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RISS 인기검색어
- 검색키워드
- 저자 : Wen-Fang Cheng (검색결과 27 건)
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Cheng Mei-Fang,Guo Yue Leon,Yen Ruoh-Fang,Wu Yen-Wen,Wang Hsiu-Po 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.6
Objective: To investigate whether the levels of inflammation detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) can predict disease relapse in immunoglobulin G4-related disease (IgG4-RD) patients receiving standard induction steroid therapy. Materials and Methods: This prospective study analyzed pretherapy FDG PET/CT images from 48 patients (mean age, 63 ± 12.9 years; 45 males and 3 females) diagnosed with IgG4-RD between September 2008 and February 2018, who subsequently received standard induction steroid therapy as the first-line treatment. Multivariable Cox proportional hazards models were used to identify the potential prognostic factors associated with relapse-free survival (RFS). Results: The median follow-up time for the entire cohort was 1913 days (interquartile range [IQR], 803–2929 days). Relapse occurred in 81.3% (39/48) patients during the follow-up period. The median time to relapse was 210 days (IQR, 140–308 days) after completion of standardized induction steroid therapy. Among the 17 parameters analyzed, Cox proportional hazard analysis identified whole-body total lesion glycolysis (WTLG) > 600 on FDG-PET as an independent risk factor for disease relapse (median RFS, 175 vs. 308 days; adjusted hazard ratio, 2.196 [95% confidence interval: 1.080–4.374]; P = 0.030). Conclusion: WTLG on pretherapy FDG PET/CT was the only significant factor associated with RFS in IgG-RD patients receiving standard steroid induction therapy.
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( Wen-fang Cheng ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
The over-expression of CHI3L1 has been identified in various types of malignancies, however the role of CHI3L1 in ovarian cancer is still unknown. We evaluated the feasibility of using CHI3L1 expression as a prognostic biomarker for patients with epithelial ovarian carcinoma. The possible biological functions of CHI3L1 in ovarian cancer were also elucidated. The expression levels of CHI3L1 in cancerous tissues were higher than those in normal tissues. The expression levels of CHI3L1 were also higher in the patients with a serous histological type, advanced stage, and chemo-resistance. The patients with a high CHI3L1 expression had significantly shorter progression-free survival and overall survival in Kaplan-Meier survival analysis. The patients with a high CHI3L1 expression also had a significant risk of recurrence and death in multivariate Cox regression analysis. In vitro studies showed that CHI3L1 up-regulated the expression of anti-apoptotic Mcl-1 protein and hampered paclitaxel-induced apoptosis of ovarian cancer cells. CHI3L1 shows potential as a prognostic biomarker for epithelial ovarian carcinoma. In addition, it may also promote chemo-resistance via inhibiting drug-induced apoptosis by up-regulating Mcl-1.
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Fang-Ying Chiu,Duen-Pang Kuo,Yung-Chieh Chen,Yu-Chieh Kao,Hsiao-Wen Chung,Cheng-Yu Chen 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.6
Objective: The aim of this study was to investigate diffusion tensor (DT) imaging-derived properties of benign oligemia, true “at risk” penumbra (TP), and the infarct core (IC) during the first 3 hours of stroke onset. Materials and Methods: The study was approved by the local animal care and use committee. DT imaging data were obtained from 14 rats after permanent middle cerebral artery occlusion (pMCAO) using a 7T magnetic resonance scanner (Bruker) in room air. Relative cerebral blood flow and apparent diffusion coefficient (ADC) maps were generated to define oligemia, TP, IC, and normal tissue (NT) every 30 minutes up to 3 hours. Relative fractional anisotropy (rFA), pure anisotropy (rq), diffusion magnitude (rL), ADC (rADC), axial diffusivity (rAD), and radial diffusivity (rRD) values were derived by comparison with the contralateral normal brain. Results: The mean volume of oligemia was 24.7 ± 14.1 mm3, that of TP was 81.3 ± 62.6 mm3, and that of IC was 123.0 ± 85.2 mm3 at 30 minutes after pMCAO. rFA showed an initial paradoxical 10% increase in IC and TP, and declined afterward. The rq, rL, rADC, rAD, and rRD showed an initial discrepant decrease in IC (from -24% to -36%) as compared with TP (from -7% to -13%). Significant differences (p < 0.05) in metrics, except rFA, were found between tissue subtypes in the first 2.5 hours. The rq demonstrated the best overall performance in discriminating TP from IC (accuracy = 92.6%, area under curve = 0.93) and the optimal cutoff value was -33.90%. The metric values for oligemia and NT remained similar at all time points. Conclusion: Benign oligemia is small and remains microstructurally normal under pMCAO. TP and IC show a distinct evolution of DT-derived properties within the first 3 hours of stroke onset, and are thus potentially useful in predicting the fate of ischemic brain.
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Application of nanofiltration membrane in the recovery of aluminum from alkaline sludge solutions
Cheng, Wen Po,Chi, Fung Hwa,Yu, Ruey Fang,Tian, Dun Ren Techno-Press 2016 Advances in environmental research Vol.5 No.2
Large amounts of aluminum hydroxide ($Al(OH)_3$) exist in water purification sludge (WPS) because of the added aluminum coagulant in water treatment process. Notably, $Al(OH)_3$ is an amphoteric compound, can be dissolved in its basic condition using sodium hydroxide to form aluminate ions ($Al(OH)_4{^-}$). However, in a process in which pH is increasing, the humid acid can be dissolved easily from WPS and will inhibit the recovery and reuse of the dissolved aluminate ions. This study attempts to fix this problem by a novel approach to separate $Al(OH)_4{^-}$ ions using nanofiltration (NF) technology. Sludge impurity in a alkaline solution is retained by the NF membrane, such that the process recovers $Al(OH)_4{^-}$ ions, and significantly decreases the organic matter or heavy metal impurities in the permeate solution. The $Al(OH)_4{^-}$ ion is an alkaline substance. Experimental results confirm that a recovered coagulant of $Al(OH)_4{^-}$ ion can effectively remove kaolin particles from slightly acidic synthetic raw water.
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The acrosswind response of the downwind prism in a twin-prism system with a staggered arrangement
Fang, Fuh-Min,Chung, Cheng-Yang,Li, Yi-Chao,Liu, Wen-Chin,Lei, Perng-Kwei Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.17 No.3
The flow interaction between two identical neighboring twin square prisms in a staggered arrangement in an open terrain was investigated experimentally. The downwind prism was mounted on a rigid-aeroelastic setup in an open-terrain boundary layer flow to measure its acrosswind root-mean-square responses and aerodynamic damping ratios. By varying the relative location of the upwind prism and the Scruton number associated with the downwind prism, the acrosswind aeroelastic behavior of the downwind prism was analyzed and compared to that of an isolated one. Results showed that the acrosswind root-mean-square response of the downwind prism could be either suppressed or enhanced by the wake flow produced by the neighboring upwind prism. Besides the assessment of the wake effect of the downwind prism, finally, regressed relationships were presented to describe the variation of the aerodynamic damping ratio so as to predict its acrosswind fluctuating response numerically.
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Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4
Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.
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The acrosswind response of the downwind prism in a twin-prism system with a staggered arrangement
Fuh-Min Fang,Perng-Kwei Lei,Cheng-Yang Chung,Yi-Chao Li,Wen-Chin Liu 한국풍공학회 2013 한국풍공학회지 Vol.17 No.3
The flow interaction between two identical neighboring twin square prisms in a staggered arrangement in an open terrain was investigated experimentally. The downwind prism was mounted on a rigid-aeroelastic setup in an open-terrain boundary layer flow to measure its acrosswind root-mean-square responses and aerodynamic damping ratios. By varying the relative location of the upwind prism and the Scruton number associated with the downwind prism, the acrosswind aeroelastic behavior of the downwind prism was analyzed and compared to that of an isolated one. Results showed that the acrosswind root-mean-square response of the downwind prism could be either suppressed or enhanced by the wake flow produced by the neighboring upwind prism. Besides the assessment of the wake effect of the downwind prism, finally, regressed relationships were presented to describe the variation of the aerodynamic damping ratio so as to predict its acrosswind fluctuating response numerically.
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Po-Han Lin,Yun-Wen Tien,Wen-Fang Cheng,Ying-Cheng Chiang,Chien-Huei Wu,Karen Yang,Chiun-Sheng Huang 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5
Objective: Genetic high-risk assessment combines hereditary breast, ovarian and pancreatic cancer into one syndrome. However, there is a lack of data for comparing the germline mutational spectrum of the cancer predisposing genes between these three cancers. Methods: Patients who met the criteria of the hereditary breast, ovarian and pancreatic cancer were enrolled and received multi-gene sequencing. Results: We enrolled 730 probands: 418 developed breast cancer, 185 had ovarian cancer, and 145 had pancreatic cancer. Out of the 18 patients who had two types of cancer, 16 had breast and ovarian cancer and 2 had breast and pancreatic cancer. A total of 167 (22.9%) patients had 170 mutations. Mutation frequency in breast, ovarian and pancreatic cancer was 22.3%, 33.5% and 17.2%, respectively. The mutation rate was significantly higher in patients with double cancers than those with a single cancer (p<0.001). BRCA1 and BRCA2 were the most dominant genes associated with hereditary breast and ovarian cancer, whereas ATM was the most prevalent gene related to hereditary pancreatic cancer. Genes of hereditary colon cancer such as lynch syndrome were presented in a part of patients with pancreatic or ovarian cancer but seldom in those with breast cancer. Families with a history of both ovarian and breast cancer were associated with a higher mutation rate than those with other histories. Conclusion: The mutation spectrum varies across the three cancer types and family histories. Our analysis provides guidance for physicians, counsellors, and counselees on the offer and uptake of genetic counseling.
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