운동부하 및 각종 신체조건이 혈압 및 EEG에 미치는 영향(제1보)

김상표,최경돈,채의업,현정애,박원균,남상육,최헌욱,최요한 啓明大學校 醫科大學 1982 계명의대학술지 Vol.1 No.1

We studied this experiment to compare the effects of blood circulatory system to exercise and changes of various physical conditions i.e., postural change, finger ergometry, Flack test, cold pressor test and bicycle ergometry. We had sixty healthy college students. Their mena±SD values of physical characteristics were as follows: age; 22.0±1.37, weight; male 61.7±5.06kg, female 46.2±47kg. We observed the changes on blood pressure (B.P.) and E.C.G. and compared each changes with references. In changes of body position from sitting to supine position, decreased diastolic B.P. and increased pulse pressure were observed. In the finger ergometry, systolic B.P. Was increased. There were no significant changes in the diastolic B.P. and heart rate. In the Flack test, there were increased systolic B.P. and bradycardia. During the cold pressor test, heart rate was increased. After the cold pressor test, B.P. and heart rate were decreased comparing to control. Amplitude of T wave was increased. In the bicycle ergometry, immediately after exercise the heart rate and systolic B.P. were increased, and diastolic B.P. was decreased. There were shortening of the P-R intervals and decreased Q-T intervals. The S-T segment was depressed after the bicycle ergometry in the lead Ⅱ and aVF, however the elevated S-T segment in lead Ⅱ and aVF after postural change, finger ergometry, Flack test and cold pressor test was obtained. In the bicycle ergometry, the depressed S-T segment was analyzed by so called S-T vector. This finding was indicated left ventricular local ischemia but the reason of the elevated S-T segment in the relatively mild stress other than this were still obscure.

靜脈還流障碍時 筋電圖의 變化

李尙道,李錫江,蔡義業 慶北大學校 醫科大學 1976 慶北醫大雜誌 Vol.17 No.1

중심성 혈액유입에 의한 심혈관계 및 내분비계의 반응

채의업,박원균,배재훈,송대규 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.1

This study was attempted to clarify the regulatory mechanism on the systemic and pulmonary vascular reponses through the low pressure receptor, the ventricular performance, and the hormonal changes to the central blood shift at-6˚head-down tilt. In 39 anesthetized dogs(8-14kg), 21dogs (tilt group) were tilted from the supine position to the -6˚head-down position(HDP) for 30 minutes, then back to the supine recovery position for the next 30 minutes. The rest 18 dogs were kept in the supine position without tilt as the control group for the same time course of the tilt group. Cardiac output(Q), heart rate(HR), stroke volume(SV), thoracic fluid volume(TFV),index of ventricular contractility(IC)and ventricular acceleration index(ACI)were determined by the impedance cardiograph(BoMed co). Systemic arterial pressure(SAP) and pulmonary arterial pressure(PAP) were measured at the brachial and pulmonary arteries respectively, and central venous pressure(CVP) also at the right atrium. And the systemic and pulmonary vascular resistances(SVR and PVR) were calculated by dividing SAP and PAP with Q respectively. The concentration of plasma atrial natriuretic peptide(ANP) and antidiuretic hormone (ADH), and plasma renin activity(PRA) in the arterial blood were measured by the radioimmunoassay in 8 dogs in each group at 5 minutes before, and 25 and 55 minutes after beginning of the tilt. At the HDP, TFV increased rapidly and maintained the elevated level during the HDP, where as it decreased gradually in the control group. Q showed the tendency to increase and SAP, PAP and HR did not change significant differences in the changes of HR, PAP and CVP between the tilt and the control group. SVR and PVR reduced in the tilt group, where as they elevated gradually in the control group. There were significant differences in the changes of SVR and PVR between the tilt and the control group at the early stage of HDP. SV, IC and ACI increased at the early stage of HDP in the tilt group, where as they decreased gradually in the control group. Plasma ANP,ADH and PRA did not change significantly in the both groups. In conclusion, the cardiopulmonary baroreceptors induced the vasodilations on both systemic and pulmonary vessels by the central blood shift and the ventricular systolic performance was enhanced at the early stage of the head-down tilt. But the concentration of the plasma ANP and ADH, and PRA did not show significant changes in this study.

胎兒 正常心電圖에 關하여

權五極,蔡義業 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

胎兒心電圖를 分析하기 위하여 觀察對象으로써는 産前管理를 위하여 來院한 妊産婦 50名을 選擇하였으며 그 妊娠週數 分布는 35週에서 42週사이 였다. 心電圖描記用 電極의 位置는 母體腹壁 觸診을 하거나 Doppler로 心音을 들어 胎兒身長의 2/3에 該當되는 母體의 上腹部中央, 子宮底部 白線上에 陽電極을 두고 母體下腹部 恥骨 結合部 上綠에 陰電極을 設定하였으며 R-S Spinco Dynograph를 使用하여 母體腹壁 雙極 誘導法으로 施行하였으며 그 結果를 要約하면 다음과 같다. 胎兒心電圖의 起電力이 微弱하여 各 波의 判別이 매우 困難하였으며, 判別이 比較的 良好한 QRS波群에 對하여 觀察하였다. R波와 S波의 合한 QRS波群의 波高는 113.3㎶ 內外였고, 그 範圍는 10-16㎶였다. R波의 波高는 平均 7.27㎶이고, 그 範圍는 4-12㎶이였다. QRS波群의 波幅은 平均 0.042 sec이고, 그 範圍는 0.03-0.058sec이었다. R-R 間幅은 平均 0.406sec이고, 이에 따른 心搏數는 平均 147/min이며 그 範圍는 0.32-0.52sec이고, 이에 따른 心搏數는 120-187/min 이었다. 心電圖 各波의 波高 및 波幅의 R-R 間幅의 長短에 따른 QRS波群의 R波와 S波를 合한 全體波高와의 사이에는 想關關係가 없었으며, R波高와 R-R 間幅과도 想關關係가 없었으며, R-R 間幅과 QRS波群의 波幅과도 想關關係가 없었다. Fifty pregnant women in their 35th to 42nd gestation weeks who visited the hospital for prenatal care were selected as subjects. The positive electrode was applied on maternal abdomen near the umbilicus which portion was determined as corresponding the 2/3 point of fetus length by palpation of the maternal abdomen or by hearing the fetal heart sound with the Doppler. The negative electrode was applied on the maternal lower abdomen to correspond the superior margin of the symphysis pubis. Then electrocardiograms (ECG) were recorded by bipolar leads with Beckman R-S Spinco Dynograph. It was difficult to discriminate each wave because of the weak electromotive force of the fetal ECG, but observations were made on QRS complexes that were relatively easy to discriminate. The amplitude of R and S waves added together averaged 13.3㎶ ranging 10-l9㎶. The amplitude of R waves averaged 7.2㎶ ranging 4-l2㎶. The QRS intervals averaged 0.042sec ranging 0.03-0.058sec. The R-R intervals averaged 0.406sec ranging 0.32-0.52sec, and the heart rates. accordingly, averaged 147/min ranging 120-187/min. There was no correlation between the amplitude or the duration of each wave and the R-R interval.

수동적 체위변동과 경사도에 따른 혈력학적 반응

채의업,송대규,서영성,박원균 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.2

The purpose of this study was to investigate the relationship between the effects of gravity and regulatory mechanisms of the cardiovascular system by obwerving hemodynamic responses to passive body tilts. The study was carried out in 12 healthy young adult males. The postural changes were passively tilted from the supine control position(SCP) to the 15˚, 30˚ and 60˚ head-up position(HU), and then the 30˚ and 15˚ head-down position(HD) using a tilting table, and lasted for 5 minutes in each grade of the tilted position. Cardiac output(Q), stroke volume(SV), acceleration index(ACI) of the heart, and thoracic electrical bioimpedance were measured by the impedance cardiograph. Thoracic fluid volume(TFV) changes were calculated by the principle of impedance plethysmography. In addition, blood pressure(BP), heart rate(HR), total systemic vascular resistance(R), and ECG were measured. In the postural changes from supine to the 15˚, 30˚ and 60˚ HU, the SV gradually decresaed(p<0.01) by 11%, 26% and 42%, and the Q also decreased by 10%(p<0.05), 19% and 24%(p<0.01) respectively as compared with SCP. However, The HR and R gradually increased. On the contrary, in the postural changes from supine to the 30˚ and 15˚ HD, the SV increased by 16% and 14%, and the Q increased by 12% and 11% respectively and the HR and R decreased. The ACI increased in the HD, but decreased in the HU with the increasing fraction of the tilting degree. There was no significant change in the systolic BP, and the mean BP and diastolic BP gradually increased proportionally to the tilting degree in the HU, but they decreased in the HD. The TFV gradually increased in the HD, and it decreased in the HU. The average electrical axis of QRS complex on ECG was 56.1˚ in the SCP and it increased in the HU, however it decreased in the HD. In general, it is speculated that changes of hemodynamic variables on the effect of gravity were positively related to the tilting degree. From the above results, it may be suggested that the cardiopulmonary baroreceptors reduce R and HR to maintain BP against the increase of central blood volume. It may be also suggested that, as the tilting degree increases in the HU, both the arterial baroreceptors and cardiopulmonary baroreceptors are involved in the regulatory mechanisms. It can ve said that changes of the SV of the heart are related to Frank-Staring's law according to the venous return. In spite of the possibility of the fact that the atrial baroreceptors may increase the HR by the Bainbridge reflex in consequence of atrial distention in the HD, however, the negative chronotropic effect through cardiopulmonary baroreceptors appeared to be predominant. This study provides enidence that the extent of the cardiovascular regulation is proportional to the effects of gravity that is demonstrated by the magnitude of hydrostatic pressure according to the tilting degree.

두부하위(-6℃)로의 체위변동이 말초혈류에 미치는 영향

채의업(Chae, E-Up),양선영(Yang, Seon-Young),배재훈(Bae, Jae-Hoon),송대규(Song, Dae-Kyu) 대한생리학회 1990 대한생리학회지 Vol.24 No.1

The purpose of the present study was to examine the hemodynamic responses, especially in arterial and skin blood flows, in conjunction with the changes of plasma catecholamine levels as an indirect marker of adrenergic tone during the early stage of head-down tilt (HDT), and to evaluate the early physiological regulatory mechanism in simulated weightlessness. Ten mongrel dogs, weighing 8 ~ 14 kg, were intravenously anesthetized with nembutal, and postural changes were performed by using the tilting table. The postural changes were performed in the following order: supine, prone, HDT (-6℃) and lastly recovery prone position. The duration of each position was 30 minutes. The measurements were made before, during and after each postural change. The arterial blood flow (Q̇) at the left common carotid and right brachial arteries was measured by the electromagnetic flowmeter. Blood pressure (BP) was directly measured by pressure transducer in the left brachial artery. To evaluate the peripheral blood flow, skin blood flow (Q̇) was calculated by the percent changes of photoelectric pulse amplitude on the forepaw, and skin temperature was recorded. The peripheral vascular resistance (PR) was calculated by dividing respective mean BP values by Q̇ of both sides of common carotid and brachial arteries. Heart rate (HR), respiratory rate (f) and PH, Po₂, Pco₂ and hematocrit of arterial and venous blood were also measured. The concentration of plasma epinephrine and norepinephrine was measured by radioenzymatic method. The results are summarized as follows: Tilting to head-down position from prone position, HR was initially increased (p<0.05) and BP was not significantly changed. While Q̇ of the common carotid artery was decreased (p<0.05) and PR through the head was increased, Q̇ of the brachial artery was increased (p<0.05) and PR through forelimbs was decreased. Q̇ of the forepaw was initially increased (p<0.05) and then slightly decreased, on the whole revealing an increasing trend. Plasma norepinephrine was slightly decreased and the epinephrine was slightly increased. f was increased and arterial pH was increased (p<0.05). In conclusion, the central blood pooling during HDT shows an increased HR via Bainbridge reflex and an increased Q̇ of the forepaw and brachial Q̇, due to decreased PR which may be originated from the depressor reflex of cardiopulmonary baroreceptors. It is suggested that the blood flow to the brain was adequately regulated throughout HDT (-6℃) in spite of central blood pooling. And it is apparent that the changes of plasma norepinephrine level are inversely proportional to those of Q̇ of the forepaw, and the changes of epinephrine level are paralleled with those of the brachial Q̇.

無重力과 加速度

蔡義業(Chae E Up) 한국항공우주의학협회 1994 항공우주의학회지 Vol.4 No.2

성장기 한국인 남녀 기초체력 향상에 관한 연구 (남자 중.고등학생을 대상으로 하여)

채의업(Chae, E-Up),김규수(Kim, Kyu-Soo),주영은(Choo, Young-Eun),김종석(Kim, Chong-Suck),우원형(Woo, Won-Hyung),정복득(Chung, Pock-Tuck) 대한생리학회 1970 대한생리학회지 Vol.4 No.2

The effects of Physical exercise, gymnastics and sports on the cardiopulmonary function were studied in the middle and high school toys. The subjects were divided into 4 groups; non-training group and training group in both middle school and high school boys. In the above groups, pulmonary function studies were performed, and blood pressure and the heart rate were also checked to evaluate physical fitness during and immediately after running exercise on the tread-mill, with the speed of 5 MPH and elevation of 9% and 11.25%. The types of sports in the training group were base ball, body building, Taekwondo (Korean style boxing) and hand ball. The results obtained were as followings: 1) In the training group, cardiopulmonary function showed some tendency of the increase comparing to the non-training group. 2) The increase in cardiopulmonary function was observed according to the age became older, but the clear changes on cardiopulmonary function was not observed as the difference of the group between the training and the non-training. 3) The expiratory volume was decreased as the increase of age except 17 years of age for the value of the per kg body weight. 4) In the non-training group, the mean value of oxygen consumption under maximum work load was increased, while those in the training group was decreased. But it may be noted that oxygen consumption for the expiratory volume was increased in the training group, and that the oxygen cost in the training group was .higher than that of the non-training group. 5) The pulse pressure of the high school group during and immediately after running exercise was observed in the higher value comparing with that of the middle school group It was suggested that the changes of the pulse pressure was owing to the method of determination and that to the decrease of diastolic pressure caused by the decrease of peripheral vascular resistance up to critical closing pressure. 6) Any differences of the changes in the heart rate between the training group and non-training group was not observed during and immediately after running exercise. 7) The relative value of the expiratory volume to the heart rate was decreased in the elder age group.

체위 변화에 수반되는 순환 및 호흡반응

채의업(Chae, E-Up),이석강(Lee, Suck-Kang),배성호(Bae, Sung-Ho) 대한생리학회 1973 대한생리학회지 Vol.7 No.1

An attempt was made to study circulatory and respiratory responses to the passive tilt. Anesthetized dogs were tilted from horizontal to upright (+90˚) and head down (-90˚) position. The arterial blood pressure was decreased in the upright position and was decreased slightly in the head down position comparing to that in the horizontal position. Cardiac index also decreased in the both upright and head down positions. The total systemic vascular resistance was slightly increased in the upright position and was markedly increased in the head down position. The mean pulmonary arterial pressure was significantly decreased in the both upright and head down positions. The total pulmonary vascular resistance was decreased in the both upright and head down positions. Oxygen consumption was slightly decreased in the upright position, whereas it was slightly increased in the head down position. The A-V O₂ difference (vol. %) was slightly increased in the upright position and increased in the head down position. From the above results, process of the circulatory compensation to the gravity in the Passive tilting test was discussed. Neuronal cardiovascular regulation to the gravity and tile adaptation of capacitance vessles to hydrostatic stress and oxygen consumption concerning anoxic endurance of the brain were also discussed.

모의무중력 상태에서 혈중 catecholamine농도 및 심박출량의 변화

채의업,여운재,박원균 최신의학사 1991 最新醫學 Vol.34 No.3