FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway

Jing Xiang,Niu Shuai,Liang Yi,Chen Huiping,Wang Ning,Peng Youmei,Ma Fang,Yue Wanying,Wang Qingduan,Chang Junbiao,Zhang Yi,Zhang Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Previously, we published that 4'-azid-2'-deoxy-2'-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. Objective: This study aimed to further explore the role and molecular mechanism of FNC in non-small cell lung cancer (NSCLC). Methods: FNC was tested in the NSCLC H460 cell line, the Lewis mouse model, and the H460 cell xenograft model. The effects of FNC were assessed by cell viability, transwell migration, and wound scratch analyses of cell migration and invasion. Apoptosis was assessed by flow cytometry. Proteins expression was assessed by western blot and immunohistochemistry staining (IHC). Results: FNC inhibits the proliferation and metastasis of H460 cells in a time- and dose-dependent manner. FNC treatment showed efficacy and low toxicity in the Lewis mouse lung cancer model as well as in the H460 cell xenograft model. Further, FNC induced H460 cell apoptosis through the activation of the mitochondrial pathway. Notably, FNC inhibited invasion by increasing E-cadherin protein and reducing the protein expression of VEGF, MMP-2, MMP-9, and CD31. Conclusion: FNC inhibits NSCLC by activating the mitochondrial apoptosis pathway and regulating the expressions of multiple proteins related to cell adhesion and invasion, highlighting its potential as an NSCLC therapeutic.

Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities

Jing Yi Yu,Xiao Long He,Santhosh Puthiyakunnon,Liang Peng,Yan Li,Li Sha Wu,Wen Ling Peng,Ya Zhang,Jie Gao,Yao Yuan Zhang,Swapna Boddu,Min Long,Hong Cao,Sheng He Huang 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.10

Spatial analysis of tuberculosis treatment outcomes in Shanghai: implications for tuberculosis control

Zhang Jing,Shen Xin,Yang Chongguang,Chen Yue,Guo Juntao,Wang Decheng,Zhang Jun,Lynn Henry,Hu Yi,Pan Qichao,Zhang Zhijie 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: Tuberculosis (TB) treatment outcomes are a key indicator in the assessment of TB control programs. We aimed to identify spatial factors associated with TB treatment outcomes, and to provide additional insights into TB control from a geographical perspective.METHODS: We collected data from the electronic TB surveillance system in Shanghai, China and included pulmonary TB patients registered from January 1, 2009 to December 31, 2016. We examined the associations of physical accessibility to hospitals, an autoregression term, and random hospital effects with treatment outcomes in logistic regression models after adjusting for demographic, clinical, and treatment factors.RESULTS: Of the 53,475 pulmonary TB patients, 49,002 (91.6%) had successful treatment outcomes. The success rate increased from 89.3% in 2009 to 94.4% in 2016. The successful treatment outcome rate varied among hospitals from 78.6% to 97.8%, and there were 12 spatial clusters of poor treatment outcomes during the 8-year study period. The best-fit model incorporated spatial factors. Both the random hospital effects and autoregression terms had significant impacts on TB treatment outcomes, ranking 6th and 10th, respectively, in terms of statistical importance among 14 factors. The number of bus stations around the home was the least important variable in the model.CONCLUSIONS: Spatial autocorrelation and hospital effects were associated with TB treatment outcomes in Shanghai. In highly-integrated cities like Shanghai, physical accessibility was not related to treatment outcomes. Governments need to pay more attention to the mobility of patients and different success rates of treatment among hospitals.

Comparison of virgin and reused 15-5 PH stainless steel powders for laser powder bed fusion process

Zhang, Jing,Hu, Bin,Zhang, Yi,Guo, Xingye,Wu, Linmin,Park, Hye-Yeong,Lee, Je-Hyun,Jung, Yeon-Gil Springer-Verlag 2018 Progress in additive manufacturing Vol.3 No.1

Vehicle Stability Enhancement Using Active Front Steering System

Jing-Yi Zhang,Dong-Ji Xuan,Yang-Hai Nan,Young-Bae Kim 한국자동차공학회 2007 한국자동차공학회 지부 학술대회 논문집 Vol.- No.-

This paper investigates a control strategy of active front wheel steering based on quantitative feedback theory (QFT). By incorporating feedback from yaw rate sensor into active steering system, the control system improves the dynamic responses of the vehicle. A multi degree-of-freedom nonlinear model is co-simulated by MATLAB Simulink and ADAMS/CAR. The performance of the control system is evaluated under various emergency maneuvers and road conditions shows that the designed robust control system has good control performance and can efficiently improve the handing qualities and stability characteristics.

Fault Detection Based on Graph Model for Dead Zone of Steam Turbine Control Valve

Yi-Jing Zhang,Ye Yuan,Li-Sheng Hu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8

The abnormal control valve dead zone in the steam turbine causes system oscillation severely, affecting the stable power generation of the power plant. In this study, a graph model is developed, and it can not only detect multiple faults at a time but also reduce the dependence on statistics. The graph topology of the steam turbine is built, including the process nodes and fault node indicating process variables and valve dead zone. Moreover, the graph convolution operation is conducted to classify the faulty and normal conditions. As a result, the simulation and experimental examples demonstrate that the accuracy of dead zone detection reaches 90% and 89% respectively, surpassing Multilayer Perceptron and Principal Component Analysis. The high-precision dead zone detection rate ensures that the method can be effectively applied to industry and improve economic benefits and operation safety.

태극권 운동이 여성 노인의 일상 체력과 면역 기능에 미치는 영향

장징이 ( Jing-yi Zhang ),김경래 ( Kyeong-lae Kim ),서한교 ( Han-kyo Seo ),안민지 ( Min-ji An ) 한국리듬운동학회 2019 한국리듬운동학회지 Vol.12 No.1

The purpose of this study was to provide basic data necessary for development of TaiChi exercise program and to provide basic data for the health maintenance of the elderly women by analyzing the effects of 18weeks TaiChi on physical fitness and immune functions of elderly women. 30 female subjects were randomly assigned to 2 groups, i.e., TaiChi exercise training group 15, control group 15. Informed consent was obtained from all subjects before enrollment into this study. All subjects participated in pre-test and post-test, that is., physical fitness test(muscle strength, muscular endurance, cardiovascular endurance, range of motion and balance), and immune functions test(IL-2, IFN-γ, IgM, IgA and IgG). Exercise training was performed 5 times per week, for 60minutes each time, for 18 weeks. A paired-sample t-test and an independent-sample t-test were conducted with the SPSS Ver. 23.0 statistic program to test of physical fitness and immune functions and differences in changes between the groups before and after exercise. The results of this study were as follows. Firts, in the changes of physical fitness variables after 18 weeks exercise training, there improved significantly of cardiovascular endurance, range of motion and balance in elderly women. Exercise group revealed exhibited significant differences statistically, but control group showed few changes during the experiment. Second, in the changes of immune functions variables after 18 weeks exercise training, there increased significantly of IFN-γ, IgA, IgG. Exercise group revealed exhibited significant differences statistically, but control group showed few changes during the experiment. In conclusion, TaiChi exercise program for 18 weeks improved in physical fitness in elderly women and positively affected immune functions-related cytokine and immunoglobulin.

HIIT 프로그램 적용이 비만 여중생의 신체구성과 체력에 미치는 효과

장징이(Zhang, Jing Yi),김창영(Kim, Chang Young),이민기(Lee, Min Ki),안민지(An, Min Ji) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.11

이 연구는 8주 동안의 HIIT(고강도 인터벌 트레이닝) 프로그램의 적용이 비만 여자 중학생의 신체구성과 체력에 미치는 효과를 분석하여, 학교 현장에서 청소년 비만을 예방하고 관리하는데 필요한 기초 자료를 제공하고자 한다. 연구 목적을 달성하기 위하여 충북 C시에 소재한 K중학교 2학년 여학생 24명을 임의로 선정한 후, 운동집단과 통제집단에 각각 12명씩 무선 배정하고 고강도 인터벌 트레이닝 전ㆍ후 신체구성과 체력을 측정하였다. 고강도 인터벌 트레이닝은 주3회 20분씩, 8주간 실시하였으며, t검증을 이용해 집단 내, 집단 간 차이를 분석하였으며, 연구 결과는 다음과 같다. 첫째, 실험 후 운동집단의 체중과 체지방률은 유의하게 감소하였고, 체지방 체중에는 차이가 나타나지 않았다. 둘째, 실험 후 운동집단의 체지방률이 통제집단에 비해 통계적으로 유의하게 감소하였다. 셋째, 실험 후 운동집단의 심폐지구력과 근지구력이 유의한 차이로 향상되었으며, 근력, 유연성, 순발력에서는 차이가 나타나지 않았다. 넷째, 운동집단의 심폐지구력이 통제집단에 비해 통계적으로 유의하게 향상되었다. The aim of this study was to investigate the influence of the exercise program that applied the 8 weeks of HIIT method on the body composition and physical fitness in obese middle school students. In order to accomplish the aim of this study, 24 2nd grade female students at K middle school located in Cheongju city, Chungbuk-do, were selected at random and the allocated 12 students each for the exercise group and control group and measured body composition and physical fitness before and after the HIIT. HIIT program is implemented for twenty minutes of three times each week for 8 weeks and the t-test was used to analyze the difference in the group and between the groups. Looking into the changes of body composition before and after the exercise group that participated regularly to the 8-week HIIT program, the weight and % body fat were noticeably reduced after the experiment and there was no difference in the fat free mass. Looking into the difference of exercise group and control group, the % bofy fat of the exercise group after the experiment was noticeably reduced statistically compared to the control group. Looking into the changes of physical fitness before and after the exercise group that participated regularly to the 8-week HIIT program, the cardiorespiratory endurance and muscular endurance of the exercise group after the experiment was noticeably improved and there was no difference with respect to the muscle strength, flexibility, and agility. Looking into the difference of exercise group and control group, the cardiorespiratory endurance of the exercise group after the experiment was noticeably improved statistically compared to the control group.

Historical Long-term Exposure to Pentachlorophenol Causing Risk of Cancer - A Community Study

Zheng, Rui-Zhi,Zhang, Qing-He,He, Yi-Xin,Zhang, Qian,Yang, Lin-Shen,Zhang, Zhi-Hua,Zhang, Xiu-Jun,Hu, Jing-Ting,Huang, Fen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Background: Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. However, few studies have focused on associations between PCP and cancer risk at the community level. Objective: The present study was to explore the cancer risk for the community population living long-term in a PCP contaminated area. Methods: All the cancer cases diagnosed in 2009-2011 in Tongling City were collected. The cancer patients' residencies were geo-referenced in each district. The historical PCP usage for each district of Tongling was calculated as the PCP pollution index, which was further used to divide into PCP exposure categories. Standardized rate ratios (SRRs) of cancer incidence were applied to detect the cancer risk as exposure grade elevated. Correlation analysis was performed to analyze the relationship between PCP pollution and cancer incidence. Results: A total of 5,288 cancer cases (3,451 male and 1,837 female) were identified. PCP usage was correlated with the incidence of leukemia (r=0.88, P=0.002) for males, and with cancer of the esophagus for males (r=0.83, P=0.008) and females (r=0.71, P=0.020). Compared with the low exposure category, significant SRRs for total cancer sites was obtained for high PCP exposure category (SRR=1.61, 95%CI=1.59-1.62). Most SRR values of the cancer sites were significantly increased as exposure grade elevated and exposure time extended. Conclusion: The present study found that community residents living in the PCP contaminated area had increased risk of cancers. Leukemias, lymphomas and nasopharyngeal and esophageal cancers are most possibly associated with PCP exposure.

A New Method to Measure the Conversion of Radiation Polymerization of Electrolyte Monomer Diallyldimethylammonium Chloride in Dilute Aqueous Solution

Zhang, Yalong,Yi, Min,Ren, Jing,Zhai, Maolin,Ha, Hongfei The Polymer Society of Korea 2003 Macromolecular Research Vol.11 No.3

The dependence of electrical conductivity on concentrations of diallyldimethylammonium chloride (DADMAC) monomer, linear poly(DADMAC) and their mixture monomer/poly(DADMAC) in dilute aqueous solution exhibits a linear relationship. It was possible to calculate conversion of DADMAC polymerization by measuring its electric conductivity. Although the electrical conductivity of the poly(DADMAC) solution decreased with increasing its molecular weight, in the process of UV or ionizing radiation polymerization the molecular weight of the polymers could be kept constant in the case of fixed temperature, UV-luminous intensity or dose rate. Based on the method mentioned above, the kinetics of UV induced polymerization of DADMAC in aqueous solution was studied; the overall activation energy of polymerization of DADMAC in the water phase was calculated to be 18.8 kJ mol$^{-1}$ . ${\gamma}$-Radiation-induced polymerization of DADMAC in aqueous solution as a function of absorbed dose was studied as well. The conversion of DADMAC increased quickly with dose before 30 kGy and then increased slowly. The experimental data of both UV- and ${\gamma}$-induced polymerization were verified to be reliable by inverted ultracentrifugation method.