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Genomic Signature for Stem Swollen of Kohlrabi Morphotype in Brassica oleracea
( Hyunjin Koo ),( Hyeonah Shim ),( Sampath Perumal ),( Ho Jun Joh ),( Tae-jin Yang ) 한국육종학회 2021 Plant Breeding and Biotechnology Vol.9 No.1
Brassica oleracea contains various morphotypes within the species, but genomic signatures differentiating each morphotype have been poorly understood of. Here, we utilized whole genome sequence data of 44 B. oleracea collections including those of seven different morphotypes such as cabbage, broccoli, cauliflower, kailan, kale, brussels sprout, and kohlrabi to elucidate the genomic signature of B. oleracea morphotypes. Molecular structure analysis divided the 44 B. oleracea lines into two groups: group I represents broccoli, cauliflower, kailan; group II represents other B. oleracea subspecies. Kohlrabi has admixed genomic structure through genetic admixture analysis. Based on the population stratification result, we have investigated genetic signatures that offer the possible evolutionary processes for the kohlrabi morphotype. Several statistical analyses were implemented to identify selective regions and explore 45 candidate loci that may contribute to stem swollen in kohlrabi. Above all, we identified two kohlrabi-unique genes, LOC106333915 and LOC106308097, showing kohlrabi-unique non-synonymous mutations, which might be candidate genes for stem swollen in kohlrabi.
소비자의 기질적 욕심이 무행동 관성에 미치는 영향: 예상되는 무행동 후회와 극대화 성향의 조절된 매개효과
구현진 ( Koo Hyunjin ),손영우 ( Sohn Young Woo ),임혜빈 ( Rim Hye Bin ) 한국소비자학회 2016 소비자학연구 Vol.27 No.5
무행동 관성이란 초기의 매력적인 기회를 놓친 이후에 마주한 후속 기회에서도 행동하지 않으려는 경향성을 의미한다. 본 연구는 소비자의 기질적 욕심과 무행동 관성 간의 관계를 예상되는 무행동 후회가 매개하며, 이와 같은 매개경로가 극대화 성향의 수준에 의해 달라지는 조절된 매개효과를 검증하고자 하였다. 이를 위해 총 251명의 참가자들에게 기질적 욕심 척도(Dispositional Greed Scale), 극대화 성향 척도(Maximization Scale)와 후속 세일 제품에 대한 구매의도를 묻는 무행동 관성 문항을 포함하는 설문을 실시하였다. 연구 결과는 다음과 같다. 첫째, 소비자의 기질적 욕심 수준이 높을수록 후속 기회에서 높은 구매의도를 보였다. 둘째, 후속 기회를 놓침으로써 예상되는 후회가 욕심과 구매의도의 관계를 매개하였다. 마지막으로, 소비자의 극대화 성향이 욕심과 예상되는 무행동 후회의 정적 관계를 강화시켜, 욕심이 예상되는 무행동 후회를 통해 구매의도에 미치는 매개효과가 극대화 수준에 따라 유의하게 변화하였다. 본 연구는 소비자의 기질적 욕심과 무행동 관성 간의 관계에 대해 처음으로 탐구해보았으며, 욕심과 무행동 관성의 관계를 설명하는 매개 및 매개된 조절 변인들을 추가적으로 검증함으로써 무행동 관성 현상에 대한 연구를 한층 더 확장시켰다고 볼 수 있다. 본 연구의 의의, 한계점 및 후속 연구 방향에 대해 제언하였다. Inaction inertia refers to a phenomenon that after having bypassed an initial attractive opportunity, people are less likely to act on subsequent similar opportunities. This phenomenon is considered as one of the negative side effects of sales marketing, and is a nuisance for retailers and marketers. Previous studies on inaction inertia have focused on the preconditions and contexts pertaining to the occurrence of the phenomenon. However, only very little attention has been paid to the effects of individual differences of the customers on inaction inertia, such as personal characteristics or decision-making styles. To address the issue, we aimed to examine the influence of consumers` personal characteristics on inaction inertia. Specifically, we explored consumers` level of dispositional greed on inaction inertia. Dispositional greed refers to an individual tendency to never being satisfied with what one currently has, and always craving for more. That is to say, people with high levels of dispositional greed would always want more than what they possess at present. Therefore, we hypothesized that greedier people would show higher purchase intention even in the face of less attractive and inferior opportunity because they would primarily focus on acquiring more products. It implies that greedier people might be less affected by the inaction inertia. Furthermore, we assumed that anticipated inaction regret would mediate the relationship between greed and purchase intention. According to previous research, regret is a negative emotion which is closely related to inaction inertia. Anticipated inaction regret is a type of regret that a person experiences when facing the bargains, anticipating how one might feel when foregoing the upcoming opportunity. According to previous studies, anticipating higher inaction regret leads to higher purchase intention under the inaction inertia contexts. As greedier people tend to want more, we presumed that they would report higher anticipated inaction regret. Taken together, we hypothesized that anticipated inaction regret would positively mediate the relationship between greed and purchase intention. In addition to the mediation model of greed, anticipated inaction regret and purchase intention, we hypothesized that consumers` level of maximizing tendency would affect the relationship between greed and anticipated inaction regret. Maximization refers to a style of decision-making, which is characterized by pursuing the best option through exhaustively searching and comparing the alternatives. Since maximizers want the best option, they are prone to feeling regrets, both before and after the decision-making process. Hence, we assumed that people with high maximization tendency would anticipate higher inaction regret, thus positively moderating the positive relationship between greed and anticipated inaction regret. In sum, our study aimed to explore the influence of consumers` dispositional greed on inaction inertia, by testing a moderated mediation model of anticipated inaction regret and maximization. We hypothesized that anticipated inaction regret would positively mediate the relationship between greed and purchase intention, and individuals` maximization tendencies would moderate the mediating effect of anticipated inaction regret. To confirm our hypotheses, we conducted an online survey via Amazon Mechanical Turk (M = 245). Using SPSS PROCESS macro, the moderated mediation model was tested. The results supported our hypotheses. Participants with stronger dispositional greed anticipated higher levels of inaction regret, and reported higher purchase intention. In addition, the mediating effect of anticipated inaction regret was greater for participants with stronger maximization tendencies. This research shed light on the psychological mechanism of inaction inertia by examining the impacts of consumers` individual difference variables. Additionally, this research is meaningful in terms of expanding previous studies of the impacts of affect on consumer behaviors by focusing on greed which was gained little attention to. Further implications, limitations and possible future studies were also discussed.
[PA-0025] Plastid Phylogenomics and Evolution of Araliaceae
Jong-Soo Kang(Jong-Soo Kang),Vo Ngoc Linh Giang(Vo Ngoc Linh Giang ),Hyunjin Koo(Hyunjin Koo),Hyeonah Shim(Hyeonah Shim),Woohyeon Cho(Woohyeon Cho),Young Ju Oh(Young Ju Oh),Hye Ji Lee(Hye Ji Lee),Jee 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Jeong Hyunjin,Hong Eun-Hye,Ahn Jae-Hee,Cho Jaewon,Jeong Jae-Hyeon,Kim Chae-Won,Yoon Byung-Il,Koo Ja Hyun,Park Yun-Yong,Yang Yoon Mee,Iwawaki Takao,Bruce A. Vallance,Chang Sun-Young,Ko Hyun-Jeong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher in the colonic tissues of patients with inflammatory bowel disease than in healthy controls, its role in inflammatory bowel disease has not yet been reported. In the current study, we used ERdj5-knockout mice to investigate the potential roles of ERdj5 in inflammatory bowel disease. ERdj5 deficiency causes severe inflammation in mouse colitis models and weakens gut barrier function by increasing NF-κB-mediated inflammation. ERdj5 may not be indispensable for goblet cell function under steady-state conditions, but its deficiency induces goblet cell apoptosis under inflammatory conditions. Treatment of ERdj5-knockout mice with the chemical chaperone ursodeoxycholic acid ameliorated severe colitis by reducing endoplasmic reticulum stress. These findings highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
Lee, Hyunjin,Son, Jihwan,Na, Chae-Bin,Yi, Gawon,Koo, Heebeom,Park, Jun-Beom D.A. Spandidos 2018 Experimental and therapeutic medicine Vol.15 No.6
<P>The aim of the present study was to evaluate the effects of anionic, cationic and neutral liposomes containing doxorubicin on the cellular viability and osteogenic differentiation of three-dimensional stem cell spheroids. Doxorubicin-loaded liposomes were prepared using the traditional thin-lipid-film-hydration method and were characterized using transmission electron microscopy and a zeta potential analyzer. The doxorubicin release profile from these liposomes was also analyzed <I>in vitro</I>. Three-dimensional cell spheroids were fabricated using silicon elastomer-based concave microwells. Qualitative results of cellular viability were observed using a confocal microscope and quantitative cellular viability was evaluated using a Cell-Counting Kit-8 (CCK-8) assay. Furthermore, the secretion of vascular endothelial growth factor was evaluated. Western blot analysis was performed to assess the expression of collagen I and glyceraldehyde 3-phosphate. Results indicated that the spheroids were well formed in silicon elastomer-based concave microwells on day 1. In general, the shapes of the cells in the in the doxorubicin-loaded anionic, cationic and neutral liposome groups were similar to the control group except for the 10 µg/ml groups on days 3, 5, and 7. No significant changes in cellular viability were noted with the addition of doxorubicin at day 1 but significant decreases in cellular viability were noted with application of doxorubicin at day 5. Notably, higher concentrations of doxorubicin reduced the secretion of vascular endothelial growth factor and stem cell marker expression. To conclude, the present study indicated that doxorubicin-loaded anionic liposomes produced the most sustained release profile and cationic liposomes produced the highest uptake of the stem cell spheroids. These findings suggested that higher concentrations of doxorubicin-loaded liposomes affected cellular viability, the secretion of vascular endothelial growth factor and stem cell marker expression.</P>