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김화영(Hwayoung Kim),김형민(Hyungmin Kim),송민수(Minsu Song),안지훈(Jihun An),김강현(Ganghyun Kim),김선민(Sunmin Kim),김찬현(Chanhyun Kim),박성우(Seoungwoo Park),이준우(Junu Lee),이준기(Joonki Rhee),임재혁(Jaehyuk Im),정승수(Seungsu Jeo 한국추진공학회 2022 한국추진공학회 학술대회논문집 Vol.2022 No.5
본 논문은 경기대학교 KURBC 팀이 설계한 모듈형 신기전K22에 대한 설계과정과 그 근거를 서술하였다. 로켓의 임무는 ‘로켓 발사 후 낙하 시 낙하산 사출 및 안전한 회수’이다. 목표 고도는 400m, 연료는 질산칼륨-소르비톨(KNSB)이다. 낙하산 사출 방법은 동체와 낙하산이 안전하게 보호되는 용수철 사출을 선택했다. 본 팀은 이번 대회에서 CFRP 카본으로 로켓의 동체를 만들고, 내부를 모듈로 구성함으로써 차별점을 두었다. 또한 RF 장거리 통신 기술을 이용하여 발사 전후의 데이터를 체계적으로 기록하여 후속 연구에 참고할 예정이다. This paper describes the design process and basis for the modular Shinkijeon-K22 designed by the KURBC team of Kyonggi University. The rockets mission is devising a method for parachute injection and safe recovery when falling after launching the rocket. The target altitude is 400 m and the fuel is potassium nitrate-solvitol (KNSB). The spring injection method was used for the parachute injection, in which the fuselage and parachute are safely protected. We made a difference by making the rockets fuselage with CFRP carbon and configuring the interior as a module. In addition, RF long-distance communication technology will be used to systematically record data before and after launch and refer it to subsequent studies.
Kim, Injung,Park, Jongkeun,Kim, Jeong-Ki,Kim, Bong-Kyu,Lee, Hwayoung,Choi, Keonwoo,Yoon, Jong-Bok,Yoon, Sungjoo Kim Springer-Verlag 2014 Genes & Genomics Vol.36 No.3
T-cadherin is frequently down regulated in various cancers, however, the underlying mechanisms responsible have yet to be elucidated. A genome wide association study of a cohort of Korean adults revealed that the T-cadherin rs3865188 single nucleotide polymorphism (SNP) was associated with serum Adiponectin levels and that its genotypic variants were correlated with risk for colorectal cancer (CRC). To test the function of rs12444338, a SNP tightly linked to the rs3865188 SNP, in T-cadherin transcriptional regulation in colorectal cancer, its effect on transcriptional activity and the capacity of binding activity attributable to allelic variation of the rs12444338 SNP was investigated. An electrophoretic-mobility-shift assay (EMSA) revealed a specific nucleoprotein complex unique to the T allele probe, which displayed lower promoter activity when compared to the G allele. Based on the results of the EMSA using mutant probes, the consensus sequence of the putative transcription factor binding site was determined. Additionally, candidates for putative binding factors to the T allele were also identified. Collectively, the study data suggested that the rs12444338 SNP was involved in transcriptional regulation of T-cadherin gene (CDH13) and that the differential binding of transcription factors at the rs12444338 SNP resulted in altered gene expression. These results elucidate, at least in part, the regulation of T-cadherin expression in CRC and provide further information regarding the effect of nucleotide variation in its promoter region.
Lee, Hwayoung,Kim, Hyung-Ki,Kwon, Jun-Tack,Park, Shohyun,Park, Hae Jeong,Kim, Su Kang,Park, Jin Kyung,Kang, Won Sub,Kim, Young Jong,Chung, Joo-Ho,Kim, Jong Woo,Kim, Hak-Jae Elsevier 2018 Psychiatry Research Vol.259 No.-
<P><B>Abstract</B></P> <P>Prenatal exposure to infectious or inflammatory insults can increase the risk of developing neuropsychiatric disorders such as bipolar disorder, autism, and schizophrenia in later life. Gamma-butyrobetaine hydroxylase (BBOX 1) is an enzyme responsible for the biosynthesis of l-carnitine, a key molecule in fatty acid metabolism. This cytosolic dimeric protein belongs to the dioxygenase family. In this study, we investigated whether BBOX 1 expression was related to psychiatric disorder in an animal model. We also conducted a case–control study using 284 schizophrenia patients and 409 controls with single-nucleotide polymorphisms (SNPs) in the 5′-near region of BBOX 1. BBOX 1 expression was increased in the medial frontal cortex of a mouse model of schizophrenia induced by maternal immune activation. Furthermore, the genotype and allele frequencies of two SNPs (rs7939644 and rs10767592) were significantly associated with schizophrenia susceptibility. Our results suggest that BBOX 1 might be associated with maternal immune activation and schizophrenia susceptibility. Therefore, it might be involved in the pathophysiology of schizophrenia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bbox 1 protein was downregulated in the medial prefrontal cortex in a poly I:C-induced model of schizophrenia. </LI> <LI> Two SNPs of BBOX 1 were associated with human schizophrenia susceptibility. </LI> <LI> Significant pre-pulse facilitation was detected in the poly I:C-induced model. </LI> </UL> </P>
Unequal Geographic Distribution of Life Expectancy in Seoul
Kim, Sangmi,Yi, Seonju,Kim, Meekyung,Kim, Bokyung,Lee, Hwayoung,Jeon, Taekryeon,Cho, Youngtae SAGE Publications 2015 Asia-Pacific journal of public health Vol.27 No.2
<P>This study examined life expectancies in 25 <I>gu</I>s, administrative districts of Seoul, the capital of Korea, by gender in 1995, 2002, and 2008 to explore trends in mortality inequality among areas. The authors constructed single-decrement life tables and employed between-group variance, the Theil index, and mean log deviation to measure absolute and relative disparities in life expectancy among areas during the periods 1995-2002 and 2002-2008. It was found that life expectancy gaps between <I>gu</I>s have widened in absolute and relative terms in both genders over the decade, and that this pattern was particularly dramatic in females after 2002. This increasing gap could be attributable to the more negative health impact on females since the late 1990s stemming from the economic crisis, eventually reflected in their places of residence. Thus, a social buffer system to narrow the health gap between geographic areas and social classes must be established.</P>
Toxicokinetics of paraquat in Korean patients with acute poisoning
Kim, Hak-Jae,Kim, Hyung-Ki,Lee, Hwayoung,Bae, Jun-Seok,Kown, Jun-Tack,Gil, Hyo-Wook,Hong, Sae-Yong The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve ($AUC_{inf}$), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution ($V_d/F$) were calculated. The maximum PQ concentration ($C_{max}$) and the time to reach maximum PQ concentration ($T_{max}$) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of $13.1{\pm}6.8h$. $C_{max}$ and $AUC_{inf}$ were $20.8{\pm}25.7mg/l$ and $172.5{\pm}160.3h{\cdot}mg/l$, respectively. Apparent volume of distribution and apparent oral clearance were $50.9{\pm}61.3l/kg$ and $173.4{\pm}111.2l/h$, respectively. There were a significant correlation (r=0.84; p<0.05) between the PQ amount ingested and $C_{max}$. $AUC_{inf}$ also showed a significant correlation (r=0.83; p<0.05) with the PQ amount ingested. These correlations provide evidence that PQ has dose-linear toxicokinetic characteristics.
<i>Salvia miltiorrhiza</i> enhances the survival of mesenchymal stem cells under ischemic conditions
Kim, Ran,Lee, Seokyeon,Lee, Chang Youn,Yun, Hwayoung,Lee, Hojin,Lee, Min Young,Kim, Jongmin,Jeong, Jee‐,Yeong,Baek, Kyungmin,Chang, Woochul John Wiley and Sons Inc. 2018 Journal of pharmacy and pharmacology Vol.70 No.9
<P><B>Abstract</B></P><P><B>Objectives</B></P><P>To validate the enhanced therapeutic effect of <I>Salvia miltiorrhiza</I> Bunge (SM) for brain ischemic stroke through the anti‐apoptotic and survival ability of mesenchymal stem cells (MSCs).</P><P><B>Methods</B></P><P>The viability and the expression level of cell apoptotic and survival‐related proteins in MSCs by treatment of SM were assessed <I>in vitro</I>. In addition, the infarcted brain region and the behavioural changes after treatment of MSCs with SM were confirmed in rat middle cerebral artery occlusion (MCAo) models.</P><P><B>Key findings</B></P><P>We demonstrated that SM attenuates apoptosis and improves the cell viability of MSCs. In the rat MCAo model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of MSCs with SM.</P><P><B>Conclusions</B></P><P>The therapy using SM enhances the therapeutic effect for brain ischemic stroke by promoting the survival of MSCs. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell‐based therapies for patients suffering from a variety of diseases.</P>