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Umbilical cord blood transplantation
Koo, Hong-Hoe,Ahn, Hyo-Seop The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.7
Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disparity. Several studies have shown that the number of cells transplanted is the most important factor for engraftment in CBT, and it limits the wide use of CB in adult patients. New strategies for facilitating engraftment and reducing transplantation-related mortality are ongoing in the field of CBT and include the use of a reduced-intensity conditioning regimen, double-unit CBT, ex vivo expansion of CB, and co-transplantation of CB and mesenchymal stem cells. Recently, the results of two international studies with large sample sizes showed that CB is an acceptable alternative source of hematopoietic stem cells for adult recipients who lack human leukocyte antigen-matched adult donors. Along with the intensive researches, development in banking process of CB will amplify the use of CB and offer the chance for cure in more patients.
Koo, Dong-Hoe,Park, Inkeun,Ahn, Jin-Hee,Lee, Dae-Ho,You, Dalsan,Jeong, In-Gab,Song, Cheryn,Hong, Bumsik,Hong, Jun Hyuk,Ahn, Hanjong,Lee, Jae-Lyun Springer-Verlag 2016 Cancer chemotherapy and pharmacology Vol.77 No.2
<P>The purpose of the current study was to evaluate the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) who interrupted vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR-TKI) therapy. A retrospective analysis of medical records was performed on all patients with mRCC treated with VEGFR-TKIs between January 2008 and July 2014 (n = 505). Patients who achieved stable disease (SD) or a better response under TKI and later discontinued TKI treatment for any reason with the exception of disease progression were included in the analysis. We identified 32 patients (sunitinib = 20, sorafenib = 7, and pazopanib = 5). The responses to VEGFR-TKIs were complete response (CR, n = 4), partial response (PR, n = 11), SD (n = 15), and controlled but nonmeasurable response (n = 2). Median time to TKI discontinuation from the initiation of VEGFR-TKI therapy was 16.6 months (95 % CI 12.8-20.3), and the main cause of VEGFR-TKI discontinuation was toxicity (n = 19, 59.4 %). At the time of analysis, 16 patients had disease progression and one patient died. With a median follow-up duration of 51.7 months (range 11.5-87.6), median progression-free survival (PFS) after TKI discontinuation was 20.2 months (95 % CI 6.4-34.0). In multivariate analysis, the duration of TKI therapy (< 1 year) before TKI discontinuation was an independent significant prognostic factor of poor PFS (p = 0.045). Among 11 patients who were retreated with the same TKI, two patients (18.2 %) achieved PR and nine achieved SD (81.8 %). VEGFR-TKI could be interrupted at least temporarily when clinically warranted in patients with mRCC sufficiently controlled by TKIs.</P>
Philadelphia chromosome-positive acute lympho-blastic leukemia in childhood
Koo, Hong-Hoe The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.3
In pediatric patients with acute lymphoblastic leukemia (ALL), the Philadelphia chromosome translocation is uncommon, with a frequency of less than 5%. However, it is classified as a high or very high risk, and only 20-30% of Philadelphia chromosome-positive (Ph+) children with ALL are cured with chemotherapy alone. Allogeneic hematopoietic stem cell transplantation from a closely matched donor cures 60% of patients in first complete remission. Recent data suggest that chemotherapy plus tyrosine kinase inhibitors (TKIs) may be the initial treatment of choice for Ph+ ALL in children. However, longer observation is required to determine whether long-term outcome with intensive imatinib and chemotherapy is indeed equivalent to that with allogeneic related or alternative donor hematopoietic stem cell transplantation (HSCT). Reports on the use of second-generation TKIs in children with Ph+ ALL are limited. A few case reports have indicated the feasibility and clinical benefit of using dasatinib as salvage therapy enabling HSCT. However, more extensive data from clinical trials are needed to determine whether the administration of second-generation TKIs in children is comparable to that in adults. Because Ph+ ALL is rare in children, the question of whether HSCT could be a dispensable part of their therapy may not be answered for some time. An international multicenter study is needed to answer the question of whether imatinib plus chemotherapy could replace sibling allogeneic HSCT in children with Ph+ ALL.
Control of Water Vapor Permeation through Oxide Films on Polymers for Flexible Displays
( Won Hoe Koo ),( Sang Hun Choi ),( Hong Koo Baik ),( Sung Man Lee ),( Se Jong Lee ) 대한금속재료학회 ( 구 대한금속학회 ) 2005 ELECTRONIC MATERIALS LETTERS Vol.1 No.2
Composite films consisting of tin oxide and silicon oxide produced via thermal evaporation were deposited on polycarbonate substrates as water-barrier films to control the polarizability and packing density of the composite films, both of which are factors significantly affecting water vapor permeation through the films. As the tin oxide was added to the silicon oxide, the polarizability and packing density of the composite films increased, and the water vapor transmission rate (WVTR) through the composite oxide films decreased. Because of their strong interaction with water vapor, the 80 % tin oxide films with the highest polarizability and packing density showed the lowest WVTR; however, the loose microstructures, which were caused by thermal evaporation, resulted in a WVTR still too high to be applied as passivation layers in organic light emitting diodes. Therefore, we deposited SnO2 films with high polarizability on polycarbonate substrates while using an ion-beam-assisted deposition process (IBAD) to increase the packing density. This process resulted in a WVTR below the measurable limit of 0.01 g/㎡/day at 100% RH and 37.8℃. The permeation mechanism of water vapor through the oxide films is discussed in terms of the chemical interaction with water vapor and the microstructure of the oxide films. The chemical interaction of water vapor with oxide films was investigated by the refractive index obtained from ellipsometry and the OH group peak obtained from x-ray photoelectron spectroscopy (XPS). The microstructure of the composite oxide films was characterized using atomic force microscopy (AFM) and transmission electron microscopy (TEM). The activation energy for water vapor permeation through the oxide films was also measured in relation to the permeation mechanism of water vapor.
Hong, Jong-Pil,Byun, Mi Young,Koo, Dal-Hoe,An, Kyungsook,Bang, Jae-Wook,Chung, In Kwon,An, Gynheung,Kim, Woo Taek American Society of Plant Physiologists 2007 The Plant cell Vol.19 No.6
<P>Although several potential telomere binding proteins have been identified in higher plants, their in vivo functions are still unknown at the plant level. Both knockout and antisense mutants of RICE TELOMERE BINDING PROTEIN1 (RTBP1) exhibited markedly longer telomeres relative to those of the wild type, indicating that the amount of functional RTBP1 is inversely correlated with telomere length. rtbp1 plants displayed progressive and severe developmental abnormalities in both germination and postgermination growth of vegetative organs over four generations (G1 to G4). Reproductive organ formation, including panicles, stamens, and spikelets, was also gradually and severely impaired in G1 to G4 mutants. Up to 11.4, 17.2, and 26.7% of anaphases in G2, G3, and G4 mutant pollen mother cells, respectively, exhibited one or more chromosomal fusions, and this progressively increasing aberrant morphology was correlated with an increased frequency of anaphase bridges containing telomeric repeat DNA. Furthermore, 35S:anti-RTBP1 plants expressing lower levels of RTBP1 mRNA exhibited developmental phenotypes intermediate between the wild type and mutants in all aspects examined, including telomere length, vegetative and reproductive growth, and degree of genomic anomaly. These results suggest that RTBP1 plays dual roles in rice (Oryza sativa), as both a negative regulator of telomere length and one of positive and functional components for proper architecture of telomeres.</P>