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Cho Min-Ji,Lee Hong-Gyun,Yoon Jae-Won,Kim Gil-Ran,Koo Ja-Hyun,Taneja Reshma,Edelson Brian T.,Lee You Jeong,Choi Je-Min 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Memory-phenotype (MP) CD4+ T cells are a substantial population of conventional T cells that exist in steady-state mice, yet their immunological roles in autoimmune disease remain unclear. In this work, we unveil a unique phenotype of MP CD4+ T cells determined by analyzing single-cell transcriptomic data and T cell receptor (TCR) repertoires. We found that steady-state MP CD4+ T cells in the spleen were composed of heterogeneous effector subpopulations and existed regardless of germ and food antigen exposure. Distinct subpopulations of MP CD4+ T cells were specifically activated by IL-1 family cytokines and STAT activators, revealing that the cells exerted TCR-independent bystander effector functions similar to innate lymphoid cells. In particular, CCR6high subpopulation of MP CD4+ T cells were major responders to IL-23 and IL-1β without MOG35-55 antigen reactivity, which gave them pathogenic Th17 characteristics and allowed them to contribute to autoimmune encephalomyelitis. We identified that Bhlhe40 in CCR6high MP CD4+ T cells as a key regulator of GM-CSF expression through IL-23 and IL-1β signaling, contributing to central nervous system (CNS) pathology in experimental autoimmune encephalomyelitis. Collectively, our findings reveal the clearly distinct effector-like heterogeneity of MP CD4+ T cells in the steady state and indicate that CCR6high MP CD4+ T cells exacerbate autoimmune neuroinflammation via the Bhlhe40/GM-CSF axis in a bystander manner.
Changes in Corneal Sensation and Ocular Surface in Patients With Asymmetrical Keratoconus
Cho, Kyong Jin,Mok, Jee Won,Choi, Min Yeong,Kim, Ja-yeon,Joo, Choun-Ki Masson Pub. USA 2013 Cornea Vol.32 No.2
PURPOSE:: To describe tear function, ocular surface changes, and corneal sensitivity in patients with asymmetrical keratoconus (KC). METHODS:: Thirty-one patients with asymmetrical KC (31 KC and 31 subclinical KC eyes) and 30 control subjects (1 eye in each subject) were enrolled in this prospective, case-control study. The patients and control subjects underwent ocular surface examinations including corneal sensitivity measurements, the Schirmer test using topical anesthesia, tear osmolarity test, and conjunctival impression cytology. RESULTS:: Mean corneal sensitivity and Schirmer test values were significantly lower in the KC and subclinical KC eyes compared with the control eyes. The conjunctiva of KC and subclinical KC eyes showed significantly higher grades of squamous metaplasia and goblet cell loss compared with the control group. However, no significant difference in tear osmolarity was found among the groups. CONCLUSIONS:: The corneal sensitivity and ocular surface changes were significant in the subclinical KC and KC eyes compared with the control subjects. Ocular surface disease in KC was characterized by tear deficiency disorder and abnormal impression cytology results. However, no significant difference in tear osmolarity was found among the groups. The decrease in corneal sensitivity and ocular surface change may be associated with the pathogenesis of ocular surface changes in KC and the progression of the disease.
Cho, Chi‐,Hyun,Nam, Myoung Hyun,Kim, Jang Su,Han, Eun Taek,Lee, Won Ja,Oh, Jun Seo,An, Seong Soo A.,Lim, Chae Seung Blackwell Publishing Ltd 2011 Tropical medicine & international health Vol.16 No.2
<P><B>Summary</B></P><P>Introduction of rapid malaria diagnostic tests (RDT) initiated numerous field evaluations in various epidemiologic settings. But the efficiency of some RTD kits based on aldolase raised reservations for direct implementation of RDT into clinical settings. We performed Binax Now malaria test in 84 Korean <I>Plasmodium vivax</I> isolates and compared it with the traditional Giemsa stain microscopy test as the reference standard. The sensitivity of Binax Now was 62.0% for <I>P.?vivax</I> cases (52/84, 95% CI 51.2–71.6%) with 100.0% specificity (50/50, 95% confidence interval 92.9–100%). After the aldolase gene sequence analysis of 84 isolates, two synonymous mutations in aldolase gene were identified in both Binax Now positive and negative samples. No significant association between the mutations and Binax Now malaria tests was found. Thus, the genetic variability would not explain the poor performance of <I>P.?vivax</I> RDTs by detecting aldolase in ROK isolates.</P>
Ja Kyung Lee,Eu Jeong Ku,Su-jin Kim,Woochul Kim,Jae Won Cho,Kyong Yeun Jung,Hyeong Won Yu,Yea Eun Kang,Mijin Kim,Hee Kyung Kim,Junsun Ryu,June Young Choi 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.106 No.1
Purpose: Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association of TSH suppression on healthrelated quality of life (HR-QoL) in patients after thyroid lobectomy is not well studied. This study aimed to evaluate the effect of TSH suppression on patient HR-QoL after thyroid lobectomy. Methods: This study included patients enrolled in an ongoing, multicenter, randomized controlled study investigating the effects of TSH suppression. Patients were randomized to either the low-TSH group (TSH target range, 0.3–1.99 μIU/mL) or the high-TSH group (TSH target range, 2.0–7.99 μIU/mL). The HR-QoL, hyperthyroidism symptom, and depression symptom questionnaires performed preoperatively and 2 weeks and 3 months postoperatively were evaluated. Results: Total of 669 patients (low-TSH group, 340; high-TSH group, 329) were included. Although total HR-QoL score changes were not different between the 2 groups, the high-TSH group had a significantly higher score in the physical domain at postoperative 3 months (P = 0.046). The 2 groups did not have significant differences in hyperthyroidism and depression scores. Conclusion: In the short-term postoperative period, the physical HR-QoL scores in thyroid lobectomy patients were better when they did not receive TSH suppression. This study suggests the importance of considering HR-QoL when setting TSH suppression targets in thyroid lobectomy patients.
The study on the participation of Korean dentists in public posts
( Ja-won Cho ),( Su-hyun Shim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.3
There have been few reports about the manpower planning of dentists in the public sector in Korea. The purpose of this study was to research dentists` opinions about the public posts, and to suggest public health policies for the new dental manpower position. A total of 536 dentists were asked to fill out questionnaires inquiring about their opinions of public posts. We used an online survey methodology to involve 500 participants. The chi-square tests and frequency distributions were implemented to analyze the dentists` opinions about the public posts. The significance level of 0.05 was applied. A statistical package SPSS 21.0 was used for the analysis. An overwhelming majority of dentists (95.6%) answered that it is necessary to set up public posts for dentists. Respondents pointed out that the Korean Dental Association (35.5%) and the Ministry of Health and Welfare (33.2%) were the main institutes that should carry out this process. Especially, 47.4% of dentists answered they would quit their job if they had opportunities to fill public posts. Most dentists wanted to work as administrative officials (36.3%) in the public sector. Many dentists (62.4%) wanted to contribute to public welfare as health care professionals in public posts. Most of all, respondents (95.6%) answered that it is imperative to improve the manpower system of dentists in public posts.
( Ja-won Cho ),( Su-hyun Shim ) 조선대학교 구강생물학연구소 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.2
This study was designed to investigate the perception of public posts between students enrolled in dental college and in graduate school of dentistry and to propose the new curriculum and public policy to be more appropriate for the future. Study participants were 397 students in dental college and 160 students in graduate school of dentistry. A self-reported questionnaire to ask about socio-demographic characteristics, career plan and the perception of public posts was conducted for 557 students. The data were analyzed using a chi-square test, frequency analysis, and Pearson’s correlation coefficient. There were significant differences in socio-demographic characteristics, major satisfaction, and career plans between the two groups. Although these two groups have different backgrounds, both groups of students were motivated by opportunities to get a specialized job and wanted to contribute to public welfare as healthcare professionals in public posts. Most students (96.2%) agreed that government should set up public posts for dentists. Significantly, students in graduate school of dentistry were more likely to quit their jobs if they had opportunities to fill public posts (48.1%) and most of them (38.5%) ranked administrative positions higher than other types of public posts as a desired job. Additionally, students living in the Korean metropolitan area showed the tendency to work in the Korean metropolitan area after graduation, while those living in other areas wanted to work in areas outside the metropolitan area (P<0.001). Though a more well-designed longitudinal study is needed, this study can be valuable for curriculum development and health policymaking.