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( Hyo Jeong Lee ),( Hyo Jeong Kang ),( Kang Mo Kim ),( Eun Sil Yu ),( Ki Hun Kim ),( Seung Mi Kim ),( Tae Won Kim ),( Ju Hyun Shim ),( Young Suk Lim ),( Han Chu Lee ),( Young Hwa Chung ),( Yung Sang L 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.1
Background/Aims: Fibroblast growth factor signaling is involved in hepatocarcinogenesis. The aim of this study was to determine the fibroblast growth factor receptor (FGFR) isotype expression in hepatocellular carcinoma (HCC) and neighboring nonneoplastic liver tissue, and elucidate its prognostic implications. Methods: Immunohistochemical staining of FGFR1, -2, -3, and -4 was performed in the HCCs and paired neighboring nonneoplastic liver tissue of 870 HCC patients who underwent hepatic resection. Of these, clinical data for 153 patients who underwent curative resection as a primary therapy were reviewed, and the relationship between FGFR isotype expression and overall survival was evaluated (development set). This association was also validated in 73 independent samples (validation set) by Western blot analysis. Results: FGFR1, -2, -3, and -4 were expressed in 5.3%, 11.1%, 3.8%, and 52.7% of HCCs, respectively. Among the development set of 153 patients, FGFR2 positivity in HCC was associated with a significantly shorter overall survival (5-year survival rate, 35.3% vs. 61.8%; P=0.02). FGFR2 expression in HCC was an independent predictor of a poor postsurgical prognosis (hazard ratio, 2.10; P=0.02) in the development set. However, the corresponding findings were not statistically significant in the validation set. Conclusions: FGFR2 expression in HCC could be a prognostic indicator of postsurgical survival. (Clin Mol Hepatol 2015;21:60-70)
( Hyo Sang Im ),( Kwang Rae Cho ),( Chee Mahn Shin ),( Young Jae Kim ),( Young Kyun Choe ),( Soon Ho Cheong ),( Kun Moo Lee ),( Jeong Han Lee ),( Se Hun Lim ),( Young Hwan Kim ),( Sang Eun Lee ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.1
There are many cause of cholinesterase deficiency, including drugs, liver disease, chronic anemia, malignant states, cardiac failure, severe acute infection, surgical shock, severe burn, collagen disease and vasculitis syndromes. Vasculitis syndromes are relatively rare, and among them, Churg-Strauss syndrome (CSS) is even rarer. We report here on a case of a patient with CSS who underwent endoscopic sinus surgery under general anesthesia. (Korean J Anesthesiol 2010; 59: 49-52)
Antioxidant activities of licorice-derived prenylflavonoids
Hyo Jung Kim,Ji-Yeon Seo,Hwa-Jin Suh,Soon Sung Lim,Jong-Sang Kim 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.6
Glycyrrhiza uralensis (or licorice) is a widely used Oriental herbal medicine from which the phenylflavonoids dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. The purpose of the present study was to evaluate the antioxidant properties of DGC, DGD, and IsoA. The three compounds showed strong ferric reducing activities and effectively scavenged DPPH, ABTS<SUP>+</SUP>, and singlet oxygen radicals. Among the three compounds tested, DGC showed the highest free radical scavenging capacity in human hepatoma HepG2 cells as assessed by oxidant-sensitive fluorescent dyes dichlorofluorescein diacetate and dihydroethidium bromide. In addition, all three compounds effectively suppressed lipid peroxidation in rat tissues as well as H2O2-induced ROS production in hepatoma cells. This study demonstrates that among the three phenylflavonoids isolated from licorice, DGC possesses the most potent antioxidant activity, suggesting it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive.
( Sung Jin Lim ),( Ji Hye Lee ),( Jin Hyo Kim ),( Geun Hyoung Choi ),( Nam Jun Cho ),( Byung Jun Park ) 한국환경농학회 2014 한국환경농학회지 Vol.33 No.3
BACKGROUND: In an environment-friendly agriculture,plant extracts have been perceived as alternatives ofsynthetic pesticides. The Environment-friendly AgriculturePromotion Act of Korea has approved cinnamon extract asa matter for the production of commercial biopesticides. Thirteen commercial biopesticides containing cinnamonextract have been marketed locally. However, the analyticalmethod for the quality control of these biopesticidescontaining cinnamon extract has not been studied. METHODS AND RESULTS: Cartridge clean-up methodfor the determination of cinnamaldehyde, cinnamylalcoholand salicylaldehyde in biopesticides containing cinnamonextract was developed and validated by gas chromatography(GC). The clean-up method was optimized with HLB SPEcartridges for the bioactive substance in biopesticidescontaining cinnamon extract, and the eluate was analyzedby GC. The developed method was validated, and the LOQand recovery rates of cinnamaldehyde, cinnamylalcoholand salicylaldehyde were 0.139, 0.067 and 0.062 mg L-1 and84.2, 86.5 and 82.1%, respectively. The contents ofcinnamaldehyde, cinnamylalcohol and salicylaldehydewere analyzed using the developed method in the 13commercial biopesticides. Results showed 0.06-17.37%,<LOQ-0.01% and <LOQ, respectively. CONCLUSION: This method would contribute tomanufacturers producing biopesticides and the qualitycontrol of biopesticides containing cinnamon extract.
( Hyo Jeong Lee ),( Hyo Jeong Kang ),( Eun Sil Yu ),( Kang Mo Kim ),( Ju Hyun Shim ),( Young Suk Lim ),( Han Chu Lee ),( Young Hwa Chung ),( Yung Sang Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Fibroblast growth factor receptor (FGFR) have been reported to be involved in the progression of hepatocellular carcinoma (HCC). There are 4 isotypes of FGFR (FGFR1-4) and the expression pattern of each FGFR isotype in HCC is still unknown. This study is aimed to assess FGFR isotype expression pattern in HCC and neighbouring non-neoplastic liver tissue and to evaluate the relationship between FGFR isotype expression pattern and overall survival (OS) of patients. Methods: We performed immunohistochemical staining of FGFR1, 2, 3 and 4 in HCC and paired neighboring nonneoplastic liver tissues of 870 HCC patients who underwent hepatic resection from 1998 to 2004. Among these patients, clinical data of 153 patients, who received curative resection as primary therapy from 2003 to 2004, was reviewed retrospectively and association of FGFR isotype expression with clinical parameter was also evaluated. Results: Among total 870 patients, expression of FGFR1, 2, 3 and 4 were observed in 5.3, 18.7, 3.8 and 52.9% of HCC tissues, respectively. FGFR1 and 4 were positive in 5.9 and 82.9% of non-neoplastic liver tissues but FGFR2 and 3 were not expressed in adjacent liver tissue. Among 153 patients whose clinical parameters were reviewed, the patients with positive FGFR2 staining in HCC tissue showed significantly shorter OS than the patients with negative FGFR2 (5-year survival rate 35.3 vs 61.8%, p=0.02). However, there was no significant difference in OS of patients according to the expression of FGFR1, 3 and 4 in HCC tissues. In multivariate analysis of potential factors to affect OS, FGFR2 expression in HCC tissue was an independent predictor of poor prognosis in postsurgical survival of HCC patients(hazard ratio 2.10, p=0.02). Conclusions: FGFR2 expression in HCC tissue might be used as a valuable prognostic biomarker for HCC patients after hepatic resection and also be a novel therapeutic target for molecular targeted agent in HCC.
Intra-operative Neurological Monitoring and Anesthesia
( Sang-ku Park ),( Sung-hyuk Lim ),( Chan-woo Park ),( Jin-woo Park ),( Dong-jun Kim ),( Ji-hyuk Kang ),( Hyo-geun Jee ),( Gi-bong Kim ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.4
The purpose of intra-operative neurological monitoring (INM) is to minimize surgically induced nerve damage, sensory nerves and motor neurons without affecting the operations to proceed during surgery such as evoked potentials (EP), electromyography (EMG), electroencephalography (EEG), transcranial doppler (TCD), etc. During the course of checking a patient’s condition, surveillance of ambulatory patients is a very different thing to check if the test is done under general anesthesia. INM can be possible or impossible depending on the type of drugs used and their concentrations because the monitoring is performed under anesthesia. Therefore, it is emphasized on the necessity of reviewing anesthesia which influences on INM.