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M. Isabel Enríquez-Salazar,Fabiola Veana,Cristóbal N. Aguilar,Iliana M. De la Garza-Rodríguez,Mercedes G. Lo´pez,Olga M. Rutiaga-Quiñones,Jesú s A. Morlett-Chávez,Raúl Rodríguez-Herrera 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4
Aguamiel is a beverage produced by some Agave species that is consumed in its fresh or fermented form. Despite its uses and popularity, seasonal effects on its microbial and chemical profiles are unknown. In this study, using aguamiel collected from A. salmiana and A. atrovirens during different seasons, we identified microorganisms by sequencing the 16S and 18S rDNA genes and determined their chemical profiles. In total, 49 microbial strains were identified (38 bacteria and 11 yeasts). The highest richness and biodiversity were observed during winter and summer. Different lactic acid bacteria and yeast genera with potential industrial applications were identified, such as Acetobacter, Lactobacillus, Leuconostoc, and Clavispora. The analysis of the chemical profiles indicated the presence of maltooligosaccharides and fructooligosaccharides, which are associated with human health improvements, during spring in Agave aguamiel. Aguamiel can be used in the food industry due to its microbiological and chemical profiles.
Treatment of autoimmune hemolytic anemia: real world data from a reference center in Mexico
José Carlos Jaime-Pérez,Patrizia Aguilar-Calderón,Lorena Salazar-Cavazos,Andrés Gómez-De León,David Gómez-Almaguer 대한혈액학회 2019 Blood Research Vol.54 No.2
BackgroundWarm autoimmune hemolytic anemia (w-AIHA) is an uncommon disease with heteroge-neous response to treatment. Steroids are the standard treatment at diagnosis, whereas rituximab has recently been recommended as the second-line therapy of choice. Our main objective was to document the response to treatment in patients with newly diag-nosed w-AIHA, including the effectiveness of low-dose rituximab as frontline treatment and for refractory disease.MethodsPatients with w-AIHA from 2002 to 2017 were included. Relapse-free survival (RFS), prob-ability of maintained response (MR), and time-to-response were analyzed using the Kaplan‒Meier method. Response was classified as complete, partial, and no response.ResultsWe included 64 adults with w-AIHA (39 women and 25 men). The median age was 37 (16‒77) years. Response rates to steroids alone were 76.7%, rituximab plus steroids, 100%; and cyclophosphamide, 80%. RFS with steroids at 6, 36, and 72 months was 86.3%, 65.1%, and 59.7%, respectively. Eighteen patients received rituximab at 100 mg/wk for 4 weeks plus high-dose dexamethasone as first-line therapy, with RFS at 6, 36, and 72 months of 92.3%, 58.7% and 44.1%, respectively. Eight patients refractory to several lines of therapy were treated with low-dose rituximab, and all achieved a response (three com-plete response and five partial response) at a median 16 days (95% confidence interval, 14.1‒17.8), with a 75% probability of MR at 103 months; the mean MR was 81.93±18months.ConclusionOutcomes of w-AIHA treatment were considerably heterogeneous. Low rituximab doses plus high dexamethasone doses were effective for refractory disease.
ALICE Collaboration,Abelev, B.,Adam, J.,Adamova, D.,Adare, A.M.,Aggarwal, M.M.,Aglieri Rinella, G.,Agocs, A.G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad, N.,Ahmad Masoodi, A.,Ahn, S.A.,Ahn North-Holland Pub. Co 2013 Physics letters: B Vol.720 No.1
<P>The inclusive transverse momentum (p(T)) distributions of primary charged particles are measured in the pseudo-rapidity range vertical bar eta vertical bar <0.8 as a function of event centrality in Pb-Pb collisions at root S-NN = 2.76 TeV with ALICE at the LHC. The data are presented in the p(T) range 0.15 < p(T) <50 GeV/c for nine centrality intervals from 70-80% to 0-5%. The results in Pb-Pb are presented in terms of the nuclear modification factor R-AA using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-p(T) particles strongly depends on event centrality. The yield is most suppressed in central collisions (0-5%) with R-AA approximate to 0.13 at p(T) = 6-7 GeV/c. Above p(T) = 7 GeV/c, there is a significant rise in the nuclear modification factor, which reaches R-AA approximate to 0.4 for p(T) > 30 GeV/c. In peripheral collisions (70-80%), only moderate suppression (R-AA approximate to 0.6-0.7) and a weak p(T) dependence is observed. The measured nuclear modification factors are compared to other measurements and model calculations. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved.</P>
Multi-strange baryon production in pp collisions at s=7 TeV with ALICE
ALICE Collaboration,Abelev, B.,Adam, J.,Adamova, D.,Adare, A.M.,Aggarwal, M.M.,Aglieri Rinella, G.,Agocs, A.G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad, N.,Ahmad Masoodi, A.,Ahn, S.U.,Aki North-Holland Pub. Co 2012 Physics letters: B Vol.712 No.4
A measurement of the multi-strange Ξ<SUP>-</SUP> and Ω<SUP>-</SUP> baryons and their antiparticles by the ALICE experiment at the CERN Large Hadron Collider (LHC) is presented for inelastic proton-proton collisions at a centre-of-mass energy of 7 TeV. The transverse momentum (p<SUB>T</SUB>) distributions were studied at mid-rapidity (|y|<0.5) in the range of 0.6<p<SUB>T</SUB><8.5 GeV/c for Ξ<SUP>-</SUP> and Ξ@?<SUP>+</SUP> baryons, and in the range of 0.8<p<SUB>T</SUB><5 GeV/c for Ω<SUP>-</SUP> and Ω@?<SUP>+</SUP>. Baryons and antibaryons were measured as separate particles and we find that the baryon to antibaryon ratio of both particle species is consistent with unity over the entire range of the measurement. The statistical precision of the current data has allowed us to measure a difference between the mean p<SUB>T</SUB> of Ξ<SUP>-</SUP> (Ξ@?<SUP>+</SUP>) and Ω<SUP>-</SUP> (Ω@?<SUP>+</SUP>). Particle yields, mean p<SUB>T</SUB>, and the spectra in the intermediate p<SUB>T</SUB> range are not well described by the PYTHIA Perugia 2011 tune Monte Carlo event generator, which has been tuned to reproduce the early LHC data. The discrepancy is largest for Ω<SUP>-</SUP> (Ω@?<SUP>+</SUP>). This PYTHIA tune approaches the p<SUB>T</SUB> spectra of Ξ<SUP>-</SUP> and Ξ@?<SUP>+</SUP> baryons below p<SUB>T</SUB><0.85 GeV/c and describes the Ξ<SUP>-</SUP> and Ξ@?<SUP>+</SUP> spectra above p<SUB>T</SUB>>6.0 GeV/c. We also illustrate the difference between the experimental data and model by comparing the corresponding ratios of (Ω<SUP>-</SUP>+Ω@?<SUP>+</SUP>)/(Ξ<SUP>-</SUP>+Ξ@?<SUP>+</SUP>) as a function of transverse mass.
Heavy flavour decay muon production at forward rapidity in proton-proton collisions at s=7 TeV
ALICE Collaboration,Abelev, B.,Adam, J.,Adamova, D.,Adare, A.M.,Aggarwal, M.M.,Aglieri Rinella, G.,Agocs, A.G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad, N.,Ahmad Masoodi, A.,Ahn, S.U.,Aki North-Holland Pub. Co 2012 Physics letters: B Vol.708 No.3
The production of muons from heavy flavour decays is measured at forward rapidity in proton-proton collisions at s=7 TeV collected with the ALICE experiment at the LHC. The analysis is carried out on a data sample corresponding to an integrated luminosity L<SUB>int</SUB>=16.5 nb<SUP>-1</SUP>. The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are measured in the rapidity range 2.5<y<4, over the transverse momentum range 2<p<SUB>t</SUB><12 GeV/c. The results are compared to predictions based on perturbative QCD calculations.
Abelev, B.,Adam, J.,Adamová,, D.,Adare, A. M.,Aggarwal, M. M.,Aglieri Rinella, G.,Agocs, A. G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad Masoodi, A.,Ahmad, N.,Ahn, S. A.,Ahn, S. U.,A Springer Berlin Heidelberg 2013 The European physical journal. C, Particles and fi Vol.73 No.6
<P>Measurements of cross sections of inelastic and diffractive processes in proton–proton collisions at LHC energies were carried out with the ALICE detector. The fractions of diffractive processes in inelastic collisions were determined from a study of gaps in charged particle pseudorapidity distributions: for single diffraction (diffractive mass <I>M</I><SUB><I>X</I></SUB><200 GeV/<I>c</I><SUP>2</SUP>) [FORMULA OMISSION], and [FORMULA OMISSION], respectively at centre-of-mass energies [FORMULA OMISSION]; for double diffraction (for a pseudorapidity gap Δ<I>η</I>>3) <I>σ</I><SUB>DD</SUB>/<I>σ</I><SUB>INEL</SUB>=0.11±0.03,0.12±0.05, and [FORMULA OMISSION], respectively at [FORMULA OMISSION]. To measure the inelastic cross section, beam properties were determined with van der Meer scans, and, using a simulation of diffraction adjusted to data, the following values were obtained: [FORMULA OMISSION] mb at [FORMULA OMISSION] and [FORMULA OMISSION] at [FORMULA OMISSION]. The single- and double-diffractive cross sections were calculated combining relative rates of diffraction with inelastic cross sections. The results are compared to previous measurements at proton–antiproton and proton–proton colliders at lower energies, to measurements by other experiments at the LHC, and to theoretical models.</P>