Oxyhydroxide 입자의 산화침전반응에 관한 연구

설수덕,신동옥 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

The aeroal oxidative precipitation and kinetics of α-FeOOH formation from aqueous solution of ferrous sulfate with KOH as a precipitant have been studied. The influence of reaction temperature and initial mole ratio, R_o=[Fe^2+]_o/[OH­]_o, value on the morphology and oxidation rate of α-oxyhydroxide particles and kinetics of seed formation are investigated by free pH drift and static pH experiment. The results show that the increase or air flow rate, reaction temperature and initial mole ratio increases the oxidation rate through the seed formation and seed growth of the pH drift experiment. Needle-like α-oxyhydroxide particle of submicron size was obtained and when R_o value was decreased the particle was grown to longitudianl direction. The oxidation reaction of seed formation is apparently first order.

자성체용 α-Ferric oxyhydroxide의 핵성장반응속도론

설수덕,신동욱 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

The kinetics of seed formation and growth of α-ferric oxyhydroxide with aerial oxidative precipitation from aqueous solution of ferrous sulfate with KOH,NaOH, Na_2 CO_3 as a precipitation have been studied by free pH drift experiment. It has been shown that all precipitants give same particle formation and growth path, and average particle length from KOH and NaOH as precipitant was shorter than that of K_2 CO_3 and Na_2 CO_3. The kinetics of α-ferric oxyhydroxide seed growth from aqueous solution of ferrous sulfate with KOH as a precipitant has been studied. The influence of air flow rate, reaction temperature and initial mole ratio, R_o=[Fe^2+]_o/[OH^-]_o, on the kinetics of seed growth are investigated by static pH experiment. The oxidation rate of seed growth increased with increasing air flow rate, reaction temperature and initial mole ratio. The activation energy of seed growth is 16.16 KJ/mol and rate equation of seed growth can be written as follows: -d[Fe^2+]/dt = 1.46×10⁴[P_O_2]^0.66[OH^-]^2.19exp(-16.16/RT)

분산재 첨가에 의한 α-Ferric oxuhydroxide 입자형성에 관한 연구

설수덕,신동욱 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

The effect of dispersers(surfactants) on the particle formation and growth of ferric oxyhydroxide from aqueous solution of ferrous sulfate with KOH as a precipitant have been studied. The influence of despersers on the morphology and size distribution of ferric oxyhydroxide particle are characterized by free pH drift experiment and scanning electron microscopy analysis. With increasing concentration of added anionic surfactant, the mean size of particle formed decreased, while nonionic and cationic surfactant did not effect on particle size control. α-Ferric oxyhydroxide was formed by two steps of particle formation and growth in the presence of nonionic, anionic and cationic surfactants. Particle sizes in the range 0.30∼0.4㎛ for fine ferric oxyhydroxide depending on the amount of anionic surfactant, with needle like morphology are formed.

廢황산제일철로부터 Goethite의 산화침전반응에 관한 연구

설수덕,신동옥 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

The influence of precipitants on the particle formation and growth of geothite by means of aerial oxidative precipitation from aqueous solution of ferrous sulfate with KOH, Ca(OH)₂, NaHCO₃, and H₂O₂ as a precipitants have been studided on the same oxidative precipitation condition. Submicron of needle-like geothite( a-FeOOH) particle was obtained from all kinds of alkaline precipitants KOH, Ca(OH)₂ and NaHCO₃. On the other hand, NaNO₃ and H₂O₂ were didn't not influence on the particle formation and growth. The kinetics of geothite particle formation and growth from aqueous solution of ferrous sulfate with KOH as a precipitant have been studied. The influence of air flow rate, reaction temperature and initial mole ratio, R_(o)=[Fe^(2+)]_(o)/[OH^(-)]_(o), on the kinetics of particle formation and growth are investigated by static pH experiment. The results show that the increase of air flow rate, reaction temperature and initial mole ratio increases the oxidation rate through the particle formation and growth. The activation energy of particle formation and growth is 11.71 KJ/mol and 16.16 KJ/mol and rate equation of particle formation and particle growth can be written as follows: <particle formation> - d[Fe^(2+)]/dt = 1.69×10 ₄ [P_(O₂)]^(0.56) [OH^(-)]^(1.71)exp(- 11.71/RT) <particle growth> - d[Fe^(2+)]/dt = 1.46×10 ₄ [P_(O₂)]^(0.66) [OH^(-)]^(2.19)exp(- 16.16/RT)

산화철 안료 합성의 속도론적인 연구

설수덕,신동욱 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

The particle formation of iron oxide pigment by means of aerial oxidative precipitation from aqueous solution of ferrous sulfate with KOH, NaOH, Na_2 CO_3 and K_2 CO_3as a precipitants have been studies on the same oxidation condition. Submicron of needle-like yellow iron oxide(α-oxyhydroxide) particle was obtained from all kinds of precipitants and the average particle length from carbonate(K_2 CO_3 and Na_2 CO_3) as precipitant was about 1.5 times longer than the other bicarbonate precipitants. The kinetics of particle growth of iron oxide from aqueous solution of ferrous sulfate with KOH as precipitant have been studied. The influence of air flow rate, reaction temperature and initial mole ratio, R_o= [Fe^2+]_o/[OH­]_o, value on the kinetics of particle growth are investigated by static pH experiment. The results show that the increase of air flow rate, reaction temperature and initial mole ratio, R_o value increases the oxidation rate through the particle growth. The activation energy of particle growth is 16.16KJ/mol and The oxidation reaction of seed formation is apparently first-order.

p-톨루엔 술폰산의 염소화 반응에 관한 연구

설수덕,신동욱,표명수 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

The chlorination of PTS was reacted at temperature 45~85℃, chlorine flow rate 158~475 cc/min, respectively, and thermal decomposed at flow rate of nitrogen 30 cc/min and heating rate(B) 4~20℃/min, respectively, in a batch reactor. Some conclusions are as follows : 1. The maximum conversion of PTSCI mixture was 81%, the optimum reaction temperature and chlorine flow rate were 65℃ and 316.5 cc/min, respectively. 2. The reaction activation energy of PTSCI and OTSCI were 2,423 kcal/mol and 2,125 kcal/mol. And the reaction order was 0.4 3. The activation energy for decomposition of the PTSCI mixture was 21.4kcal/mol and the reaction was first order. 4. The PTSCI mixture was the best for thermal degradation that was reacted at reaction temperature and chlorine volume were 65℃ and 316.5 cc/min, respectively.

모유 수유에 대한 일반인들의 인식에 관한 설문조사

반성환,이동환,박재옥,신상만 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

OBJECT : From the late in 1970, the incidence of breast-feeding have been increased in the developed countries. But, there is a marked contrast in Korea, inspite of the campaign of breast-feeding. We researched the general opinions of general populations on breast feeding to find out a better way on successful breast-feeding and helping people's understanding. METHODS : To find out the factors influencing the incidence of breast-feeding, we made on ingury study in 234 women and their family member including their husbands during the period of April, 1995 to August, 1995. We analysed the results according to sex, age, and the status of education and marriage. RESULT People in the inquiry answered as follows : - breast feeding is to be taken for granted.(93-94%) - the reason of breast feeding is for protecting baby from disease.(81-83%) - feeding breast milk is much better than cow's milk.(82-83%) - breast feeding is good for hepling the bonding between mother and her baby.(89%) - most of them would like to follow the spouse's opinion to keep on breast feeding.(73-75%) - breast feeding could cause some inconveniences in sexual-life/(74-78%) - breast feeding woman are regarded more admiarable when compared with non-breast feeding woman.(80-84%) - breast feeding woman is less attactive.(22-23%) - the purpose of creating breast is to feed baby.(14-17%) - breast feeding in public place is permissible.(43%) - breast feeding can make breast shapeless.(22%) CONCLUSIONS : Every effort should be made so as to increase the recognition of the value of breast feeding, not only for pregnant women but also for their husbands. Both of them have to attend the breast feeding education classes given before and after childbirth. Students have to be taught about the merit and the way of breast feeding through school education. Doctors are expected to encourage people to realize the advantages of breast-feeding, participate in the campaign and never advise to give up breast feeding.

수영운동과 솔잎분말 첨가식이 섭취 흰쥐의 L-FABP, CPT-1의 발현량과 항비만에 미치는 영향

신동아(Shin, Dong-A),서효빈(Seo, Hyo-Bin),정석호(Jung, Suk-Ho),남주옥(Nam, Ju-Ock),권태동(Kwon, Tae-Dong) 한국체육과학회 2020 한국체육과학회지 Vol.29 No.2

The purpose of this study is to examine how a pine needle powder-added diet and swimming exercise influence fat metabolism and inflammatory cytokine in a high cholesterol diet. 42 male Sprague-Dawley rats were made to practice a pine needle powder-added diet and swimming exercise along with a high cholesterol diet for six weeks. The HCE and the HCPEN showed significant decrease in their weight in the sixth week, and according to the results of dispersion analysis, it was found to be significant in the group × week. About the change of intake in the diet, the HC and HCE were found to be significant high, and according to the results of dispersion analysis, it was not significant in the group × week and regarding diet efficiency, the EX, HCPN, and HCPNE were found to be significant high. About the change of fat, abdominal fat was significantly high in the HC and HCPN, and testicle fat was significantly high in the HC, and mesenteric fat did not indicate significant difference. According to the results of fat metabolism, regarding the change of L-FABP expression in liver tissues, the CON and EX indicated a significantly higher expression compared to each of the other groups, and CPT-1 expression did not show significant difference. herefore, according to the results of this study, reduction in weight, body fat, and blood lipids led by the exercise and pine needle powder-added diet activated AMPK and the acceleration of PPAR-γ, FABP, and CPT-1 as the result of the exercise, and this led to the regulation of fat metabolism. Moreover, regarding the results of pine needle powder intake in the diet, pharmacological compounds contained in pine needles such as phenols and flavonoids are thought to influence fat metabolism positively. This author deems that the results of this study provide foundational material regarding the influence of exercise and pine needle powder-added diet’s complex treatment on anti-obesity improvements.

Simultaneous detection of Prevotella intermedia and Prevotella nigrescens by 16S rDNA-directed multiplex PCR

Seong, Jin Hyo,Kim, Dong Kie,Shin, Kwang Yong,Kim, Byung Ock,Kim, Myong Soo,Kim, Mi Kwang,Kook, Joong Ki 대한구강보건학회 2002 大韓口腔保健學會誌 Vol.26 No.4

본 연구는 치주질환과 관련된 병원성 세균 중 그람 음성 협기성 세균 종인 Prevorella intermedia (P. intermedia)와 Prevotella nigrescens (P. nigrescens)를 동시에 동정 및 검출할 수 있는 중합효소연쇄반응 프라이머를 개발하기 위하여 시행하였다. 모든 세균 종에 있어서 165 라이보송 RNA의 염기서 열에는 잘 보존된 부위와 종에 따라 다양한 부위가 있다. 이러한 특성을 이용하여 P. nigrescens와 P. intermedia의 알려진 165라이보솜 RNA의 염기서 열을 분석하여 두 세균 종에 공동으로 존재하는 하나의 프라이머와 각각의 세균 종에 특이하게 존재하는 다른 프라이머를 설계 및 제작하였으며, 이때 설계된 프라이머의 이름을 각각 Pin-F, Pi-R 및 Pn-R이라고 명명하였다. 이들의 종 특이성을 조사하기 위해 두 균주의 P. intermedia와 P. nigrescens지놈 DNA를 추출하여, 종 특이성을 중합효소연쇄반응법으로 관찰하였다. 이때 구강 내 6가지 다른 세균 종에서 같은 방법으로 중합효소연쇄반응을 실시한 결과 P. nigrescens와 P. intermedia 두 종만을 특이하게 검출함을 알 수 있었다. 또한 민감도를 조사하기 위해 두 세균 종에서 추출한 지놈 DNA를 4 ng에서 4 fg까지 희석하여 중합효소연쇄반응을 실시한 결과 400 fg의 지놈 DNA까지도 검출할 수 있었다. 이러한 결과를 종합할 때 이들 Pin-F, Pi-R 및 Pn-R프라이머 쌍은 P. inermedia와 P. nigrescens를 동시에 종특이적이며, 민감도 높게 검출 및 동정할 수 있을 것으로 사료된다.

갈색세포종의 임상적 고찰

신동현,김신곤,김동림,김난희,최경묵,백세현,최동섭,서성옥 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 갈색세포종은 부신 수질과 교감신경절 또는 침크롬성조직이 있는 곳에서 발생하는 종양으로 카테콜아민을 생성, 저장 및 분비를 함으로 고혈임이나 심계항진, 발한, 두통 등 발작 증상을 특징적으로 나타낸다. 정확한 진단 및 적절한 약물, 수술 요법으로 효과적인 치료를 할 수 있으나 비특이적인 증상들로 인해 진단, 치료에 어려움을 겪는 질환이기도 하다. 이에 본 교실에서 최근 10년간 경험한 갈색세포종 환자들을 대상으로 임상적 소견 및 수술 후 혈압변동 등을 검토하였다. 방법: 부신에서 발생한 갈색세포종 29예와 부신경절종 16예 등 총 45예에 대해 임상 증상, 생화학적 검사, 수술전 처치 및 수술후 결과를 검토하였다. 결과: 총 45예 중 남자가 20예, 여자가 25예였으며, 평균 연령 43세로 30∼40대에 가장 많이 발생하였다. 임상 양상은 부신 종양은 고혈압, 두통, 심계항진, 내당능장애 순으로 많았고 부신외 종양은 복부통증, 고혈압 순이었다. 생화학 검사에서는 부신 종양에서 소변내 카테콜아민 및 그 대사물질의 민감도가 65에서 88%의 소견을 보였다. 종양은 우측 부신이 16예, 좌측 부신이 12예, 양측성이 1예였으며, 부신외 종양이 16예로 전체의 36%를 차지했다. 수술 전 고혈압을 보이던 환자 중 76%가 수술 후에 혈압이 정상화되었다. 결론: 갈색세포종은 고혈압 등 다양한 임상 형태로 나타날 수 있고 수술로써 증상 치료가 가능함으로 임상적인 의심과 정확한 진단, 적절한 수술 전 처치 및 수술이 필수적인 질환이다. 향후 더 많은 예를 대상으로 연구를 진행하여 다양한 갈색세포종의 임상양상과 생화학적 검사의 유용성 및 수술 후 결과를 확인하는 것이 필요하리라 생각된다. Background: Pheochromocytoma may arise within the adrenal medulla, or in other locations where sympathetic ganglia or chromaffin tissues are known to exist. Approximately 0.1% of hypertensive patients have pheochromocytoma. Most of this hypertension can be cured by surgical removal of the tumor, but lethal complication can develop if proper treatment is not prepared. Therefore, accurate diagnosis and preoperative preparation is very important. The objective of this study was to evaluate the clinical characteristics of pheochromocytoma and the blood pressure change following tumor removal. Method: The medical records of 445 patients [29 cases of intra-adrenal, 16 cases of extra-adrenal(paraganglioma)] diagnosed with of pheochromocytoma at Korea University Medical Center between 1991 and 2001 were reviewed. Results: Twenty of the cases were male and 25 were female. The mean age of these patients was 43 years old. Hypertension, headaches, palpitations and impaired glucose tolerance were observed more frequently in cases of intra-adrenal tumor than in those of extra-adrenal. In the extra-adrenal, group, abdominal pain, hypertension and nausea were more frequently observed. A biochemical study showed that the sensitivity of the test for catecholamines and metabolites in 24 hours urine was over 80%. For the localization of tumors we used abdominal CT and MIBG. The sensitivities of the CT and MIGB for the tumor localization were 97 and 91%, respectively. Blood pressures during the operations were effectively controlled by preoperative treatment with phenoxybenzamine (non-competitive, non-selective α-adrenoreceptor antagonists). Conclusion: Surgical treatment cured 23 of the 30 cases of hypertension with pheochromocytoma. We have to take careful approaches in the care of the patient who may have phechromocytoma, due to the various clinical signs and symptoms (J Kor Soc Endocrinol 17:554∼563, 2002).