Staphylococcus lugdunensis에 의한 감염성 심내막염 1예

최성호,박현구,변승운,구동회,강호석,장항제,김양수,우준희,김영휘,최상호 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CNS) that is commonly found on the human perineal skin. Contrary to other CNS, S. lugdunensis is a rare contaminant in cultures and has the potential to cause clinically significant infections, including infective endocarditis. Infective endocarditis due to S. lugdunensis have been known to resemble endocarditis due to S. aureus because of its aggressive clinical course and high mortality. We report a case of infective endocarditis caused by S. lugdunensis in a 21-year-old woman. She was cured of the infection with surgical and antibiotic therapy. S. lugdunensis에 의한 감염성 심내막염은 국내에서보고가 없었던 매우 드물지만 다양한 합병증과 높은 사망률을 보이는 감염증이다. 저자들은 S. lugdunensis가 수술적 치료와 항생제 치료로 완치된 감염성 심내막염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Fuzzy 임계치 함수를 이용한 근사 추론

鄭丸默,卞成熙 대구효성가톨릭대학교 1993 연구논문집 Vol.46 No.1

The fuzzy input information is determined interval values using fuzzy threshold functions. In this paper, we present truth table that is a set of values from fuzzy threshold function. The truth table which derived from a rule table is represented by the fuzzy logic function. We propose an inference method that use variations of fuzzy logic function.

Ru(Ⅲ) : 거대고리 착물의 합성과 이를 촉매제로 이용한 올레핀의 산화반응 Macrocyclic Complexes and Catalytic Oxidation of Olefins

朴裕哲,金聖洙,申相姬,卞鍾轍 慶北大學校 1992 論文集 Vol.52 No.-

The complexes were prepared by the controlled dropwise addition method . Reactions of K_2[RuCl_2·H_2O] with cyclam, meso, and rac (cyclam=1,4,8,11- tetraazacyclotetradecane, meso =C-meso-5, 7, 7, 12, 14, 14-hexamethyl-1,4,8,11-tetraazacyclotrtradecane, rac=C-rac-5, 7, 7,12, 14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane) in ethanol yielded trans-[RuLCl_2]Cl (L= cyclam, meso, rac) complexes. The ligand-to-metal charge-transfer transition in the UV vis spectrum of trans-[Ru(meso)Cl_2] Cl determined at 20℃ has been appeared at 370nm and 314㎚, while the spectrum for trans-[Ru(cyclam)Cl_2]Cl complex is considerably red-shifted. Oxidation of olefins using trans-[RuLCl_2]Cl complexes as catalyst was investigated in dichloroethane, in with sodium hypocholrite, hydrogen peroxide and tert-butyloxide were used as terminal oxidant and olefins were styrene,cyclohexene, 1-hexene, cyclooctene, and 1-octene. In this experimental condition, sodium hypochlorite was rather efficient terminal oxidant than hydrogen peroxide and tert-butylperoxide. In addition trans-[Ru(meso)Cl_2]Cl complex was rather efficient catalyst than trans-[Ru(cyclam) Cl_2]Cl complex, when sodium hypocholrite was used as terminal oxidant.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

Atypical clinical manifestation of prurigo pigmentosa involving the extremities

( Hee Seong Yoon ),( Seon Bok Lee ),( Ji Hye Heo ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Prurigo pigmentosa (PP) is a pruritic skin disease in young adult. It is associated with external factors such as sweating and irritation by clothes and internal factors such as diabetes and diet. It has characteristic clinical features of recurrent eruptions of severely pruritic erythematous papules healing with reticulated hyperpigmentation. Many PP cases were reported in Korean dermatologic literature, but there has been no case involving the extremities with the clinical manifestation with plaques. A 36-year-old woman presented with relapsing pruritic erythematous papulopatches on the back and arms and dusky erythematous plaques on the buttock and shin for 8 months. Reticulated pigmentation observed on the lower back. She had treated with oral and topical steroid at local clinics, but the lesion was not improved. Before the lesions developed, she went on a diet for a month. Though PP was suspected, we performed skin biopsy on the right buttock to know the character of the plaques. Histologic findings showed severe spongiosis, irregular acanthosis, and parakeratosis in the epidermis and perivascular and perifollicular lymphocyte, eosinophil, and neutrophil infiltration and melanosis in the dermis. We diagnosed her with PP involving extremities. Minocycline and mid-potency topical steroid for a month relieved skin lesions leaving hyperpigmentation, but plaques improved slowly. There is no recurrence for 6 months after the treatment.

Clinical study on health-related behaviors of Korean rosacea patients

( Hee Seong Yoon ),( Seon Bok Lee ),( Ji Hye Heo ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Rosacea is a chronic skin disease characterized by erythema, telangiectasia, papule, and pustule involving the central face. Risk factors of rosacea include exposure to ultraviolet light, heat, spicy food, alcohol, smoking, stress, and topical steroid application. Previous Korean studies showed the risk factors of rosacea patients but there are no study investigating detailed behaviors in Korean rosacea patients. Objectives: The purpose of this study was to investigate health-related behaviors of Korean rosacea patients. Methods: We included rosacea patients at their first visit who diagnosed by a dermatologist and agreed to the survey from February 2016 to August 2018. We recorded demographic information and behaviors such as caffeine containing beverage, alcohol, and smoking. Mann-Whitney U test and Fisher’s exact test were performed to compare difference by gender. Results: A Total of 45 patients (male: 15.6%, female: 84.4%, range: 20-68 years old) included. Patients who had previous treatment experiences was 71.1%, of these, 46.9% used topical steroid. In health-related behaviors, the most frequent response was caffeine containing beverage (75.6%), followed by outdoor activity and spicy food (each 66.7%). Facial cleanser, exposure to warm/cold air, and spicy food showed sexual difference (p<0.05). Conclusion: We investigated health-related behaviors of Korean rosacea patients and found that intake of caffeine containing beverage, spicy food, and outdoor activity were frequent.

Therapeutic Effect of Glucosamine on an Atopic Dermatitis Animal Model

( Hee Seong Yoon ),( Ji Won Byun ),( Jeonghyun Shin ),( Young Hyo Kim ),( Gwang Seong Choi ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5

Background: Recent studies have reported that glucosamine (GlcN) showed therapeutic effects in allergic diseases such as asthma and rhinitis, and its mechanisms include the suppression of T helper type 2 immune responses and the nuclear factor-κB pathway. Objective: We aimed to investigate the effect of GlcN on atopic dermatitis (AD) in an animal model. Methods: Twenty-five BALB/c mice were divided into five groups (groups A∼E). Group A was the phosphate- buffered saline (PBS)-treated group without AD induction. Group B was the PBS control group with AD induction. Groups C to E were the AD induction groups, which were treated with three different doses of GlcN (10 mg, 20 mg, and 40 mg, respectively). Histopathological examination was performed after GlcN administration. Interleukin (IL)-4, IL-13, and IL-17 cytokine levels were measured by enzyme- linked immunosorbent assay using skin biopsy specimens. Serum total immunoglobulin E (IgE) concentrations were measured before and after administration with GlcN or PBS. Results: Clinical dermatitis scores decreased with increasing GlcN dose (p<0.001). Concentrations of tissue IL-13 and IL-17 decreased after GlcN administration (each group: p=0.002 and p<0.001, respectively), but the concentrations of tissue IL-4 did not show differences across groups. Serum IgE levels tended to be lower after GlcN administration (p=0.004). Histopathological scores were not significantly different among groups B∼E (p=0.394). Conclusion: GlcN improved AD symptoms and decreased tissue IL-13, IL-17, and serum total IgE levels in an animal model. (Ann Dermatol 31(5) 538∼544, 2019)

Overproduction of Recombinant Human VEGF (Vascular Endothelial Growth Factor) in Chinese Hamster Ovary Cells

( Seong Baek Lee ),( Jeong Soo Park ),( Seung Hee Lee ),( Jun Ho Park ),( Sung Ryul Yu ),( Hee Chan Kim ),( Dong Jun Kim ),( Tae Ho Byun ),( Kwang Hee Baek ),( Young Joon Ahn ),( Jae Seung Yoon ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.1

Vascular endothelial growth factors (VEGFs) are a family of proteins that mediate angiogenesis. VEGF165 is a VEGF-A isoform and has been extensively studied owing to its potential use in therapeutic angiogenesis. This study established Chinese hamster ovary (CHO) cells overexpressing recombinant human VEGF165 (rhVEGF165) protein. The production rate of the established CHO cells was over 80 mg/l of rhVEGF165 protein from a 7-day batch culture process using a 7.5-l bioreactor with a 5-l working volume and serum-free medium. The rhVEGF165 protein was purified to homogeneity from the culture supernatant using a two-step chromatographic procedure that resulted in a 48% recovery rate. The purified rhVEGF165 protein was a glycosylated homodimeric protein with a higher molecular weight (MW) than the protein expressed from insect cells, suggesting that the glycosylation of the rhVEGF165 protein in CHO cells differed from that in insect cells. The purified rhVEGF165 protein in this study was functionally active with a half-maximal effective concentration of 3.8 ng/ml and specific activity of 2.5×105 U/mg.

Basal cell carcinoma arising from multiple trichoepithelioma

( Hee Seong Yoon ),( Seon Bok Lee ),( Ji Hye Heo ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Trichoepithelioma (TE) is a benign adnexal neoplasm that originates from hair follicle and malignant transformation is very rare. TE is classified as solitary TE, multiple familial TE, and desmoplastic TE. There are some reports of multiple familial TE transformed to malignant tumor such as basal cell carcinoma (BCC) and trichoblastic carcinoma. A 82-year-old man presented with asymptomatic skin colored papules and nodules on the central face for 10 years. The patient was not aware of his TE family history. The lesions initially appeared in skin color, but some lesions turned black. Clinically, TE was suspected and punch biopsy was performed from nodules on the left nose alar and both inner canthi which turned black. Histopathologic findings were consistent with BCC. We performed Mohs micrographic surgery for BCC lesions. Histopathologic examination of left nose alar showed dermal tumor composed of atypical basaloid cell with peritumoral cleft and epidermal connection on the central portion and well-circumscribed dermal tumor composed of basaloid cell with many horn cysts on the peripheral portion. Clinical features and histologic findings demonstrated his BCC arising from multiple TE and the patient is under observation without recurrence until 11 months later.

Three cases with postoperative complications

( Hee Seong Yoon ),( Seon Bok Lee ),( Ji Hye Heo ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Surgery is a treatment that can achieve a very dramatic effect, but any surgery can lead to complications. Therefore, in order to perform safe operation, proper evaluation of the lesion should be performed before surgery and it is necessary to predict complications that may occur in each operation and prepare for preventing it. In general, complications that can occur after surgery include persistent bleeding, hematoma, secondary infection, and necrosis of the surgical site. We report three cases in which complications occurred after the residents performed the surgry. These cases are examples of common complications that we may encounter during surgery and we will look at what we could do to prevent complications.