T 세포활성항원 CTLA-4의 기능에 관한 연구 : T 세포에서 표적세포 살해능과 CTLA-4 발현과의 연관성 Target Cytotoxicity of T Cell Correlates with CTLA-4 Production

노만택,조양자,김용식,최용,조보현,최장원,정용훈 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4

CTLA-4, a T cell activation antigen and a homologue of CD28, was originally identified as a gene by a series of reverse genetic approaches. While CD28 molecule has been characterized well as a stimulator of T-cell function via enhanced lymphokines production and stablilization of those mRNA, most of the functions of CTLA-4 remain unknown. It has been widely accepted that CTLA-4 functions as an immune suppressor which is down-regualting the function of CD28. We previously showed that 34 KD form of this antigen mainly expressed CD8+ subset, a cytotoxic or suppressor, of activated peripheral blood lymphocyte. Based on our previous finding this study was conducted to further characterize immunological function of CTLA-4 especially in terms of involvement of this molecule in T-cell effector function mediating target cell cytotoxicity. 4 human T cell clones with different target cytotoxicities were employed in this study. NBL46 (CD4+) and NBL77 (CD8+) were cytotoxic and NBL32 (CD4+) and NBL58 (CD 8+) were non-cytotoxic to target LBF cell in target cell chromium release assay. And in Western blot assay 34 kD antigen was detected in NBL46 (CD4+) and NBL77 (CD8+) clones but not in NBL32 (CD4+) and NBL58 (CD8+) clones. It was summarized that expression of the CTLA-4 antigen was associated with cytotoxicity but not with subset phenotypes of T cells. In conclusion CD8+ T subset of PHA-stimulated PBL was major and only CTLA-4 producer and this molecule was induced during mid to late stage of T cell activation. The cytotoxicity of T cell clones to its target cell was directly correlated with its CTLA-4 production and vice versa. And it was highly suggested that primary function of CTLA-4 may involved in T cell effector function which mediates target cell killing.

손등 정맥 패턴의 회전 왜곡을 보상한 개인 식별 알고리즘의 연구

최환수,안장용 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper proposes an enhanced algorithm for person identification system utilizing hand vein pattern. The conventional algorithm does not cope with distortion caused by image rotation caused by misplaced hands on the imaging device. A straightforward approach to consider the rotaional compensation required too much computational load, thus, we devised an approach to expect the rotation direction along with image translation, reducing the compuational requirement dramatically. In this paper, we present the detail of the algorithm with experimental results with the new algorithm.

스포츠센터 직원들의 인구학적 특성에 따른 직무스트레스 및 직무만족의 차이

최종삼,조용철,장순용,정석진 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

This study purposes the influence of job stress upon job satisfaction of Sports Centers Employees demonstratively. I set up the employees of sports centers in Seoul and Gyeonggi Province as Population and took 300 employees in 13 sports centers using a stratified cluster random sampling. The actually used data were 278 workers except 22 employees who were judged to respond unfaithfully or to leave out some of the surveyed questions. I made a conclusion as follows through statistical analyses including reliability analysis, frequency analysis, t-test, one-way ANOVA and Scheffe's multiple range test. First, there was a statistical significance according to age, education, position, and working years in the job stress under personal characteristics and personalities of employees in sports centers. Second, there was a statistical significance according to age, education, position, and working years in the job satisfaction under personal characteristics and personalities of employees in sports centers.

재구성 가능형 공작기계의 주축 시스템 설계

장성현,정용민,황현영,최영휴,박종권 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

During a decade, there are many researches on microfactory which is the miniature, flexible, and efficient manufacturing system for the micro/meso scale machining device. Moreover many micro machine tool has developed in Japan, U.S., Europe, and Korea. Already we developed a 3-axis micro milling machine with 300×200×320 ㎣ machine size for microfactory. In this study, we introduce the design of a high speed spindle system with air bearings for our micro milling machine. Desired operation speed range of the spindle system is 100,000 ~ 150,000 rpm. In. design step, we have consideration for minimum critical speed, compliance, and weight construction of the spindle system. The shaft length, the shaft outer diameter, bearing positions and bearing stiffness were set as the design values. After the final design of spindle model, we carried out dynamic analysis a spindle system for a micro milling machine by using ADROS, which is our own developed S/W for dynamic design analysis of rotor systems. As the result, we designed a spindle system having the critical speed above the operating speed.

Acinetobacter sp. BE-254에 의한 유화제의 생산

최경숙,장경립,임이종,김순한,정영기,이태호 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The strain producing bioemulsifier was isolated from soil samples. The isolated strain was identified as the genus Acinetobacter through its morphological, cultural and physiological characteristics. The highest emulsification activity and stability by Acinetobacter sp. BE-254 was observed after 5 days of cultivation in the culture medium containing n-hexadecane 4%, NaNO₃0.2%, KH₂PO₄0.01%, MgSO₄·7H₂O 0.01%, CaCl₂0.01%, and yeast extract 0.01%. The optimum pH and temperature for bioemulsifier production were pH 7.0 and 30℃, respectively. Furthermore the most of bioemulsifier was produced during the exponential growth phase, and this suggested that the bioemulsifier production was growth-associated. The bioemulsifier showed good emulsification activity on various emulsifying substrates such as hydrocarbons, edible oils, and petroleum fractions.

보안정책 검증용 사양언어를 위한 파서의 구현 : SPSLP

장재혁,양태연,최용락 대전대학교 산업기술연구소 2001 산업기술연구소 論文集 Vol.12 No.1

It in vary difficult to guarantee the system security when security policy systems have different policy syntax in it. It means that policy data can't be transported correctly because the security negotiation could be failed. So, we have to verify the database of security policy through investigating the syntax and function of the security policy system whether wrong or not. This paper presents the parser, which is developed for the verification of security policy. The implemented SPSL parser makes offers to classify the error, to create the information of the verified security policy used for building the SPS DB and to give both the convenience of management and the flexibility of security policy.

中國國有企業의 民營化改革에 관한 硏究

최장호,박영일 단국대학교 1999 論文集 Vol.34 No.-

Under the System of Chinese Socialism, the position and the role of state enterprises is very important in Chinese national economy. However, state enterprises were getting worse. The lack of efficiency and accumulated deficit caused the loss of government subsidies each year. Therefore, need of reform in state enterprises is evident. The reform with various new policies has begun from 1978 by planning and implementation. Chinese private enterprises has been taking rapid growth. But it still shows many problems. From these empirical studies, many problems of the privatization of state enterprises were found. Those are government interference, ownership structure, conditions of competitions between companies, financial difficulty and so on. As a conclusion, some solutions and future directions for more effective privatization of state enterprises were suggested. The reform of state enterprises in china may be the precedent of the reform of Korea's public enterprises.

선속 변화에 의한 능동형 횡 동요감쇠장치의 효과

최찬문,안장영,서두옥,정용진 濟州大學校 海洋硏究所 2004 해양과환경연구소 연구논문집 Vol.28 No.1

제주대학교 실습선 아라호에 장착된 능동형 횡 동요 감쇠장치의 성능이 선박의 속력과의 관계를 파악 하기 위하여 선박을 정지, 미속, 중속, 전속으로 구분하여 횡 동요 감쇠장치를 정지(Passive A.R.T), 작동(Active A.R.T)을 했을 때 경사계에 의한 횡 동요각 및 종 동요각, 풍속계에 의한 풍속의 변화에 의한 분석한 결과를 요약하면 다음과 같다. 1. 선박이 정지했을 때가 능동형 횡 동요 감쇠장치의 1/3, 1/10 횡 동요각 유의 진폭에서 감소률이 가장 높아 47.2%, 50.3%를 나타냈으며, 반면에 중속인 경우 가장 낮은7.1%, 7.4% 나타내므로, 이 장치는 선속의 변화에 차이가 있는 것으로 판단된다. 2. 선속의 변화에 따라 그 효율이 많은 차이가 있으므로 이 장치를 장착한 선박의 운항자는 이를 감안하여 작동하여야 할 것으로 생각되며, 통계분석 결과에 의해서 선속과 감소률의 관계를 회귀분석식으로 나타내어 보면 다음과 같았다. 즉, 횡동요각 유의 진폭 (Amplitude of and significant roll (φ_(1/3)) : y= -3.233χ + 45.613 횡동요각 유의 진폭 (Amplitude of and significant roll (φ_(1/10)) : y= -3.157χ + 46.840을 각각 얻을 수 있었다. This experimental paper deals with the performance of tanks that are turned the active A.R.T(Anti-Rolling Tank) when the fluid transfers from wing tanks to the opposite tank by the power developed by the automatic control system (INTERING Stabilizer), which was installed in the fishery training ship T/S. A - RA (G/T : 990 tons) of Cheju National University. In this paper, the author has tested the performance of INTERING Stabilizer from the signals obtained by the inclinometer in irregular waves and compared with the results obtained in passive mode operation at stop and at various ship speeds. The performances of the system were confirmed the results as follows through the tests : 1. The Rates of reduction in significant roll(φ_(1/3)) of performance of Active-Rolling Tank at stop. dead slow ahead, half ahead, full ahead were obtained 47.2%, 26.3%, 7.7% 9.7%, respectively. 2. The operators had to consider to be different to change according to the various ship speeds for working. and the author could get the linea regressions about the rates of reduction at the results of a statistical analysis through the time histories of rolling angles in A.R.T. in irregular waves using various ship's speeds. Rates of reduction in significant roll(φ_(1/3)) : y = -3.233χ + 45.613 Rates of reduction in significant roll(φ_(1/10)) : y = -3.157χ + 46.840

이산화된 탐색공간에서 다구찌 방법을 이용한 구조 최적설계에 관한 연구

장성현,정우영,정용민,권봉철,최영휴 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Nowadays, there are several design problem having discrete variables in the industrial fields. The researchers are using the optimization method, such as genetic algorithm (GA), simulated annealing (SA), design of experiment (DOE) and taguchi method (TM), to solve it's design problem. Moreover, people want to decrease the computational cost and time. Therefore, in this paper, we proposed the iterative optimization algorithm which repetitively searched a local region to find best solution in discrete searching space using TM. The optimal solution in each local region is obtained by S/N ratio for the evaluation function that consists of the objective function and penalty function. Also, we have applied our algorithm to 3-bar, 10-bar, and 25-bar truss optimization problem.

레슬링 선수들의 정신건강에 관한 연구

장호성,최종균,구용판 龍仁大學校 體育科學硏究所 2003 體育科學硏究論叢 Vol.13 No.1

The purpose of this study is to determine how a wrestler's sex, age, match experience and education level relate to his/her psychological health. A sample group was formed from 197 male and female players (senior high-school level or higher) who participated in the 2002 Korean Wrestling Tournament. The players are registered with the Korea Wrestling Federation. The questionnaire, which contained total 94 questions (i.e., 4 on sociodemographic characteristics and 90 on psychological health-related factors), showed the confidence level falling between .5006 and .8844 (Cronbach's alpha). The study, which relied on frequency analysis, t-test, One-way ANOVA, and Scheffe test, produced the following results. First, wrestlers' psychological health showed no statistically significant difference with regard to all sub-variables depending on sex. Second, wrestlers' psychological health showed a statistically significant difference regarding overall psychological health, somatizing disorder, obsession, oversensitivity to others, depression and hostility depending on age while no difference was noticed regarding insecurity, fear, paranoia and psychosis. Third, wrestlers' psychological health showed a statistically significant difference regarding overall psychological health, somatizing disorder, obsession, depression, paranoia and psychosis depending on match experience while no difference was noticed regarding oversensitivity to others, insecurity, hostility and fear. Fourth, wrestlers' psychological health showed a statistically significant difference regarding overall psychological health, somatizing disorder, obsession, depression, insecurity and hostility depending on education level while no difference was noticed regarding oversensitivity to others, fear, paranoia and psychosis.