Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

슬관절에 히야루론산 주입후 발생한 활막성 연골종증 : 증례 보고

최의성,김용민,김동수,손현철,박경진,조병기,배승환 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.18 No.2

활막성 연골종증은 비교적 드문 양성 종양으로 관절내 활액막 결체조직의 양성 반응성 이형성에 의해 여러 개의 연골성 결절을 형성하고 이것이 관절내로 유리되어 유리체를 형성하는 질환으로 주로 슬관절에 발생한다. 활막성 연골종증의 정확한 발생 기전은 아직 밝혀지지 않았으나 외상, 감염 등이 원인으로 제시되고 있다. 저자들은 슬관절 내 히야루론산 주입후 발생한 슬관절내 활막성 연골종증을 1 례 경험하였으며, 관절경적 제거술을 통해 만족스런 결과를 얻었다. As a relatively rare benign tumor, synovial chondromatosis forms several cartilaginous nodules by the benign reactive metaplasia of synovial connective tissues within joints, which are loosed into the joints and cause a disease forming loose body mainly in knee joint. Accurate mechanism of synovial chondromatosis has not been clarified yet; however, trauma, infections and others have been suggested as its possible causes. The authors of this study experienced an example of a patient with synovial chondromatosis in knee joint occurred after the injection of hyaluronic acid in the joints and had a satisfactory outcome through the arthroscopic resection.

14세 여환에서 쇄골에 발생한 동맥류성 골 낭종 : 증례보고

김동수,김용민,최의성,손현철,박경진,조병기,홍경호 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

동맥류성 골낭종(aneurysmal bone cyst)은 Jaffe와 Lichtenstein(1942)에 의해 처음 기술된 이래 많은 증례가 보고되었다. 동맥류성 골낭종은 주로 장관 골의 골간단과 척추에서 발생한다. 병인은 정확히 밝혀지지 않았으나, 반응성 현상으로 생각되며, 원발성 또는 다른 병변과 동반될 수 있다. 쇄골 등 기타 골에서 발생하는 경우는 매우 드물다. 저자들은 우측 쇄골에서 동맥류성 골낭종 1예를 경험하여 보고하는 바이다. 14세 여자환자가 우측 견갑부의 우연히 발견된 종괴를 주소로 내원하였다. 환자는 종괴에 대해 이학적 검사 및 혈액 검사상 측이한 소견을 보이지 않았다. 방사선 검사상, 쇄골 내측부에 골 용해성으로 팽윤된 병변이 관찰되었고, 동맥류성 골낭종, 단순 골낭종, 전이성 골종양 등의 의증 하에 절제술을 시행하였다. 절제된 종괴의 육안 소견상, 얇은피질 골로 쌓여 있으며, 노란색 액체로 차있는 4x5cm 종괴가 관찰되었고, 완전 절제술을 시행하였다. 광학현미경상, 혈액으로 차있는 다양한 크기의 낭성 구조가 보였고, 여러 개의 거대세포가 격막을 이루고 있었다. 조직학적 소견과 MRI소견, 임상 소견을 종합하였을 때, 쇄골에서 원발성으로 발생한 동맥류성 골낭종을 진단할 수 있었다. Many cases of aneurysmal bone cyst(ABC) have been reported since Jaffe and Lichtenstein(1942) first reported. Aneurysmal bone cyst mostly occurs in metaphysis of the long bones and vertebral column. The reason for this disease has not be clearly explained yet, but it is estimated as reactive change and can be accompanied with primary lesion or another lesion. It rarely occurs in clavicle or other bones. We report one case of ABC in right clavicle. 14-year-old female patient who accidentally found palpable mass on right shoulder visited hospital. We did not find any specifics regarding this patient's mass after physical exam and blood test. Radiologic exam showed a large expansile mass with osteolytic lesion, The differential diagnosis includes ABC, simple bone cyst, metastatic bone tumor, etc. Based on visual observation on excised 4×5 cm mass, it was covered by thin cortical bone and filled with yellow fluid, and complete excision was done. On histological examination, the mass consist of various size of cystic structures. and several giant cells comprised septae. Based on histological examination, MRI, clinical examination, we made a diagnosis that it was primary anuerysmal bone cyst in clavicle

기초주의 관점에서 본 인격교육

박의수 안암교육학회 2010 한국교육학연구 Vol.16 No.3

기초주의는 한국 교육철학의 정립을 위하여 한기언이 제창하고 발전시킨 “전통과 개혁의 조화를 통한 인간형성의 논리”이다. 이 논문은 기초주의의 개념과 구조를 명료화 하고, 기초주의의 전체 구조 속에서 ‘인격’이 차지하는 위상과 교육적 의미를 밝히고, 아울러 기초주의의 틀과 관점에서 인격교육의 과제와 방향을 모색하는데 목적이 있다. 이를 위하여 먼저 기초주의의 개념과 구조를 명료화하고 다음으로 기초주의 구조 속에서의 인격의 위상을 고찰한 후에 기초주의의 관점에서 한국교육의 본질적 문제를 진단하고 기초로서의 인격교육의 방향을 탐구하여 다음 몇 가지 결론을 얻었다. 첫째, 복잡한 기초주의 이념체계를 하나의 표로 정리함으로써 일목요연하게 기초주의의 개념과 구조를 이해할 수 있게 되었다. 둘째, 인격은 사람됨의 기초인 동시에 교육의 기초이며 최종 목표이다. 셋째, 오늘날 한국교육의 본질적 문제는 결국 총체적인 기초의 부실, 즉 기초학력의 부실과 인격적 기초의 부실에서 비롯되는 것이며, 따라서 그 해법은 지적․인격적 측면에서 기초 교육을 공고히 하는데서 찾아야 한다는 것이다. Foundationism(Kichojuii) is widely known as "a human shaping logic through a harmony of tradition and reformation" that Hahn, Ki-Un initiated and developed in order to establish Korean Educational Philosophy. The purpose of this study is to clarify the concept and structure of Foundationism and to disclose the position and educational meaning of character in the context of Foundationism and to research the tasks and directions of character education from the viewpoint of Foundationism. For these purposes, clarifying the meaning and structure of Foundationism was proceeded first and investigating the position and meaning of character was carried out and examining the essential problems of Korea education from the viewpoint of Foundationism and searching the direction of character education as a foundation was finally proceeded. The conclusions of this study are as followings: First, a table that can clearly understand the whole complex system of Foundationism was completed. Second, character is the base of human being, as well as education, and also the eternal goal of education. Third, the essential problems of contemporary Korea education were derived from the weakness of basic scholastic ability and sincerity. So the sure method of solving the problems is to strengthen the foundation of knowledge education, as well as character education.

Fordyce Granules

박의수,송준영,최윤애 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

Fordyce granules are small yellow spots that are multifocal and slightly elevated. They may occur in clusters or coalesce to from yellow plaques. They are bilaterally symmetrical and are located most frequently on the buccal mucosa of the cheeks, the inner surface of the lips, and on the mucosa distal to the mandibular molars. Fordyce spots are extremely common: probably 80% of the population have them. They are often not noticeable in children until after puberty, and they seem to be more obvious in males, in patients with greasy skin and in the elderly. The granules are totally benign, though the occasional patient or physician becomes concerned about them or misdiagnoses them as thrush, lichen planus or other diseases. We present two cases of Fordyce granules a 64 and a 50 year-old male who have cancer phobia, showing multiple involvement of minute yellowish white colored spots on the buccal mucosa and inner surface of the lip. Histopathologic finding shows a group of small but mature sebaceous lobules situated around a small sebaceous duct leading to the surface epithelium. We did not give any specific treatment but gave reassurance, presently under observation.

하악 무치악 인공치아매식술시 하치조신경 전위술

최의환,하정완,김수관,정태영,김수흥 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

Modified surgical technique for transposition of the inferior alveolar nerve followed by immediate placement of endosseous implants in mandibles with moderate to severe atrophy are presented. Five transpositions of the inferior alveolar nerve together with the installation of 10 implants were performed in four patients. The mean postoperative follow-up time was 17 months, with a range of 8 to 20 months. All implants with functioning pontics remained stable, with no mobility or symptoms of pain and infection during the follow-up period. Neurosensory evaluation was performed using the two-point discrimination test. Two patients had objective neurosensory dysfunction at postoperative, but all the nerve function were reported as normal by the patients 4 months postoperatively.

제2형 당뇨병 환자에서의 지속적 피하 인슐린 주입 치료시 관해

최의광,최수봉,박선민 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background: It is well known that chronic hyperglycemia can deteriorate pancreatic beta cell function and insulin sensitivity in animal and human studies, and the normalization of blood glucose can reverse them. Our purpose of the study was to investigate the remission pattern after treating patients with continuous subcutaneous insulin infusion (CSII) therapy, and compare the clinical characteristics of remitted and non-remitted patients in a retrospective way. Methods: We selected 91 type 2 diabetic patients who had been admitted to KonKuk University hospital from January 1993 to August 1993. After hospitalization, all subjects were treated with insulin pump (Sooil, Seoul, Korea) for intensive blood glucose control until remission occurred. Remission is defined as long-term good glycemic control without any medication. After fifteen to seventeen months of CSII therapy, the induction of remission was examined. Serum c-peptide levels, hemoglobin A1c, and serum lipid profiles were measured after hospitalization and before discharge. Results: Overall 34.4% of all subjects had remission after 53.6±38.9 days of CSII therapy and remission lasted for average 13.6 ± 8.9 months during the study periods. Some clinical characteristics of the patients prior to CSII therapy influenced the remission occurrence. The remission was more frequently induced when patients started CSII therapy with insulin pump in younger age, higher body mass index, shorter diabetic duration, lower post-prandial blood glucose levels, higher post-pandial serum c-peptide levels, and less chronic diabetic complications. Conculsion: These findings suggest that long-term CSII therapy can induce remission in a significant proportion of mild type 2 diabetic patients. Thus, it is desirable that the intensive insulin treatment by CSII is considered as not the last treatment., but an initial management of mild type 2 diabetic patients.

Rudolf Steiner의 유아교육론

박의수 강남대학교 인문과학연구소 1996 인문과학논집 Vol.1 No.-

골격계의 원발성, 전이성 혈관외피세포종 : 증례 보고

김동수,김용민,최의성,손현철,박경진,조병기,이형준 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.19 No.2

혈관악성종양은 혈관내피종(hemangioendothelioma), 혈관육종(angiosarcoma), 혈관외피세포종(hemangio pericytoma) 및 카포지 육종(Kposi's sarcoma) 등이 있으며, 이 중 혈관외피세포종은 비전형적인 외피 세포가 증식된 경우를 말한다. 골의 혈관외피세포종은 드문 악성종양으로 문헌상 보고되어 있는 예들은 주로 성인의 대퇴골, 골반골에 발생된 경우이다. 이 경우 원발성은 드물며 주로 비골격계에서 기원하여 골로 전이되어 발생하는 것으로 알려져 있다. 남녀 발생 빈도는 거의 동일하며, 12세부터 90세까지 어느 연령층에서도 발생할 수 있으나, 호발 연령은 40대에서 50대 사이 이다. 대개 연부조직 종양으로 신체 어디에서도 일어날 수 있고, 하지 특히 서혜부 및 대퇴부에서 가장 많이 발생하며, 후복막, 두경부 및 흉복부의 순으로 나타난다. 전이도 빈번하게 발생하는데, 그 경로는 주로 혈행성으로, 발생부위는 폐와 골이 제일 많다. 저자들은 8년 전, 우측 아래턱의 원발성 혈관외피세포종으로 절제술을 시행한 환자에서 술후 3년 뒤, 우 경골 근위부에 원격 전이가 발생하여 절제술, 예방적 골수강내 금속정 삽입술 및 골시멘트 충전술을 시행하였다. 현재 2차 수술 후 5년여가 경과한 상태로 경골에 재발의 증거가 없어 만족할 결과를 가져다주었다고 판단하여 문헌 고찰과 함께 보고하는 바이다. Hemangiopericytoma is a rare tumor of blood vessels, first described and named by Stout and Murray in 1942, arising from the contractile, elongated cells the pericytes of Zimmermann which surround capillaries. It can develop whereever there are capillaries and mostly in the connective tissue of the human body. It can also develop in any age from 12 to 90 years, and the rate of metastasis and prognosis depend on its histologic grade. We report a case of hemangiopericytoma metastasized to the right proximal tibia from the right mandible, resected three years ago. The hemangiopericytoma is a extremely rare primary malignant tumor in the bone and bone to bone metastasis is never been found in the literature before. So, we report this case and also report the good result.

반도체 레이저의 온도 및 주입전류 의존성에 관한 연구

김의훈,김필수,이제형 漢陽大學校 基礎科學硏究所 1992 基礎科學論文集 Vol.11 No.-

반도체 레이저의 온도와 주입전류 변화에 따른 방출스펙트럼의 특성을 조사하고 파장조정 가능성을 연구하였다. 실온에서 피크파장 780nm를 가지는 Mitsubishi사의 GaAlAs계의 레이저 다이오우드에 대해 주입전류를 일정하게 유지하고 온도를 변화시켰을 때의 방출피크파장은 계단적으로 증가하였으며 파장의 의존도는 0.20nm/℃였다. 온도를 일정하게 유지하고 주입전류를 변화시켰을 때의 방출피크파장 역시 계단적인 변화양상을 보였으며 파장의 전류 의존도는 0.11nm/mA였다. 한편 레이저 다이오우드의 문턱전류는 다이오우드의 온도 증가에 따라 거의 지수함수적으로 증가하였다. 온도와 주입전류 변화로 얻은 최소 방출파장은 770nm이었다. Spectral characteristics and wavelength tunability of a semiconductor diode laser have been studied by examining the wavelength dependence on temperature and injection current. The results show that the output peak wavelength from a Mitsubishi GaAlAs laser diode increases stepwise with increasing temperature at constant injection current, showing the wavelength dependence on temperaure of 0.20nm/℃. On the other hand, the output peak wavelength also varies stepwise with increasing injection current at constant temperature, representing the wevelength dependence on injection current of 0.11nm/mA. The measured threshold currents of the diode laser increase exponentially as a function of temperature. By control of temperature and injection current of laser diode, the output peak wavelength can be attained down to 770nm.