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강주섭,이주원,지옥화,Haidan Yuan,김태화,김동선,이민호,Ae-Son Om,이보배,박성국 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
A number of alternative medicines (AMs) have often been used as traditional therapies for various diseaseswithout scientific or clinical evidence supporting their use. The present study examined the pharmaceutical effects of an AMextract with a long history of use as a traditional medicine for various bone diseases. To evaluate it as a potential candidatefor use as an anti-osteoporotic drug, we investigated the effects of the AM extract on the progression of bone loss in ovariec-tomized (OVX) rats fed a calcium (Ca)-deficient diet for 4 or 12 weeks. We also compared the AM extract with alendronate,an anti-resorptive drug. The AM extract did not influence bone turnover as indicated by biochemical markers [i.e., de-oxypyridinoline (DPD)]. In contrast, alendronate treatment seemed to reduce bone turnover via inhibition of bone resorptionas evidenced by reduced urinary DPD concentrations accompanied by a tendency for decreased serum tartrate-resistant acidphosphatase. Administration of alendronate or AM extracts did not significantly affect bone density, although both tended toincrease bone mineral density (BMD) and bone strength of the femur. Although both treatments did not affect vertebral BMDand bone strength, histological analysis of vertebrae showed well-developed trabecular networking in OVX rats treated withalendronate or AM extract, in contrast to the thin and disconnected trabecule in OVX rats. In conclusion, the AM extract pro-duced a very weak effect on the prevention of bone loss induced by OVX and Ca deficiency in rats, but was similar to theresults observed with alendronate. Further verification is necessary to justify the use of the AM extract as a treatment for os-teoporosis.