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남세현,Chong-hai Lee1,Yu-wei Tang,Yuan-sheng Liu,Ki-chul Kim,Sang-yeol Chun,염유림,Hyung chang Kim,Myoung-deok Lee 대한한의학회 2015 대한한의학회지 Vol.36 No.4
The purpose of this report is to evaluate effect of Korean medical treatment on idiopathic gonadotropin-dependent precocious puberty (G-DPP) patient received herbal medicine. We administered Aesopjiyoun-tang remedy to idiopathic G-DPP and analyzed the delay effect by hormonal value and radiographs; the height growth effect by measurement of height. After Korean medical treatment, suppression effect to peak- Luteinizing Hormone level (LHL) is 14.39IU/L to 10.9IU/L for 13month, growth effect to height value is 11cm/13month; and change of mean growth velocity (MGV) is 6.08cm/year to 10.06cm/year. The gain in height by treatment is 3.98cm/year. The result suggests Aesopjiyoun-tang can be an effective treatment for G-DPP. Herbal medicine can be used as an alternative treatment in place of the GnRH treatment.
Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Lee, Yongjae,Choi, Wonjun,Seo, Seungwon,Kim, Hwan-Yeol,Kim, Sung Joong Atomic Energy Society of Japan 2016 Journal of nuclear science and technology Vol.53 No.10
<P>If any severe accident occurs, application of the Severe Accident Management Guidance (SAMG) is initiated by the Technical Support Center (TSC). In order to provide advisory information to the TSC, required safety injection flow rate for maintaining the coolability of the reactor core has been suggested in terms of the depressurization pressure. In this study, mechanistic development of the safety injection flow map was performed by post-processing the core exit temperature (CET) data from MELCOR simulation. In addition, effect of oxidation during the core degradation was incorporated by including simulation data of core water level decrease rate. Using the CET increase rate and core water level decrease rate, safety injection flow maps required for removing the decay and oxidation heat and finally for maintaining the coolability of the reactor core were developed. Three initiating events of small break loss of coolant accidents without safety injection, station black out, and total loss of feed water were considered. Reactor coolant system depressurization pressure targeting the suggested injection flow achievable with one or two high pressure safety injections was included in the map. This study contributes on improving the current SAMG by providing more practical and mechanistic information to manage the severe accidents.</P>
Global Regulation of Plant Immunity by Histone Lysine Methyl Transferases
Lee, Sanghun,Fu, Fuyou,Xu, Siming,Lee, Sang Yeol,Yun, Dae-Jin,Mengiste, Tesfaye American Society of Plant Biologists 2016 The Plant cell Vol.28 No.7
<P>Posttranslational modification of histones modulates gene expression affecting diverse biological functions. We showed that the Arabidopsis thaliana histone methyl transferases SET DOMAIN GROUP8 (SDG8) and SDG25 regulate pep1-, flg22-, and effector-triggered immunity as well as systemic acquired resistance. Genome-wide basal and induced transcriptome changes regulated by SDG8 and/or SDG25 showed that two genes of the SDG-dependent transcriptome, CAROTENOID ISOMERASE2 (CCR2) and ECERIFERUM3 (CER3), were also required for plant immunity, establishing mechanisms in defense functions for SDG8 and SDG25. CCR2 catalyzes the biosynthesis of carotenoids, whereas CER3 is involved in the biosynthesis of cuticular wax. SDG8 and SDG25 affected distinct and overlapping global and locus-specific histone H3 lysine 4 (H3K4) and histone H3 lysine 36 (H3K36) methylations. Loss of immunity in sdg mutants was attributed to altered global and CCR2- and CER3-specific histone lysine methylation (HLM). Loss of immunity in sdg, ccr2, and cer3 mutants was also associated with diminished accumulation of lipids and loss of cuticle integrity. In addition, sdg8 and sdg25 mutants were impaired in H2B ubiquitination (H2Bubn) at CCR2, CER3, and H2Bubn regulated R gene, SNC1, revealing crosstalk between the two types of histone modifications. In summary, SDG8 and SDG25 contribute to plant immunity directly through HLM or indirectly through H2Bubn and by regulating expression of plant immunity genes, accumulation of lipids, biosynthesis of carotenoids, and maintenance of cuticle integrity.</P>
Roles of Aspartate 44 in Heme Stability and Oxygen Binding of Vitreoscilla Hemoglobin
Lee, Sang-Yeol The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.6
Vitreoscilla hemoglobin (VHb) has been known to interact with various oxygenases and supply oxygen to oxygenase reactions. To investigate the possibility to generate engineered VHb's with increased/decreased oxygen affinities, two mutant VHb's for D44 (D44E and D44K) were generated and characterized using UV-visible/FTIR spectroscopy. Oxygen affinities of wild-type and mutant VHb's were determined. These data suggest that position 44 may be a promising target for engineering oxygen affinity of VHb.
( Lee Sang Yeob ),( Kim Yong Jun ),( Kang San Hyeon ),( Lee Dong Yeol ),( Cho Duk Song ),( Kim Kyong Han ),( Lee Sung Won ),( Chung Won Tae ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
The purpose of this study was to compare with uveitis accompanied rheumatic disease and uveitis unaccompanied rheumatic disease in immunosuppressive therapy response. An observational study was conducted of 432 patients diagnosed with uveitis who visited the rheumatologic department to evaluate with rheumatic disease between 2000 and 2009. We divided patients into two groups: uveitis related to rheumatic disease and unrelated to rheumatic disease. All patients were treated and a response to treatment was measured at the end of the observation period. The 432 patients were diagnosed to uveitis, 33 (7.6%) patients had rheumatic diseases related uveitis and 399 (92.4%) patients had uveitis unrelated rheumatic disease. the each group were similar to gender and body mass index. but the mean age at onset of uveitis was younger uveitis with rheumatic disease than uveitis without rheumatic disease(44.06 vs 48.23 years). The rheumatic disease accompanied uveitis was consisted of spondyloarhtropathy (31%), bechet`s disease (27%), rheumatoid arthritis (18%), systemic lupus erythematosus (15%), sjogren`s syndrome (6%) and mixed connective tissue disease (3%). The state of inflammation, ESR and CRP levels in patients with uveitis associated with rheumatic diseases were increased but the ocular complications did not increase in uveitis associated with rheumatic disease. The response of immunosuppressive therapy in patients with uveitis associated with rheumatic diseases was good and was statistically significant (p<0.05). The uveitis accompanied rheumatic disease was better response to immunosuppressive therapy and less frequent complications than uveitisu naccompanied rheumatic disease in early treatment.
Lee, Seung-Hyung,Yoo, Gwang-Yeol,Park, Gun-Jun,Kim, Young-Chul,Lee, Jun-Ho,Bai, Sung-Chul C. The Korean Society of Fisheries and Aquatic Scienc 2008 Fisheries and Aquatic Sciences Vol.11 No.4
In this study, tests were conducted to investigate the effects of three dietary growth hormones, administered in various amounts, on the growth performance and lysozyme activity in juvenile olive flounder, Paralichthys olivaceus. Three dietary growth hormones, recombinant human growth hormone (rHGH), recombinant bovine somatotropin A (rBST A) and recombinant bovine somatotropin B (rBST B) were tested at three different supplemental levels (10, 20 or 40 mg/kg body weight per week) by a $3{\times}3$ factorial design and a complete randomized design in comparison to a control group. Fish were fed one of the ten experimental diets (control, $rHGH_{10}$, $rHGH_{20}$, $rHGH_{40}$, rBST $A_{10}$, rBST $A_{20}$, rBST $A_{40}$, rBST $B_{10}$, rBST $B_{20}$ and rBST $B_{40}$) for 6 weeks and afterward were analyzed for growth performance by measuring weight gain (WG), feed efficiency (FE), specific growth rate (SGR) and protein efficiency ratio (PER). Based on the factorial design analysis, fish fed rHGH diets demonstrated significantly higher growth performance than fish fed rBST A or rBST B diets. However there were no significant differences in WG, FE, SGR and PER between fish fed rBST A and rBST B diets. Neither hormone level nor the interaction between the different hormones and their various levels had a significant effect on WG, FE, SGR, PER, lysozyme activity or whole-body proximate composition. A complete randomized design analysis confirmed fish fed $rHGH_{10}$, $rHGH_{20}$, $rHGH_{40}$, rBST $A_{10}$, rBST $A_{20}$, rBST $A_{40}$, rBST $B_{20}$ and rBST $B_{40}$ diets for 6 weeks showed higher WG than fish fed the control diet (P<0.05). A higher FE was observed in fish fed $rHGH_{10}$, $rHGH_{20}$, $rHGH_{40}$, rBST $A_{20}$ and rBST $A_{40}$ diets in comparison to fish fed the control diet. Fish fed all graded rHGH, rBST A and rBST B supplemented diets showed a higher SGR than fish fed the control diet. Regarding PER, fish fed $rHGH_{10}$, $rHGH_{20}$, $rHGH_{40}$, rBST $A_{10}$, rBST $A_{20}$, rBST $A_{40}$ and rBST $B_{20}$ diets were higher than fish fed the control diet. Furthermore, the lysozyme activity of fish fed a diet of $rHGH_{20}$ was significantly higher than that of fish fed any other diet. The results measuring the growth and development of the fish clearly suggest the biopotency of dietary rHGH could be higher than those of both dietary rBST A and rBST B. Further implied is the probability that within the range of 10 to 40 mg/kg BW/week the dietary growth hormones could accelerate growth performance, and that 20 mg rHGH/kg BW/week could possibly enhance lysozyme activity in juvenile olive flounder, Paralichthys olivaceus.