HCV : PE-093 ; Insulin resistance in nonalcoholic steatohepatitis associated with metabolic syndrome

( Kyong Yeun Jung ),( Byoung Woon Kwon ),( Yong Hyun Kim ),( Rhan Noh ),( Ha Yan Kang ),( Hyun Deok Shin ),( Suk Bae Kim ),( Il Han Song ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Nonalcoholic steatohepatitis (NASH) is regarded as a hepatic manifestation of metabolic syndrome. Insulin resistance has been suggested as an essential requirement of the pathogenic mechanism of NASH. The aims of this study were to determine the association of NASH with the insulin resistance and to assess the correlation of insulin resistance to metabolic components accompanied by patients with NASH. Methods: A total of 89 subjects with NASH (mean age 38±15 year, male 77%) was enrolled, of whom 34 had available quantitative value of insulin resistance. Clinical characteristics including insulin resistance and accompanying metabolic syndrome in NASH subjects were compared with those of 52 diabetes patients (disease controls) and 21 health examinee (normal controls). In NASH patients, the relationship between insulin resistance and metabolic syndrome was analyzed according to the different clustering of metabolic components. Diagnosis of NASH was performed by histology or nonhistologic criteria, and insulin resistance was calculated as homeostasis model assessment of insulin resistance (HOMA-IR). Results: NASH subjects had a stronger association with metabolic syndrome than normal controls. HOMA-IR was significantly higher in NASH patients than that of normal controls (5.1±3.1 vs 1.7±0.6, p<0.001) but not diabetes disease controls (5.1±3.1 vs 4.5±3.2, p>0.05). The proportion of impaired fasting glucose or DM (p=0.002), hypertension (p=0.013), obesity (p=0.023), hypertriglyceridemia (p=0.001), and low HDL cholesterol (p<0.001) significantly increased in accordance with the number of different clustering of accompanying metabolic components in patients with NASH. HOMA-IR was positively correlated with BMI (r=0.432, p=0.014) but not correlated with the other metabolic components. Conclusions: NASH subjects showed increased insulin resistance with significant association of metabolic syndrome. Further prospective study should be challenged for assessing a causal and evolutional relationship in NASH and metabolic syndrome related to insulin resistance.

HCV, Alcoholic : PE-093 ; Insulin resistance in nonalcoholic steatohepatitis associated with metabolic syndrome

( Kyong Yeun Jung ),( Byoung Woon Kwon ),( Yong Hyun Kim ),( Rhan Noh ),( Ha Yan Kang ),( Hyun Deok Shin ),( Suk Bae Kim ),( Il Han Song ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Nonalcoholic steatohepatitis (NASH) is regarded as a hepatic manifestation of metabolic syndrome. Insulin resistance has been suggested as an essential requirement of the pathogenic mechanism of NASH. The aims of this study were to determine the association of NASH with the insulin resistance and to assess the correlation of insulin resistance to metabolic components accompanied by patients with NASH. Methods: A total of 89 subjects with NASH (mean age 38±15 year, male 77%) was enrolled, of whom 34 had available quantitative value of insulin resistance. Clinical characteristics including insulin resistance and accompanying metabolic syndrome in NASH subjects were compared with those of 52 diabetes patients (disease controls) and 21 health examinee (normal controls). In NASH patients, the relationship between insulin resistance and metabolic syndrome was analyzed according to the different clustering of metabolic components. Diagnosis of NASH was performed by histology or non- histologic criteria, and insulin resistance was calculated as homeostasis model assessment of insulin resistance (HOMA-IR). Results: NASH subjects had a stronger association with metabolic syndrome than normal controls. HOMA-IR was significantly higher in NASH patients than that of normal controls (5.1±3.1 vs 1.7±0.6, p<0.001) but not diabetes disease controls (5.1±3.1 vs 4.5±3.2, p>0.05). The proportion of impaired fasting glucose or DM (p=0.002), hypertension (p=0.013), obesity (p=0.023), hypertriglyceridemia (p=0.001), and low HDL cholesterol (p<0.001) significantly increased in accordance with the number of different clustering of accompanying metabolic components in patients with NASH. HOMA-IR was positively correlated with BMI (r=0.432, p=0.014) but not correlated with the other metabolic components. Conclusions: NASH subjects showed increased insulin resistance with significant association of metabolic syndrome. Further prospective study should be challenged for assessing a causal and evolutional relationship in NASH and metabolic syndrome related to insulin resistance.

Inhibition of DNA Topoisomerases Ⅰ and Ⅱ and Cytotoxicity by Lignans from Saururus chinensis

Yeun-Kyung Lee,Chang-Seob Seo,이종순,Kyong-Seon Lee,Shin-Jung Kang,Yurngdong Jahng,Hyun Wook Chang,Jong-Keun Son 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC50 values; 13, 12, 11, and 10μM, respectively) and HepG2 cell lines (IC50 values; 16, 11, 12, and 11 μM, respectively).

바이모달 트램의 실시간 시뮬레이터 프로그램 개발

윤경한(kyong-Han Yun),김영철(Young-Chol Kim),이용상(Yong-Sang Lee),정해봉(Hae-Bong Jung),변윤섭(Yeun-Sub Byun) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

본 논문은 한국 철도기술연구원에서 바이모달 트램의 안내/추진/도킹 제어기 검증을 위해 제작중인 LabVIEW, PXI기반의 실시간 시뮬레이터를 위한 시뮬레이션 프로그램 개발에 대한 내용을 다루었다. 시뮬레이터 프로그램은 바이모달 트램의 비선형 동적모델, 위치추정필터, 안내/추진/도킹 제어기로 구성되며, 비선형 동적모델에는 실제 차량에서 제어기나 관측기에 사용되는 각종 측정값들을 모사하기 위한 센서계측시스템이 포함된다.

기관지내 전암성 병변 발견을 위한 자가 형광 기관지 내시경의 유용성

이연선 ( Yeun Seun Lee ),정미경 ( Mi Kyong Jeuong ),이유진 ( Yu Jin Lee ),장필순 ( Pill Soon Jang ),이정은 ( Jeung Eun Lee ),박희선 ( Hee Sun Park ),정재욱 ( Chae Uk Chung ),정성수 ( Sung Soo Jung ),김선영 ( Sun Young Kim ),김주옥 대한내과학회 2006 대한내과학회지 Vol.71 No.1

목적: 형광 기관지 내시경을 시행시 기관지 상피의 전암성 병변(dysplasia II-III & severe dysplasia)의 발견율의 향상을 가져 오는 것으로 알려져 있다. 이에 저자들은 백색빛 기관지 내시경 검사에 추가하여 형광기관지 내시경 시행시 전암성 병변의 유병률 및 백색빛 기관지 내시경 단독 검사에 비교하여 추가 검사시의 유용성을 알아보고자 연구를 계획하였다. 방법: 2005년 1월부터 2005년 12월까지 본원에서 폐암 의증 하에 진단과정 중의 환자, 기존 폐암으로 추적관찰 중인 환자를 대상으로 백색빛 기관지 내시경(Pentax; BP 3500, 일본) 및 형광 기관지 내시경(Richard Wolf, 독일) 시행 후 육안 소견상 이상이 있다고 판단되었던 모든 병변에 대하여 조직검사를 시행하였다. 결과: 사람에 대한 전암성 병변의 유병률은 전체 환자 169명 중 11명(6.5%)이었고, 암으로 의심하에 진단과정 중의 환자에서는 6.7% (9/134)이었고, WLB상 이상이 있어 추가 AFB를 시행하였던 군에서는 11.8% (2/17)이었지만, 이미 암으로 진단받고 추적관찰 중이던 환자중에서는 한명도 발견할 수 없었다. 조직결과에 따른 WLB+AFB와 WLB의 판정결과를 분석시 전암성 병변의 민감도는 77.8% vs. 22.2% (p=0.04, RR=3.5; 95% CI 0.93-13.24), 특이도 89.2% vs. 56.9% (p<0.01, RR=0.64; 95% CI 0.54-0.75), 양성 예측률은 5.6% vs. 2.8% (p=0.20, RR=2.0; 95% CI 0.43-9.37) 그리고 음성 예측률은 93.7% vs. 87.2% (p=0.06, RR=1.07; 95% CI 0.99-1,17)이었다. 결론: 백색빛 기관지 내시경 검사에 형광 기관지 내시경 검사의 추가시 전암성 병변의 발견율을 높일 수는 있으나, 전체적인 전암성 병변의 유병률이 높지 않아 고위험군에 대한 대상 환자의 선별이 필요하리라 생각된다. Background: Autofluorescence bronchoscopy (AFB), when used as an adjunct to conventional white light bronchoscopy (WLB) improves the bronchoscopist`s ability to localized small intraepithelial lesions. Current study was undertaken to evaluate prevalence of preinvasive intraepithelial lesions (dysplasia II-III & CIS) and efficacy of additional AFB system to WLB in comparison with WLB alone. Methods: In patients with suspicion of lung cancer or follow-up ones with known lung cancer, WLB (Pentax; BP 3500, Japan) and AFB (Richard Wolf, Germany) were done and all subjects with endoscopic abnormalities underwent biopsies from January 2005 to December 2005. Results: 169 patients (134 suspected to have lung cancer radiologically, 18 with known lung cancer, and 17 with initial abnormal WLB visual findings) were enrolled. Overall preinvasive intraepithelial lesions were detected in 6.5% (11 persons). Biopsy based sensitivity of WLB+AFB and WLB alone for detecting preinvasive intraepithelial lesions was 77.8% compared with 22.2% (relative ratio 3.5, 95% CI 0.93-13.24). Corresponding specificity was 56.9% compared with 89.2% (relative ratio 0.64, 95% CI 0.54-0.75). The positive predicitve value was 6% and 3%, and the negative predictive value was 94% and 87%, respectively, for WLB+AFB and WLB alone. Conclusions: WLB+AFB was superior to WLB alone in detecting preinvasive intraepithelial lesions, but general use of AFB as a screening tool seems to be limited in suspected or known lung cancer group because of low prevalence. It is necessary of further study for precise indication for AFB among the lung cancer risk groups.(Korean J Med 71:67-74, 2006)

연쇄알구균 감염에 의한 급성 인후염 후 반응성 관절염 1예

박은하,도연실,양정채,강미라,서현주,정숙인,손준성,기현균,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

연쇄알구균에 의한 급성 인후염 후 발생한 반응성 관절염은 급성 류마티스열의 개정된 진단기준을 충족하지 못하면서, 지속적 혹은 재발성의 비이동성 관절염과 발열, 홍반성 결절, 일시적 간기능 이상 등을 보이면서 심장염과 무도증을 드물게 동반하는 질환이다. 따라서, 발열을 동반한 급성 관절염 환자에서 감별해야 할 질환 중의 하나이며, 심근염 예방을 위한 페니실린 요법의 적응증 및 기간에 대해서는 아직 이론이 많은 상황으로, 보다 광범위한 연구가 필요하다. 저자들은 연쇄알구균에 의한 급성 인후염 1주 후에 발생한 하지의 다발성 비이동성 관절염과 함께 결절홍반 및 일시적 간기능 이상을 보인 환자에서 PSRA로 진단하고 비스테로이드성 항염증제 및 스테로이드로 성공적인 치료를 하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Poststreptococcal reactive arthritis (PSRA) is associated with recent streptococcal infections. However, PSRA is distinct from acute rheumatic fever by its clinical manifestations: non-migrating arthritis, erythema nodosum or erythema multiforme, and transient elevation of serum transaminases. We experienced a 33-year-old man who presented with fever, arthritis of both knees and ankles, and erythema nodosums on extensor surfaces of lower legs which developed 6 days after the onset of pharyngitis symptoms. Blood and urine cultures were negative. Throat culture was negative for group A β-hemolytic streptococcus. The ASO titers increased up to 2080 IU/mL in sequential monitoring. The result of bone scan was compatible to arthritis of both knees and ankles. There were no signs or symptom of carditis. He showed clinical improvement with anti-inflammatory drugs (naproxen 1,000 mg/day and prednisolone 7.5 mg/d). PSRA should be included in the differential diagnosis of patients presenting with arthritis combined with fever.

Comparison of three human liver cell lines for in vitro drug-induced liver injury assessment: Huh7, HepaRG, and stem cell-derived hepatocytes

So Yoon Yun,Ju Yeun Kim,Moon Jung Back,Hee Soo Kim,Hae Chan Ha,Ji Min Jang,Dae Kyong Kim 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3

Backgrounds: Drug-induced liver injury (DILI) is a major causal factor for failure in clinical trials and withdrawal of drugs from pharmaceutical markets. Therefore, a human cell-based in vitro system has been established to overcome the limitations of preclinical trials. However, previous studies focused on the drug metabolism in each cell line or described to be superior in one single cell line for assessing DILI. In this study, we used Huh7, HepaRG, and Hepatosight-S cells to evaluate the liver toxicity and dysfunction driven by DILI-inducing drugs. Methods: Cytotoxicity of 17 DILI-inducing drugs was assessed by LDH release assay and the drug-induced liver dysfunction was confirmed by albumin secretion. Furthermore, we analyzed the expression levels of phase I and phase II enzymes and nuclear receptors in each cell lines. Results: DILI-inducing drugs were differently detected in each cell line because each cell line differs on the expression of drug metabolic enzymes which associated with reactivity on DILI inducing drugs. Conclusion: To predict the responses of DILI-inducing drugs in human liver cells, using diverse cell lines having different drug metabolic capabilities is more suitable for predicting DILI.

A case of reversible heart failure and rhabdomyolysis caused by primary hypoparathyroidism during lactation (초)

( Sung Hwahn Hahn ),( Kyong Yeun Jung ),( Hyun Suk Lee ),( Won Kyung Lee ),( Yong Hyun Kim ),( Hee Jin Kim ),( Hyun Kyung Chung ),( Do Hee Kim ) 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-

Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis

Jin Taek Kim,You Mi Kim,Kyong Yeun Jung,Hoonsung Choi,So Young Lee,Hyo-Jeong Kim 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.1

Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications. Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and osteoporosis were enrolled. Twenty patients received denosumab plus calcium carbonate and vitamin D, and seven controls received calcium carbonate and vitamin D for 1 year. Dual-energy X-ray absorptiometry and coronary artery calcium (CAC) scoring computed tomography were performed before and after treatment. Hypocalcemic symptoms and serum calcium levels were evaluated. Results: After 1 year of treatment, the percent changes of femur neck (3.6 ± 3.2% vs. -0.7 ± 4.4%, p = 0.033) and total hip (3.4 ± 3.8% vs. -1.9 ± 2.1%, p = 0.001) bone mineral density (BMD) were significantly increased in the denosumab treated group compared to the control group. However, the percent change of lumbar spine BMD did not differ between two groups (5.6 ± 5.9% vs. 2.7 ± 3.9%, p = 0.273). The percent change of bone alkaline phosphatase was significantly different in the denosumab-treated group and control group (-31.1 ± 30.0% vs. 0.5 ± 32.0%, p = 0.027). CAC scores did not differ between groups. No hypocalcemic events occurred in both groups. Conclusions: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b–4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.

원형보간을 이용한 바이모달 트램용 경로 생성 기법

이용상(Yong-Sang Lee),정해봉(Hae-Bong Jung),김영철(Young-Chol Kim),윤경한(Kyong-Han Yun),변윤섭(Yeun-Sub Byun) 대한전기학회 2009 정보 및 제어 심포지엄 논문집 Vol.2009 No.10

본 논문에서는 바이모달 트램의 기준경로로 주어지는 이산적인 데이터를 연속적인 데이터로 보간하는 보간알고리즘 설계에 대해 다루었다. 기준경로는 바이모달 트램이 주행할 경로로써 데이터베이스 형태로 주어지며, 각 데이터들은 경로의 곡률반경에 따라 일정하지 않은 간격으로 구성되어 있다. 이 데이터를 이용하여 경로오차를 계산하기 위해서는 연속적인 데이터로의 변환이 필요하며, 데이터 변환을 위한 보간 알고리즘으로 본 논문에서는 원형보간 알고리즘을 이용하였다.