Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

Shin, S.J.,Kim, N.K.,Keum, K.C.,Kim, H.G.,Im, J.S.,Choi, H.J.,Baik, S.H.,Choen, J.H.,Jeung, H.C.,Rha, S.Y.,Roh, J.K.,Chung, H.C.,Ahn, J.B. Elsevier Science Publishers 2010 Radiotherapy and oncology Vol.95 No.3

Background and purpose: The aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with S-1 and irinotecan (SI) in LARC. Materials and methods: Patients were considered LARC if they had a T3/T4 lesion or node positive. Weekly doses of 40mg/m<SUP>2</SUP> irinotecan were intravenously administered once per week during weeks 1-5 of radiotherapy. S-1 (70mg/m<SUP>2</SUP>) was given from Monday to Friday in all weeks of radiotherapy. 3-D conformal radiotherapy was given at daily fractions of 1.8Gy for 5days for a total dose of 50.4 (45+5.4)Gy. Surgery was performed 4-6weeks following the completion of chemoradiation. Results: Between June 2006 and November 2007, 43 pts were enrolled. The stage was: cT3 24 patients, cT4 6 patients; 28 patients were cN+. Forty-one patients completed the chemoradiation and 42 patients underwent operation: a low anterior resection was performed in 36 patients, a total colectomy in 1 patient, and an abdominal perineal resection in 5 patients. T downstaging was observed in 50%; 23 N+ patients became N- (55%). The complete pathological response was observed in 9 patients (21%). The 3-year locoregional failure rate, distant failure rate, disease-free survival, and overall survival were 9.5%, 18.6%, 72.1%, and 94.3%, respectively. Only three patients experienced G3 diarrhea; one had G3 sepsis and two had septic shock. Hematological toxicity (G3-G4) was observed in five patients. Conclusions: This study demonstrated the efficacy of preoperative CRT with S-1 and irinotecan with 21% of complete response. However, prompt recognition and management of infection is needed to use it in patients with locally advanced rectal cancer.

J/ψ production as a function of charged particle multiplicity in pp collisions at s =7 TeV

ALICE Collaboration,Abelev, B.,Adam, J.,Adamova, D.,Adare, A.M.,Aggarwal, M.M.,Aglieri Rinella, G.,Agocs, A.G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad Masoodi, A.,Ahmad, N.,Ahn, S.U.,Aki North-Holland Pub. Co 2012 Physics letters: B Vol.712 No.3

The ALICE Collaboration reports the measurement of the relative J/ψ yield as a function of charged particle pseudorapidity density dN<SUB>ch</SUB>/dη in pp collisions at s=7 TeV at the LHC. J/ψ particles are detected for p<SUB>t</SUB>>0, in the rapidity interval |y|<0.9 via decay into e<SUP>+</SUP>e<SUP>-</SUP>, and in the interval 2.5<y<4.0 via decay into μ<SUP>+</SUP>μ<SUP>-</SUP> pairs. An approximately linear increase of the J/ψ yields normalized to their event average (dN<SUB>J/ψ</SUB>/dy)/<dN<SUB>J/ψ</SUB>/dy> with (dN<SUB>ch</SUB>/dη)/<dN<SUB>ch</SUB>/dη> is observed in both rapidity ranges, where dN<SUB>ch</SUB>/dη is measured within |η|<1 and p<SUB>t</SUB>>0. In the highest multiplicity interval with <dN<SUB>ch</SUB>/dη(bin)≥24.1, corresponding to four times the minimum bias multiplicity density, an enhancement relative to the minimum bias J/ψ yield by a factor of about 5 at 2.5<y<4 (8 at |y|<0.9) is observed.

J/ψ Elliptic Flow in Pb-Pb Collisions at sNN=5.02 TeV

Acharya, S.,Adamová,, D.,Adolfsson, J.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Al-Turany, M.,Alam, S. N.,Albuquerque, D. S. D. American Physical Society 2017 Physical Review Letters Vol.119 No.24

<P>We report a precise measurement of the J/psi elliptic flow in Pb-Pb collisions at root s(NN) = 5.02 TeV with the ALICE detector at the LHC. The J/psi mesons are reconstructed at midrapidity (|y| < 0.9) in the dielectron decay channel and at forward rapidity (2.5 < y < 4.0) in the dimuon channel, both down to zero transverse momentum. At forward rapidity, the elliptic flow v(2) of the J/psi is studied as a function of the transverse momentum and centrality. A positive v(2) is observed in the transverse momentum range 2<p(T)<8GeV/c in the three centrality classes studied and confirms with higher statistics our earlier results at root s(NN) = 2.76 TeV in semicentral collisions. At midrapidity, the J/psi v(2) is investigated as a function of the transverse momentum in semicentral collisions and found to be in agreement with the measurements at forward rapidity. These results are compared to transport model calculations. The comparison supports the idea that at low p(T) the elliptic flow of the J/psi originates from the thermalization of charm quarks in the deconfined medium but suggests that additional mechanisms might be missing in the models.</P>

R 곡선상의 안정균열개시점 결정을 위한 수정옵셋방법

안광주,최재강,박준수 한국산업안전학회 1999 한국안전학회지 Vol.14 No.3

This paper were performed to evaluate the elastic-plastic fracture toughness J_(IC) by the unloading compliance method for 1/2 CT specimen of A5083-H112 aluminum alloy. A modified offset method for negative crack growth effect is presented and compared with Voss offset method. We found that the modified offset method presented can be used efficiently for a determination of the stable crack onset. The J_(IC) by Voss offset method can be overestimated, but the suggested offset method showed a high reliability within 5% of tolerence from the results by the multi-specimen method.

5-Nitro-5'-hydroxy-indirubin-3'-oxime (AGM130), an indirubin-3'-oxime derivative, inhibits tumor growth by inducing apoptosis against non-small cell lung cancer in vitro and in vivo

Ahn, M.Y.,Kim, T.H.,Kwon, S.M.,Yoon, H.E.,Kim, H.S.,Kim, J.I.,Kim, Y.C.,Kang, K.W.,Ahn, S.G.,Yoon, J.H. Elsevier 2015 European journal of pharmaceutical sciences Vol.79 No.-

This study examined the anti-tumor effects of AGM130, a novel indirubin-3'-oxime derivative in A549 human non-small cell lung cancer cells. AGM130 significantly inhibited the proliferation and arrested the cell cycle of G2/M phase. Induction of apoptosis was detected in AGM130-treated A549 cells. The protein levels of Cytochrome c release, Bax, cleaved caspases and PARP were increased in AGM130 treated cells, whereas Bcl-2 levels were decreased. AGM130 inhibited Insulin-like growth factor 1 receptor (IGF1R), AKT/mTOR signaling and inactivated mitogen-activated protein kinases (MAPK). AGM130 also induced slight autophagy as pro-survival function and autophagy inhibition by chloroquine (CQ) induced necrosis. In vivo tumor xenograft model, AGM130 dose-dependently suppressed transplanted A549 cell tumor growth and induced the expression of proliferative cell nuclear antigen (PCNA). AGM130 also increased TUNEL positive apoptotic cell populations and the induction of glandular differentiation with mucin pool compared with vehicle-treated control in tumor tissue. These results suggest that AGM130 is an effective novel indirubin-3'-oxime derivative of anti-cancer drug and may be an attractive candidate for non-small cell lung cancer therapy.

Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-α suppression

Ahn, J.,Kim, S.G.,Kim, M.K.,Kim, D.W.,Lee, J.H.,Seok, H.,Choi, J.Y. Butterworths ; Elsevier 2016 BURNS -OXFORD- Vol.42 No.7

<P>Objective: The objective of this study was to evaluate (1) the effect of 4-hexylresorcinol (4HR) application on TNF-alpha expression in RAW264.7 cells and (2) the effect of 4HR ointment on burn wound healing in a rat burn wound model. Materials and methods: RAW264.7 cells were cultured in the presence of different concentrations of 4HR, and the attached cells were sampled for western blot analysis at each time point. Animal studies were conducted on male Wistar rats (n = 24). Three treatment groups were evaluated in this study: (1) treatment with ointment alone (negative control), (2) treatment with ointment containing 0.2 wt% 4HR, and (3) treatment with ointment containing 2 wt% 4HR. For the assessment of wound healing, digital photographs were taken at 1, 5, and 14 days. Animals were sacrificed at 1, 5, and 14 days for histological examination or ELISA analysis. Results: Western blot analysis showed that TNF-alpha protein levels were reduced following treatment with 4HR at concentrations between 1 and 10 mu g/mL. In animal studies, the average denuded area 14 days after burn was smaller in the 2 wt% 4HR treatment group compared with the control group (P = 0.022). Immunohistochemical analysis revealed lower TNF-alpha expression in the 2 wt% 4HR treatment group compared with the control group 14 days after burn (P = 0.027). Conclusion: 4HR reduced TNF-alpha expression in RAW264.7 cells and in the burn wounds of rats. Burn wounds dressed with ointment containing 4HR also exhibited rapid epithelization and collagen regeneration. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.</P>

Erratum to ''2'-Benzoyloxycinnamaldehyde inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells via regulation of the AP-1 pathway'' [Eur. J. Pharmacol. 696 (2012) 179-186]

Kwon, J.Y.,Hong, S.H.,Park, S.D.,Ahn, S.G.,Yoon, J.H.,Kwon, B.M.,Kim, S.A. North-Holland ; Elsevier Science Ltd 2013 european journal of pharmacology Vol.700 No.1

Measurement of an Excess in the Yield ofJ/ψat Very LowpTin Pb-Pb Collisions atsNN=2.76 TeV

Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandro, B.,Alexandre, D.,Alfaro M American Physical Society 2016 Physical review letters Vol.116 No.22

<P>We report on the first measurement of an excess in the yield of J/psi at very low transverse momentum (pT < 0.3 GeV/c) in peripheral hadronic Pb-Pb collisions at root s(NN) = 2.76 TeV, performed by ALICE at the CERN LHC. Remarkably, the measured nuclear modification factor of J/psi in the rapidity range 2.5 < y < 4 reaches about 7 (2) in the p(T) range 0-0.3 GeV/c in the 70%-90% (50%-70%) centrality class. The J/psi production cross section associated with the observed excess is obtained under the hypothesis that coherent photoproduction of J/psi is the underlying physics mechanism. If confirmed, the observation of J/psi coherent photoproduction in Pb-Pb collisions at impact parameters smaller than twice the nuclear radius opens new theoretical and experimental challenges and opportunities. In particular, coherent photoproduction accompanying hadronic collisions may provide insight into the dynamics of photoproduction and nuclear reactions, as well as become a novel probe of the quark-gluon plasma.</P>

Carbon nanofiber/cobalt oxide nanopyramid core-shell nanowires for high-performance lithium-ion batteries

An, G.H.,Ahn, H.J. Elsevier Sequoia 2014 Journal of Power Sources Vol.272 No.-

Carbon nanofiber (CNF)/Co<SUB>3</SUB>O<SUB>4</SUB> nanopyramid core-shell nanowires (NWs) are synthesized using an electrospinning method followed by reduction and hydrothermal treatment in order to improve the capacity, cycle stability, and high-rate capability of the electrodes in Li ion batteries (LIBs). The morphology, crystal structure, and chemical states of all samples are investigated by means of field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and thermogravimetric analysis. For comparison, conventional CNFs, octahedral Co<SUB>3</SUB>O<SUB>4</SUB>, and Co<SUB>3</SUB>O<SUB>4</SUB>/CNF composite electrodes are prepared. LIB cells fabricate with the CNF/Co<SUB>3</SUB>O<SUB>4</SUB> nanopyramid core-shell NWs exhibit superb discharge capacity (1173 mAh g<SUP>-1</SUP> at the 1st cycle), cycle stability (795 mAh g<SUP>-1</SUP> at 50 cycles), high initial Coulombic efficiency (84.8%), and high-rate capability (570 mAh g<SUP>-1</SUP> at a current density of 700 mA g<SUP>-1</SUP>) as compared to the conventional CNF, octahedral Co<SUB>3</SUB>O<SUB>4</SUB>, and Co<SUB>3</SUB>O<SUB>4</SUB>/CNF composite electrodes. The performance improvement is owing to the introduction of one-dimensional CNFs relative to efficient electron transport in the core region, extensive utilization of Co<SUB>3</SUB>O<SUB>4</SUB> nanopyramids with high capacity grown closely on the CNFs in the shell region, and the network structures of the electrode relative to the improvement of Li ion diffusion.

가족공동체를 떠난 간호대학생들의 대학생활체험

김고은,김유은,김희진,조유진,안주영,허다연,홍서우,차지영,박송이 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52

Purpose: The purpose of this study was to understand and explain the experiences of college life among junior nursing students who live apart from their families. Methods: 14 junior nursing students living apart from their families for at least one semester were recruited through snowballing and convenience sampling. Participants were interviewed individually using open ended questions. Data were collected from July to October in 2017 until data saturation. Interviews were transcribed verbatim and analyzed by using hermeneutic phenomenological method proposed by van Manen. Results: Five essential theme clusters emerged: (1) faced with diverse problems while living apart from family, (2) depend on family when stressed, (3) adapt to college life by being independent and forming self-initiative lifestyle, (4) confront with difficulties once again when adapting to academic curriculum restructured by practicum, (5) pave the way to nursing career and feel proud of overcoming the difficulties independently. Conclusion: Although most participants faced diverse problems in college life, they tried to adapt independently by forming self-initiative lifestyle and overturn the difficulties to positive experiences. In conclusion, the process of living apart from families transformed participants into proactive individuals. Adopting counseling programs could support starting their junior years successfully.