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Origin and evolution of Korean ginseng revealed by genome sequence
Cho, Woohyeon,Shim, Hyeonah,Yang, Tae-Jin The Korean Society of Ginseng 2021 인삼문화 Vol.3 No.-
인삼은 세계에서 가장 중요한 약용식물 중 하나이다. 본 연구실에서는 국립종자원에 최초로 등록된 인삼 품종 '천풍'을 이용하여 대략 3Gbp의 완성도 높은 유전체 서열과 60,000여개의 유전자를 동정하여 공개하였다. 인삼속 근연종들과의 비교유전체연구를 통해 종의 분화 시기 등을 추정하였고, 이를 통해 고려인삼의 기원과 두 번의 대륙이동을 통한 인삼속의 진화와 분포모델을 확립하였다. 인삼속 18종 중 2종 (고려인삼, 화기삼)은 24쌍의 염색체를 가지는 사배체 식물이며 나머지 16종은 12쌍의 염색체를 가지는 이배체 식물이다. 인삼속과 두릅나무속은 두릅나무과에 속하는 가장 가까운 식물로서 약 8백만년 전에 분화하였다. 인삼속은 약 6백만년 전 베트남 등의 동남아시아에서 러시아와 같은 동북아시아에 이르는 지역의 깊은 숲 속 서늘한 기후와 숲 속의 음지조건에 적응하며 음지식물로 진화했다. 그 기간은 빙하기와 간빙기가 반복되는 시기로 월동 능력이 없는 이배체 인삼종은 대부분 동북아시아 지역에서 멸종하였고 이 과정에 이배체간 종간 교잡종인 이질사배체가 약 2백만년전 만들어졌으며 한반도를 위시한 동북아시아를 중심으로 월동능력을 가진 고려인삼이 태동되었다고 추정된다. 북미에 분포하는 화기삼은 동북아시아 전역에 분포하던 고려인삼이 약 1백만년전에 빙하의 이동과 더불어 대륙간 이주를 통해 새로운 생태 환경에 적응하면서 분화되었다고 판단된다. 반면 대부분의 이배체 인삼종은 고온을 견디지 못하고 월동능력도 없어 동남아시아 지역에서 1,600미터 이상의 고산 지역으로 쫓겨 올라가 연중 서늘한 기후에서 생존하고 있다. 유전체 해독 정보는 인삼의 기원과 진화기작을 추정하는 학문적 성과 뿐 아니라 인삼산업을 보호하고 우수 인삼을 개발하기 위한 실용적인 분자육종 수단에도 매우 효율적으로 활용될 수 있다. Panax ginseng (Ginseng or Korean ginseng) is one of the most important medicinal herbs in the world. We made a high-quality whole genome sequence of P. ginseng using 'Chunpoong' cultivar, which is the first cultivar registered in Korea Seed and Variety Service (KSVS) with relatively similar genotypes and superior phenotypes, representing approximately 3 Gbp and 60,000 genes. Genome sequence analyses of P. ginseng and related speciesrevealed the origin of Korean ginseng and the ecological adaptation of 18 Panax species around the world. Korean ginseng and American ginseng (P. quinquefolius) are tetraploid species having 24 chromosome pairs, while the other 16 species are diploid species with 12 chromosome pairs. Panax and Aralia are the closest genera belonging to the Araliaceae family that diverged approximately 8 million years ago (MYA). All Panax species evolved as shade plants adapting to cool climates and low light conditions under the canopy of deep forests from Southeast Asia such as Vietnam to Northeast Asia such as Russia approximately 6 MYA. However, through recurrent ice ages and global warming, most diploid Panax species disappeared due to the freezing winter, while tetraploid P. ginseng may have appeared by allotetraploidization, which contributed to the adaptation to cold temperaturesin Northeast Asian countries including the Korea peninsula approximately 2 MYA. American ginseng evolved by the adaptation of P. ginseng in Northeast America after the intercontinental migration 1 MYA. Meanwhile, most of diploid Panax species survived in high-altitude mountains over 1,600 meters in Southeast Asia because they could not endure the hot temperature and freezing cold. The genome sequence provides good basisto unveil the origin and evolution of ginseng and also supports practical gene chips which is useful for breeding and the ginseng industry.
[PA-0025] Plastid Phylogenomics and Evolution of Araliaceae
Jong-Soo Kang(Jong-Soo Kang),Vo Ngoc Linh Giang(Vo Ngoc Linh Giang ),Hyunjin Koo(Hyunjin Koo),Hyeonah Shim(Hyeonah Shim),Woohyeon Cho(Woohyeon Cho),Young Ju Oh(Young Ju Oh),Hye Ji Lee(Hye Ji Lee),Jee 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
( Woohyeon Kim ),( In Seok Lee ),( Chul Hyun Lim ),( Jin Su Kim ),( Yu Kyong Cho ),( Jae Myung Park ),( Bo In Lee ),( Sang Woo Kim ),( Myung Gyu Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Primary diffuse large B-cell lymphoma(DLBCL) in the terminal ileum and/ or colorectum can be classifi ed endoscopically into protrusion and infi ltrative types. Colonoscopy allows a more direct evaluation of these lesions and a defi nitive biopsy diagnosis before surgical exploration. However, there are few informations regarding colonoscopic fi ndings and their clinical utility. The aim of this study was to investigate the relationship between initial colonoscopic appearances and therapeutic response after treatment for the tumor. Methods: This was a retrospective study of 23 consecutive patients who were diagnosed with ileocolonic DLBCL with initial colonoscopic fi ndings and treated from June 2009 to July 2014 in Seoul St. Mary`s hospital. We reviewed fi rst complete remission( CR) rate according to their colonoscopic appearances (protrusion and infi ltrative types with or without ulceration) after standard treatment. Results:Twenty-three lesions in 23 patients were endoscopically classifi ed as follows: protrusion(15, 65.2%), infi ltrative(8, 34.8%). All patients underwent curative treatment as follows: chemotherapy only in 13(56.5%), surgical resection with chemotherapy in 8(34.8%) and autologous peripheral blood stem cell transplantation with chemotherapy in 2(8.7%). Patients with protrusion type showed higher CR rate than patients with infi ltrative type (15/15 [100%] vs 6/8[75%], respectively), but there was no statistically signifi cant difference between two groups(P=0.11). Among 15 patients who achieved CR in protrusion group, 2 patients had fi rst relapse at 2 months after fi rst CR and there was no recurrence in patients with infi ltrative type (median follow-up period [23 months], range 2-56 months). Conclusions:There was no relationship between the colonoscopic appearances and the outcomes of treatment of primary ileocolonic DLBCL.