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Developmental Modulation of Specific Receptor for Atrial Natriuretic Peptide in the Rat Heart
Kim, Yoon-Ah,Kim, Soo-Mi,Kim, Suhn-Hee,Kim, Sung-Zoo The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.3
Although cardiac distribution of specific receptors for atrial natriuretic peptide (ANP) was mainly observed in the ventricular endocardium, the modulation of ANP receptors in relation to cardiac development is not defined. The present study was undertaken to investigate ANP receptor modulation in rat during development. In the developmental stages examined (fetus, after postnatal 3-days, 1-, 2-, 3-, 4-, and 8-week-old Sprague Dawley rats) specific ANP binding sites were localized in the right and left ventricular endo-cardia by quantitative in vitro receptor autoradiography using (equation omitted)-rat ANP as labeled ligand. The specific bindings to endocardium were much higher in the right than the left ventricle. The binding affinities of ANP were much higher in the right than the left ventricular endocardium. The difference of these binding affinities among various developmental stages was not observed in the right ventricle, whereas the binding affinity in left ventricle was gradually increased with aging and reached the peak value at 8 weeks. No significant difference in maximal binding capacities of endocardial bindings was observed in the right and left ventricular endocardia during developmental stages. Also, cGMP production via activation of particulate guanylyl cyclase-coupled receptor subtypes in the ventricular membranes was gradually decreased with close relationship to aging. Therefore, the present study show that the endocardial ANP receptor is modulated with close relationship to cardiac development in the left ventricle rather than the right ventricle, and may be involved in regulating myocardial contractility in left heart.
Hee Zoo Kim,Seung Hwan Oh,Chung Guk Park,Eun Hye Koo,Hye Ran Oh,Mi Kyoung Lee,Sang Ho Lim Korean Society of Critical Care Medicine 2005 Acute and Critical Care Vol.20 No.1
We had done one-lung ventilation using 9 Fr wire-guided endobronchial blocker and outer diameter 41-mm flexible fiberoptic bronchoscope in ruptured esophageal patient who expected difficult tracheal intubation and in esophageal cancer patient who was in need of mechanical ventilation during and after the operation.
증례보고 : 승모판 치환술 후 발생한 의인성 대동맥 박리
김희주 ( Hee Zoo Kim ),임상호 ( Sang Ho Lim ),박성우 ( Sung Woo Park ),김난숙 ( Nan Suk Kim ),이미경 ( Mi Kyoung Lee ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.4
Iatrogenic aortic dissection (IAD) is a life-threatening complication that can occur during open heart surgery, therefore IAD requires early diagnosis and prompt management. We describe here a case of IAD that occurred during mitral valve replacement. The transesophageal echocardiography (TEE) evaluation revealed features indicative of acute aortic dissection and the tear was successfully repaired by interposition of a graft. (Korean J Anesthesiol 2007; 53: 524~7)
Postnatal Changes in Atrial Compliance and Stretch-Induced ANP Secretion in Rabbits
Suhn Hee Kim,Kyung Sun Lee,Sung Zoo Kim,Kyung Hwan Seul,Kyung Woo Cho 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.5
<P> To define the postnatal changes in ANP secretion in response to mechanical stretch and atrial compliance, experiments have been done in perfused nonbeating rabbit atria with different ages: 1-day, 1-, 2-, 3-, 4-, and 8-wk-old. In 1-day-old-rabbits, an increase in intraatrial pressure resulted in an increase in atrial volume, which was higher than that in 1-wk-old rabbits. Increases in atrial volume stimulated the secretion of ANP with concomitant translocation of extracellular fluid (ECF) into the atrial lumen. However, mechanically stimulated ECF translocation was lower in 1-day-old rabbits than that in 1-wk-old rabbits. Therefore, positive relationship between mechanically stimulated ECF translocation and ANP secretion was shifted upward in 1-day-old rabbits, as compared to 1-wk-old rabbits. Changes in atrial volume and ECF translocation were gradually increased with aging and reached the peak value at 4 wk. The stretch-induced ANP secretion in terms of ECF translocation (the interstitial ANP concentration) was also increased with aging and reached the peak value at 4 wk. The interstitial ANP concentration was dependent on the atrial content of ANP. These data suggest that the higher level of atrial ANP secretion is related to the postnatal changes in atrial volume and unidentified factor.
Jeong Hee Han,Bing-Zhe Hong,Young Geun Kwak,Kuichang Yuan,Woo Hyun Park,Sung Zoo Kim,Suhn Hee Kim 대한생리학회-대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of gap junction in renin secretion and its underlying mechanisms using As 4.1 cell line, a renin-expressing clonal cell line. Renin release was increased proportionately to incubation time. The specific gap junction inhibitor, 18-beta glycyrrhetinic acid (GA) increased renin release in dose-dependent and time- dependent manners. Heptanol and octanol, gap junction blockers, also increased renin release, which were less potent than GA. GA-stimulated renin release was attenuated by pretreatment of the cells with amiloride, nifedipine, ryanodine, and thapsigargin. GA dose-dependently increased intracellular Ca<SUP>2+</SUP> concentration, which was attenuated by nifedipine, nimodipine, ryanodine, and thapsigargin. However, RP-cAMP, chelerythrine, tyrphostin A23, or phenylarsine oxide did not induced any signi</SUP>ficant change in GA-stimulated increase of intracellular Ca2+ concentration. These results suggest that gap junction plays an important role on the regulation of renin release and intracellular Ca<SUP>2+</SUP> concentration in As 4.1 cells.
Han, Jeong-Hee,Hong, Bing-Zhe,Kwak, Young-Geun,Yuan, Kui-Chang,Park, Woo-Hyun,Kim, Sung-Zoo,Kim, Suhn-Hee The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of gap junction in renin secretion and its underlying mechanisms using As 4.1 cell line, a renin-expressing clonal cell line. Renin release was increased proportionately to incubation time. The specific gap junction inhibitor, 18-beta glycyrrhetinic acid (GA) increased renin release in dose-dependent and time-dependent manners. Heptanol and octanol, gap junction blockers, also increased renin release, which were less potent than GA. GA-stimulated renin release was attenuated by pretreatment of the cells with amiloride, nifedipine, ryanodine, and thapsigargin. GA dose-dependently increased intracellular $Ca^{2+}$ concentration, which was attenuated by nifedipine, nimodipine, ryanodine, and thapsigargin. However, RP-cAMP, chelerythrine, tyrphostin A23, or phenylarsine oxide did not induced any significant change in GA-stimulated increase of intracellular $Ca^{2+}$ concentration. These results suggest that gap junction plays an important role on the regulation of renin release and intracellular $Ca^{2+}$ concentration in As 4.1 cells.
오현희(Hyun Hee Oh),황금택(Keum Taek Hwang),김무열(Muyeol Kim),이희권(Hee Kwon Lee),김성주(Sung Zoo Kim) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.6
본 연구에서는 국내에서 재배되거나 야생의 나무딸기류 20 종류를 수집하여 무게, 수분함량, 과즙의 당도, pH, 산도, pH를 측정하고, 과즙의 당 조성 및 유기산 조성 분석하여 각각의 특성을 검토하였다. 실험에 사용한 나무딸기류 과일의 무게는 0.9~7.8 g이었고, 과일의 수분함량은 82.0~90.3%였다. 나무딸기류 과즙의 당도는 6.9~16.9%(Brix)로 다양하였다. HPLC로 분석한 나무딸기류 과즙의 당은 glucose(총당 함량의 40.7~84.0%(w/w))와 fructose(6.5~57.5%)가 주를 이루고 있었고, 일부 과일에는 sucrose와 xylose도 미량 존재하였다. 과즙의 pH는 2.8~3.9였고, 적정 산도는 0.6~2.9%(w/v, citric acid)였다. 나무딸기류 과즙의 유기산을 HPLC로 분석한 결과, citric acid(총산 함량의 14.6~87.5%(w/w))와 malic acid (9.6~87.1%)가 주를 이루고 있었고, 일부 과일에는 tartaric acid, succinic acid, oxalic acid 등이 함유되어 있었다. In this study, 20 kinds of raspberries and blackberries, cultivated or wild in Korea, were collected. Weight, moisture content, sugar content, sugar composition, pH, titratable acidity and acid composition of the fruits were determined. Weight of each of the fruits and moisture contents in the fruits were 0.9~7.8 g and 26~62%, respectively. The sugar contents in the fruit juices were 6.9~16.9% (Brix). The major sugars in the fruits were glucose (40.7~84.0% (w/w) of the total sugars) and fructose (6.5~57.5%). Sucrose and xylose were also detected in a small quantity. pH and titratable acidity of the berry juices were 2.8~3.9% (w/v, citric acid) and 0.6~2.9%, respectively. The major organic acids were citric acid (14.6~87.5% (w/w) of the total acids) and malic acid (9.6~87.1%). Succinic, tartaric and oxalic acids were also detected in a small amount.