고속액체크로마토그래피를 이용한 혈장중 로바스타틴산의 분석 : 시료전처리로서 단백침전법 및 고상추출법의 비교 Comparison of Protein Precipitation Method and Solid Phase Extraction Method for Sample Pretreatment

송우헌,장정수,박은우,이상길,최영욱 중앙대학교 약학연구소 1997 약학 논총 Vol.11 No.-

Lovastatin(LV), one of the potent cholesterol-lowering agents, is an inactive lactone prodrug which is metabolized to its active open acid (Lovastatin acid. LVA). In order to optimize the assay procedure of LVA by high performance liquid chromatography(HPLC). solid phase extraction(SPE) method and protein precipitation method were employed for the pretreatment of plasma sample containing LV and LVA, and plasma sample was hydrolyzed under alkaline condition to transform all LV to LVA. Following pretreatment of plasma sample. 100ul of sample was injected onto a reversed-phase C_18 column and eluted with a acetonitrile-pH 3.0 phosphate buffer mixture(45:55 v/v) at a flow rate of 2.0ml/min. Ultraviolet detection was carried out at 238nm. It has been shown that all of LV in plasma was converted to LVA in vitro under alkaline condition. On SPE method, elution with acetonitrile-methanol mixture(75:25 v/v) indicated the highest recovery of LVA, but acid treatment of plasma sample before loading on SPE cartridge revealed little effect on recovery of LVA. Compared with two different pretreatment of plasma sample, SPE indicated better sensitivity and recovery.

鬱血性心不全症에 對한 臨床的 觀察

徐明洙,金吉洙,金佑泰,張錫源,金承源,宋昌燮 대한적십자사 1983 적십자병원지 Vol.10 No.2

편측성 하악 과두 과증식으로 인한 안모비대칭의 치험례

김상규,이상한,장현중,우길상,이은진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Condylar hyperplasia is an uncommon malformation of the mandible created by excessive growth of one of the condyles. Condylar hyperplasia is a self-limiting condition, and treatment is determined by the degree of functional difficulty and aesthetic change. Some patients can be treated with unilateral condylectomy, whereas others require unilateral or bilateral mandibular osteotomies. Our method includes a condylectomy to arrest the continued condylar growth or to excise the neoplastic condyle, unilateral vertical ramus osteotomy to allow horizontal rotation of the mandible without significantly altering the temporomandibular articulations, and an arthroplasty by superior repositioning of the stump of the proximal condylar segment into the condylar fossa. Both the facial asymmetry and the occlusion were corrected by rotation of the mandible around the unaffected condyle.

Commercial Application of Cryogenic High Mn steel in LNG Fueled ship

Woo Kil Jang(장우길),Jong Kyo Chio(최종교),Il Wook Han(한일욱),Soon Gi Lee(이순기) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.5

Study of the Optimal Calcination Temperature of an Al/Co/Ni Mixed Metal Oxide as a DeNO_x Catalyst for LNT

Jang, Kil Nam,Han, Kwang Seon,Hong, Ji Sook,You, Young-Woo,Suh, Jeong Kwon,Hwang, Taek Sung The Korean Society of Clean Technology 2015 청정기술 Vol.21 No.3

대부분의 LNT 촉매는 낮은 온도 영역에서의 NO_x 산화를 위하여 Pt와 같은 귀금속류를 사용하는 것은 경제적인 부담을 가지고 있다. 따라서, 본 연구는 이러한 문제를 해결하기 위하여 시도되었다. 즉, Pt, Pd, Rh 등과 같은 귀금속류(platinum group metal, PGM)를 사용하지 않는 LNT (lean NO_x trap)용 DeNO_x 촉매를 개발하기 위해 시도하였다. 이를 위해서 예비실험을 통해 Pt등 귀금속류등의 PGM (platinum group metal)을 사용하지 않는 Al/Co/Ni 혼합 금속 산화물을 선정하였다. 궁극적으로는, 선정된 촉매의 소성온도에 따른 물리화학적 특성 변화가 NO_x 전환율에 미치는 영향을 살펴보고자 하였다. 이들의 물리화학적인 성질을 평가하기 위해 XRD, EDS, SEM, BET 분석을 실시하였다. 이러한 평가를 실시한 결과, 모든 소성온도에서 혼합금속 산화물은 Co₂AlO₄ 및 NiAl₂O₄의 스피넬 구조가 혼재되어 있는 것으로 나타났고, NO_x 기체들의 산화-환원 반응이 이루어지기에는 충분한 기공부피와 기공크기를 갖고 있음을 알 수 있었다. 그러나 NH₃-TPD 분석 결과에서는 소성온도가 700 ℃ 이하를 유지해야 하는 것으로 판단되었다. 더욱이 ramp test를 통해서는 NO 및 NO_x 전환율을 동시에 만족할 수 있는 시료는 소성온도는 500 ℃에서 처리된 경우임을 알 수 있었다. 이러한 결과 등을 바탕으로, Al/Co/Ni=1.0/2.5/0.3 혼합 금속 산화물의 최적 소성온도는 500 ℃임을 알 수 있었다. Most of LNT catalysts use noble metals such as Pt for low temperature NO_x oxidation but there is an economic weakness. For the purpose of overcoming this, this study is to develop DeNO_x catalyst for LNT excluding PGM (platinum group metal) such as Pt, Pd, Rh, etc. To do so, Al/Co/Ni catalyst selected as a preliminary test is used to study fundamental property and NO_x’s conversion according to calcined temperature. Ultimately, that is, Al/Co/Ni mixed metal oxide which does not use PGM is selected and physicochemical characterization is performed by way of XRD, EDS, SEM, BET and ramp test and NO_x conversion is also analyzed. This study shows that all samples consist of mixed oxides of spinel structure of Co₂AlO₄ and NiAl₂O₄ and have enough pore volume and size for redox. But as a result of NH₃-TPD test, it is desired that calcined temperature needs to be maintained at 700 ℃ or lower. Also only samples which are processed under 500 ℃ satisfied NO and NO_x conversion simultaneously through ramp test. Based on this study’s results, optimum calcined temperature for Al/Co/Ni=1.0/2.5/0.3 mixed metal oxide catalyst is 500 ℃.

Repeat Operations in Pediatric Patients with Recurrent Craniopharyngiomas

Jang, Woo Young,Lee, Kwan-Sung,Son, Byung Chul,Jeun, Sin-Soo,Hong, Yong-Kil,Lee, Sang Won,Yang, Seung-Ho S. Karger AG 2010 Pediatric neurosurgery Vol.45 No.6

<P><I>Background:</I> Controversy continues over the optimal management of recurrent craniopharyngiomas. Our strategy for approaching repeatedly recurrent craniopharyngiomas in pediatric patients has been to decompress vital structures and relieve the symptoms as early as possible. The purpose of this study was to present our experiences of repeatedly recurrent craniopharyngiomas and the pattern of failure associated with treatment. <I>Methods:</I> A retrospective review was conducted on 7 pediatric patients who underwent resection >2 times in a single institution between 1990 and 2004. Resections were performed 3-8 times for each patient. Variables including tumor size, consistency and location, extent of resection, adjuvant therapy and morbidity were evaluated. <I>Results:</I> Thirty-two operations were performed in 7 pediatric patients. Total resection was not achieved by the third surgery and thereafter, and the interval between each surgery became shorter. Appetite disorders, neurocognitive disorders and behavioral disorders occurred following repeat surgeries. <I>Conclusion:</I> Repeat operations are associated with a high failure rate of tumor control, even though they can help relieve neurologic symptoms. It is suggested that the number of repeat operations should be limited.</P><P>Copyright © 2010 S. Karger AG, Basel</P>

신경베체트병의 자기공명영상소견

장한원,변우목,조길호,황미수 영남대학교의과대학 1998 Yeungnam University Journal of Medicine Vol.15 No.2

1994년 1월에서 1998년 8월까지의 영남대학교 의과대학 부속병원에서 신경베체트병으로 진단받은 9명의 환자를 대상으로 전신적인 임상증상과 자기공명영상소견을 분석한 결과 주된 전신적인 증상은 구강궤양, 안질환, 음부궤양이었으며, 자기공명영상소견에서 병소부위는 중뇌, 내포, 뇌교, 시상, 대뇌기저핵, 중소뇌각, 연수, 그리고 피지하단백질 순으로 호발되었다. 이들 병소는 T2강조영상에서 불균질의 고신호강도, T1강조영상에서 저신호 강도로 보였으며, 국소적인 조영증강이 비교적 흔하게 관찰되었다. 추적영상에서 병변의 호전 및 재발이 관찰되었으나 1년이상 추적검사에서 병변이 있던 부위에 뇌조직의 위축이 관찰되었다. 결론적으로 신경베체트병의 전신적인 임상증상과 특징적인 자기공명영상소견을 앎으로서 신경베체트병의 진단에 도움이 되리라 생각한다. MR findings in nine patients(three female, six male) with neuro-Behcet's disease were retrospectively analyzed. NeuroBehcet's disease was diagnosed on the basis of typical clinical symptoms. Involved site, pattern, signal intensity, and contrast enhancement pattern on MRI were evaluated. In addition, follow up MR imaging was performed in four patients. The midbrain(7/9), internal capsule(7/9), pons(6/9), thalamus(6/9), basal ganglia(5/9), middle cerebella peduncle(4/9), medulla oblongata(2/9) and subcortical white matter(2/9) are involved on MRI. The size of lesions was 1cm to 3cm and their margin was ill-defined and patchy. Inhomogeneous high signal intensity on the T2-weighted images and low signal intensity on T1-weighted images was seen respectvley. In four of nine cases, there was focal enhancement. On follow up MR imaging, improvement or recurrance of the lesions was found. Also in two cases of follow up cases, there was artophy in brainstem and(or) middle cerebellar peduncles. In conclusion, MR imaging with systemic clinical symptoms is useful for diagnosing neuro-Behcet's disease.

[Free Paper] Constipation severity does not reflect the pathologic progression of colorectal cancer : a prospective large-scale quantitative study

Kil-Yong Lee,Sung-Min Lee,Je-Ho Jang,Duck-Woo Kim,Seung Chul Heo,Kyu Joo Park,Sung-Bum Kang 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11

Supratentorial Leptomeningeal Hemangioblstoma : Case Report

Jang, Han Won,Byun, Woo Mok,Lee, Jae Kyo,Cho, Jae Ho,Cho, Kil ho,Hwang, Mi Soo,Park, Bok Hwan,Choi, Joon Hyuk 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

혈관아세포종은 소뇌에 가장 흔하게 발생하며 von Hippel-Lindau disease와 연관될 수 있다. 저자들은 천막상부 연수막에서 기원한 혈관아세포종의 자기공명영상과 병리학적 소견에 대해서 기술하고자 한다. Hemangioblastoma is a benign tumor that most commonly occurs in the cerebellum and associated with von Hippel-Lindau (VHL) disease. Supratentorial hemanigoblastomas are exceptionally rare. We describe the magnetic resonance imaging (MRI) and histopathologic findings of a supratentorial leptomeningeal hemangioblastoma.

Comparison of Drug-Eluting Stent and Bare Metal Stent in Reducing Adverse Cardiac Event after Coronary Stenting in Hemodialysis Patients

( Jang Han Lee ),( Hyun Woo Kim ),( Mi Hyen Yu ),( Jai Won Chang ),( Won Seok Yang ),( Soon Bae Kim ),( Su Kil Park ),( Sang Koo Lee ),( Jung Sik Park ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.1

Purpose: The patients treated with hemodialysis have been known to have a high 1-year mortality rate after percutaneous coronary intervention (PCI). We evaluated the clinical benefits of drug-eluting stent (DES), compared to bare-metal stent (BMS) in Korean hemodialysis patients. Methods: We studied 72 hemodialysis patients (M:F=49:23, age 60±11 years) treated with percutaneous coronary intervention (PCI) from January, 1999 to February, 2006. Forty four patients (M:F=28: 16, age 60±11 years) treated with DES and 28 patients (M:F=21:7, age 60±12 years) with BMS were enrolled. A composite of major adverse cardiac and cerebral endpoints (MACCE) was defined as all-cause death, myocardial infarction, stroke, and target-vessel revascularization (TVR). We compared the incidence of MACCE between DES and BMS group. Results: A composite of MACCE occurred in none in DES group (n=44) and 4 in BMS group (n=28) within 3 months after coronary stenting (Kaplan-Meier survival analysis: 0% vs 14%, respectively, p=0.02). After 3 months, there was no difference in the incidence of primary end points between two groups. Multi-vessel disease (OR 2.47, 95% CI 1.02-6.11, p<0.05) was associated with a significant increase in the incidence of MACCE within 18 months after coronary artery stenting Conclusion: DES may be superior to BMS in reducing adverse cardiac outcome at early period after coronary stenting in HD patients. However, this study showed no significant difference with the lapse of time.