면이 깜박거리는 현상을 제거하기 위해 double scanning 하고 interlace 주사를 noninterlace로 주사하는 방식을 도입한다. 그리고 실시간 처리를 위하여 TMS320C6711을 이용한 Digital X-ray 신호처리 시스템을 개발하고자 한다. The TV injection method of general X-ray image system has a problem because of the fluorescent increased dividend tube and the TV itself. As the screen trembling by interlace injection decreases the camera resolution, the total quality of monitor is not so clear. In this paper, we make the analog signal of X-ray fluorescent increased dividend tube into digital signal by using A/D converter. Also, to remove the twinkles from interlace method, we adapt the double scanning and the noninterlace method. For realtime processing we develop the digital X-ray signal processing system which uses a TMS320C6711.

FPD 결함검사를 위한 Vision Inspection System 설계에 관한 연구

박성재,김민수,김준식,주효남 湖西大學校 工業技術硏究所 2005 工業技術硏究所論文集 Vol.24 No.-

A system is designed and developed to acquire accurate images and to detect cell defects of Flat Panel Displays. Detailed analysis and experiments are performed to design and select the lighting, optical and camera sub-system as well as mechanical motion and position control sub-system. Sample images are acquired using the developed system and the processed result shows the good performance in detecting simple cell defects.

화상처리를 이용한 연삭공구 인식 및 안면인식 응용

백재용,송무건,유송민 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

An image processing method was applied to characterize a shape of the flexible grinding disk. A disk surface image was taken by CCD camera. Depth of cut was changed to be 2 and 4mm. Circles marked on the disk were captured to extract the key features of the deflection. Notable correlation has been observed between the intervals and the process conditions. Same methodology has been applied to check the symmetry of the human face. Tentative results revealed that symmetry could be checked using the filtered face image.

저작근 골막하 박리를 이용한 만성 재발성 탈구의 치험례

심재환,김기홍,문진석,민병진,이원학,홍광진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.3

Chronic recurrent dislocation(CRD) of the jaw has various etilogical causes, including trauma, congenital or acquired neurological illness, ingestion of certain medicines, incorrdination of the neuromuscular astivity of the chewing muscles, articular anatomical alteration, etc. Various surgical methods have been advocated for the treatment of the CRD. They may be divided into two groups: procedures designed to limit translation of the condyle and procedures eliminating obstacles in the condylar path. Hypomobility of mandible can be developed after BSSRO and it is probably caused by scar contracture, atrophy, and myofibrosis. Many authors, therefore, emphasized the importance of physical therapy especially after BSSRO to prevent the complication. Based on that idea, we designed more conservative surgical method to limit mandibular openning compared the methods that previously introduced and tried to treat the CRD. This new method consists of extensive subperiosteal dissection of masseter and the temporalis muscle under local anesthesia and use of intermaxillary elastics for some periods.

위치 기반 서비스에서 미래 위치 검색을 위한 이동 객체 색인

서동민,복경수,유재수 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1

최근 위치 기반 기술에 대한 활용이 증가하면서 이동 객체를 효율적으로 관리하기 위한 색인 구조의 필요성이 증가하고 있다. 하지만, 기존에 제안된 색인 구조들은 이동 객체의 계속되는 위치 이동으로 빈번한 색인의 변경과 성능 저하 문제를 가진다. 본 논문에서는 미래 위치 검색 및 갱신 비용을 최소화하기 위한 새로운 시공간 색인 구조를 제안한다. 제안하는 색인 구조는 갱신 비용을 최소화하기 위해 이동 객체의 현재 위치를 직접 접근하기 위한 보조 색인 구조와 공간 분할 기반의 KDB-트리를 결합한 색인 구조이다. 제안하는 색인 구조에서는 이동 객체의 미래 위치 검색 및 갱신 비용을 줄이기 위해 KDB-트리의 중간 노드에 시간에 대한 파라미터를 유지한다. 또한 제안하는 색인 구조에서는 공간활용도 및 검색 효율을 극대화하기 위한 새로운 갱신 및 분할 기법을 제안한다. 제안하는 색인 구조의 우수성을 입증하기 위해 다양한 실험을 통해 성능 평가를 수행한다. Recently, with the rapid development of location-based techniques, index structures to efficiently manage moving objects have been required. Existing index structure frequently need updates because moving objects change continuatively its position. That caused entire performance loss of index structure. In this paper, we propose a new spatio-temporal index structure that supports a future position retrieval and minimizes a update cost. The proposed index structure combines an assistant index structure that directly accesses current positions of moving objects with KDB-tree that is a space partitioning access method. The internal node in our proposed index structure keeps time parameters in order to support the future position retrieval and to minimize a update cost. Moreover, we propose new update and split methods to maximize the space utilization and the search performance. We perform various experiments to show that our proposed index structure outperforms the existing index structure.

퍼지제어기를 이용한 분산 Multi Vehicle의 Color인식을 통한 물체이송 연구

우지민,경제문,최승민,김훈모 기계기술연구소 2000 성균관대학교 논문집 기계기술편 Vol.2 No.1

In this paper, we present a collaboration method for material delivery with distributed vehicle agents system. Generally used AGV(Autonomous Guided Vehicle) systems in FA need extraordinary facilities like guidepaths, landmarks and have lots of limitation for applying in various environments and in case of controlling multi vehicles including different types is increasing nowadays for automation of materials between vehicles including different types is increasing nowadays for automation of material of material flow. Thus to compensate and improve functions of AGV, it is important to endow vehicles with intelligence to recognize environments, goods and determine goal point to approach. In this study we propose interaction method between hetero-type vehicles and fuzzy logic controller for sensor based path planning method and material identifying method by recognizing color. For the purpose of carrying materials to the goal, instead of intricate vision system, simple color sensor is used to search for material, and recognize its color to determine goal point to transfer it to. The ability for proposed method will be demonstrated by computer simulation and experiment.