A retrospective analysis of 20-year data of the surgical management of ulcerative colitis patients in Taiwan: a study of Taiwan Society of Inflammatory Bowel Disease

( Chun-chi Lin ),( Shu-chen Wei ),( Been-ren Lin ),( Wen-sy-tsai ),( Jinn-shiun Chen ),( Tzu-chi Hsu ),( Wei-chen Lin ),( Tien-yu Huang ),( Te-hsin Chao ),( Hung-hsin Lin ),( Jau-min Wong ),( Jen-kou 대한장연구학회 2016 Intestinal Research Vol.14 No.3

Background/Aims: With the recent progress in medical treatment, surgery still plays a necessary and important role in treating ulcerative colitis (UC) patients. In this study, we analyzed the surgical results and outcomes of UC in Taiwan in the recent 20 years, via a multi-center study through the collaboration of Taiwan Society of IBD. Methods: A retrospective analysis of surgery data of UC patients from January 1, 1995, through December 31, 2014, in 6 Taiwan major medical centers was conducted. The patients’ demographic data, indications for surgery, and outcome details were recorded and analyzed. Results: The data of 87 UC patients who received surgical treatment were recorded. The median post-operative follow-up duration was 51.1 months and ranged from 0.4 to 300 months. The mean age at UC diagnosis was 45.3±16.0 years and that at operation was 48.5±15.2 years. The 3 leading indications for surgical intervention were uncontrolled bleeding (16.1%), perforation (13.8%), and intractability (12.6%). In total, 27.6% of surgeries were performed in an emergency setting. Total or subtotal colectomy with rectal preservation (41.4%) was the most common operation. There were 6 mortalities, all due to sepsis. Emergency operation and low pre-operative albumin level were significantly associated with poor survival (P =0.013 and 0.034, respectively). Conclusions: In the past 20 years, there was no significant change in the indications for surgery in UC patients. Emergency surgeries and low pre-operative albumin level were associated with poor survival. Therefore, an optimal timing of elective surgery for people with poorly controlled UC is paramount.

Innovative Development and Applicability Evaluation of a Composite Tubing Fixer

Zu-Chun Lin,Yu-Ju Lin,Shu-Min Yeh,Tzu-Chuan Hsu 한국간호과학회 2023 한국간호과학회 학술대회 Vol.2023 No.11

만삭전 조기양막파열 산모에서 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향

구천회 ( Chun Hoe Ku ),박교훈 ( Kyo Hoon Park ),우헌탁 ( Hun Tack Woo ),김문영 ( Moon Young Kim ),김유미 ( You Mi Kim ),이철민 ( Chul Min Lee ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Lin Kim ),이홍균 ( Hong Kyo 대한주산의학회 2002 Perinatology Vol.13 No.2

연구목적:본 연구의 목적은 만삭전 조기양막파열 산모에서 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향을 살펴보고자 한다. 방법:조기양막파열로 입원한 임신 26주에서 35주의 단태임신 98명을 대상으로 후향적 관찰 연구를 시행하였다. 모든 대상 환자에서 입원 직후 경복부 초음파를 시행하여 양수 지수를 측정하였으며 모든 산모와 신생아 의무 기록을 검토하여 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향을 조사하였다. 양수과소증은 양수지수가 5 이하일때로 정의하였고 분만 잠복기의 정의는 양막파열부터 분만까지의 시간으로 하였다. 통계 처리는 비율의 비교는 Chi-spuare test 또는 Fisher`s exact test를 사용하였으며, 연속형 변수의 비교는 변수의 특성에 따라 Student-t test 또는 Mann-Whitney U test를 사용하였다. 결과:1) 총 98명의 연구 대상자 중 양수과소증이 존재하지 않은 군이 59명(60%)이었고 양수과소증 군은 39명(40%)이었다. 조기양막파열 산모에서 분만 주수, 분만시 신생아 체중은 양수과소증이 존재한 군에서 양수과소증이 존재하지 않은 군보다 유의하게 낮았으나 1분 아프가 점수 7점 미만의 빈도, 5분 아프가 점수 7점 미만의 빈도, 신생아 이환율 및 주산기 사망률은 두 군 사이에 유의한 차이가 없었다. 2) 조기양막파열 산모에서 양수과소증이 분만 잠복기에 미치는 영향을 알아보기 위하여 산모 및 태아적응증으로 유도분만이나 제왕절개술을 시행한 산모 73명을 제외한 25명을 대상으로 하였다. 분만 잠복기는 양수과소증이 존재하지 않은 군의 중앙값이 41.5시간으로 양수과소증이 존재한 군의 중앙값 44시간과 유의한 차이를 나타내지 않았다. 결론:만삭전 조기양막파열 산모에서 양수과소증은 불량한 주산기 예후 및 분만 잠복기와는 유의한 관련성을 나타내지 않았다. Objectives:To examine the effects of the oligohydramnios on perinatal outcome and latency period in patients with preterm premature rupture of membranes. Methods:We performed a retrospective analysis of 98 singleton pregnancies complicated by preterm premature rupture of membranes, with delivery between 26 and 35 weeks` gestation. Amniotic fluid index was determined using transabdominal ultrasound at admission. All medical records of mothers and neonates were reviewed. Oligohydramnios was defined as amniotic fluid index less or equal to 5.0cm and latency period was defined as time interval from membrane rupture to delivery. Chi-spuare test, Fisher`s exact test, Student-t test, Mann-Whitney U test were used for statistical analysis. Results:1) Of the 98 patients, 59 patients(60%) were oligohydramnios group(AFI≤5.0) and 39 patients(40%) were non-oligohydramnios group(AFI>5.0). Both groups were similar with respect to selected dermographics, gestational age at rupture of the membranes, chorioamnionitis, 1 min Apgar score and 5 min Apgar score. Patients with oligohydramnios demonstrated a lower gestatoinal age at birth and lower birth weight. There were no statistically significant correlations in neonatal morbidity and perinatal mortality between both groups. 2) For comparing latency period, we excluded deliveries of Cesarean section or induction. Comparing the remained group(25 patients), median of latency period in oligohydramnios group were 41.5 hours and median of latency period in non-oligohydramnios group were 44 hours. There were no statistically significant correlations in oligohydramnios and latency period. Conclusion:There were no significant effects of the oligohydramnios on poor perinatal outcome and latency period in patients with preterm premature rupture of membranes

COVID-19 감염병 대응 의료진용 개인보호복 착용 시 온열 심리반응: 기온과 보호수준의 영향

이도신(Do-Shin Lee),임가영(Ga-Young Lim),이혜린(Hye-Lin Lee),전영민(Young-Min Chun),이주영(Joo-Young Lee) 한국생활환경학회 2021 한국생활환경학회지 Vol.28 No.6

We aimed to evaluate discomfort levels while wearing personal protective equipment (PPE) of healthcare workers to protect from COVID-19 in a hot and humid environment. Six types of PPE (0.18~1.77 clo in thermal insulation; 0.227 ~ 0.319 kPa·m²·W<SUP>-1</SUP> in water evaporative resistance) were chosen and eight subjects (23.1 ± 3.3 y in age) were participated in a neutral (25ºC, 50%RH) and a hot and humid environment (33ºC, 70%RH). A trial consisted of 90 min (10-min rest, 60-min walking and 20-min recovery). Thermal sensation, thermal comfort, humidity sensation, shortness of breath and ratings of perceived exertions (RPE) were recorded. The results showed that the PPE were classified as three levels in terms of discomfort in 33ºC and 70%RH (Low, Middle, and High). Local thermal comfort, shortness of breath and RPE were more valid to classify the discomfort level, rather than overall thermal sensation or comfort. Furthermore, there were no relationships between thermal insulation (or water evaporative resistance) and overall thermal sensation or comfort. Using a powered air purifying respirator was beneficial in the neutral environment only. To conclude, the three levels of discomfort can be applied to improve subjective perceptions of healthcare workers who wear PPE in hot and humid environments.

Biotransformation of Ginsenoside Rb_1 to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F_2, and Compound K by Leuconostoc mesenteroides DC102

Lin-Hu Quan,Jin-Ying Piao,Jin-Woo Min,Ho-Bin Kim,Sang-Rae Kim,Dong-Uk Yang,Deok Chun Yang 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.3

Ginsenoside Rb_1is the main component in ginsenosides. It is a protopanaxadiol-type ginsenoside that has a dammarane-type triterpenoid as an aglycone. In this study, ginsenoside Rb_1 was transformed into gypenoside XVII, ginsenoside Rd, ginsenoside F_2 and compound K by glycosidase from Leuconostoc mesenteroides DC102. The optimum time for the conversion was about 72 h at a constant pH of 6.0 to 8.0 and the optimum temperature was about 30°C. Under optimal conditions, ginsenoside Rb_1was decomposed and converted into compound K by 72 h post-reaction (99%). The enzymatic reaction was analyzed by highperformance liquid chromatography, suggesting the transformation pathway: ginsenoside Rb_1→ gypenoside XVII and ginsenoside Rd→ginsenoside F_2→compound K.

Dickson Charge Pump with Gate Drive Enhancement and Area Saving

Lin, Hesheng,Chan, Wing Chun,Lee, Wai Kwong,Chen, Zhirong,Zhang, Min The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

This paper presents a novel charge pump scheme that combines the advantages of Fibonacci and Dickson charge pumps to obtain 30 V voltage for display driver integrated circuit application. This design only requires four external capacitors, which is suitable for a small-package application, such as smart card displays. High-amplitude (<6.6 V) clocks are produced to enhance the gate drive of a Dickson charge pump and improve the system's current drivability by using a voltage-doubler charge pump with a pulse skip regulator. This regulation engages many middle-voltage devices, and approximately 30% of chip size is saved. Further optimization of flying capacitors tends to decrease the total chip size by 2.1%. A precise and simple model for a one-stage Fibonacci charge pump with current load is also proposed for further efficiency optimization. In a practical design, its voltage error is within 0.12% for 1 mA of current load, and it maintains a 2.83% error even for 10 mA of current load. This charge pump is fabricated through a 0.11 μm 1.5 V/6 V/32 V process, and two regulators, namely, a pulse skip one and a linear one, are operated to maintain the output of the charge pump at 30 V. The performances of the two regulators in terms of ripple, efficiency, line regulation, and load regulation are investigated.

Health Care Utilization and Expenditures of Patients with Diabetes Comorbid with Depression Disorder: A National Population-Based Cohort Study

Chun-Jen Huang,Hui-Min Hsieh,Herng-Chia Chiu,Peng-Wei Wang,Mei-Hsuan Lee,Chih-Yi Li,Ching-Hua Lin 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6

Objective: The study investigated to compare health care utilization and expenditures between diabetic patients with and without depression in Taiwan. Methods: Health care utilization and expenditure among diabetic patients with and without depression disorder during 2000 and 2004 were examined using Taiwan’s population-based National Health Insurance claims database. Health care utilization included outpatient visits and the use of inpatient services, and health expenditures were outpatient, inpatient, and total medical expenditures. Moreover, general estimation equation models were used for analyzing the factors associated with outpatient visits and expenditures. Multiple logistic regression analysis was applied for identifying the factors associated with hospitalization. Results: The average annual outpatient visits and annual total medical expenditures in the study period were 44.23–52.20; NT$87,496–133,077 and 30.75–32.92; NT$64,411–80,955 for diabetic patients with and without depression. After adjustment for covariates, our results revealed that gender and complication were associated with out-patient visits. Moreover, the time factor was associated with the total medical expenditure, and residential urbanization and complication factors were associated with hospitalization. Conclusion: Health care utilization and expenditures for diabetic patients with depression were significantly higher than those without depression. Sex, complications, time, and urbanization are the factors associated with health care utilization and expenditures.

The Beneficial Effects of Raffinee in Permanent Occulted Stroke Mice

Chun-Ching Chiu,Jer-Min Lin,Li-Yi Wu,Tsai-Ching Hsu,Bor-Show Tzang 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.12

Ischemic stroke is a major cause of disability and mortality globally. Although thrombolytic therapy is routinely adopted in cases of ischemic stroke, various alternative natural neuroprotectants are also used as effective adjuvant therapies to recover neurofunction following ischemic stroke. Raffinee, a natural fermented product with strong antioxidant and neuroprotective activities, has antiatherogenic effects in animals and has exhibited neuroprotective effects in a clinical trial by recovering motor and sensory function following spinal cord lesion. This study reveals the advantageous effects of Raffinee on PC12 cells by decreasing hypoxia-induced apoptosis in mice with permanent middle cerebral artery occlusion (pMCAO) by increasing the levels of neurotrophic factors such as S100β, reducing serum inflammatory factors such as matrix metalloproteinases (MMP)-9/MMP-2 ratio, tumor necrosis factor-α, and interleukin (IL)-6 level, and increasing IL-10 levels. Significantly reduced brain infarct volume along with a favorable survival ratio was observed for pMCAO mice that received Raffinee, suggesting a neuroprotective potential of Raffinee in cases of acute ischemic stroke by suppressing apoptosis.

Highly anisotropic power generation in piezoelectric hemispheres composed stretchable composite film for self-powered motion sensor

Chun, Jinsung,Kang, Na-Ri,Kim, Ju-Young,Noh, Myoung-Sub,Kang, Chong-Yun,Choi, Dukhyun,Kim, Sang-Woo,Lin Wang, Zhong,Min Baik, Jeong Elsevier 2015 Nano energy Vol.11 No.-

<P><B>Abstract</B></P> <P>Highly-stretchable piezoelectric hemispheres composed composite thin film nanogenerators are fabricated as a self-powered, exceptionally sensitive sensor for providing sensitive motion information from a human body. The composite films are based on the highly-ordered piezoelectric hemispheres embedded in a soft matrix, polydimethylsiloxane (PDMS) and generate large power output up to 6V and 0.2μA/cm<SUP>2</SUP> under normal bending force. The electrical outputs increase by stacking such hemispheres layer-by-layer. The strain sensitivity of the films differs according to the bending direction, and the high sensitivity is achieved by convex bending for hemisphere composite due to the strong electric dipole alignment. The films are attached on the surface of a wrist and its output voltage/current density provides the information on the wrist motion.</P> <P><B>Graphical abstract</B></P> <P>Highly-stretchable piezoelectric composite-type nanogenerators are fabricated as a self-powered, exceptionally ultrasensitive sensor for providing sensitive direction information from a human body. The composite films are based on the highly-ordered piezoelectric hemispheres embedded in a soft matrix, polydimethylsiloxane (PDMS) and generate large power output up to 6V and 0.4µA under normal bending force. The electrical outputs increase by stacking such hemispheres layer-by-layer.</P> <P>[DISPLAY OMISSION]</P>

Biotransformation of Ginsenoside Rb₁ to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F₂, and Compound K by Leuconostoc mesenteroides DC102

Lin-Hu Quan,Jin-Ying Piao,Jin-Woo Min,Ho-Bin Kim,Sang-Rae Kim,Dong-Uk Yang,Deok Chun Yang 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.3

Ginsenoside Rb₁is the main component in ginsenosides. It is a protopanaxadiol-type ginsenoside that has a dammarane-type triterpenoid as an aglycone. In this study, ginsenoside Rb₁ was transformed into gypenoside XVII, ginsenoside Rd, ginsenoside F₂ and compound K by glycosidase from Leuconostoc mesenteroides DC102. The optimum time for the conversion was about 72 h at a constant pH of 6.0 to 8.0 and the optimum temperature was about 30℃. Under optimal conditions, ginsenoside Rb₁ was decomposed and converted into compound K by 72 h post-reaction (99%). The enzymatic reaction was analyzed by high-performance liquid chromatography, suggesting the transformation pathway: ginsenoside Rb₁→gypenoside XVII and ginsenoside Rd→ginsenoside F₂→compound K.