Seismic signatures of the continental crust in the Korean Peninsula

Xiaobo He,Tae-Kyung Hong 대한지질학회 2009 대한지질학회 학술대회 Vol.2009 No.

Computing Pore Size Distribution in Non-woven Fibrous Filter Media

He Bai,Xiaoming Qian,Jintu Fan,Yao Qian,Yongchao Duo,Yongsheng Liu,Xiaobo Wang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1

Fundamental understanding of transport properties of non-woven fibrous material is depended on in dept cognitionof their microstructure. Non-woven fibrous filter media are formed by the random distribution of fibers in a specific spaceexhibit a complicated pore size structure. Computing pore size distribution (PSD) is a vital parameter in studying materialtransport dynamics. In this work, a theoretical model was suggested based on the gamma distribution and fiber orientationdistribution to predict the PSD in non-woven fibrous filter media. In parallel, the analytical model was compared with theprevious PSD theories and experimental results. The 3D virtual fiber structure was constructed by using GeoDict code, andthe pore size was represented by the inscribed circle diameter. Parameters influencing the PSD were studied, including fiberdiameter, porosity, and fiber orientation. Comparison of simulation results with analytical model was made. The resultsdemonstrate that the angle between the fiber and the Z-axis has little effect on the PSD. When the porosity is consistent,smaller pores can be formed by reducing fiber diameter. With the fiber diameter is constant, larger pores can be formed byincreasing the porosity.

Distributed Fuzzy Extended Kalman Filter for Multiagent Systems

Xiaobo Zhang,Haoshen Lin,Gang Liu,Bing He 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5

In this study, a novel distributed Kalman filter based on a possibilistic framework was proposed to mitigate fuzzy noisein nonlinear multiagent systems. To describe fuzzy uncertainty, noises were modeled as fuzzy random variables with trapezoidal probability distributions instead of Gaussian distributions. A fuzzy information fusion (FIF) algorithm was proposed to fuse fuzzy state estimations from neighboring nodes. The nonlinear problem was solved by using local linearization. A distributed extended fuzzy information filter was designed by combining the FIF algorithm and local linearization in distributed sensor networks. The stability of this filter was analyzed. Finally, a target tracking simulation was performed to detail the effectiveness of the proposed filter algorithm.

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

He, Meian,Xu, Min,Zhang, Ben,Liang, Jun,Chen, Peng,Lee, Jong-Young,Johnson, Todd A.,Li, Huaixing,Yang, Xiaobo,Dai, Juncheng,Liang, Liming,Gui, Lixuan,Qi, Qibin,Huang, Jinyan,Li, Yanping,Adair, Linda S IRL Press 2015 Human molecular genetics Vol.24 No.6

<P>Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at <I>P</I> < 5 × 10<SUP>−8</SUP>, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.</P>

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

Yang, Shangbin,He, Shun,Zhou, Xiaobo,Liu, Mei,Zhu, Hongxia,Wang, Yihua,Zhang, Wei,Yan, Shuang,Quan, Lanping,Bai, Jingfeng,Xu, Ningzhi Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.11

The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.

Behavior and molecular physiology of nurses of worker and queen larvae in honey bees (Apis mellifera)

Xu Jiang He,Liu Qing Tian,AndrewB. Barron,Cui Guan,Hao Liu,Xiaobo Wu,Zhi Jiang Zeng 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.4

In a honey bee colony, worker bees rear a newqueen by providing herwith a larger cell inwhich to develop and alarge amount of richer food (royal jelly). Royal jelly and worker jelly (fed to developing worker larvae) differ interms of sugar, vitamin, protein and nucleotide composition. Here we examined whether workers attendingqueen andworker larvae are separate specialized sub-castes of the nurse bees.We collected nurse bees attendingqueen larvae (AQL) and worker larvae (AWL) and compared gene expression profiles of hypopharyngeal glandtissues, using Solexa/Illumina digital gene expression tag profiling (DGE). Significant differences in gene expressionwere found that included a disproportionate number of genes involved in glandular secretion and royal jellysynthesis. However behavioral observations showed that thesewere not two entirely distinct populations. Nurseworkers were observed attending both worker larvae and queen larvae, and there was no evidence of a specializedgroup of workers that preferentially or exclusively attended developing queens. Nevertheless, AQL attendedlarvaemore frequently compared toAWL, suggesting that nurses sampled attending queen larvaemay have beenthe most active nurses. This study serves as another example of the relationship between differences in gene expressionand behavioral specialisation in honey bees.

Melting Cell Based Compensated Design Method for Improving Dimensional Accuracy of Additively Manufactured Thin Channels

Li Sun,Xiaobo Ren,Jianying He,Zhiliang Zhang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2

Powder-bed fusion additive manufacturing technology makes it possible to produce parts with complicated geometry and high accuracy. However, dimensional deviation caused by powder overmelting and dross formation is still a challenge for manufacturing thin channels. In this study, the origins of the overmelting of printed thin channels were analyzed and a concept called “melting cell” is proposed to describe and quantify the geometric error. Based on the geometrical relationship between the melting cell and target channel, a method for predicting and optimizing the final geometry of thin channels is outlined. In order to verify the method, geometries of thin horizontal circular channels in various sizes are studied as examples. The predicted results by the proposed method show a remarkable agreement with available experimental results. Moreover, a new egg-shaped compensated design, which is able to improve the dimensional accuracy of thin horizontal circular channels, is presented. The proposed method is simple yet very effective. It can be easily extended to the manufacturing of thin channels with various shapes, materials, and different powder bed fusion processes.

De novo transcriptome analysis of Rhododendron molle G. Don flowers by Illumina sequencing

Zheng Xiao,Jiale Su,Xiaobo Sun,Chang Li,Lisi He,Shangping Cheng,Xiaoqing Liu 한국유전학회 2018 Genes & Genomics Vol.40 No.6

Rhododendron molle G. Don occupies an important phylogenetic node in the genus rhododendron with unique yellow flower and medicinal functions. However, only limited genetic resources and their genome information are available for the generation of rhododendron flowers. The next generation sequencing technologies enables generation of genomic resources in a short time and at a minimal cost, and therefore provide a turning point for rhododendron research. Our goal is to use the genetic information to facilitate the relevant research on flowering and flower color formation in R. molle. In total, 66,026 unigenes were identified, among which 31,298 were annotated in the NCBI non-redundant protein database and 22,410 were annotated in the Swiss-Prot database. Of these annotated unigenes, 9490 and 18,680 unigenes were assigned to clusters of orthologous groups and gene ontology categories, respectively. A total of 7177 genes were mapped to 118 pathways using the Kyoto Encyclopedia of Genes and Genomes Pathway database. In addition, 8266 simple sequence repeats (SSRs) were detected, and these SSRs will undoubtedly benefit rhododendron breeding work. Metabolic pathway analysis revealed that 32 unigenes were predicted to be involved in carotenoid biosynthesis. Our transcriptome revealed 32 engines that encode key enzymes in the carotenoid biosynthesis pathway, including PSY, PDS, LCYB, LCYE, etc. The content of β-carotene was much higher than the other carotenoids throughout the flower development. It was consistent with the key genes expression level in the carotenoid biosynthesis pathway by the Illumina expression profile analysis and the qRT-PCR analysis. Our study identified genes associated with carotenoid biosynthesis in R. molle and provides a valuable resource for understanding the flowering and flower color formation mechanisms in R. molle.

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

Shangbin Yang,Shun He,Xiaobo Zhou,Mei Liu,Hongxia Zhu,Yihua Wang,Wei Zhang,Shuang Yan,Lanping Quan,Jingfeng Bai,Ningzhi Xu 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.11

The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together,our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.

Fe/N-doped carbon framework derived from ZIF-8 on graphene oxide for efficient oxygen reduction reaction

Yating Zhang,Pei He,Dongxian Zhuo,Jianlan Zhang,Nana Zhang,Xiaobo Wang,Gang Lin,Zhenghan Kong 대한금속·재료학회 2024 ELECTRONIC MATERIALS LETTERS Vol.20 No.2

Exploration of highly effi cient non-noble metal oxygen reduction reaction (ORR) catalysts is essential for the widespreadindustrial utilization of fuel cells. Herein, we demonstrated a hierarchical porous catalyst (denoted as Fe-NC-Gs) using asimple stirring and one-step pyrolysis method. ZIF-8-derived N-doped carbon framework loaded on graphene oxide, on whichFe 3 O 4 and FeS nanoparticles are uniformly dispersed. In the composite nanostructure, a high surface area (470.58 m 2 g −1 )and hierarchical porous structure were observed. The obtained Fe-NC-G-2 exhibits superior ORR properties. The half-wavepotential (E 1/2 ) and the limiting current density in alkaline media were up to 0.85 V and − 5.39 mA cm −2 , respectively, comparableto the commercially available Pt/C. The four-electron-dominated process was exhibited in the ORR catalysis. It alsomanifests a better methanol tolerance and electrochemical stability during the chronoamperometry measurement in 0.1 MKOH. These results suggest that the proposed strategy provides a new pathway to construct effi cient electrocatalysts for ORR.