방광의 이행상피암에서 p53과 PCNA 분포에 관한 연구

최은정,강상균,양승하,김대중,김의한 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Immunohistochemical studies were carried out to observe the expression of p53 protein and PCNA in transitional cell carcinoma (TCC), then analyzed according to the tumor grade and progression. 38 cases of TCC consist of 13 cases grade Ⅰ, 12 cases grade Ⅱ and 13 cases grade Ⅲ respectively. Results obtained are as follows. 1. p53 protein expression was seen in 60% of cases(15 out of 38 cases) In the poorly differentiated area and infiltrated lesion, tumor cell showed more strong positive reaction of p53 protein compared with well differentiated area. 2. All of 38 cases of TCC showed PCNA positive expression. The more strong positivity was seen in the poorly differentiated area and the more intense positive reaction was noted in the basal layer of the tumor nests. 3. The above results showed that positivity of p53 protein and PCNA are closely related with tumor cell differentiation(grade) and progression. It is concluded that positive reaction of p53 protein and PCNA may contribute to detection of tumor growth and prognosis of patient.

Cl_2/Ar 프라즈마에 의한 (Ba,Sr)TiO_3 박막의 식각 Damage에 관한 연구

최성기,장의구 중앙대학교 기술과학연구소 2000 기술과학연구소 논문집 Vol.30 No.-

고유전율의 (Ba,Sr)TiO_3 박막을 Cl_2/Ar의 비율을 변화하면서 ICP(inductively coupled plasma) 이용하여 식각하였다. Cl_2(20)/Ar(80)에서 최대 식각률인 400A˚/min을 얻었고, Pt와 감광막과의 선택비는 0.4와 0.2를 나타내었다. XPS (x-ray photoelectron spectroscopy), AFM(atomic force microscopy), XRD (x-ray diffraction)를 이용하여 식각 후 박막 표면을 분석하였다. 높은 비등점 때문에 Ba-Cl과 Ti-Cl 결합의 식각 잔여물이 BST 박막의 표면의그레인 사이에 재증착하여, 표면 rms 거칠기를 감소시키고 결정성을 변화시켰다. High dielectric (Ba,Sr)TiO_3 thin films were etched in an inductively coupled plasma(ICP) as a function of Cl_2/Ar gas mixing ratio. Under Cl_2(20)/Ar(80), the maximum etch rate of the BST films was 400A˚/min and selectivities of BST to Pt and PR were obtained 0.4 and 0.2, respectively. We investigated the etched surface of BST by x-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and x-ray diffraction (XRD). Residues of Ba-Cl and Ti-Cl bonds remained between grains of BST surface for high boiling point, decreased surface rms roughness and changed crystallinity of BST surface.

두부규격방사선사진에서 정상 sella turcica의 형태 및 크기에 관한 연구

최욱진,황의환,이상래 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.1

Purpose : To investigate the shape and size of normal sella turcica on cephalometric radiograms. Materials and Methods : Cephalometric radiograms of 200 orthodontic patients of age ranging 6-42 years were examined. All subjects were divided into 5 groups by age, the dimensional change of sella turcica was examined according to age, and the configurations of sella turcica floor, tuberculum sella, and anterior and posterior clinoid process were also observed. Results : The contours of sella turcica floor were flat type in 54% and concave type in 46%. The contours of tuberculum sella were right angle type in 55% and obtuse angle type in 44%; Acute angle type and plane type were very rare comprising 0.5%, 0.5% each. The configurations of anterior clinoid process were point type in 80% and round type In 20% of cases, and those of posterior clinoid processes were point type in 60% and round type in 40% of cases. The dimensional change of sella turcica according to age range had significantly positive linear trend to sella turcica length, height, and width until 25 years. After 26 years, no significant increase was found in sella turcica dimension. Especially, the sella turcica length had more proportional increase than that of sella turcica height and width. Conclusion : The results of this study revealed that the configuration of normal sella turcica was variable and the dimensional change of normal sella turcica had a linear tendency with age until 26 years.(Korean J Oral Maxillofac Radiol 2001;31:43-9)

이하선에 발생된 양성 혼합종에서 유래된 암종의 증례보고

최용석,황의환,이상래 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.1

Carcinoma ex mixed tumor is a mixed tumor in which a second neoplasm develops from the epithelial component that fulfills the criteria for malignancy. This tumor occurs frequently in the parotid glands. Individuals in whom carcinoma ex mixed tumor have a past history of benign mixed tumor. These lesions contain both a benign mixed tumor as well as a malignant neoplasm. We report a case of carcinoma ex mitred tumor which occurred in the parotid gland. A 67-year-old woman presented with movable right mass. she complained pain and facial paralysis. The clinical presentation, several diagnostic images, and histopathologic findings are presented. (Korean J Oral maxillofac Radiol 2000; 30: 92-99)

하악과두에 발생된 골연골종의 증례보고

최욱진,황의환,이상래 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.2

The osteochondroma, also known as osteocartilagenous exostosis, is one of the most common benign tumors of the axial skeleton, but is rarely found in the facial bones. When present, the tumor is most often reported to affect the mandibular coronoid process. Osteochondroma of the mandibular condyle is extremely rare and may cause signs and symptoms like those seen in patients with temporomandibular joint dysfunction. Sometimes, differentiation between osteochondroma and condylar hyperplasia is not possible on histologic grounds alone, but the radiographic and intraoperative findings together are usually sufficient to establish a definite diagnosis, This report reviews the literature concerning osteochondroma, especially of the maxillofacial region, and describes a case of osteochon droma of the condyle. (Korean J Oral Maxillofac Radiol 2000; 30: 138-143)

슬관절에 히야루론산 주입후 발생한 활막성 연골종증 : 증례 보고

최의성,김용민,김동수,손현철,박경진,조병기,배승환 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.18 No.2

활막성 연골종증은 비교적 드문 양성 종양으로 관절내 활액막 결체조직의 양성 반응성 이형성에 의해 여러 개의 연골성 결절을 형성하고 이것이 관절내로 유리되어 유리체를 형성하는 질환으로 주로 슬관절에 발생한다. 활막성 연골종증의 정확한 발생 기전은 아직 밝혀지지 않았으나 외상, 감염 등이 원인으로 제시되고 있다. 저자들은 슬관절 내 히야루론산 주입후 발생한 슬관절내 활막성 연골종증을 1 례 경험하였으며, 관절경적 제거술을 통해 만족스런 결과를 얻었다. As a relatively rare benign tumor, synovial chondromatosis forms several cartilaginous nodules by the benign reactive metaplasia of synovial connective tissues within joints, which are loosed into the joints and cause a disease forming loose body mainly in knee joint. Accurate mechanism of synovial chondromatosis has not been clarified yet; however, trauma, infections and others have been suggested as its possible causes. The authors of this study experienced an example of a patient with synovial chondromatosis in knee joint occurred after the injection of hyaluronic acid in the joints and had a satisfactory outcome through the arthroscopic resection.

rhBMP-2가 저칼슘식이 투여 백서의 골결손부 이유에 미치는 영향

최용석,황의환,이상래 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To investigate the effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat. Materials and Methods : To prepare the experimental model, control group was fed a normal diet and experimental group was fed a low calcium diet for 3 weeks. And then, 4 mm bicortical perforated bone defect was made on mandibular body of each rats. Experimental group was subdivided into two groups; experimental group 1 (rats given a low calcium diet before and after bone defect) and experimental group 2 (rats given a low calcium diet before and after bone defect with rhBMP-2 application). At 1, 3, 5 and 7 weeks after bone defect formation, the rats Were terminated. The healing of bone defect was assessed by three-dimensional computerized tomography, soft xray radiography, and histopathological examination. Results : The wound healing of the bone defect for control group, experimental group 1, and experimental group 2 showed a increase from 3 weeks after bone defect formation. The experimental group 2 showed a more increase in healing amount than control group and experimental group 1 from 5 weeks after bone defect formation and the experimental group 2 showed a complete recovery of bone defect at 7 weeks after bone defect formation. Conclusion : The healing process of bone defect is accelerated by rhBMP-2 application in the low calcium diet rats.

위점막병소에서의 Carcinoembryonic Antigen과 Secretory Component의 분포에 관한 비교연구

김의한,최종상,이대일 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

Recently, carcinoembryonic antigen (CEA) and secretory component (SC) are both detected immunohistochemically in the pathologic lesions of the stomach, such as metaplastic, dysplastic or anaplastic lesion. However, interrelationship between CEA and SC in their localization in the stomach is not understood well. Therefore, to understand correlation of intestinal metaplasia and carcinoma of the stomach and interrelationship between localization of CEA and SC in stomach lesions, the author collected serial 67 cases (35 cases of chronic gastritis and 32 cases of carcinorca of stomach) of formalin fixed, paraffin embedded gastric mucosa obtained by fiberscopic biopsy, performed immunoenzyme histologic reaction by Avidin-Biotin-Complex method using anti-human CEA and antihuman SC rabbit sera and analyzed their immunohistologic reactions. Results obtained are as following; 1. Intestinal metaplasia was noted in 10 of 35 cases of chronic gastritis. And metaplastic cells in each case revealed positive reaction to both anti CEA and anti SC sera. 2. Carcinoma of stomach revealed positive reaction to anti-CEA in 71.9% (23 of 32 cases) and rate of positive reaction was higher as the differentiation of cancer cell poorer. 3. Association of metaplasia among CEA positive carcinoma of stomach was noted in 78.3% (18 of 23 cases). 4. Rate of SC positive carcinoma of stomach was 56.2% (18 of 32 cases) and there Bras no remarkable difference between degree of cancer cell differentiation and rate of SC positivity. And the cases showing SC positive carcinoma of stomach were all accompanied with metaplastic change in the lesion. 5, Carcinoma of stomach showing SC negactive reation revealed no metaplastic change in the lesions. 6. Carcinoma of stomach showing SC positive reaction were all CEA positive and also CEA negative cases were all SC negative. Above findings show that metaplastic .and dysplastic cells in chronic gastritis are positive both CEA and SC, and SC is specific indicator of carcinoma of stomach originated from intestinal metaplasia.

전산화 신경인지 검사를 이용한 외상후 스트레스장애 환자의 인지기능 측성

한상우,최의정,한선호 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

objective: Among the patient who injured by traffic accident, they complaint decreased cognitive functioning from severe traumatic brain injury and mild traumatic brain injury such as 'post-concussional syndrome' to 'compensation neurosis' But Physicions ignore the evaluation and treatment of the patient with mild traumatic brain injury and no head trauma history who complaint cognitive disturbance, because they are tend to considered as malingering or 'compensation neurosis'. In this study, the authors evaluated cognitive functioning of the patient with post-traumatic stress disorder who were admitted by traffic accident and were no evidence of head trauma. method : Among the thirty patients who were admitted by traffic accident in Soonchunhyang university hospital, authors selected the patients that 1) had no evidence of head trauma, and 2) have no prominent faking-bad attitude, and 3)have the symtomatology of posttraumatic stress disorder. The number of the selected patient was eighteen, and authors performed physical and psychiatric examination including computed neuropsychological test. results : the result of computed neuropsychological test, thirteen patients had mild attention impariment and, six patients had impairment of immediate recalling, ten patients had mild visuoperceptual disablilty. conclusions : In this study, some patients with posttraumatic stress disorder had impaired attention, immediate recalling, visuoperceptual functioning in computed neuopsychological test.

충남 서북부지역의 개발 잠재력 분석 : 아산시를 중심으로

배성의,박동진,윤준상,황인극,최승철 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

This study was purpose for develop potential analysis of Chungnam north-west area and propose to regional development strategy. To arrived at a result for develop direction of Chungnam north-west area, Asan city will be development of central city for Asan bay, new indusrial city, tourist industrial city and ecological city.