Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms

Changwoo Han,Donghyun Ahn,Woong Hahm,Junghyun Nam,Yongchon Park,Seulgi Lim,Dai-Jin Kim 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.1

Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol depend-ence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck’s Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alco-hol-dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.

Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation

Changwoo Han 대한한의학회 2020 대한한의학회지 Vol.41 No.4

Air quality management policy and reduced mortality rates in Seoul Metropolitan Area: A quasi-experimental study

Han, Changwoo,Lim, Youn-Hee,Yorifuji, Takashi,Hong, Yun-Chul Elsevier 2018 Environment international Vol.121 No.1

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The air quality management policy was introduced in Seoul and Incheon metropolitan cities in the Republic of Korea, from 2005 to 2014. Despite particulate matter concentrations decreasing after policy implementation, the consequent health benefits have not been evaluated. Therefore, we evaluated the effects of the air quality management policy on cause-specific mortality rates in Seoul and Incheon.</P> <P><B>Methods</B></P> <P>Using interrupted time series analysis with a generalized Poisson regression model, we compared daily average mortality rates before (baseline, 2004–2005) and after (2006–2007, 2008–2009, 2010–2011, 2012–2013) the policy implementation. To account for the long term mortality trends, we weighted daily mortality rate of Seoul and Incheon with daily mortality rate of Daejeon (another metropolitan city with no air quality management policy implemented during the same period).</P> <P><B>Results</B></P> <P>Decline in the particulate matter concentration was greater in Seoul and Incheon than in Daejeon. After adjusting for potential confounders, there were 8% decrease in cardiovascular disease mortality rates and 10% decrease in cerebrovascular disease mortality rates in Seoul in 2012–2013 compared to the baseline period. In Incheon, an 8% reduction in cerebrovascular disease mortality rates in 2012–2013 was calculated. There was no change in mortality rates due to external causes or respiratory disease after policy implementation.</P> <P><B>Conclusions</B></P> <P>Our study suggests that the air quality management policy was effective in reducing cardiovascular and cerebrovascular mortality rates in Seoul and cerebrovascular mortality rates in Incheon.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The air quality management policy was introduced in Seoul and Incheon cities in the Republic of Korea. </LI> <LI> We used interrupted time series analysis to evaluate the health effects of the policy. </LI> <LI> There were decrease in cardiovascular and cerebrovascular disease mortality after the policy implementation. </LI> <LI> The policy was associated with improvements of both air quality and health. </LI> </UL> </P>

The Development of the Mission · Vision · Core Values for Korean NeuroPsychiatric Association

Changwoo Han,Kounseok Lee,Han Yong Jung,Kang Joon Lee,Chul Eung Kim 대한신경정신의학회 2017 신경정신의학 Vol.56 No.4

Awareness of public mental health has increased due to drastic changes in society, and issues concerning the rights of mentally ill patients have emerged. The Korean NeuroPsychiatric Association (KNPA) has examined the current environment and proposed directions for improvement of this field. As the step for the implementation of the development of the mission · vision · core values for KNPA, KNPA have gone on the effort to improve public mental health letting people realize of the work that KNPA have carried out and help members work together. The committee of special mission of KNPA began in 2016 and held its first meeting on March 25 with professional consultants. They researched and collected information, carried out interviews, surveys, analyzed various opinions, and examined information and materials throughout 7 meetings. The special members of KNPA submitted agendas to the board of directors on September 9th, and the provisional board committee debated and decided the final agendas on September 24th. They announced the mission · vision · core values for KNPA on October 28th at the great autumn congregation held in Kimdaejung Convention Center in Kwangju. The event has proved that all members of KNPA have cooperated for the rights and interest of the committee, and will lead the public mental health of our society. This will provide the basis for the better life of our society.

The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study

Han, Changwoo,Lim, Youn-Hee,Hong, Yun-Chul The Korean Society for Preventive Medicine 2016 Journal of Preventive Medicine and Public Health Vol.49 No.5

Objectives: Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biomarker of oxidative stress and depressive symptom scores using repeatedly measured panel data from a community-dwelling elderly population. Methods: From 2008 to 2010, a total of 478 elderly participants residing in Seoul, Korea, were evaluated three times. Participants underwent the Korean version of the Short Form Generic Depression Scale (SGDS-K) test for screening depression, and urinary malondialdehyde (MDA) levels were measured as an oxidative stress biomarker. We used a generalized estimating equation with a compound symmetry covariance structure to estimate the effects of oxidative stress on depressive symptom scores. Results: A two-fold increase in urinary MDA concentration was significantly associated with a 33.88% (95% confidence interval [CI], 21.59% to 47.42%) increase in total SGDS-K scores. In subgroup analyses by gender, a two-fold increase in urinary MDA concentration was significantly associated with increased SGDS-K scores in both men and women (men: 30.88%; 95% CI, 10.24% to 55.37%; women: 34.77%; 95% CI, 20.09% to 51.25%). In bivariate analysis after an SGDS-K score ${\geq}8$ was defined as depression, the third and the fourth urinary MDA quartiles showed a significantly increased odds ratio(OR) of depression compared to the lowest urinary MDA quartile (third quartile OR, 6.51; 95% CI, 1.77 to 24.00; fourth quartile OR, 7.11; 95% CI, 1.99 to 25.42). Conclusions: Our study suggests a significant association between oxidative stress and depressive symptoms in the elderly population.

컨볼루션 신경망 기반 인루프 필터링 기술 동향

한창우(Changwoo Han),김홍일(Hongil Kim),김동현(Donghyun Kim),정승원(Seung-Won Jung) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6

갈망 : 생물학적 이해와 치료적 접근

한창우(Changwoo Han),최영숙(Young Sook Choi),김영호(Young-Ho Kim),이건석(Kounseok Lee) 한국중독정신의학회 2018 중독정신의학 Vol.22 No.2

Objectives : Craving is defined as the desire for using the substance. It plays an important role in the recurrence of the substance- related disorder. The purpose of this review was to summarize the pathophysiology behind craving and pharmacological and psychological treatment of craving. Methods : We searched and reviewed articles on craving for the substance. Results : The neurotransmitters involved in craving are dopamine and serotonin. Dopamine acts on the enhancement of action, while serotonin acts by inhibiting the release of γ-Aminobutyric acid. Both acamprosate and naltrexone could be used for craving treatment. Moreover, cognitive behavioral therapeutic methods have been employed for the treatment. Conclusion : The systematic management of craving aimed at preventing the recurrence of substance- related disorders could result in improvement of compliance and reduction in recurrence and treatment cost.

직교형 고소작업차 구조 안정성 평가에 관한 연구

한창우(Changwoo Han),손재환(Jaehwan Son),박기진(Keejin Park),장은실(Eunsil Jang),우승민(Seungmin Woo) 한국자동차공학회 2013 한국자동차공학회 지부 학술대회 논문집 Vol.2013 No.4

This study is investigated on the structural stability estimation of the vehicle with 4 wheels and 2 rectangular-type lifting utilities. This vehicle can be moved on the dirt sloping load and carried heavy fruits with a heavy motor, batteries, hydraulic balancer, and power-pack that controls lifting utilities. Through the multi-body dynamics analysis on the vehicle mechanism, overturning angles in the right-left and front-rear direction for st-r conditions can be determined. It is verified whether tractive resistances and required powers of the wheels which have been calcurded in climbing different gradients are allowable. Through the analysis on the position of batteries the overturning stability of the vehicle can be determined. And through the finite element analysis on the frame of lifting utility which is loaded maximum von Mises stress and deformation structure are calculated. Therefore it is known that the vehicle for high place operation in the wheel type has dynamical and structural stability.

조현병 환자의 항정신병 약물에 대한 부정적 태도 및삶의 질에 미치는 영향

한창우(Changwoo Han),신경민(Kyoung Min Shin),손상준(Sang Joon Son),국소담(Sodahm Kook),배활립(Hwallip Bae),정경희(Kyung Hi Jung),김현수(Hyun Soo Kim) 대한사회정신의학회 2013 사회정신의학 Vol.18 No.2

목 적 : 조현병은 다양한 정신병적 증상과 함께 인지능력 감소와 사회적 기능저하 등을 초래하여 일상생활에 장애를 일으킨다. 조현병 환자들이 삶의 질에 영향을 미치는 요인들은 다양한데, 그 중 환자들이 항정신병 약물에 대해서 갖는 태도는 조현병 환자들의 삶의 질을 떨어뜨릴 수 있는 주요 원인으로 알려져 있다. 따라서 본 연구에서는 조현병 환자들의 항정신병 약물에 대해서 갖고 있는 주관적 태도를 확인하고, 이것이 환자들의 삶에 질에 어떠한 영향을 주는 지를 알아보고자 하였다. 방 법 : 정신보건 센터에 등록된 조현병 환자 248명을 대상으로 구조화된 설문지를 사용하여 자기 기입 방식으로 정보를 수집하였다. 우선, 참가자들의 동반된 비정신과적 신체질환을 조사하였다. 신체질환이 있는 조현병 환자들을 대상으로 한국판 약물태도 검사(Korean version of Drug Attitude Inventory-10)을 사용하여 항정신병 약물에 대한 태도를 확인하였으며, 이것을 신체질환 약물에 대한 태도와 paired t-test를 실시하여 비교 분석하였다. 또한 조현병 환자들의 약물에 대한 태도가 삶의 질에 미치는 영향을 확인하기 위하여, 항정신병 약물에 대해서 한국판 세계보건기구 삶의 질 척도 단축형(WHOQOL-BREF)을 시행하고, Pearson 상관분석을 통해서 비교하였다. 결 과 : 조현병 환자들 중 신체 질환이 있는 환자들은 43.9%에 해당하는 107명 이었다. 신체질환이 있는 조현병 환자들의 항정신병 약물에 대한 태도 및 반응과 신체질환 약물에 대한 태도는 긍정적 태도 점수 및 전체 점수에서 유의한 차이가 나타나지 않았으나, 부정적 태도 점수에서는 유의미한 차이를 보였다. 삶의 질과 약물 태도의 상관관계를 분석해본 결과, 항정신병 약물에 대한 주관적인 긍정적 태도는 삶의 질 척도의 심리건강, 환경, 전체 평균 영역과 유의한 정적 상관관계를 보였으나 항정신병 약물에 대한 부정적 태도는 삶의 질 척도의 모든 영역과 유의미한 정적 상관을 보였다. 결 론 : 조현병 환자들은 항정신병 약물에 대해서 신체질환 약물보다 부정적인 태도를 보였다. 또한 조현병 환자들의 이러한 항정신병 약물에 대한 태도는 다양한 영역에서 환자들의 삶의 질에 영향을 미치는데, 항정신병 약물에 대한 부정적인 태도가 긍정적인 태도에 비해 다양한 영역에서 관련성이 있는 것으로 조사되었다. 따라서 조현병 환자들은 항정신병 약물에 대해서 부정적인 태도를 보이며, 이러한 항정신병 약물에 대한 태도는 조현병 환자들의 삶의 질에 영향을 미치는 중요한 요인이 될 수 있다. Objectives : The aim of this study was to examine the drug attitude toward antipsychotics in schizophrenic patients. This study also evaluated the relationship between drug attitude and quality of life in patients with schizophrenia. Methods : The study was carried out on the 248 patients with schizophrenia attending a Community Mental Health Center in Gangdong-gu. This study protocol included sociodemographic variables, information about physical health, Korean version of Drug Attitude Inventory-10 (KDAI-10), and World Health Organization Quality of Life (WHOQOL-BREF). Data were analyzed using One way ANOVA, χ 2 -test, paired t-test, and Pearson correlation coefficients with SPSS 17.0 program. Results : The participants showed significantly more negative attitude toward antipsychotics than somatic medicines. The nega-tive attitude toward antipsychotics was correlated with all domain of quality of life and the positive drug attitude toward antipsychotics was correlated with some domain of quality of life. Conclusion : The results of this study suggest that schizophrenic patients have the negative attitude toward antipsychotics. And the subjective attitude toward antipsychotics seems to be correlated with quality of life in schizophrenic patients.

6T-/8T-SRAM bit-cell의 읽기/쓰기 성능에 대한 정량적 분석

한창우(Changwoo Han),윤석찬(Seok Chan Yoon),신창환(Changhwan Shin) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6

The conventional/large-scale analysis for read/write stability in 6T-/8T-SRAM bit-cell are quantitatively estimated/compared using TCAD and in-house SPICE tool. All conventional/large-scale read/write metrics in 6T-/8T-SRAM were extracted/compared. In addition, the minimum operating voltage (VMIN) in each read/write metric was also quantitatively estimated using ‘cell sigma’. As a result, the read/write operation analysis and yield estimation of 6T-/8T-SRAM were compared to each other, and the reliability of large-scale analysis was confirmed.