Glutamate Induces Ceramide Generation through Activation of the 60 kDa Membrane-bound Neutral pH Optimum Sphingomyelinase in Rat Cerebrocortical Neurons

HC Jeong,SY Jung,KM Jung,MR Chin,DK Kim 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

Energy Demand and it’s Forecast of Jeju

( Hc Kim ),( Ds Lim ) 한국환경경제학회·한국자원경제학회(구 한국환경경제학회) 2018 한국환경경제학회 학술발표논문집 Vol.2018 No.하계

이차 추시수술을 시행한 악성과립막세포종

이흥철(HC Lee),오보훈(BH Oh),목정은(JE Mok) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.1

We had undertaken "second-look" operation in patient with malignant granulosa cell tumor after four courses of chemotherapy. Complete remission of malignant granulosa cell tumor was confirmed by "second-look" operation. At the time of initial laparotomy, we could not extirpate the total tumor mass and debulking procedure was perfomed remaining substantial tumor mass in the cul-de-sac. We present a case of malignant granulosa cell tumor showing complete remission with brief review of literature.

Doppler 초음파를 이용한 정상임신주수에 따른 태아제대동맥 혈류속도파형의 변화양상

신희철(HC Shin),윤보현(BH Yoon),김승욱(SW Kim) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.3

서울대학교병원 산부인과를 내원한 정상임산부의 제대동맥에서 doppler초음파검사를 시행하 고 임신의 결과가 정상으로 확인된 104명의 임산부에서 시행된 188회의 검사결과를 임신주 수에 따라 분석하였다. 제대동맥의 혈류속도파형은 최고수축기속도(A)와 이완기속도(B)의 비 (A/B ratio), pulsatility index(PI), resistance index(RI)의 3가지 지표를 사용하여 분석하였다. 임신 14주이하에 검사가 불가능하였던 경우는 없었으며 임신이 진행됨에 따라서 A/B ratio, PI, RI모두 감소하여, 임신이 진행됨에 따라서 태반의 저항이 감소하여 제대정맥의 이완기말 의 혈류속도파형의 변화양상이 확립되었으며 앞으로 태아의 산전건강평가에 유용한 지표로 사용될것으로 여겨진다. Time-velocity waveforms or sonograms obtained by pulsed doppler ultrasound from the umbilical artery were analysed in the fetuses from 104 normal pregnancy women. One hundred eighty-eight determinations were carried out from the 13th to the 41th weeks of pregnancy. The ratio of peak systolic to end-diastolic flow velocity pulsatility index of a ratio overcomes the obstcle of not knowing the angle between the incindence beam and the direction progressively, indicating a gradual fall in resistance in the umbilical-placental circulation in normal pregnancy. The analysis of umbilical artery blood flow velocity waveforms provieds a new and non-invasive measure of fetoplacental blood flow resistance and has the potential of being an important aid in prenatal care.

유착태반의 1예

정한종(HC Chung),김숙희(SH Kim),이재억(JA Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.7

과거 4회의 인공임신중절술을 받았던 경산부가 최종분만후 1년 5개월후에 자궁출혈로 자궁 근종의 임상적 진단하에 자궁적출술을 시행하였으나 유착태반이었던 1례를 보고하는 바이다. One case ofvery unusual adhesive placenta which was encounted 17 months after term delivery is reported in view of its rarity and literature concerned are reviewed briefly.

정상출산부 오로의 임상세균학적 관찰

김현준(HC Kim),이홍균(HK Lee),양석기(SK Yang),박성구(SK Park) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.4

본원 산부인과에서 1969년 1월 초부터 동연 3월말 사이 만 3개월간 질식 분만후 12-72시간(평균 39시간)내에 무균조작으로 자궁경관 및 후질궁융뷰에서 채취한 오로를 호기성과 혐기성 조건하에서 혈액한천배지 및 Thioglycollate배지에서 배양한 후 균의 분포를 분석 관찰하였으며 몇가지 항생제에 대한 감수성검사를 Disk방법으로 일부 균주에 대하여 시행하여 다음과 같은 결과를 얻었다. 1) 총 107례 중에서 균이 배양된 례는 101례로 94.3%이었고 배양되지 않았던 례는 6례로 5.7% 이었다. 균이 배양된 경우 2종의 균이 동시에 배양된 예가 제일 많아 36례이었고 단일균이 28례, 3종의 균이 18례, 4종의 균이 16례, 5종의 균이 3례로 각각 동시 배양되었다. 단 1균종이 배양된 28례 중에서는 E.coli가 7례로 가장 많았다. 유산균의 순수 배양례는 1례도 없었다. 2) 배양균들을 그 빈도순위로 보면 Unidentified Gram negative bacilli가 40.2%, Streptococci( -hemolytic, Viridans 포함)가 33.7%, Staphylococci(S. aureus, S. epidermis)와 Lactobacillus species가 각각 19.6%, E.coli가 18.7%, Micrococcus와 Corynebacterium species (Diphtheroids 포 함)이 각각 14.0%, Enterococcus가 10.1%, Coliform bacilli와 Hemophilus species가 각각 6.5%, Yeast like cells 가 4.7%, Unidentified Gram positive bacilli와 Clostridium species 가 각각 3.7%, Neisseria species가 1.9%, Bacterium anitratum, Proteus mirabilis, Klebsiella aerogenes와 Providence group이 각각 0.9%이었다. 3) 배양균의 분포와 제요인 즉 산모의 연령, 분만횟수, 분만방법, 회음절개 및 경관 열창등의 요 인들과의 상호관계를 살펴본 결과 배양균 분포와 밀접한 관계는 찾아 볼 수 없었다. 4) 항생제에 대한 감수성검사에서 각 균주에 대하여 감수성이 있는 항생제는 다음과 같은 것들 이었다. a) E.coli는 전례에서 Neomycin, Ampicillin과 Colistin에 Sensitive하였고 대부분의 경우에 Chloramphenicol과 Streptomycin에 Sensitive하였지만 일반적으로 Kanamycin에는 Moderately sensitive하였다. b) Staphylococcus는 전례에서 Methicillin과 Cloxacillin에 Sensitive하였고 대부분은 Leucomycin 과 Erythromycin에 Sensitive하였지만 일부는 Resistant하였다. c) Enterococci는 대부분 Ampicillin과 Erythromycin에 Sensitive하였고 일부는 Chloramphenicol 과 Neomycin에 Sensitive하고 일부는 Resistant하였다. d) Coliform bacilli는 전례가 Neomycin에 Sensitive하였고 대부분은 Chloramphenicol, Streptomycin, Colistin과 Ampicillin에 Sensitive 하였지만 Kanamycin에는 Moderately sensitive 하였다. e) Clostridium species는 Tetracycline과 Erythromycin에 Sensitive하였다. During the period from January 1 to March 31, 1969, lochia was taken for the bacteriological culture and sensitivity test from 107 patient of normal afebrile postpartum women, aged 20 to 40, who had given birth vaginally at the Dept. of Obstetrics and Gynecology, Naotional Medical Center, Seoul. The specimens were taken aseptically from cervical canal or posterior vaginal fornix within postpartum 12 to 72 hours (Av. 39 hrs.) and then cultured on blood agar or thioglycollate media under aerobic and anaerobic conditions. With cultured several organisms, sensitivity test was done by Disk method to some current antibiotics. The results were obtained as follows: 1. Among 107 cases, culture was positive in 101 cases (94.3%) and sterile cultrue(negative cultrue) was in 6 cases (5.7%). Among the above 101 cases of positive culture, mixed culture of two different bacteria were found the most commonly at the same time in 36 cases, pure culture in 28 cases, mixed culture of three bacteria in 18 cased, four bacteria in 16 cases and five bacteria in three cases. Among the above 28 cases of pure culture of Lactobacillus was sepcies found. 2. the cultured organisms and its incidence in order were as follows; Unidentified anaerobic gram negative bacilli in 40.2%, Streptococci (anaerobic, beta hemolytic and viridans) in 33.7%, Staphylococci (aureus and edpidermis) and Lactobacillus species in 19.6%, respectively, E. coli in 18.7%, Bacteroides in 15.9%, Micrococcus species and Corynebacterium species including Diphtheroids in 14.0%, respectively, Enterococcus in 10.1%, Coliform bacilli and Hemophilus species in 6.5%, respectively, Yeast like cells in 4.7%, Unidentified gram positive bacilli and Clostridium species in 3.7%, respectively, Neisseria species in 1.9%, Bacterium anitratum, Proteus miarbilis, Klebsilia aerogenes and Providence group in 0.9%, respectively. 3. Relationships between the distribution of cultured organisms and several factors such as age, parity, mode of delivery and presence or absence of episiotomy or cervical repair, were analysed. However no remarkable difference in distribution of cultured organisms could be found. 4. The results of sensitivity test (as to the sensitive antibiotics) were as follows; a) E. coli was sensitive to Neomycin, Ampicillin and Colistin in all cases. Most of them were sensitive to Chloramphenicol and Streptomycin. Generally, it was moderately sensitive to Kanamycin. b) Staphylococcus aureus was sensitive to Methicillin and Cloxacillin in all cases. Most of them were sensitive but part of them were resistnat to Leucomycin and Erythromycin. c) Most of Enterococci were snesitive to Ampicillin and Erythromycin but part of them were sensitive or resistant to Chloramphenicol and Neomycin. d) Coliform bacilli were sensitive to Neomycin in all cases and most of them were sensitive to Chloramphenicol, Streptomycin, Colistin and Ampicillin. They were moderately sensitive to Kanamycin. e) Clostridium species were sensitive to Tetracycline and Erythromycin in all cases.

국군수도병원에서의 항암요법

신현춘 ( Hc Shim ),엄현석 ( Hs Um ),장대국 ( D G Jang ),이석호 ( Sh Lee ),장경순 ( Ks Jang ),민태형 ( Th Min ),김승육 ( Sy Kim ) 국군의무사령부 1996 대한군진의학학술지 Vol.27 No.1

임신중 난소종양의 임상적 고찰

김현찬(HC Kim),김순애(SA Kim),이명근(MK Lee),유석권(SK Yoo) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

국립의료원 산부인과에서 1960년 1월초부터 1976년 7월말까지 경험한 임신중 난소종양 66예 에 대한 임상적 고찰을 하여 다음과 같은 결론을 얻었다. 1. 양성난소종양의 임신 및 분만에 대한 빈도는 각각 1:353, 1:312 이었으며 악성종양의 경우 는 각각 1:7771, 1:6546이었다. 2. 양성난소종양의 7.8%, 악성난소종양의 2.0%가 임신과 합병되었다. 3. 평균 연령은 30세이었으며 연령폭은 21-43세이었다. 4. 평균임신회수는 2.9회(1-21회) 평균 분만수는 1.8회(0-7회)이었다. 5. 병리조직학적 소견에서 양성낭성기형종이 제일 많아 32예(48.5%) 이었으며 장액성낭선종 10예(15.2%), 점액성낭선종 9예(13.6%) 단순낭종 5예(7.6%) 난포막황체낭종 4례(6.1%) 의 순위 이었고, 난소갑상선종, 양성간충조직종, 황체낭포가 각각 1례(1.5%)이었다. 악성종양 으로서 는 위암에서 전이한 Krunkenberg 종양, 장액성낭선암, 악성기형종이 각각 1례있었다. 6. 종양의 발생부위는 우측이 약간 많아 34례(51.5%) 좌측이 25례(37.9%)이었으며 7례(10.6%) 에서 양측성 이었으며 이중 4례의 양성낭성기형종, 2례의 난포막 황체낭종, 1례의 이차성 Krukneberg 종양이 있었다. 7. 초진시 주소, 증상 및 증후로는 하복통이 27례(40.9%)로 제일많았고, 부속기종양 18례 (27.3%), 질출혈 7례(10.6%) 압박증상 5례(7.6%) 하복보 불괘감과 진통이 각각 4례(6.1%) 위장 장애와 복부팽만이 각각 3예(4.5%) 의 순위었으며 증상 및 증후가 없었던 14례(21.2%)는 산 전관호시 진단되었다. 8. 총 66례중 50례(75.6%)에서 수술전 혹은 분만전에 정확히 진단되었다. 9. 임신초기에 30례(45.5%) 증기에 20예(30.3%) 말기 또는 만삭시에 12예(18.2%) 산욕기에 4 례(6%)수술을 시행하였다. 1. The incidence of benign tumors in pregnancy was 1 in 353 pregnancy and 312 delivery. Malignant tumors was 1 in 7771 pregnancy and 6546 delivery 2. Benign tumors complicating pregnancy was found in 7.8% among all operated benign tumors and the malignancy was in 2.0% among all malignant tumors operated. 3. Mean age was 30 years old and the range was 21-43 years old 4. Mean gravidity was 2.9 (1-21) and mean parity was 1.8 (0-7) 5. According to the histopatholgical type, benign cystic teratoma was found in 32cases (48.5%) serous cystadenoma in 10 cases (15.2%) mucinous cystadenoma in 9 caes (13.6%) simple cyst in 5 cases (7.6%) theca lutein cyst in 4 cases (6.1%) and 1 cases (1.5%) of struma ovarii benign mesenchymal tumor and corpus leteum cyst were found the malignant tumors were 1 case of metastatic krukenberg tumor serous cystadenocarcinoma and malignant teretoma. 6. The right side tumor was more common being 34 cases (51.5%) and the left was in 25 cases (37.9%) 4 cases of benign cystic teratoma 2 cases of theca lutein cyst and 1 case metastatic Krukenberg tumor were bilateral. 7. As to the initial chief complaints or the mode of presentation low abdominal pain was found in 27 cases (40.9%) adnexal mass in 18cases (27.3%) vaginal spotting or bleeding in 7 cases (10.6%) pressure symptoms in 5 cases (7.6%) abdominal discomrfort in 4 cases (6.1%) labor pain 4 cases (6.1%) gastroinitestinal troubles in 3 cases (4.5%) and abdominal distension in 3 cases (4.5%) etc. the fourteen cases (21.2%) free of symptoms or signs, were detected at anetnatal care. 8. Among the 66 cases 50 cases (75.6%) were correctly diagnosed before operation or delivery. 9. Thirty cases (45.5%) were operated in the first trimester, 20 cases (30.3%) in the second trimeseter 12 cases (18.2%) in the third trimester and 4 cases (6.01%) in the puerperium.

Fetal Monitor를 사용한 Contraction Stress Test의 임상적 이용에 관한 연구

신희철(HC Shin) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.4

During the past decade . There has been significant improvement in the obstetrician`s ability to acheive antenatal surveillance of the high risk pregnancy. The function of antepartum fetal heart rate testing should be to identify fetuses at risk for intrauterine demise so that intervention was be undertaken before irreversible fetal compromise ensues. This study was performed in an attempt to evaluate the significance of contraction stress test in antepartum fetal surveillance. Contraction stress test of 203 pregnant women who were admitted at obstetric wards of Seoul National University Hospital from 1st of July, 1980 to 31th of December, 1980 was analyzed and the results were as follow; 1. Indications for CST were normal pregnancy (38.7%), preeclampsia and eclampsia (36.9%), premature rupture of membranes (9.4%) previous obstetric history (6.4%), postdatism(2.6%) 2. A total 266 contraction stress tests were performed on 203 patients. The results were negative in 161 (79.3%) positive in 11 (5.4%) equivocal in 13 (6.4%). unsatisfactory in 18 (8.9%) of these 203 patients. 3. the incidence of abnormal fetal heart rate during labor was negative in 19(12.4%) for 153 patients, positive in 7 (70%) of 10 patients, equivocal 4 (36.4%) in 11 patients and unsatisfactory 3 (20%) in 15 patients.

난관불임수술에 관한 임상적 고찰

정한종(HC Chung),우인호(IH Woo),이진호(JH Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.9

1. 난관불임수술의 빈도는 7.4%엿으며 산과적 빈도는 7.1% 부인과적 빈도는 8.3%였다. 2. 322예의 난관불임수술중 복식수술은 86.0%였으며 질식 수술은 14.0%였다. 3. 난관불임수술의 동기는 다산부가 38.2%였으며 산과적 적응증이 32.3% 부인과적 적응증이 26.1%, 내과적 적응증이 3.4%였다. 4. 난관불임수술을 받은 연령은 30내지 34세군이 49.4%로 가장 높았으며 평균 연령은 32.5 세였다. 5. 난관불임수술을 받은 환자는 대개가 2남 1녀의 3자녀 정도를 가진 부인에서 많이 시행되 었으며 질식 난관수술을 받은 환자는 과거 임신중절수술의 수가 많았다. 6. 마취는 대부분이 전신마취를 하였다. 7. 산욕기 난관불임수술의 시기도 약 80%가 30시간이내에 시행되었으며 대부분의 수술이 11내지 30분의 수술 소요시간이 걸렸다. 8. 수술후 재원일수는 산욕기 난관불임수술시는 정상 산욕기 재원기간과 비슷하였으며 질식 난관불임수술은 평균 재원기간이 4.5일로 비교적 짧았다. 9. 질식난관수술시 겸행된 수술은 질 후벽 교정수술이 84.4%에서 시행되었고, 약 60.0%에서 임신중절수술이 겸행되었다. 1. frequency of operations was 7.4% obstetric and gynecologic frequency being 7.1% and 8.3% respectively 2. abdominal procedure was 86.0% nad vaginal procedure 14.0% 3. The indication of operation was as follow ; multiparous 38.2% obstetrical 32.3%, gynecological 26.1% and medical 3.4% 4. Pedominant age group consisted of those 30-34 years old with frequency of 49.4%, the average being 32.5% years old 5. In the majority of cases those who underwent tubal sterilization operatoins had 3 children and many of those who underwent vaginal procedures had frequent artificial abortions. 6. General anesthesia was performed in the majority of cases 7. Eighty percent of puerperal sterilization operations was performed within 30 hours after bearing and the operation time took 11 to 30 minutes in the majority of cases 8. Posoperative hospital stay of those who underwent puerperal sterilization operation was almost as long as non-sterilized postpartum hospital stay , and postoperative hospital stay of those who underwent vaginal sterilization operation was 4 or 5 days. 9. Of the associated operation in the vaginal procedures posterior vaginal wall repairs were 84.4% induced abortion 60.0%.