원보 : 경피흡수촉진제의 영향에 따른 인다파마이드의 피부투과

서희 ( Hui Seo ),정상영 ( Sang Young Jeung ),박지선 ( Ji Seon Park ),신병철 ( Byung Cheol Shin ),황성주 ( Sung Joo Hwang ),조선행 ( Sun Hang Cho ) 한국약제학회 2007 Journal of Pharmaceutical Investigation Vol.37 No.4

관절내 종골 골절에 있어 전산화 단층 촬영을 이용한 비골 건초여의 발생예측

정주영,서정탁,유총일,김휘택,정흥태,황성호 대한골절학회 2000 대한골절학회지 Vol.13 No.3

Purpose: The purpose of the current study is that CT can predict peroneal tenosynovitis in the intraarticular calcaneal fracture. Materials and Method: Sixty five calcaneal fractures in 55 patients were evaluated with CT scan. The follow-up period after operation was averaged 19 months (ranging from 4 to 79 months). A classification for peroneal tendon injury was developed, based on CT scan. Results: Of the 65 intraarticular calcaneal fractures, the incidence of peroneal tenosynovitis were 14 cases(26%)[open reduction and internal fixation group 7/43(16%), Essex-Lopresti group 7/22(32%)]. According to the author's classification, the incidence of peroneal tenosynovitis among open reduction and internal fixation subgroup was followed; type I was none(0/4), type II 11%(2/19), type III 20%(3/15) and type IV 40%(2/5) respectively(p=0.074). The incidence of peroneal tenosynovitis among Essex-Lopresti subgroup was followed; type I was none(0/4), type II 16%(1/6), type III 33%(3/9) and type IV 100%(3/3) respectively(p=0.009). Conclusion: CT can be used to evaluate the status of the peroneal tendon as well as to predict the development of peroneal tenosynovitis. The open reduction and internal fixation in type III and IV is preferable to achieve a alignment of peroneal tendon and a accurate reduction of subtalar joint.

보중익기합대칠기탕(補中益氣合大七氣湯) 추출물의 유전독성 평가

황희정,변준석,허진일,Hwang, Hui-Jeung,Byun, Joon-Seok,Heo, Jin-Il 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.1

The genotoxicity of water extract of Bojungikkeehapdaechilki-tang was tested by In Vitro Chromosome Aberration Test. Bacterial Reverse Mutation Assay and Micronucleus test according to OECD Guidelines and KFDA Guidelines. The obtained results were as follows : 1. Chromosome Aberration Test: In Vitro Chromosome Aberration Test of Bojungikkeehapdaechilki-tang extracts was carried out using cultured Chinese hamster lung cells in the presence and absence of metabolic activation system(S-9 mix). No significant changes in the number of aberrant metaphases having structural and number of aberrations were detected in Bojungikkeehapdaechilki-tang extracts treated groups. 2. Bacterial Reveres Mutation Assay: Bojungikkeehapdaechilki-tang extracts was evaluated for its potential to induce reverse mutation in the histidine auxotroph strains of Salmonella typhimurium such as TA100, TA1535, TA98 and TAl537 and the tryptophan auxotroph strain of Escherichia coli WP2 uvrA. No significant changes in the number of revertant colonies compared to its negative control were detected in Bojungikkeehapdaechilki-tang extracts treated groups against all 5 strains. 3. Micronucleus test: Micronucleus test of Bojungikkeehapdaechilki-tang extracts were performed using specific pathogen free 7-week old male ICR mouse. No significant changes in the number of micronucleated polychromatic erythrocytes among 2000 polychromatic erythrocytes compared to negative control were detected in all Bojungikkeehapdaechilki-tang extracts treated groups. In summarized above-mentioned results, it is concluded that Bojungikkeehapdaechilki-tang extracts have not genotoxicity against In Vitro Chromosome Aberration Test, Bacterial Reverse Mutation Assay and Micronucleus test.

반하사심탕(半夏瀉心湯)이 Doxorubicin에 의해 유발(誘發)된 간장(肝臟) 및 비장(脾臟) 독성(毒性)에 미치는 영향(影響)

황희정,신민규,곽민아,이윤희,김상찬,변준석,Hwang, Hui-Jeung,Shin, Min-Kyu,Kwak, Min-Ah,Lee, Yun-Hee,Kim, Sang-Chan,Byun, Joon-Seok 대한암한의학회 2002 大韓癌韓醫學會誌 Vol.8 No.1

Object The effect of Banhasasim-tang extracts on the hepatic, splenic toxicity and induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Method The changes of body weigh, organ weights of liver and spleen were observed with blood GOT and GPT level. Results 1. Increase of absolute and relative liver weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of liver congestion and necrotic spot were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in Doxorubicin treatment group were significantly decreased in Banhasasim-tang extracts dosing groups. 2. Decrease of absolute and relative spleen weight observed in Doxorubicin treatment group were dose dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group.

반하사심탕(半夏瀉心湯)이 Doxorubicin에 의해 유발(誘發)된 심장독성(心臟毒性) 및 임상증상(臨床症狀)에 미치는 영향(影響)

신민규,황희정,김상찬,변준석,Shin Min-Kyu,Hwang Hui-Jeung,Kim Sang-Chan,Byun Joon-Seok 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.1

The effect of Banhasasim-tang extracts on the cardiac toxicity and general symptom induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. The changes of body weight, clinical signs, necropsy findings and organ weights of heart were observed. The results were as followed. 1. Decrease of body weight after Doxorubicin treatment were dose-dependently inhibited by Banhasasim-tang extracts. 2. The degrees of anorexia, ataxia and dehydration that were observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. 3. Increase of absolute and relative heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition. the degrees of heart congestion and enlargement were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group. In conclusion, the toxicity of Doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of heart) was inhibited and/or prevented by Banhasasim-tang extracts. According to these results. it is considered that Banhasasim-tang has some preventive effect against to toxicity induced by Doxorubicin.

半夏瀉心湯이 Doxorubicin에 의해 誘發된 毒性에 미치는 影響

신민규(Min-Kyu Shin),황희정(Hui-Jeung Hwang),김상찬(Sang-Chan Kim),변준석(Joon-Seok Byun) 대한한의학회 2003 대한한의학회지 Vol.24 No.1

정천화담항기탕(定喘化痰降氣湯)이 ovalbumin으로 유발된 천식(喘息)에 미치는 영향(影響)

안태호,황희정,김대준,박지현,최해윤,김종대,An Tae-Ho,Hwang Hui-Jeung,Kim Dae-Jun,Park Ji-Hyeon,Choi Hae-Yun,Kim Jong-Dae 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

Objectives: In order to evaluate the effect of jungcheonwhadamgangki-tang on Balb/c mouse of allergy-sensitive to bronchial asthma induced by ovalbumin. Methods: The changes of diameter lumen of trachea which was upper respiratory organ, weight and gross appearance of lung, histology of lung and trachea, numbers of inflammatory cells in the bronchoalveolar lavage fluld(BALF) were observed. Results : The results are obtained as follows. 1. The diameters of trachea lumen were significantly increased in Jungcheonwhadam gangki-tang treated group as compared with control group. 2. Inflammatory cells including neutrophil and eosinophil in BALF were significantly. in Jungcheonwhadamgangki-tang treated group as compared with control group. 3. Weight of lung and black spots, which resulted from infiltration of inflammatory were significantly decreased in Jungcheonwhadamgangki-tang treated group as compared with control group.4. Hypertrophy of mucous membrane of trachea and bronchus and bronchioles in the lung, peritracheal, peribronchus and peribronchiolar inflammatory cell infiltration, and mucoid exudate deposit in the lumen were significantly decreased in Jungcheonwhadamgangki-tang treated group as compared with control group. Conclusions : It is considered that Jungcheonwhadamgangki-tang has somewhat favorable effect on the bronchial asthma because the bronchial asthma specific series of abnormalities in respiratory system were decreased after oral administration of Jungcheonwhadamgangki-tang in this study. In future, it is needed that the toxicological and dosage specific study of Jungcheonwhadamgangki-tang to use against bronchial asthma with safe.

철겹핍성 빈혈 치험(治驗) 1례(例) 보고(報告)

이윤희,김종대,황희정,Lee, Yoon-Hee,Kim, Jong-Dea,Hwang, Hui-Jeung 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

We extended to find out the effect of serveral kinds of herbal medicion that administated to the patient suffer from iron deficiency anemia, that was prescribed according to differentiation of syndromes. Iron deficiency anemia is generlly differentiated as defiency of Ki and blood, hypofunction of the spleen and stomach, and insufficiency of the spleen and kidney in orinetal medicine. This patient was differentiated as defiency of Ki and blood. hypofunction of the spleen and stomach. So we prescribed Hyangsayangwi-tang, Ickibohyoul-tang and Ickibohyoul-tang ga Antler for the patient in turn. When administated Hyangsayangwi-tang and Ickibohyoul-tang, there was a little improvement in symptom but no improvement in hemonalysis. When administrated Ickibohyoul-tang ga Antler there was dominent improvement in both of symptom and hemonalysis. From this case. it is thought that added Antler-tonifying recipe is very effective to iron deficiency anemia and that more studies and examinations are needed in futher.

동원(東垣) ${\ll}$비위론(脾胃論)${\gg}$ 수록(收錄) 처방(處方)의 치법(治法)에 대(對)한 문헌적(文獻的) 고찰(考察)

이윤희,황희정,김상찬,박순달,변준석,Lee, Yun-Hee,Hwang, Hui-Jeung,Kim, Sang-Chan,Park, Soon-Dal,Byun, Joon-Seok 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

Objectives : 'Pi Wei Lun' is the principal medical work of Li Dongyuan's writings, which contains most of his medical theories. There are sixty-three prescriptions in 'Pi Wei Lun', and fifty-two of them were originated from him. This study was planned to present assistance to those who apply Dongyuan's theory clinically. Methods : We investigated those fifty-two prescriptions literary, and studied them from a viewpoint of the principle and method of treatment. Results : Dongyuan's fifty-two prescriptions can be classified into eight groups from the viewpoint of the principles and methods of treatment which are composed of 'tonify the spleen and stomach & elevate the spleen Yang', 'elevate the spleen Yang & expel fire', 'elevate the spleen Yang & relieve dampness', 'promote blood flow to eliminate blood stasis', 'invigorate the spleen', 'replenish Ki & and dispel phlegm', 'purgation with drugs warm in nature', and 'the other' eight methods. Conclusions : From above, we concluded that Dongyuan considered 'the primordial energy of the spleen and stomach' as the most important when making up prescriptions, but, at the same time, he used diverse methods of treatment on the ground of differentiation of syndromes.

차광 및 혐기처리에 따른 청차의 성분과 향미 특성 변화

권미진(Mi Jin Kwon),손용휘(Yong-Hwi Son),이재순(Jae Sun Lee),정광희(Gwang Hui Jeong),조경환(Kyung Hwan Cho),황정규(Jung Gyu Hwang),김민정(Min Jung Kim),신지훈(Jihun Shin),신의철(Eui-Cheol Shin),안정희(Jeung Hee An),김종철(Jong Cheol 한국차학회 2021 한국차학회지 Vol.27 No.4

찻잎은 수확 전⋅후 외부스트레스에 의해 뇌기능개선, 혈압조절 기능이 있는 가바함량이 증가한다. 본 연구는 수확 전 차광처리와 수확 후 혐기처리를 통해 찻잎의 가바함량을 증진시켜 각각을 청차로 제다하여 그 성분과 품질을 비교해 보았다. 생엽의 혐기처리 조건은 탄산가스 주입 후 25℃에서 24시간 반응 시키는 조건에서 가바함량이 315.1 mg/100 g으로 가장 높았다. 가바와 테아닌 함량은 비차광 대비 차광 조건에서 증가하였다. 그중가바함량은 차광⋅혐기조건에서 182.7 mg/100 g으로 가장 높았다. 반면 테아닌은 혐기조건에서 감소하는 경향을 보였다. 카페인함량은 차광조건이 비차광조건, 혐기 보다 무혐기에서 높았으며, 카테킨함량은 비차광조건이차광조건보다 높았으며, 혐기처리시 감소하는 경향을 보였다. 테아플라빈함량은 차광 유무에 따른 차이는 없었으나, 혐기처리시 증가하는 경향을 보였다. 맛분석 결과 차광⋅혐기처리에서 무혐기처리 대비 신맛, 우마미는감소하는 반면, 짠맛, 단맛, 쓴맛, 떫은맛, 매운맛 등이 증가하였다. 전자코를 통한 향기 성분은 비차광⋅무혐기, 차광⋅혐기에서 propane, propenal, butane이 주요 성분으로 확인 되었으며, 비차광⋅혐기, 차광⋅무혐기에서는propane, propyzamide이 주요 성분으로 확인 되었다. The content of γ-aminobutyric acid (GABA), which improves brain function and regulates blood pressure, increases in tea leaves due to external stress before and after harvesting. This study compared the ingredients of oolong tea by increasing the GABA content in tea leaves through shading before harvest and anaerobic treatment after harvest. In the anaerobic treatment of raw leaves, the highest GABA content was 315.1 mg/100 g under the condition of reacting at 25℃ for 24 hours after carbon dioxide gas injection. The content of GABA and theanine had increased in oolong tea under the shading condition compared to the non-shading condition. The GABA content was the highest in oolong tea at 182.7 mg/100 g under shading and anaerobic conditions. On the other hand, theanine tended to decrease under anaerobic conditions. Caffeine content was higher in the shaded condition than in the non-shading condition, and it was higher in the aerobic condition than in the anaerobic condition. The catechin content was higher in the non-shading condition than in the shading condition and tended to decrease during anaerobic treatment. There was no difference in the theaflavin content with or without shading, but it tended to increase during anaerobic treatment. In the case of oolong tea, sourness and umami decreased compared to aerobic treatment in shading and anaerobic treatment, while salty, sweet, bitter, astringent, and spicy taste increased.