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Yeon, Han-Wool,Lim, Seung-Min,Jung, Jung-Kyu,Yoo, Hyobin,Lee, Young-Joo,Kang, Ho-Young,Park, Yong-Jin,Kim, Miyoung,Joo, Young-Chang Nature Publishing Group 2016 NPG Asia Materials Vol.8 No.-
<P>The electronic states of oxygen vacancies (V-O s) in amorphous oxide semiconductors are shallow donors, deep donors or electron traps; these are determined by the local atomic structure. Because the amorphous phase is metastable compared with the crystalline phase, the degree of structural disorder is likely to decrease, which is referred to as structural relaxation (SR). Thus SR can affect the V-O electronic state by changing the local atomic conditions. In this study, we demonstrated that electron doping is possible through the SR of amorphous oxides without redox reactions using a novel device structure that prevents extrinsic reactions with electrodes and ambient atmosphere during annealing. The concentration of V-O s in the shallow-donor state in amorphous In-Ga-Zn-O (a-IGZO) increases from similar to 10(16) to similar to 10(19) cm(-3) with increasing annealing temperatures between 300 and 450 degrees C. The SR-driven doping effect is strongly dependent on the annealing temperature but not on the annealing time. The Arrhenius activation energy of the SR-driven doping effect is 1.76 eV, which is similar to the bonding energies in a-IGZO. Our findings suggest that the free volume in a-IGZO decreases during SR, and the V-O s in either deep-donor or electron-trap states are consequently transformed into shallow-donor states.</P>
( Su Jung Lee ),( Kyung Tae Noh ),( Tae Heung Kang ),( Hee Dong Han ),( Sung Jae Shin ),( Byoung Yul Soh ),( Jung Hee Park ),( Yong Kyoo Shin ),( Han Wool Kim ),( Cheol Heui Yun ),( Won Sun Park ),( I 생화학분자생물학회 2014 BMB Reports Vol.47 No.2
In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-α, and IL-1β) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized CD4+ and CD8+ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. Paratuber-culosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of CD4+ and CD8+ T cells. [BMB Reports 2014; 47(2): 115-120]
교사들이 인식한 유치원 R-러닝 수업활동의 가능성과 한계
정한울(Jung, Han-Wool),한수정(Han, Soo-Jeong) 한국어린이미디어학회 2012 어린이미디어연구 Vol.11 No.3
본 연구의 목적은 유치원 교사들이 인식한 R-러닝 수업에 대한 가능성과 한계를 알아보는 것이다. 연구대상은 R-러닝 로봇을 사용한 경험이 있는 유치원 교사 6명이며, 반 구조화된 인터뷰와 교사 저널을 통해 분석되었다. 연구결과는 다음과 같다. R-러닝 수업의 가능성으로는 로봇 자체에 대한 매력적인 교수매체로서의 역할에 가능성이 있고, R-러닝을 통해 유아는 자신의 사회성 개발을 향상시키는데 도움이 되는 것으로 나타났다. 그러나, R-러닝 수업의 한계로 첫째, 교사는 R-러닝 수업에 대한 방법을 이해할 필요가 있다. 둘째, R-러닝을 하기 위한 로봇의 일부 기능적 문제가 있으며 셋째, R-러닝의 컨텐츠 내용의 부족하다는 것이 한계로 지적되었다. The purpose of this study was to analyze Early Childhood Teachers’ possibility and limit of R-Learning. The Subjects were 6 Early Childhood Teachers who experienced to use Robot in their teaching and learning. The data was analyzed through semi-structured in-depth interview and teachers’ journals. The results showed possibilities and limitations of R-learning. As possibilities of R-learning, it was found that robot is an attractive teaching materials. In addition, it was found that robot might be an assistant teacher. Third, robot helps children improving their social development. Fourth, teachers might get confident while using robots in their teaching and learning. However, there was limitations of R-learning. First, teachers need to understand what R-learning means. Second, there are some functional problems of R-learning. Third, there are lack of qualitative contents of R-learning. Finally, robots need to be general to every children.
Fang, Zhenghuan,Jung, Kyung Hee,Yan, Hong Hua,Kim, Soo-Jung,Rumman, Marufa,Park, Jung Hee,Han, Boreum,Lee, Ji Eun,Kang, Yeo wool,Lim, Joo Han,Hong, Soon Sun S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.47 No.5
<P><B><I>Background/Aims:</I></B> Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with poor prognosis. Conventional chemotherapies including gemcitabine have failed owing to weak response and side effects. Hence novel treatment regimens are urgently needed to improve the therapeutic efficacy. In this study, we aimed to assess the anticancer activity of melatonin and sorafenib as a novel therapy against PDAC. <B><I>Methods:</I></B> We used various apoptosis assay and PDAC xenograft model to assess anticancer effect <I>in vitro</I> and <I>in vivo</I>. We applied phospho-receptor tyrosine kinase (RTK) array and phospho-tyrosine kinase array to explore the mechanism of the combined therapy. Western blotting, proximity ligation assay, and immunoprecipitation assay were also performed for validation. <B><I>Results:</I></B> Melatonin synergized with sorafenib to suppress the growth of PDAC both <I>in vitro</I> and <I>in vivo</I>. The effect was due to increased apoptosis rate of PDAC cells that was accompanied by mitochondria dysfunction. The enhanced anticancer efficacy by the co-treatment could be explained by blockade of PDGFR-β/STAT3 signaling pathway and melatonin receptor (MT)-mediated STAT3. <B><I>Conclusions:</I></B> Melatonin reinforces the anticancer activity of sorafenib by downregulation of PDGFR-β/STAT3 signaling pathway and melatonin receptor (MT)-mediated STAT3. The combination of the two agents might be a potential therapeutic strategy for treating PDAC.</P>
KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer
Kang, Yeo Wool,Lee, Ji Eun,Jung, Kyung Hee,Son, Mi Kwon,Shin, Seung-Min,Kim, Soo Jung,Fang, Zhenghuan,Yan, Hong Hua,Park, Jung Hee,Han, Boreum,Cheon, Min Ji,Woo, Min Gyu,Lim, Joo Han,Kim, Yong-Sung,Ho Elsevier 2018 Cancer letters Vol.438 No.-
<P><B>Abstract</B></P> <P>Pancreatic cancer exhibits an oncogenic KRAS mutation rate of ∼90%. Despite research and drug development efforts focused on KRAS, no targeted therapy has been clinically approved for the treatment of pancreatic cancer with KRAS mutation. Also, the efficacy of gemcitabine is poor due to rapidly acquired resistance. We developed RT11-i antibody, which directly targets the intracellularly activated GTP-bound form of oncogenic RAS mutants. Here, we investigated the combined effects of RT11-i and gemcitabine <I>in vitro</I> and <I>in vivo</I>, and the mechanism involved. RT11-i significantly sensitized pancreatic cancer cells to gemcitabine. Also, the co-treatment synergistically inhibited angiogenesis, migration, and invasion, and showed synergistic anticancer activity by inhibiting the RAF/MEK/ERK or PI3K/AKT pathways. Furthermore, co-treatment inhibited endothelial barrier disruption in tumor vessels, which is a critical step in vascular leakiness of metastasis, and improved vessel structural stability. Importantly, co-treatment significantly suppressed tumor growth in an orthotopic tumor model. Taken together, our findings show that RT11-i synergistically increased the antitumor activity of gemcitabine by inhibiting RAS downstream signaling, which suggests RT11-i and gemcitabine be viewed a potential combination treatment option for pancreatic cancer patients with KRAS mutation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pancreatic cancer exhibits an oncogenic KRAS mutation rate of ∼90%. KRAS gene silencing increased gemcitabine sensitivity in pancreatic cancer. </LI> <LI> RT11-i antibody directly targets the intracellularly activated GTP-bound form of RAS after being internalized into cytosol. </LI> <LI> RT11-i significantly sensitized pancreatic cancer cells to gemcitabine, as evidenced by reduced cell growth. </LI> <LI> The co-treatment showed synergistic anticancer activity by inhibiting the RAF/MEK/ERK or PI3K/AKT pathways. </LI> <LI> RT11-i and gemcitabine could be a potential combination treatment option for pancreatic cancer patients with KRAS. </LI> </UL> </P>
IEC 60364 전기설비의 점검검사 계측장비 개발에 관한 연구
정진수(Jin-Soo Jung),김선구(Sun-Gu Kim),서상규(Sang-Gyu Seu),한운기(Woon-Ki Han),정종욱(Jung-Wool Jung),박찬엄(Chan-Um Park) 한국조명·전기설비학회 2011 한국조명·전기설비학회 학술대회논문집 Vol.2011 No.5월
본 논문은 IEC 60364에 따라 시설된 전기설비의 점검검사를 위한 계측장비의 개발에 관한 논문이다. 본 논문은 현재 개발 완료된 2개의 장비와 현재 개발 중인 계측장비의 사양을 비교분석하였다. 본 논문에서 언급한 장비의 경우 휴대가 가능하도록 소형화 및 경량화에 중점을 두었다. 또한, 측정오차가 5 % 이내로 장비의 성능이 매우 양호한 것으로 나타났다. 본 논문을 통해 개발되고 있는 장비는 향후 국내에 도입되고 있는 IEC 60364에 활용될 것으로 판단된다.
Jung, In Duk,Shin, Sung Jae,Lee, Min-Goo,Kang, Tae Heung,Han, Hee Dong,Lee, Seung Jun,Kim, Woo Sik,Kim, Hong Min,Park, Won Sun,Kim, Han Wool,Yun, Cheol-Heui,Lee, Eun Kyung,Wu, T.-C.,Park, Yeong-Min The American Association of Immunologists, Inc. 2014 JOURNAL OF IMMUNOLOGY Vol.193 No.3
<P>Despite the potential for stimulation of robust antitumor immunity by dendritic cells (DCs), clinical applications of DC-based immunotherapy are limited by the low potency in generating tumor Ag-specific T cell responses. Therefore, optimal conditions for generating potent immunostimulatory DCs that overcome tolerance and suppression are key factors in DC-based tumor immunotherapy. In this study, we demonstrate that use of the <I>Mycobacterium tuberculosis</I> heat shock protein X (HspX) as an immunoadjuvant in DC-based tumor immunotherapy has significant potential in therapeutics. In particular, the treatment aids the induction of tumor-reactive T cell responses, especially tumor-specific CTLs. The HspX protein induces DC maturation and proinflammatory cytokine production (TNF-α, IL-1β, IL-6, and IFN-β) through TLR4 binding partially mediated by both the MyD88 and the TRIF signaling pathways. We employed two models of tumor progression and metastasis to evaluate HspX-stimulated DCs in vivo. The administration of HspX-stimulated DCs increased the activation of naive T cells, effectively polarizing the CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells to secrete IFN-γ, as well as enhanced the cytotoxicity of splenocytes against HPV-16 E7 (E7)–expressing TC-1 murine tumor cells in therapeutic experimental animals. Moreover, the metastatic capacity of B16-BL6 melanoma cancer cells toward the lungs was remarkably attenuated in mice that received HspX-stimulated DCs. In conclusion, the high therapeutic response rates with tumor-targeted Th1-type T cell immunity as a result of HspX-stimulated DCs in two models suggest that HspX harnesses the exquisite immunological power and specificity of DCs for the treatment of tumors.</P>
Han Wool Lee,Hyoung Jean Beak,Eun-Jung Yoon,김주영 대한운동학회 2021 아시아 운동학 학술지 Vol.23 No.2
[OBJECTIVES] This study aims to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) on ankle range of motion (ROM) and balance in older women. [METHODS] The 20 older women with a history of falls participated in the study, and the study subjects were randomly divided into the IASTM group (n=10) and control group (n=10). [RESULTS] There were no significant interactions between group and time for ankle ROM and functional reach after 8 weeks of IASTM on older women (P>0.05). Meanwhile, there were significant interactions between group and time for one-leg standing and star excursion balance (P<0.05), and in particular, the IASTM group had greater improvements compared to the control group. [CONCLUSION] In conclusion, the regular application of IASTM has been shown to improve the balance of older women with a history of falls.