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Antonio Olivas-Martinez,Eduardo Corona-Rodarte,Adrián Nuñez-Zuno,Olga Barrales-Benítez,Daniel Montante-Montes de Oca,Jesús Delgado-de la Mora,Diana León-Aguilar,Hilda Elizeth Hernández-Juárez,Elena Tu 대한혈액학회 2021 Blood Research Vol.56 No.3
Background Thrombotic events are well documented in primary erythrocytosis, but it is uncertain if secondary etiologies increase the risk of thrombosis. This study aimed to determine the causes of erythrocytosis and to identify its impact as a risk factor for thrombosis. Methods Data were obtained from patients with erythrocytosis between 2000 and 2017 at a referral hospital in Mexico City. Erythrocytosis was defined according to the 2016 WHO classification. Time to thrombosis, major bleeding, or death were compared among groups of patients defined by the etiology of erythrocytosis using a Cox regression model, adjusting for cardiovascular risk factors. Results In total, 330 patients with erythrocytosis were studied. The main etiologies of erythrocytosis were obstructive sleep apnea (OSA) in 29%, polycythemia vera (PV) in 18%, and chronic lung disease (CLD) in 9.4% of the patients. The incidence rate of thrombosis was significantly higher in patients with PV and CLD than that in patients with OSA (incidence rates of 4.51 and 6.24 vs. 1.46 cases per 100 person-years, P=0.009), as well as the mortality rate (mortality rates of 2.72 and 2.43 vs. 0.17 cases per 100 person-years, P=0.003). Conclusion The risk of thrombosis in CLD with erythrocytosis was comparable to that in patients with PV. Further larger-scale studies are needed to confirm these findings and evaluate the benefits of preventive management of COPD with erythrocytosis similar to PV
Rosa Jiménez-Lucena,Antonio Camargo,Juan Francisco Alcalá-Diaz,Cristina Romero-Baldonado,Raúl Miguel Luque,Ben van Ommen,Javier Delgado-Lista,Jose María Ordovás,Pablo Pérez-Martínez,Oriol Alberto Rang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
We aimed to explore whether changes in circulating levels of miRNAs according to type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers to evaluate the risk of developing the disease. The study included 462 patients without T2DM at baseline from the CORDIOPREV trial. After a median follow-up of 60 months, 107 of the subjects developed T2DM, 30 developed prediabetes, 223 maintained prediabetes and 78 remained disease-free. Plasma levels of four miRNAs related to insulin signaling and beta-cell function were measured by RT-PCR. We analyzed the relationship between miRNAs levels and insulin signaling and release indexes at baseline and after the follow-up period. The risk of developing disease based on tertiles (T1-T2-T3) of baseline miRNAs levels was evaluated by COX analysis. Thus, we observed higher miR-150 and miR-30a-5p and lower miR-15a and miR-375 baseline levels in subjects with T2DM than in disease-free subjects. Patients with high miR-150 and miR-30a-5p baseline levels had lower disposition index (p = 0.047 and p = 0.007, respectively). The higher risk of disease was associated with high levels (T3) of miR-150 and miR-30a-5p (HRT3-T1 = 4.218 and HRT3-T1 = 2.527, respectively) and low levels (T1) of miR-15a and miR- 375 (HRT1-T3 = 3.269 and HRT1-T3 = 1.604, respectively). In conclusion, our study showed that deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM.
Domingo Cruz-Labana José,Antonio Tarango-Arámbula Luis,Luis Alcántara-Carbajal José,Delgado-Alvarado Adriana,Magdalena Crosby-Galván María,Manuel Ruiz-Vera Víctor 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
Ants are among the organisms that are considered habitat engineers due to their ability to induce changes in the soil. An economically significant ant species is Liometopum apiculatum MAYR, 1870, as its pupae are utilized for human consumption. This ant has been extensively studied using various biological and ecological approaches in diverse habitats across North America. However, there is limited research documenting the properties of the soil in which they nest. The objective of this research was to analyze the physical and chemical properties of soil from Liometopum apiculatum nests and random sites, and to explain how ants can modify the soil in a semi-arid area of north-central Mexico. A sample size of 45 nests distributed in scrub vegetation was determined. Soil samples (2.5 kg) were collected from nests and random sites (20 m in a random direction) at a depth of 20 cm, and aggregates of 3 to 4 cm in length were included during the excavations. The physical variables evaluated were moisture, texture, bulk density and mechanical penetration resistance (MPR); while the chemical ones were pH, electrical conductivity, organic matter, nitrogen, phosphorus and potassium. The variables moisture (p = 0.031), bulk density (p < 0.01), MPR (p = 0.0289); pH (p < 0.001), electrical conductivity (p < 0.01) and organic matter (p < 0.01) had statistical differences between soil from nests and random sites. This research adds to the existing body of knowledge on Liometopum apiculatum by presenting information on the physical and chemical properties of the soil in which they establish their nests.
Lower Airway Microbiota and Lung Cancer
Sanchez-Hellin, Victoria,Galiana, Antonio,Zamora-Molina, Lucia,Soler-Sempere, Maria J.,Grau-Delgado, Justo,Barbera, Victor M.,Padilla-Navas, Isabel,Garcia-Pachon, Eduardo The Korean Society for Microbiology and Biotechnol 2019 한국미생물·생명공학회지 Vol.47 No.3
This study was aimed at identifying the lower airway microbiota in patients with lung cancer (LC) using protected brush sampling. We enrolled 37 patients undergoing diagnostic bronchoscopy for suspected LC, 26 with LC and 11 with benign diseases. Protected brush specimens were obtained from the contralateral lung and the side of the tumor; these specimens were analyzed by 16S rRNA-based-next-generation sequencing. The results indicated that the biodiversity was not different between groups, and there were no significant differences between the proportion of microorganisms in the tumor and in the contralateral side of patients with LC. In patients with LC, there was a higher abundance of several microorganisms including Capnocytophaga, Haemophilus, Enterococcus, and Streptococcus; whereas, in individuals without LC, Bacteroides, Lactobacillus, or Methylobacterium were more abundant. Malignancy could be determined with an accuracy of 70% by isolating Enterococcus, Capnocytophaga, or Actinomyces. Microbispora indicated benignity with a sensitivity of 55%, specificity of 88%, and accuracy of 78%. Lower airway microbiota in patients with LC is fairly similar in both the tumor and contralateral sites. Endobronchial microbiota is different in patients with and without LC, and these differences may have a potential clinical value as diagnostic or prognostic biomarkers.
Myrthala Juárez-Treviño,Antonio Costilla Esquivel,Lilia Marytza Leal Isida,Dionicio Ángel Galarza Delgado,Manuel E. de la O Cavazos,Lourdes Garza Ocañas,Rosalinda Sepúlveda Sepúlveda 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1
Objective: This study was conducted to compare the efficacy of clozapine vs. risperidone in the treatment of aggression in conduct disorder in children and adolescents. Methods: Twenty-four children with conduct disorder aged 6 to 16 years were randomized in a prospective, double- blind trial into two groups to receive clozapine or risperidone for 16 weeks. The Modified Overt Aggression Scale score was used as the primary outcome of the study. Secondary outcomes were Child Behavior Checklist (CBCL) externalization (CBCL-E) and internalization factors; Aggression, Hyperactivity and Delinquency subscales of CBCL-E, Child Global Assessment Scale (CGAS), Barnes Akathisia Rating Scale, and Simpson-Angus Scale. Results: Both antipsychotics were similarly effective in the primary outcome and in most of the secondary ones. Clozapine was more effective in CBCL-E, the delinquency subscale and the CGAS scores than risperidone (p =0.039, 0.010, and 0.021). Two subjects from the clozapine group were excluded due to a low neutrophil count at week four. Conclusion: Clozapine and risperidone are effective for short-term treatment of aggression in children and adolescents with conduct disorder. Clozapine was more effective than risperidone in conduct externalization factors, delinquency trait and global functioning in children and adolescents. Stronger efficacy of clozapine should be investigated in larger sample sizes using pharmacogenomic studies. White blood cell counts need to be monitored when prescribing clozapine.
Real-time state observers based on multibody models and the extended Kalman filter
Javier Cuadrado,Daniel Dopico,Antonio Barreiro,Emma Delgado 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.4
This work is a preliminary study on the use of the extended Kalman filter (EKF) for the state estimation of multibody systems. The observers based on the EKF are described by first-order differential equations, with independent, non-constrained coordinates. Therefore, it should be investigated how to formulate the equations of motion of the multibody systems so that efficient, robust and accurate observers can be derived, which can serve to develop advanced real-time applications. In the paper, two options are considered: a state-space reduction method and the penalty method. Both methods are tested on a four-bar mechanism with a linear spring-damper. The results enable us to analyze the pros and cons of each method and provide clues for future research.
Lower Airway Microbiota and Lung Cancer
( Victoria Sanchez-hellin ),( Antonio Galiana ),( Lucia Zamora-molina ),( Maria J. Soler-sempere ),( Justo Grau-delgado ),( Victor M. Barbera ),( Isabel Padilla-navas ),( Eduardo Garcia-pachon ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 한국미생물·생명공학회지 Vol.47 No.3
This study was aimed at identifying the lower airway microbiota in patients with lung cancer (LC) using protected brush sampling. We enrolled 37 patients undergoing diagnostic bronchoscopy for suspected LC, 26 with LC and 11 with benign diseases. Protected brush specimens were obtained from the contralateral lung and the side of the tumor; these specimens were analyzed by 16S rRNA-based-next-generation sequencing. The results indicated that the biodiversity was not different between groups, and there were no significant differences between the proportion of microorganisms in the tumor and in the contralateral side of patients with LC. In patients with LC, there was a higher abundance of several microorganisms including Capnocytophaga, Haemophilus, Enterococcus, and Streptococcus; whereas, in individuals without LC, Bacteroides, Lactobacillus, or Methylobacterium were more abundant. Malignancy could be determined with an accuracy of 70% by isolating Enterococcus, Capnocytophaga, or Actinomyces. Microbispora indicated benignity with a sensitivity of 55%, specificity of 88%, and accuracy of 78%. Lower airway microbiota in patients with LC is fairly similar in both the tumor and contralateral sites. Endobronchial microbiota is different in patients with and without LC, and these differences may have a potential clinical value as diagnostic or prognostic biomarkers.
Organ-on-a-Chip: The Future of Therapeutic Aptamer Research?
Tran Thoa Thi Thanh,Delgado Antonio,정세훈 한국바이오칩학회 2021 BioChip Journal Vol.15 No.2
The aptamer, known as a chemical antibody, has proven to be of high diagnostic and therapeutic value with the FDA’s first aptamer drug in 2004 and many aptamers under clinical validation. However, the clinical translation of aptamer for therapeutics has been delayed because of the limitation of using the target model during selection and a lack of information on several crucial factors, including their inherent physicochemical characterization and safety, and the function. Three-dimensional (3D) structure tissue provides proof of in-depth functionality due to their maturity and 3D complexity, enabling them to get information on the natural structure of the target for human treatment. The organ-on-a-chip integrates microfl uidic technology with 3D cell culture that possesses in vivo-like tissue-based models that have been engineered for validation to transform the commercial drug discovery. Thus, the organ-on-a-chip may off er a promising solution for the addressed problems, enhancing the clinical translation procedure for aptamer-based therapeutics. Motivated by the advantageous function of the aptamerbased organ-on-a-chip system, we update the current technology to generate aptamers using SELEX (Systematic Evolution of Ligands by EXponential Enrichment) and confi rm the application of aptamers to various long-term treatments. We can also accurately analyze the advantages of organ-on-a-chips and present the necessity of developing aptamer-based organon-a-chip systems. In this regard, the aptamer-based organ-on-a-chip is expected to increase the possibility of creating an aptamer as a therapeutic agent by more accurately selecting and verifying the aptamer that aff ects specifi c organ treatment.