Absorptive capacity, appropriability depth and new product development in Taiwanese service firms

Chen Min-Nan,Chang Yuan-Chieh 기술경영경제학회 2019 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.27 No.1

Absorptive capacity and appropriability depth are two concepts based on a firm’s capabilities that leverage external knowledge to facilitate new product development performance. This study analyzes the joint effects of absorptive capacity and depth of appropriability regime forms on a firm’s new product development. Specifically, we distinguished absorptive capacity between the potential and realized absorptive capacities and appropriability depth as formal and strategic forms. To test our research hypotheses, we analyzed empirical evidence from 311 Taiwanese service firms. The results reveal that the potential and realized absorptive capacities have significant effects that help explain a firm’s new product development. Additionally, there are moderating effects of absorptive capacity on new product development performance. The formal appropriability depth exerts a positive effect on the relationship between the realized absorptive capacity and a firm’s new product development. The strategic appropriability depth positively moderates the influence of the potential absorptive capacity on a firm’s new product development. Finally, the study concludes that complementary nature of absorptive capacity and appropriability strength plays a critical role in contributing to new product development.

The Effects of ALA-PDT on Leukemia Cells and Hepatoma Cells

Chen, Ji-Yao,Ren, Qing-Guang,Wu, Su-Min,Wang, Pei-Nan Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

S-aminolevulinic acid (ALA) is a new kind drug used in photodynamic therapy. ALA-PDT have successfully used in superficial malignancies and some skin diseases. Here the effects of ALA-PDT were studied on leukemia cells and hepatoma cells to explore the application on different kind cancers. It was found from the fluorescence emission spectra, that after ALA incubation the sensitizer - protoporphyrin IX (PpIX) was endogenously produced in both leukemia and hepatoma cells. The fluorescence images showed that the PpIX distribute in cytoplasm. However the efficiency of ALA photodynamic inactivation to two cell lines was different. The leukemia cells were more sensitive for ALA-PDT than hepatoma cells, revealing that the ALA-PDT effect is cell line dependent. However by using ALA-Hexyl ester (He-ALA) instead of ALA, the cell photo-inactivation was improved. The PDT efficiency of He-ALA was 10 times high than that of ALA, showing He-ALA is a very promising drug in ALA-PDT.

Switching Noise Suppression for Hybrid IGBT Modules

Nan Zhu,Dehong Xu,Xingyao Zhang,Min Chen,Seiki Igarashi,Tatsuhiko Fujihira 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

In a hybrid IGBT module with SiC diodes as free-wheeling diodes, high frequency oscillation occurs during turn-on, which will cause higher EMI noise due to the larger capacitance of SiC diode. To evaluate the influence of gate drive parameters on turn-on oscillation, different gate voltages and gate charge currents are used. It is found that by changing gate drive parameters alone cannot reduce the settling time of the oscillation significantly. Then an oscillation suppression method with damping circuits is proposed. According to the analytical and experimental results, the damping circuits are able to effectively accelerate the damping of turn-on oscillation without significant increase in current overshoot and turnon energy loss. Finally to suppress the turn-on current overshoot, active gate driver method is also used without large increase in the turn-on energy loss. The combination of damping circuit and active gate driver may be an optimized choice to achieve the lowest EMI noise.

Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes

Xiao-Lin Liu,Ya-Nan Ming,Jing-Yi Zhang,Xiao-Yu Chen,Min-De Zeng,Yi-Min Mao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to establish nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH) and NAFL+type 2 diabetes mellitus (T2DM) in rat models, respectively. Transcriptomics and metabolomics analyses were performed in rat livers and serum. A functional network-based regulation model was constructed using Cytoscape with information derived from transcriptomics and metabolomics. The results revealed that 96 genes, 17 liver metabolites and 4 serum metabolites consistently changed in different NAFLD phenotypes (42-fold, Po0.05). Gene-metabolite network analysis identified ccl2 and jun as hubs with the largest connections to other genes, which were mainly involved in tumor necrosis factor, P53, nuclear factor-kappa B, chemokine, peroxisome proliferator activated receptor and Toll-like receptor signaling pathways. The specifically regulated genes and metabolites in different NAFLD phenotypes constructed their own networks, which were mainly involved in the lipid and fatty acid metabolism in HFD models, the inflammatory and immune response in MCDD models, and the AMPK signaling pathway and response to insulin in HFD+STZ models. Our study identified networks showing the general and specific characteristics in different NAFLD phenotypes, complementing the genetic and metabolic features in NAFLD with hepatic and extra-hepatic manifestations.

Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi

( Yan Huang ),( Zhuo Lu ),( Min Ma ),( Nan Liu ),( Yi Jun Chen ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.8

Diketoreductase (DKR) from Acinetobacter baylyi contains two tryptophan residues at positions 149 and 222. Trp-149 and Trp-222 are located along the entry path of substrate into active site and at the dimer interface of DKR, respectively. Single and double substitutions of these positions were generated to probe the roles of tryptophan residues. After replacing Trp with Ala and Phe, biochemical and biophysical characteristics of the mutants were thoroughly investigated. Enzyme activity and substrate binding affinity of W149A and W149F were remarkably decreased, suggesting that Trp-149 regulates the position of substrate at the binding site. Meanwhile, enzyme activity of W222F was increased by 1.7-fold while W222A was completely inactive. In addition to lower thermostability of Trp-222 mutants, molecular modeling of the mutants revealed that Trp-222 is vital to protein folding and dimerization of the enzyme. [BMB Reports 2012; 45(8): 452-457]

배달앱의 구매의사결정과정에 대한 통합적 접근 : AIDA모델과 MGB를 중심으로

송학준(Song, Hak-Jun),윤민철(Youn, Min-Chul),진남(Chen, Nan) 한국호텔외식관광경영학회 2019 호텔경영학연구 Vol.28 No.4

Recent Developments in the Effects of Different Dopants on the Structure and Property of Lithium Titanate Material

Xi-Yang Li,Qian-Lin Chen,Min Yang,Ya-Nan Li,Jing-Bo Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3

The lithium titanium spinel Li4Ti5O12 has attracted more and more attention as anode materials applied in lithium ion batteries. Li4Ti5O12 material has been found to be able to intercalate lithium ions without deformation of the lattice. However, compared with graphite and other anode materials, the low conductivity of Li4Ti5O12 restricts its charging and discharging rate. Doping is deemed to be a businesslike method to enhance ionic and electronic conductivity of Li4Ti5O12. This paper reviews the effects of Li4Ti5O12 with different doping ions on different crystal lattice states. And it has been found by a summary that the doping objective of doping ions at Li4Ti5O12 is also different. Moreover, the applications of ion doping in different fields of Li4Ti5O12 are prospected.

Expression Vectors for Human-mouse Chimeric Antibodies

Hua Xiong,Yu Liang Ran,Jin Liang Xing,Xiang Min Yang,Yu Li,Zhi Nan Chen 한국생활환경학회 2005 BMB Reports Vol.38 No.4

Comparing Outcomes of Banana-Shaped and Straight Cages in Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis

Guang-Xun Lin,Li-Ru He,Jin-Niang Nan,Wen-Bin Xu,Keyi Xiao,Zhiqiang Que,Shang-Wun Jhang,Chien-Min Chen,Ming-Tao Zhu,Gang Rui 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: This meta-analysis aims to refine the understanding of the optimal choice between different cage shapes in transforaminal lumbar interbody fusion (TLIF) by systematically comparing perioperative data, radiological outcomes, clinical results, and complications associated with banana-shaped and straight bullet cages. Methods: A meticulous literature search encompassing PubMed, Embase, Scopus, Web of Science, China Knowledge Network, and Wanfang Data was executed up to October 5, 2023. Inclusion criteria focused on studies comparing banana-shaped and straight bullet cages in TLIF. The quality of included studies was assessed using appropriate tools such as the Newcastle-Ottawa Scale (NOS) for nonrandomized studies. Rigorous evaluations were performed for radiographic outcomes, including disc height (DH), segmental lordosis (SL), lumbar lordosis (LL), subsidence, and fusion rates. Clinical outcomes were meticulously evaluated using visual analogue scale (VAS), Oswestry Disability Index (ODI), and complications. Results: The analysis incorporated 7 studies, involving 573 patients (297 with banana-shaped cages, 276 with straight cages), all with NOS ratings exceeding 5 stars. No statistically significant differences were observed in operative time, blood loss, or hospitalization between the 2 cage shapes. Banana-shaped cages exhibited greater changes in DH (p = 0.001), SL (p = 0.02), and LL (p = 0.01). Despite statistically higher changes in ODI for straight cages (26.33, p < 0.0001), the actual value remained similar to banana-shaped cages (26.15). Both cage types demonstrated similar efficacy in VAS, complication rates, subsidence, and fusion rates. Conclusion: Although banana-shaped cages can excel in restoring DH, SL, and LL, straight bullet cages can provide comparable functional improvements, pain relief, and complication rates.