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      • KCI등재

        Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan

        Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4

        Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.

      • KCI등재

        Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

        An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

        Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

      • A Cross-Cultural Comparative Study of Cultural Characteristics and Informa tion Search Behaviours of Business Travellers

        Che-Chao Chiang,Min-chi Chang,Po-Tsang Chen,Fu-Ming Chiang 세계문화관광학회 2010 Conference Proceedings Vol.11 No.0

        This study examines the information searching of business travelers and their behavior based on the cultural differences. Despite growing academic interest in business travel i n recent years, there has been little investigation of the information search behaviors of business travelers in a cross-culture context. The above themes are rational assumed that information search behaviour are necessary to understand. To address the identified gap s in the literature, the proposed relationships are examined and presented through using chi-square method with a survey sample. The research sample included Japanese, English and Chinese business travellers. A self-administrated questionnaire was distributed to 211 business travelers attending international conventions in Taipei. The research findings reveal that information preferences of business travelers are significantly differed from the three recognized groups in the case of Taiwan. Some significant differences in information search behaviors were recognized amongst the three recognized respondent groups. Marketing implications were also proposed and presented.

      • SCIESCOPUS

        Curved laminate analysis

        Chiang., Yih-Cherng Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.39 No.2

        This paper is devoted to the development of the equations which describe the elastic response of a curved laminate subjected to in-plane loads and bending moments. Similar to the classic $6{\times}6$ ABD matrix constitutive relation of a flat laminate, a new $6{\times}6$ matrix constitutive relation between force resultants, moment resultants, mid-plane strains and deformed curvatures for a curved laminate is formulated. This curved lamination theory will provide the fundamental basis for the analyses of curved laminated structures. The stress predictions by the present curved lamination theory are compared to those by the curved laminate analysis that neglected the nonlinear terms in the derivation of the constitutive relation. The results show that the curved laminate analysis that neglected the nonlinear terms cannot reflect the effect of curvature and can no longer predict the stresses accurately as the curvature becomes noticeable. In this paper, a curved lamination theory that retains the nonlinear terms and, therefore, accounts for the effect of the non-flat geometry of the structure will be developed.

      • Factors Related to Treatment Refusal in Taiwanese Cancer Patients

        Chiang, Ting-Yu,Wang, Chao-Hui,Lin, Yu-Fen,Chou, Shu-Lan,Wang, Ching-Ting,Juang, Hsiao-Ting,Lin, Yung-Chang,Lin, Mei-Hsiang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

        Background: Incidence and mortality rates for cancer have increased dramatically in the recent 30 years in Taiwan. However, not all patients receive treatment. Treatment refusal might impair patient survival and life quality. In order to improve this situation, we proposed this study to evaluate factors that are related to refusal of treatment in cancer patients via a cancer case manager system. Materials and Methods: This study analysed data from a case management system during the period from 2010 to 2012 at a medical center in Northern Taiwan. We enrolled a total of 14,974 patients who were diagnosed with cancer. Using the PRECEDE Model as a framework, we conducted logistic regression analysis to identify independent variables that are significantly associated with refusal of therapy in cancer patients. A multivariate logistic regression model was also applied to estimate adjusted the odds ratios (ORs) with 95% confidence intervals (95%CI). Results: A total of 253 patients (1.69%) refused treatment. The multivariate logistic regression result showed that the high risk factors for refusal of treatment in cancer patient included: concerns about adverse effects (p<0.001), poor performance(p<0.001), changes in medical condition (p<0.001), timing of case manager contact (p=.026), the methods by which case manager contact patients (p<0.001) and the frequency that case managers contact patients (${\geq}10times$) (p=0.016). Conclusions: Cancer patients who refuse treatment have poor survival. The present study provides evidence of factors that are related to refusal of therapy and might be helpful for further application and improvement of cancer care.

      • SSCISCOPUSKCI등재
      • SCIESCOPUSKCI등재

        The Effect of Wet Pad and Forced Ventilation House on the Reproductive Performance of Boar

        Chiang, S.H.,Hsia, L.C. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.1

        There were two trials involved in the experiment. Trial 1: the trial was conducted on two Taiwan Sugar Corporation (TSC) pig farms. One was located in the north of Taiwan and the other was located in the south. Both farms had wet pad and forced ventilation (WPFV) and conventional open design (COD) boar and sow houses. There were 12 Duroc boars, age ranging from 12-24 months. Half of them (6 boars) were raised in a WPFV pig house, and the other half were kept in a COD house. Semen was collected at 5-day intervals from May $1^{st}$ to the end of October. Sixteen sows (2-8 parity) were served by artificial insemination each week from the beginning of May to the end of Oct. These sows were checked for heat from 18 days to 25 days after insemination. Trial 2: there were four MPFV boar houses involved in the test. Two houses were located in the north of Taiwan, and the other two houses were located in the south. The test was conducted from January 2000 to December 2001. The total number of serviced sows by MPFV-housed boars was 35,105 head and for COD-housed boars 103,065 head. The results showed that the total semen volume, density of sperm, total sperm per ejaculate, sperm motility and morphological abnormality were significantly better (p<0.01) for boar raised in WPFV house than for COD houses. Average sperm motility in June and July was lower than for the other months. Morphological abnormality was higher during May, June and July. Although the results did not reach a significant level, the average value showed that the total volume of boar semen was higher in the north than for the south. The total semen volume production of boar raised in WPFV was higher than for boars raised in COD house, reaching a significant level only in summer. Boars kept in WPFV house had higher total sperm number than boars kept in COD house, reaching a significant level in spring (p<0.05), summer (p<0.01), and fall (p<0.05) but not in winter (p>0.05). Boars raised in WPFV house had significantly higher sperm motility than boars in COD house during spring (p<0.001), summer (p<0.001), fall (p<0.01) and winter (p<0.05). The average farrowing rate and piglets born alive were higher for boars in WPFV house than for boars in COD house, but neither reached a significant level (p>0.05). The present experiment shows that WPFV house can improve the reproduction performance of boars.

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