The Analysis of New Generation S-DMB system

InKi Lee,DaeIg Chang 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

Current S-DMB service in the Korea, one of such personal mobile multimedia services, provides broadcasting with 11 video and 26 audio channels. To provide this service more differently from other multimedia services, enhancement in transmission quality or increase in transmission bandwidth is requested. But this enhancement(or increase) should be Backwards Compatible(BC) to the legacy system for saving system migration expenses. In this paper, we propose a method for enhancing transmission quality or bandwidth, using H- 16APSK for BC and LDPC for powerful channel code. As the enhancement in transmission rate can be allowed as far as the resulted performance degradation and the resulted increase in transmission rate have been simulated and analyzed.

Novel peptides functionally targeting in vivo human lung cancer discovered by in vivo peptide displayed phage screening.

Lee, Kyoung Jin,Lee, Jae Hee,Chung, Hye Kyung,Choi, Jinhyang,Park, Jaesook,Park, Seok Soon,Ju, Eun Jin,Park, Jin,Shin, Seol Hwa,Park, Hye Ji,Ko, Eun Jung,Suh, Nayoung,Kim, InKi,Hwang, Jung Jin,Song, S Springer-Verlag ; Springer 2015 Amino acids Vol.47 No.2

<P>Discovery of the cancer-specific peptidic ligands have been emphasized for active targeting drug delivery system and non-invasive imaging. For the discovery of useful and applicable peptidic ligands, in vivo peptide-displayed phage screening has been performed in this study using a xenograft mouse model as a mimic microenvironment to tumor. To seek human lung cancer-specific peptides, M13 phage library displaying 2.9 ?? 10(9) random peptides was intravenously injected into mouse model bearing A549-derived xenograft tumor through the tail vein. Then the phages emerged from a course of four rounds of biopanning in the xenograft tumor tissue. Novel peptides were categorized into four groups according to a sequence-homology phylogenicity, and in vivo tumor-targeting capacity of these peptides was validated by whole body imaging with Cy5.5-labeled phages in various cancer types. The result revealed that novel peptides accumulated only in adenocarcinoma lung cancer cell-derived xenograft tissue. For further confirmation of the specific targeting ability, in vitro cell-binding assay and immunohistochemistry in vivo tumor tissue were performed with a selected peptide. The peptide was found to bind intensely to lung cancer cells both in vitro and in vivo, which was efficiently compromised with unlabeled phages in an in vitro competition assay. In conclusion, the peptides specifically targeting human lung cancer were discovered in this study, which is warranted to provide substantive feasibilities for drug delivery and imaging in terms of a novel targeted therapeutics and diagnostics.</P>

Comparison of ^99m Tc-methyl diphosphonate bone scintigraphy and ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma

Lee, Inki,Byun, Byung Hyun,Lim, Ilhan,Kim, Byung Il,Kong, Chang-Bae,Song, Won Seok,Cho, Wan Hyeong,Koh, Jae-Soo,Lim, Sang Moo Williams & Wilkins Co 2018 Medicine Vol.97 No.37

<P><B>Abstract</B></P><P>We compared the usefulness of <SUP>99m</SUP>Tc-methyl diphosphonate (<SUP>99m</SUP>Tc-MDP) bone scintigraphy and <SUP>18</SUP>F-fluorodeoxyglucose (FDG) for positron emission tomography/computed tomography (PET/CT) in predicting histologic response in patients with osteosarcoma receiving neoadjuvant chemotherapy (NAC).</P><P>We retrospectively reviewed 62 patients with high-grade osteosarcoma who had received 2 cycles of NAC and surgery. All patients underwent <SUP>99m</SUP>Tc-MDP bone scintigraphy and <SUP>18</SUP>F-FDG PET/CT before and after NAC. <SUP>99m</SUP>Tc-MDP uptake in the primary tumor was measured quantitatively as the maximum tumor-to-nontumor ratio (T/NT<SUB>max</SUB>) and <SUP>18</SUP>F-FDG uptake was measured as the maximum standardized uptake value (SUV<SUB>max</SUB>), before and after NAC. The percent changes of T/NT<SUB>max</SUB> (percent changes of the maximum tumor-to-nontumor ratio [Δ%T/NT<SUB>max</SUB>]) and SUV<SUB>max</SUB> (percent changes of the maximum standardized uptake value [Δ%SUV<SUB>max</SUB>]) after NAC were calculated and the correlations between these parameters were evaluated. After surgery, the effects of NAC were graded histopathologically (good vs poor) and the optimum cut-off values of Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> for predicting histologic response were assessed using the receiver operating characteristic (ROC) curve analysis.</P><P>Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> were positively correlated with each other (<I>r</I> = 0.494, <I>P</I> < .01). Based on the ROC curve analysis, both Δ%T/NT<SUB>max</SUB> (area under the curve [AUC] = .772, <I>P</I> < .01) and Δ%SUV<SUB>max</SUB> (AUC = .829, <I>P</I> < .01) predicted good histologic response. However, there was no significant difference between the AUCs of Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> (<I>P</I> = .44). The sensitivity and specificity for predicting good histologic response were 83.3% and 75.0%, for the criterion Δ%T/NT<SUB>max</SUB> <–12.5%, and 80.0% and 81.3% for the criterion Δ%SUV<SUB>max</SUB> <−49.0%, respectively.</P><P>The <SUP>99m</SUP>Tc-MDP bone scan and <SUP>18</SUP>F-FDG PET scan are non-inferior to each other in predicting the histologic response of osteosarcoma treatments. The <SUP>99m</SUP>Tc-MDP bone scan and <SUP>18</SUP>F-FDG PET scan showed respective advantages with differing features. Therefore, physicians should consider which scan is appropriate for their own institute based on the advantages of each scan and the circumstances of the institute.</P>

The Value of SPECT/CT in Localizing Pain Site and Prediction of Treatment Response in Patients with Chronic Low Back Pain

Lee, Inki,Budiawan, Hendra,Moon, Jee Youn,Cheon, Gi Jeong,Kim, Yong Chul,Paeng, Jin Chul,Kang, Keon Wook,Chung, June-Key,Lee, Dong Soo The Korean Academy of Medical Sciences 2014 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.29 No.12

잡음분산추정에 따른 터보복호기 성능 향상 방안 연구

이인기(InKi Lee),오덕길(DeokGil Oh),오왕록(WangRok Oh) 한국통신학회 2015 한국통신학회 학술대회논문집 Vol.2015 No.1

건축물의 디지털기술 기반 기획-설계-건설관리 프로세스 - 광명동굴 디지털광산체험관 사례를 중심으로 -

이인기(Lee, Inki),김지윤(Kim, Jiyun) 한국BIM학회 2018 한국BIM학회 학술대회 논문집 Vol.2018 No.-

본 연구는 시대에 따라 변하는 경제적 배경, 사회적 인식, 문화적 욕구, 기술의 수준이 건축분야에 미치는 영향에 대한 연구자의 문제인식에서 출발한다. 건축설계자의 관점에서 디지털건축기술에 대한 정의를 내리고, 기존 업무 프로세스에 적용한 실무 사례를 통해 관련 분야 종사자들의 이해도를 높이고 접근성을 향상시키는 데에 그 목적이 있다. 디지털 기술 및 BIM에 관련된 특정 기술의 나열을 지양하고, 사업과정의 목적과 건축가의 의도에 따라 관련 기술을 적정한 방법으로 선택하고 활용했을 때의 효과를 살펴보고자 한다. 본 사례를 통해, 사업 구상부터 설계자와 시공자의 객관적 정보 구축의 필요성과 효율성을 확인하며, 디지털 건축이 갖는 가치는 발주처-설계자-시공자에게 동일한 데이터를 제공하고 활용할 수 있는 환경을 구축하는 것이라는 결과를 얻는다. 설계자의 역할은 프로젝트 전 과정의 정보를 설계하는 역할을 하여 건축의 품질을 높이는 것으로 건축 환경의 수준을 높이는 것으로 결론 짓는다. This research starts with awareness of the latest trends in the architectural industry have come to associate with socioeconomic status, cultural influences and the development of technology. The intent of this report is to define the concept of digital engineering from the architect s point of view, and share the benefits of the adoption of technology with the related professionals. We are presenting projects to demonstrate how to implement an effective digital workflow for design team, engineers, clients and end users. When completed, the digital building infrastructure that incorporates relevant data required to all parties involved in the construction, management and maintenance. The role of architect in this collaborative process will provide flexible workflow in terms of precise supervision and quality control in the building environment.

Effects of Soil pH on Nutritional and Functional Components of Chinese Cabbage (Brassica rapa ssp. campestris)

Jo-Eun Lee(이조은),Pingjuan Wang(왕평연),Gyungyun Kim(김경연),Sunghan Kim(김성한),Suhyoung Park(박수형),Yong-Soo Hwang(황용수),Yong-Pyo Lim(임용표),Eun Mo Lee(이은모),InKi Ham(함인기),Man Hyun Jo(조만현),Gilhwan An(안길환) 한국원예학회 2010 원예과학기술지 Vol.28 No.3

비닐하우스의 낮은 pH 토양(pH6.2)과 노지의 높은 pH 토양(pH7.6) 의 pH 차이가 배추 품질에 미치는 영향을 알아보기 위하여 13종 배추의 기능성 성분과 영양성분을 분석하였다. 낮은 pH 토양에서 재배된 배추는 높은 pH 토양에서 재배된 배추에 비하여 펙틴, 조단백질, 비타민 C, 비타민 E의 함량이 현저히 높았으며 회분과 무기질(Ca, Fe, Na, Mn) 또한 높았다. 그러나 환원당, 셀룰로오스, 조지방의 함량은 낮은 pH 토양의 배추가 높은 pH 토양의 것 보다 40-50% 낮았다. 글루코시놀레이트의 일종인 gluconasturtiin(18.33 vs. 1.16nmol · g?¹ wet weight)과 gluconapin(145 vs. 2nmol · g?¹ wet weight) 은 높은 pH 토양의 배추에서 낮은 pH 것보다 의미 있게 높았다. 본 연구 결과 낮은 pH 토양에서 재배된 배추는 펙틴의 함량이 높고 셀룰로오스의 함량이 낮아 조직감이 좋으며 단백질, Ca, Fe, vitamin C와 E의 함량이 높아 영양성분이 향상 되었으나 높은 pH 토양에서 재배된 배추는 환원당과 글루코시놀레이트의 함량이 많아 맛과 항암성은 높음을 알 수 있었다. The contents of functional and nutritional components of 13 cultivars of Chinese cabbage (CC, Brassica rapa subspecies campestris) were analyzed to compare the effects of soil pH of the greenhouse (pH 6.2) and outdoor (pH 7.6). The CC cultivated on pH 6.2 (CC-6.2) soil contained significantly increased amounts (2-9 fold) of pectin, crude protein, vitamin C and vitamin E compared to the counterpart (CC-7.6). The contents of ash and the minerals (Ca, Fe, Na, and Mn) were also significantly increased in CC-6.2. However, CC-6.2 contained 40-50% lower contents of reducing sugars, cellulose and crude fat than CC-7.6. CC-7.6 contained more glucosinolates, gluconasturtiin (18.33 vs. 1.16 nmol · g?¹ wet weight) and gluconapin (145 vs. 2 nmol · g?¹ wet wt), than CC-6.2. In conclusion, CC-6.2 had an improved texture (high pectin and low cellulose) and nutritional value (high in protein, Ca, Fe, vitamin C, and E), whereas the CC-7.6 had better taste (high in reducing sugars) and anticancer functionality (high in glucosinolates).

Therapy of heavy menstrual bleeding in Korea: Subanalysis and results from a multinational clinical trial in the Asian region investigating the levonorgestrel-releasing intrauterine system versus conventional therapy

( Byung Seok Lee ),( Xu Ling ),( Shaheena Asif ),( Peter Kraemer ),( Jens Ulrich Hanisch ),( Pirjo Inki ),( Jung Eun Lee ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.2

Objective To compare real-life clinical outcomes with the levonorgestrel-releasing intrauterine system (LNG-IUS) and conventional medical therapies (CMTs), including combined oral contraceptives and oral progestins in the treatment of idiopathic heavy menstrual bleeding (HMB) in South Korea. Methods This prospective, observational cohort study recruited a total of 647 women aged 18 to 45 years, diagnosed with HMB from 8 countries in Asia, including 209 women from South Korea (LNG-IUS, 169; CMTs, 40), who were followed up to one year. The primary outcome was cumulative continuation rate (still treated with LNG-IUS and CMTs) at 12 months. Secondary outcomes included bleeding pattern, assessment of the treatment efficacy by treating physician and safety profile. Results The continuation rate at 12 months was significantly higher with the LNG-IUS than CMTs (85.1% vs. 48.5%, respectively; P<0.0001). The 51.5% of CMTs patients discontinued treatment and 18.8% of LNG-IUS patients discontinued treatment. The most common reasons for discontinuation for CMTs were switching to another treatment and personal reasons. When compared to CMTs, the LNG-IUS offered better reduction in subjectively assessed menstrual blood loss and the number of bleeding days, tolerability and with better efficacy in HMB, as assessed by physician’s final evaluation. Conclusion This study provides novel information on the real-life treatment patterns of HMB in South Korea. The efficacy of CMTs was inferior compared to the LNG-IUS in the clinical outcomes measured in this study. Due to the better compliance with LNG-IUS, the cumulative continuation rate is higher than CMTs. We conclude that the LNG-IUS should be used as the first-line treatment for HMB in Korean women, in line with international guidelines.

<i>Angelica gigas</i> Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

Jeon, Yong-Joon,Shin, Jong-Il,Lee, Sol,Lee, Yoon Gyeong,Kim, Ji Beom,Kwon, Hak Cheol,Kim, Sung Hun,Kim, Inki,Lee, Kyungho,Han, Ye Sun Hindawi 2018 BioMed research international Vol.2018 No.-

<P>Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system. In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells. Of the 420 plant extracts screened, the extract of<I> Angelica gigas</I> Nakai (AGN) was the most effective in reducing cell viability of HeLa cells. Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract. Treatment of the AGN extract increased expression of PKR as well as ATF4 and CHOP, the unfolded protein response genes. In addition, cotreatment of doxorubicin and the AGN extract significantly increased doxorubicin-induced apoptosis in HeLa cells. Decursin and decursinol angelate, which were known to have anticancer effects, were the main components of the AGN extract. These results suggest that the extract of AGN containing, decursin and decursinol angelate, increases doxorubicin susceptibility.</P>

Patient’s Perspective on Psychiatric Drugs: A Multicenter Survey-Based Study

Seoyun Han,Sun-Young Kim,Young-Eun Jung,Won Kim,Jeong Seok Seo,Inki Sohn,Kwanghun Lee,Jong Hun Lee,Sang-Keun Chung,Sang-Yeol Lee,Jung Wan Hong,Bo-Hyun Yoon,Young Sup Woo,Changwoo Han,Jhin Goo Chang,Wo 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.1

Objective We aimed to identify the expectations and preferences for medication and medical decision-making in patients with major psychiatric disorders.Methods A survey was conducted among patients with major psychiatric disorders who visited psychiatric outpatient clinics at 15 hospitals between 2016 and 2018 in Korea. The survey consisted of 12 questions about demographic variables and opinions on their expectations for medication, important medical decision-makers, and preferred drug type. The most preferred value in each category in the total population was identified, and differences in the preference ratio of each item among the disease groups were compared.Results A total of 707 participants were surveyed. In the total population, patients reported high efficacy (44.01%±21.44%) as the main wish for medication, themselves (37.39%±22.57%) and a doctor (35.27%±22.88%) as the main decision makers, and tablet/capsule (36.16%±30.69%) as the preferred type of drug. In the depressive disorders group, the preference ratio of high efficacy was significantly lower, and the preference ratio of a small amount was significantly higher than that of the psychotic disorder and bipolar disorder groups. The preference ratio of a doctor as an important decision maker in the bipolar disorder group was higher compared to the other groups.Conclusion This study revealed the preference for medications and showed differences among patients with psychiatric disorders. Providing personalized medicine that considers a patient’s preference for the drug may contribute to the improvement of drug compliance and outcomes.