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New results on mesonic weak decay of <i>p</i>-shell <i>Λ</i>-hypernuclei
Agnello, M.,Andronenkov, A.,Beer, G.,Benussi, L.,Bertani, M.,Bhang, H.C.,Bonomi, G.,Botta, E.,Bregant, M.,Bressani, T.,Bufalino, S.,Busso, L.,Calvo, D.,Camerini, P.,Dalena, B.,De Mori, F.,D'Erasmo, G. Elsevier 2009 Physics letters: B Vol.681 No.2
<P><B>Abstract</B></P><P>The FINUDA experiment performed a systematic study of the charged mesonic weak decay channel of <I>p</I>-shell <I>Λ</I>-hypernuclei. Negatively charged pion spectra from mesonic decay were measured with magnetic analysis for the first time for <SUP>7</SUP><SUB><I>Λ</I></SUB>Li, <SUP>9</SUP><SUB><I>Λ</I></SUB>Be, <SUP>11</SUP><SUB><I>Λ</I></SUB>B and <SUP>15</SUP><SUB><I>Λ</I></SUB>N. The shape of the <SUP>π−</SUP> spectra was interpreted through a comparison with pion distorted wave calculations that take into account the structure of both hypernucleus and daughter nucleus. Branching ratios <SUB>Γ<SUP>π−</SUP></SUB>/<SUB>Γtot</SUB> were derived from the measured spectra and converted to <SUP>π−</SUP> decay rates <SUB>Γ<SUP>π−</SUP></SUB> by means of known or extrapolated total decay widths <SUB>Γtot</SUB> of <I>p</I>-shell <I>Λ</I>-hypernuclei. Based on these measurements, the spin-parity assignment 1/<SUP>2+</SUP> for <SUP>7</SUP><SUB><I>Λ</I></SUB>Li and 5/<SUP>2+</SUP> for <SUP>11</SUP><SUB><I>Λ</I></SUB>B ground-state are confirmed and a spin-parity 3/<SUP>2+</SUP> for <SUP>15</SUP><SUB><I>Λ</I></SUB>N ground-state is assigned for the first time.</P>
Correlated Λt pairs from the absorption of K<sup>-</sup> at rest in light nuclei
FINUDA Collaboration,Agnello, M.,Andronenkov, A.,Beer, G.,Benussi, L.,Bertani, M.,Bhang, H.C.,Bonomi, G.,Botta, E.,Bregant, M.,Bressani, T.,Bufalino, S.,Busso, L.,Calvo, D.,Camerini, P.,Caponero, M.,D North-Holland Pub. Co 2008 Physics letters: B Vol.669 No.3
Novel data from the K<SUB>stop</SUB><SUP>-</SUP>A absorption reaction in light nuclei <SUP>6,7</SUP>Li and <SUP>9</SUP>Be are presented. The study aimed at finding Λt correlations. Regardless of A, the Λt pairs are preferentially emitted in opposite directions. Reaction modeling predominantly assigns to the K<SUB>stop</SUB><SUP>-</SUP>A->Λt(N)A<SUP>'</SUP> direct reactions the emission of the Λt pairs whose yield is found to range from 10<SUP>-3</SUP> to 10<SUP>-4</SUP>/K<SUB>stop</SUB><SUP>-</SUP>. The experiment was performed with the FINUDA spectrometer at DAΦNE (LNF).
FINUDA Collaboration,Agnello, M.,Beer, G.,Benussi, L.,Bertani, M.,Bhang, H.C.,Bianco, S.,Bonomi, G.,Botta, E.,Bregant, M.,Bressani, T.,Bufalino, S.,Busso, L.,Calvo, D.,Camerini, P.,Caponero, M.,Cerell North-Holland Pub. Co 2007 Physics letters: B Vol.649 No.1
The inelastic charge exchange reaction (K<SUP>+</SUP>, K<SUP>0</SUP>) on <SUP>7</SUP>Li has been experimentally investigated close to threshold with the FINUDA spectrometer at the e<SUP>+</SUP>e<SUP>-</SUP> collider DAΦNE by searching for K<SUB>S</SUB><SUP>0</SUP> decays. It is the first time that this process has been studied at such low momentum. An upper limit of 2.0 mb (at 95% confidence level) has been measured for the total cross section.
Correlated Λd pairs from the K<sub>stop</sub><sup>-</sup>A->ΛdA<sup>'</sup> reaction
FINUDA Collaboration,Agnello, M.,Beer, G.,Benussi, L.,Bertani, M.,Bhang, H.C.,Bianco, S.,Bonomi, G.,Botta, E.,Bregant, M.,Bressani, T.,Bufalino, S.,Busso, L.,Calvo, D.,Camerini, P.,Caponero, M.,Cerell North-Holland Pub. Co 2007 Physics letters: B Vol.654 No.3
Correlated Λd pairs emitted after the absorption of negative kaons at rest K<SUB>stop</SUB><SUP>-</SUP>A->ΛdA<SUP>'</SUP> in light nuclei <SUP>6</SUP>Li and <SUP>12</SUP>C are studied. Λ-hyperons and deuterons are found to be preferentially emitted in opposite directions. The Λd invariant mass spectrum of <SUP>6</SUP>Li shows a bump whose mass is 3251+/-6 MeV/c<SUP>2</SUP>. The bump mass (binding energy), width and yield are reported. The appearance of a bump is discussed in the realm of the [K@?3N] clustering process in nuclei. The experiment was performed with the FINUDA spectrometer at DAΦNE (LNF).
Biomarkers for Prognosis and Treatment Response in COVID-19 Patients
Bivona Giulia,Agnello Luisa,Ciaccio Marcello 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.6
During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost all analytes can change, presenting a correlation with disease severity and survival; however, a biomarker cannot be translated into clinical practice for treatment guidance until it is proven to have a significant impact. Several studies have documented the association between COVID-19 severity and circulating levels of C-reactive protein (CRP) and interleukin-6, and the accuracy of the CRP level in predicting treatment responses has been evaluated. Moreover, promising findings on prothrombin and D-dimer have been reported. However, the clinical usefulness of these biomarkers in COVID-19 is far from proven. The burst of data generation during this pandemic has led to the publication of numerous studies with several notable drawbacks, weakening the strength of their findings. We provide an overview of the key findings of studies on biomarkers for the prognosis and treatment response in COVID-19 patients. We also highlight the main drawbacks of these studies that have limited the clinical use of these biomarkers.
김병건,주민경,유수진,Grazia Dell’Agnello,Hans-Peter Hundemer,Tommaso Panni,Sara Prada Alonso,Sarah Louise Roche,한정희,조수진 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.5
Background and Purpose Several studies have found that the prevalence of migraine is higher among healthcare professionals than in the general population. Furthermore, several investigations have suggested that the personal experiences of neurologists with migraine can influence their perception and treatment of the disease. This study assessed these relationships in Korea. Methods A survey was used to investigate the following characteristics among neurologists: 1) the prevalence rates of migraine, primary stabbing headache, and cluster headache, and 2) their perceptions of migraine and the pain severity experienced by patients, diagnosing migraine, evaluation and treatment patterns, and satisfaction and difficulties with treatment. Results The survey was completed by 442 actively practicing board-certified Korean neurologists. The self-reported lifetime prevalence rates of migraine, migraine with aura, primary stabbing headache, and cluster headache were 49.8%, 12.7%, 26.7%, and 1.4%, respectively. Few of the neurologists used a headache diary or validated scales with their patients, and approximately half were satisfied with the effectiveness of preventive medications. Significant differences were observed between neurologists who had and had not experienced migraine, regarding certain perceptions of migraine, but no differences were found between these groups in the evaluation and preventive treatment of migraine. Conclusions The high self-reported lifetime prevalence rates of migraine and other primary headache disorders among Korean neurologists may indicate that these rates are underreported in the general population, although potential population biases must be considered. From the perspective of neurologists, there is an unmet need for the proper application of headache diaries, validated scales, and effective preventive treatments for patients. While the past experiences of neurologists with migraine might not influence how they evaluate or apply preventive treatments to migraine, they may influence certain perceptions of the disease
Byung-Kun Kim,Soo-Jin Cho,Jeong Hee Han,Grazia Dell’Agnello,Tommaso Panni,Manho Kim,Kyungmi Oh,Heui-Soo Moon,Min Kyung Chu 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.5
Background and Purpose The estimated prevalence of migraines in South Korea is 6.0%, with affected patients having unmet needs. The efficacy, safety, and tolerability of galcanezumab, a humanized monoclonal antibody, for episodic migraine (EM) prevention was evaluated in South Korean patients. Methods During the double-blind period of the EVOLVE-2 phase 3 trial, patients with EM were randomized into placebo, 120 mg-galcanezumab, and 240-mg galcanezumab treatment groups. The primary endpoint was the overall mean change from baseline in the number of monthly migraine headache days during the 6-month double-blind period. We conducted a post-hoc analysis of the South Korean cohort in EVOLVE-2. Results Among 98 South Korean patients in the intent-to-treat population, significant changes from baseline were observed in the number of monthly migraine headache days in the 240- mg galcanezumab group compared with the placebo group (-2.64, p=0.013), in the percentage of patients with ≥50% reduction in the number of monthly migraine headache days (120 mg: odds ratio=2.43, p=0.030; 240 mg: odds ratio=2.60, p=0.019), in the number of monthly migraine headache days with acute medication use (120 mg: -2.22, p=0.006; 240 mg: -2.23, p=0.005), and in the Migraine-Specific Quality-of-Life Role Function-Restrictive (120 mg: 8.34, p=0.040). Numerical improvements from baseline were observed relative to the placebo group in at least one galcanezumab group for: the percentage of patients with ≥75% reduction in the number of monthly migraine headache days functional impairment, and disease severity. The most common treatment-emergent adverse event in the combined galcanezumab group was injection site reaction, which led to treatment discontinuation for one patient. Conclusions Galcanezumab treatment demonstrated efficacy and a favorable safety and tolerability profile in South Korean patients with EM.
Inclusive quarkonium production at forward rapidity in pp collisions at [FORMULA OMISSION] TeV
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandro, B.,Alexandre, D.,Alfaro M Springer Berlin Heidelberg 2016 The European physical journal. C, Particles and fi Vol.76 No.4
<P>We report on the inclusive production cross sections of [FORMULA OMISSION], [FORMULA OMISSION], [FORMULA OMISSION](1S), [FORMULA OMISSION](2S) and [FORMULA OMISSION](3S), measured at forward rapidity with the ALICE detector in [FORMULA OMISSION] collisions at a center-of-mass energy [FORMULA OMISSION] TeV. The analysis is based on data collected at the LHC and corresponds to an integrated luminosity of 1.23 pb[FORMULA OMISSION]. Quarkonia are reconstructed in the dimuon-decay channel. The differential production cross sections are measured as a function of the transverse momentum [FORMULA OMISSION] and rapidity <I>y</I>, over the [FORMULA OMISSION] ranges [FORMULA OMISSION] GeV/<I>c</I> for [FORMULA OMISSION], [FORMULA OMISSION] GeV/<I>c</I> for all other resonances, and for [FORMULA OMISSION]. The cross sections, integrated over [FORMULA OMISSION] and <I>y</I>, and assuming unpolarized quarkonia, are [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] nb, [FORMULA OMISSION] nb and [FORMULA OMISSION] nb, where the first uncertainty is statistical and the second one is systematic. These values agree, within at most [FORMULA OMISSION], with measurements performed by the LHCb collaboration in the same rapidity range.</P>