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- 저자 : Ho-Yin LEE (검색결과 107 건)
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파킨슨병의 한의학적 고찰 -병인병리(病因病理)와 침구요법(鍼灸療法)을 중심으로-
박상민,이상훈,인창식,강미경,장대일,강성길,이윤호,Park, Sang-min,Lee, Sang-hoon,Yin, Chang-shik,Kang, Mi-kyeong,Chang, Dae-il,Kang, Sung-keel,Lee, Yun-ho 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1
Objective: In order to find oriental medical therapies on Parkinson's disease and to make a fundamental basis for clinical application, this study was performed. Methods: We reviewed 35 kinds of the ancient and modern text, and related articles. Results: Parkinson's disease is an extrapyramidal disease characterized by akinesia, tremor at rest, rigidity, and slowness of movement. In old oriental medical text, Parkinson's disease is described as Jinjeon(振顫), Chi, Gyeong (痙), Gyejong, Ryeon(攣) and Pyeongo(偏枯), Tantan, Jungbu(中腑症) of Jungpung(中風). According to the text, major pathological causes were Wind(風), Fire(火), Phlegm(痰), and Blood stasis(瘀血). And Parkinson's disease can be classified into four clinical types as liver & kidney yin-deficiency, qi & blood deficiency, retention of phlegm-heat, and qi-stagnation & blood stasis. Standardized acupuncture points are GV20, GB20, GV14 on head, CV12, ST25 on abdomen, GV26, ST7, GB1, S14, LI20 on face, LI4, LI11, TE5, SI3, HT3, LI15, SI6 on upper extremity, and ST36, GB34, SP6, LR3, KI1, GB30, BL40 on lower extremity. Other methods, such as scalp acupuncture, electro-acupuncture, and herb-acupuncture, can be applied to treat Parkinson's disease. Conclusions: We find out that there are oriental medical concepts related with Parkinson's disease such as Jinjeon(振顫), Chi, Gyeong (痙), Gyejong, Ryeon(攣) and Pyeongo(偏枯), Tantan, Jungbu(中腑症) of Jungpung(中風), of which major causes are Wind(風), Fire(火), Phlegm(痰), and Blood stasis(瘀血). We can also apply many effective acupuncture points and acupuncture therapies according to differential diagnosis, for example, liver & kidney yin-deficiency. qi & blood deficiency, retention of phlegm-heat, and qi-stagnation & blood stasis.
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孫仁煥,길인호,李鐘燮,李起男 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2
A study on the antitoxic effects of Flos Carthami against Cadmium Chloride Toxicity in Live and Kidney of Rats. This study was performed to find out the effect of Flos Carthami against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of Flos Carthami and cadmium. Rat were given pellets administration with three dosage of Flos Carthami such as 4mg/kg body weight for four weeks. The results were summarized as follows on: 1. The simultaneously administration of Flos Carthami and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone(p<O.05). 2. The simultaneously administration of Flos Carthami and cadmium significantly more increased metallothionein concentration in liver and kidney tissues compared to administration alone(p<O.05).
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Diphenylhydantoin이 백서뇌신경세포막의 Na^+, K^+ -ATPase에 미치는 영향
황인방,허강민,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1
To study the effect of diphenylhydantoin on the synaptosomal Na^+ K^+ -ATPase in the rat with Goldblatt kidney, one kidney was removed and renal artery on the other side was partially ligated (external diameter=0.38mm). One kidney was removed in the control group. Synaptosome was prepared from the control and hypertensive rat and ATPase activity (total, EGTA, Azide and ouabain sensitive) was measured in the presence or absence of saponin. The effect of diphenylhydantoin on the synaptosomal ATPase was observed in the presence of diphenylhydantoin and/or ouabain. To investigate the maximal binding of ouabain to synaptosome, ouabain binding study was also carried out. Results as follows: 1. Blood pressure was significantly increased in 1-kidney, 1-clip hypertensive rat. 2. ATPase activity(Total, EGTA and ouabain sensitive) was increased to 2 times in the presence of saponin in the hypertensive and control group. 3. Na^+, K^+ -ATPase activity in hypertensive group was significantly decreased, compared with the control group. 4. Diphenylhydantoin slightly increased the ATPase activity in the control and hypertensive group, but it was not significant. 5. Total activity of ATPase was significantly decreased in the case with dephenylhydantoin and ouabain, but there was not difference between ouabain and ouabain with diphenylhydantoin treated case. 6. In the experiment of oubain binding, diphenylhydantoin did not alter Bmax and Kd of hypertensive and control group. From the above results, it is suggested that diphenylhydantoin will decrease the intracellular sodium without dependence on the stimulation of Na^+, K^+ -ATPase-in hypertensive rat.
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( Ho Yin Henry Lee ),( Wai Yin Angus Chu ),( Chi Chuen Clarence Mak ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: An alternative technique in endoscopic sphincteroplasty is using a large CRE wireguided balloon dilatation as an adjunct to endoscopic sphincterotomy in removing common bile duct (CBD) stone. However, there are few evidence demonstrating the outcomes and complication using CRE balloon dilatation sphincteroplasty during acute phase of cholangitis. This study aims to reveal the outcome of the technique from a single hospital experience. Methods: A retrospective descriptive study was conducted at the Endoscopy Center of Yan Chai Hospital over a period of 2 years from January 2018 to December 2019. A total of 45 cases was identified where patients, presented with acute cholangitis, had endoscopic papillary balloon dilatation with CRE wireguided balloon during the index admission. Acute cholangitis was defined according to “Tokyo Classication - Cholangitis” (guidelines). Cases with concomitant malignancy and obstruction causes other than common bile duct stones were excluded. The stone clearance rates as defined with occlusive cholangiogram and post ERCP complications were analyzed. Results: There were 14 (31%) male and 31 (69%) females. Age of the study population ranged from 36-95 years. Stone clearance proven by occlusive cholangiogram in first session was achieved 29/45 (64%) cases. For complication, 6 (13%) cases developed mild papillary bleeding and 3/42 (7%) cases mild pancreatitis. No septic shock was documented. Conclusions: Endoscopic sphincteroplasty using CRE Wireguided balloon dilatation as an adjunct to endoscopic sphincterotomy is a safe and effective technique for CBD stone removal during acute cholangitis. This procedure can potentially avoid further attempt of ERCP for residual CBD stones.
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Lee, Seung-Ho,Han, You-Kyoung,Yun, Sung-Hwan,Lee, Yin-Won American Society for Microbiology 2009 EUKARYOTIC CELL Vol.8 No.8
<B>ABSTRACT</B><P>The glyoxylate and methylcitrate cycles are involved in the metabolism of two- or three-carbon compounds in fungi. To elucidate the role(s) of these pathways in <I>Gibberella zeae</I>, which causes head blight in cereal crops, we focused on the functions of <I>G. zeae</I> orthologs (Gz<I>ICL</I><I>1</I> and Gz<I>MCL1</I>) of the genes that encode isocitrate lyase (ICL) and methylisocitrate lyase (MCL), respectively, key enzymes in each cycle. The deletion of Gz<I>ICL1</I> (ΔGz<I>ICL1</I>) caused defects in growth on acetate and in perithecium (sexual fruiting body) formation but not in virulence on barley and wheat, indicating that GzICL1 acts as the ICL of the glyoxylate cycle and is essential for self-fertility in <I>G. zeae</I>. In contrast, the ΔGz<I>MCL1</I> strains failed to grow on propionate but exhibited no major changes in other traits, suggesting that GzMCL1 is required for the methylcitrate cycle in <I>G. zeae</I>. Interestingly, double deletion of both Gz<I>ICL1</I> and Gz<I>MCL1</I> caused significantly reduced virulence on host plants, indicating that both Gz<I>ICL1</I> and Gz<I>MCL1</I> have redundant functions for plant infection in <I>G. zeae</I>. Thus, both Gz<I>ICL1</I> and Gz<I>MCL1</I> may play important roles in determining major mycological and pathological traits of <I>G. zeae</I> by participating in different metabolic pathways for the use of fatty acids.</P>
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GzSNF1 Is Required for Normal Sexual and Asexual Development in the Ascomycete Gibberella zeae
Lee, Seung-Ho,Lee, Jungkwan,Lee, Seunghoon,Park, Eun-Hee,Kim, Ki-Woo,Kim, Myoung-Dong,Yun, Sung-Hwan,Lee, Yin-Won American Society for Microbiology 2009 EUKARYOTIC CELL Vol.8 No.1
<B>ABSTRACT</B><P>The sucrose nonfermenting 1 (<I>SNF1</I>) protein kinase of yeast plays a central role in the transcription of glucose-repressible genes in response to glucose starvation. In this study, we deleted an ortholog of <I>SNF1</I> from <I>Gibberella zeae</I> to characterize its functions by using a gene replacement strategy. The mycelial growth of deletion mutants (ΔGz<I>SNF1</I>) was reduced by 21 to 74% on diverse carbon sources. The virulence of ΔGz<I>SNF1</I> mutants on barley decreased, and the expression of genes encoding cell-wall-degrading enzymes was reduced. The most distinct phenotypic changes were in sexual and asexual development. ΔGz<I>SNF1</I> mutants produced 30% fewer perithecia, which matured more slowly, and asci that contained one to eight abnormally shaped ascospores. Mutants in which only the Gz<I>SNF1</I> catalytic domain was deleted had the same phenotype changes as the ΔGz<I>SNF1</I> strains, but the phenotype was less extreme in the mutants with the regulatory domain deleted. In outcrosses between the ΔGz<I>SNF1</I> mutants, each perithecium contained ∼70% of the abnormal ascospores, and ∼50% of the asci showed unexpected segregation patterns in a single locus tested. The asexual spores of the ΔGz<I>SNF1</I> mutants were shorter and had fewer septa than those of the wild-type strain. The germination and nucleation of both ascospores and conidia were delayed in ΔGz<I>SNF1</I> mutants in comparison with those of the wild-type strain. GzSNF1 expression and localization depended on the developmental stage of the fungus. These results suggest that Gz<I>SNF1</I> is critical for normal sexual and asexual development in addition to virulence and the utilization of alternative carbon sources.</P>
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Occurrence of Fusarium Mycotoxins in Rice and Its Milling By-Products in Korea
LEE, THERESA,LEE, SOO-HYUNG,LEE, SEUNG-HO,SHIN, JEAN YOUNG,YUN, JONG-CHUL,LEE, YIN-WON,RYU, JAE-GEE International Association for Food Protection 2011 Journal of food protection Vol.74 No.7
<P>A total of 201 samples of brown rice, polished rice, and two types of by-products, blue-tinged rice and discolored rice, were collected from rice stores maintained at 51 rice processing complexes in Korea. These samples were analyzed for the presence of Fusarium mycotoxins such as deoxynivalenol (DON), nivalenol (NIV), and zearalenone (ZEA). Contaminants (and their ranges) found in discolored rice samples were DON (59 to 1,355 ng g−1), NIV (66 to 4,180 ng g−1), and ZEA (25 to 3,305 ng g−1); those found in blue-tinged (less-ripe) rice were DON (86 to 630 ng g−1), NIV (50 to 3,607 ng g−1), and ZEA (26 to 3,156 ng g−1). Brown rice samples were contaminated mostly with NIV and ZEA (52 to 569 ng g−1 and 47 to 235 ng g−1, respectively). Polished rice samples were largely free from mycotoxins, although one sample was contaminated with NIV (77 ng g−1). When the fungal flora associated with each rice sample was investigated, blue-tinged rice was the most often contaminated with Fusarium graminearum (3.8%), followed by the discolored rice (2.4%) and brown rice (1.6%) samples. Using PCR, toxin genotyping of 266 isolates of F. graminearum revealed that most isolates (96%) were NIV producers. In conclusion, this survey is the first report of the cocontamination of Korean rice and its by-products with trichothecenes and ZEA. Importantly, it also provides new information on the natural contamination of rice by Fusarium mycotoxins.</P>
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