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Ahn, Sung-Hyeon,Choi, Jae-Won,Jeon, Yong-Chan,Jeong, Chang-Mo,Yoon, Mi-Jung,Lee, So-Hyoun,Huh, Jung-Bo Korean Academy of Dental Science 2017 Journal of korean dental science Vol.10 No.1
Purpose: The purpose of this study was to evaluate the microleakage of various types of resin-bonded fixed partial dentures (RBFPDs) after artificial aging. Materials and Methods: Forty models with missing first molar were fabricated using artificial resin teeth and were divided into four groups: Group A, conventional RBFPDs design; Group B, modified RBFPDs design; Group C, assembled 3-piece RBFPDs design; and Group D, assembled 3-piece RBFPDs with different occlusal rest positions. Half of the specimens underwent chewing simulation process (240,000 cycles, 50 N load, 1.7 Hz) and thermocycling (temperatures $5^{\circ}C{\sim}55^{\circ}C$, dwelling time 30 seconds) and the remaining 20 specimens didn't receive any treatment. All the specimens were immersed in 2% methylene blue solution for 24 hours to evaluate microleakage, and were sectioned at the middle part of abutment teeth. To evaluate the microleaskage, a dye penetration was calculated. Result: With artificial aging, cyclic loading and thermocycling, a 3-piece RBPFD and a 2-piece RBPFD using original tooth undercuts have significantly lower microleakge (P<0.05) compared to the conventional design of RBPFD and modified RBPFD. Conclusion: Within the limit of this experiment, the assembled RBFPDs exhibited a smaller microleakage than the conventional RBFPDs, implying that the assembled RBFPDs can be more effective for reducing the dislodgement of the RBFPDs.
Ahn, Ji Hyeon,Chen, Bai Hui,Yan, Bing Chun,Park, Joon Ha,Kang, Il Jun,Lee, Tae-Kyeong,Cho, Jeong Hwi,Shin, Bich-Na,Lee, Jae-Chul,Jeon, Yong Hwan,Hong, Seongkweon,Lee, Young Joo,Choi, Soo Young,Won, Mo SPANDIDOS PUBLICATIONS 2018 MOLECULAR MEDICINE REPORTS Vol.17 No.1
<P>GABAergic projections terminate on numerous hippocampal interneurons containing calcium binding proteins (CBPs), including calbindin D-28k (CB), calretinin (CR) and parvalbumin (PV). Memory deficits and expression levels of CB, CR, and PV were examined in the hippocampal subregions following systemic scopolamine (Scop; 1 mg/kg) treatment for 4 weeks in mice. Scop treatment induced significant memory deficits from 1 week after Scop treatment. CB, CR and PV immunoreactivities distributions were in hippocampal subregions [CA1 and CA3 regions, and the dentate gyrus (DG)]. CB immunoreactivity (CB<SUP>+</SUP>) was gradually decreased in all subregions until 2 weeks after Scop treatment, and CB<SUP>+</SUP> was decreased to the lowest level in all subregions at 3 and 4 weeks. CR<SUP>+</SUP> in the CA1 region was gradually decreased until 2 weeks and hardly observed at 3 and 4 weeks; in the CA3 region, CR<SUP>+</SUP> was not altered in all subregions at any time. In the DG, CR+ was gradually decreased until 2 weeks and lowest at 3 and 4 weeks. PV<SUP>+</SUP> in the CA1 region was not altered at 1 week, and gradually decreased from 2 weeks. In the CA3 region, PV<SUP>+</SUP> did not change in any subregions at any time. In the DG, PV<SUP>+</SUP> was not altered at 1 week, decreased at 2 weeks, and lowest at 3 and 4 weeks. In brief, Scop significantly decreased CBPs expressions in the hippocampus ≥3 weeks after the treatment although memory deficits had developed at 1 week. Therefore, it is suggested that Scop (1 mg/kg) must be systemically treated for ≥3 weeks to investigate changes in expression levels of CBPs in the hippocampus.</P>
Ahn, Song Vogue,Kim, Hyeon Chang,Nam, Chung Mo,Suh, Il Elsevier 2018 Journal of cardiology Vol.71 No.2
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Diabetic women have a greater relative risk of coronary heart disease than diabetic men. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women.</P> <P><B>Methods</B></P> <P>The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up.</P> <P><B>Results</B></P> <P>The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110mg/dL) compared to normal glucose levels (<100mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (<I>p</I> for interaction with sex=0.021).</P> <P><B>Conclusions</B></P> <P>The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110mg/dL).</P> <P><B>Highlights</B></P> <P> <UL> <LI> The risk of coronary heart disease increased from a prediabetic range (≥110mg/dL) in women. </LI> <LI> Women have a higher relative risk of coronary heart disease associated with the fasting serum glucose level than men do. </LI> <LI> More careful glycemic control in women with hyperglycemia is needed to prevent coronary heart disease. </LI> </UL> </P>
Ahn, Ji Hyeon,Choi, Jung Hoon,Park, Joon Ha,Kim, In Hye,Cho, Jeong-Hwi,Lee, Jae-Chul,Koo, Hyun-Mo,Hwangbo, Gak,Yoo, Ki-Yeon,Lee, Choong Hyun,Hwang, In Koo,Cho, Jun Hwi,Choi, Soo Young,Kwon, Young-Guen SAGE Publications 2016 Neurorehabilitation and neural repair Vol.30 No.9
<P>Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term exercise begun after ischemic neuronal death as a chronic neurorestorative strategy has not yet been thoroughly examined. Objective. The purpose of this study is to investigate possible mechanisms by which exercise ameliorates ischemia-induced memory impairment in the aged gerbil hippocampus after transient cerebral ischemia. Methods. Treadmill exercise was begun 5 days after ischemia-reperfusion (I-R) and lasted for 1 or 4 weeks. The animals were sacrificed 31 days after the induction of ischemia. Changes in short-term memory, as well as the hippocampal expression of markers of cell proliferation, neuroblast differentiation, neurogenesis, myelin and microvessel repair, and growth factors were examined by immunohistochemistry and/or western blots. Results. Four weeks of exercise facilitated memory recovery despite neuronal damage in the stratum pyramidale (SP) of the hippocampal CA1 region and in the polymorphic layer (PoL) of the dentate gyrus (DG) after I-R. Long-term exercise enhanced cell proliferation and neuroblast differentiation in a time-dependent manner, and newly generated mature cells were found in the granule cell layer of the DG, but not in the SP of the CA1 region or in the PoL of the DG. In addition, long-term exercise ameliorated ischemia-induced damage of myelin and microvessels, which was correlated with increased BDNF expression in the CA1 region and the DG. Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus.</P>
충격량 측정시스템을 이용한 농산물선별시스템의 압상의 요인에 관한 연구
이현우 ( Hyeon-woo Lee ),안치국 ( Chi-kook Ahn ),김영태 ( Young-tae Kim ),한철우 ( Cheol Woo Han ),모창연 ( Chang-yeun Mo ) 한국농업기계학회 2021 한국농업기계학회 학술발표논문집 Vol.26 No.2
농산물의 선별 및 등급판정 과정은 농산물 품질향상과 가격을 결정하는 주요 요인이다. 농산물 선별 기술을 이용한 고품질 농산물 선별 과정은 소비자의 만족도를 높이고 농업인의 소득 증대를 끌어낼 수 있으며 상품의 부가가치를 높일 수 있다. 이와 관련하여 농산물 선별 기술과 관련한 다양한 연구를 수행하고 있으며 그 중 비파괴 선별기술은 농산물을 파괴하지 않고 품질을 평가할 수 있는 기술로 대부분의 선별시설에서 사용되고 있다. 농수산물유통공사의 산지유통 종합평가 결과에 따르면 농산물산지유통센터는 599개로 대부분 비파괴선별시설을 이용하여 선별을 시행하고 있다. 지금까지의 농산물선별기술의 연구ㆍ개발은 당도 및 중량 등 선별 정확도 향상을 위한 연구가 주를 이루고 있었으나 최근 과일의 멍, 표면결함 등 외부요인에 대한 문제점이 대두되고 있다. 특히 과일의 멍은 발생초기에는 육안으로 확인이 불가능하여 판별이 어렵고 유통과정을 거치는 동안 숙성되어 소비자가 구입할 때 발현되어 불만이 야기되고 있다. 농산물선별시스템은 디팔렛타이저 등 투입부터 세척, 선별, 배출, 포장까지 전체 자동화된 시스템이다. 과일을 덤프형태로 투입하여 세척, 선별, 배출단계에서 이송 시 과일간의 충격 및 선별 후 배출 시 낙하에 의한 손상 등 압상이 많이 발생한다. 많은 선별시설이 압상을 줄이기 위해 프리트레이 이송방식이 활용되고 있으나, 선별속도의 한계점을 가지고 있어 캐리어나 컵방식으로 변화하고 있는 추세이다. 그러나, 두 방식의 이송방식은 처리속도는 빠르나 프리트레이에 비해 압상 발생률이 높아 이를 보완하기 위한 연구개발이 필요하다. 본 연구에서는 캐리어 선별시스템의 압상이 발생되는 요소 및 요인을 파악하고 요인별 충격량을 계측하여 선별시스템 개발에 기초자료로 활용하고자 한다. 본 연구는 선별시스템에서 발생되는 압상의 요소 및 충격량 확인을 위해 시스템을 개발하고 실제 대형 농산물선별시스템에 적용되기 전 시험실 조건에서 간이 선별기를 제작하여 실험을 실시하였다. 제작한 선별기는 캐리어타입의 시험용 선별기이며, 대형 선별시스템과 같은 공정으로 구성하였다. 충격량 측정을 위한 시스템은 농산물품질관리원의 농산물 표준규격에 제시한 사과의 크기 중 가장 분포 많은 2L 크기(약400g)의 사과모형에 가속도센서와 Wireless Module로 구성하여 대형 선별기에서도 적용 가능한 무선 계측시스템을 개발하였다. 본 연구에서 개발된 충격량 계측시스템을 통해 선별 시 발생하는 압상에 대한 기초 연구 자료 및 차후 농산물선별기 성능평가에 활용될 예정이다.
가토에서 헤파린은 허혈 재관류로 인한 신장의 조직 손상을 완화하는가?
정현주,신증수,김갑수,방은치,안진모,김정열 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.1
Background : Increasing degrees of medullary hyperemia induced by ischemia reperfusion injury were associated with renal dysfunction. A possible mechanism may be that ischemia causes alterations in the structure and function of vascular membranes which leads to an aggregation of red blood cells in the medullary vessel. It has been shown that heparin prevents postischemic endothelial cell dysfunction. Aim of this study was to evaluate heparin effects on renal hyperemia induced by ischemia reperfusion injury. Method : In this study, fifteen rabbits were randomized to either heparin treatment group(500 IU/kg IV bolus 10 minutes before renal artery occlusion, n=8) or control group(n=7). One side kidney underwent 60 minutes ischemia only by clamping renal pedicle and after that kidney tissue sample was obtained for histologic evaluation. The other side of kidney were permitted 60 minutes ischemia following 60 minutes reperfusion and after that kidney tissue sample was obtained for histologic evaluation. Results : There was significant difference in the degree of congestion(2.6±0.2 vs 1.1±0.3, P<0.05) between outer medulla of control and heparin treatment group. Conclusion : Heparin significantly attenuated outer medullary congestion induced ischemic injury. (Korean J Anesthesiol 1998; 35: 23∼28)