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고속액체크로마토그래피에 의한 나프록센 광학이성질체의 분리 및 품질관리
정수진,진전성,이은주,이은실,강종성 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
Enantiomeric separation of naproxen is necessary in drug evaluation processes as the pharmacological activity of naproxen resides mainly in the (S)-enantiomer, The enantioseparation of naproxen was carried out with three different stationary phases. The methods were validated with the terms of linearity, intraday and interday precision, accuracy, selectivity and recovery. Among the selected stationary phases, ChiroSil DMB column with hexane : t-butylmethylether : acetic acid (60:40:0.1, v/v/v) as mobile phase showed the best enantioseparation of the naproxen in the commercial preparations. The wavelength for detection was 270 nm and flow rate was 2.0 mL/min. The contents of (S)-naproxen in the commercial preparations were 92.7 - 98.3%, indicating that all tested preparations were satisfactory to current regulation. However, the contents of (R)-naproxen as impurity in the commercial preparations were varied from 0.08% to 1.08%.
토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험
황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1
This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.
Random vibration analysis of structures by a time-domain explicit formulation method
Su, Cheng,Xu, Rui Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2
Non-stationary random vibration of linear structures with uncertain parameters is investigated in this paper. A time-domain explicit formulation method is first presented for dynamic response analysis of deterministic structures subjected to non-stationary random excitations. The method is then employed to predict the random responses of a structure with given values of structural parameters, which are used to fit the conditional expectations of responses with relation to the structural random parameters by the response surface technique. Based on the total expectation theorem, the known conditional expectations are averaged to yield the random responses of stochastic structures as the total expectations. A numerical example involving a frame structure is investigated to illustrate the effectiveness of the present approach by comparison with the power spectrum method and the Monte Carlo simulation method. The proposed method is also applied to non-stationary random seismic analysis of a practical arch bridge with structural uncertainties, indicating the feasibility of the present approach for analysis of complex structures.
An Online Response System for Anomaly Traffic by Incremental Mining with Genetic Optimization
Su, Ming-Yang,Yeh, Sheng-Cheng The Korea Institute of Information and Commucation 2010 Journal of communications and networks Vol.12 No.4
A flooding attack, such as DoS or Worm, can be easily created or even downloaded from the Internet, thus, it is one of the main threats to servers on the Internet. This paper presents an online real-time network response system, which can determine whether a LAN is suffering from a flooding attack within a very short time unit. The detection engine of the system is based on the incremental mining of fuzzy association rules from network packets, in which membership functions of fuzzy variables are optimized by a genetic algorithm. The incremental mining approach makes the system suitable for detecting, and thus, responding to an attack in real-time. This system is evaluated by 47 flooding attacks, only one of which is missed, with no false positives occurring. The proposed online system belongs to anomaly detection, not misuse detection. Moreover, a mechanism for dynamic firewall updating is embedded in the proposed system for the function of eliminating suspicious connections when necessary.
Cheng-gang Ci,Hong-bo Yu,Su-qin Wan,Jing-yao Liu,Chia-Chung Sun 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The hydrogen abstraction reaction of CF_3CH_2CHO + OH has been studied theoretically by dual-level direct dynamics method. Two stable conformers, trans- and cis-CF_3CH_2CHO, have been located, and there are four distinct OH hydrogen-abstraction channels from t-CF_3CH_2CHO and two channels from c-CF_3CH_2CHO. The required potential energy surface information for the kinetic calculation was obtained at the MCG3-MPWB//M06-2X/aug-cc-pVDZ level. The rate constants, which were calculated using improved canonical transitionstate theory with small-curvature tunneling correction (ICVT/SCT) were fitted by a four-parameter Arrhenius equation. It is shown that the reaction proceeds predominantly via the H-abstraction from the -CHO group over the temperature range 200-2000 K. The calculated rate constants were in good agreement with the experimental data between 263 and 358 K.