코일과 클립을 선택적으로 적용해서 성공적으로 치료했던 다발성뇌동맥류 1례 : A case report

이덕구,김범태,황선철,임수빈,이세영,신원한 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The author report a case of multiple cerebral aneurysm successfully treated with an appropricate selection of surgical clipping and coil embolization. A 64 years old female patient was admitted with stuporous consciousness. Initial 3D CT angiography showed diffuse subrarachnoid hemorrhage on the basal cisterns, saccular aneurysms on the terminal basilar artery and right middle cerebral artery(MCA). Converntional angiography confirmed the ruptured aneurysm was basilar one. Coil embolization was perfromed on the basilar aneurysm with 6 Guglielmi detachable coils(GDC) on the 3 days after ictus. Sugical clipping was done on the unruptured right MCA aneurysm on 10 days after ictus without any morbidity. Each treatment modalities can be appropriate indicated for the coiling or clipping aneurysms.

Jones Jig를 이용한 하악 제 1 대구치 원심이동의 치험례

이상민,한세현,김종범 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

The first permanent molar takes important place in the occlusion. Malposition of the lower first molar is frequently due to mesial migration, which is occurred by early exfoliation of the second deciduous molar or proximal caries of deciduous teeth. Above things happen without any consideration of space maintainer, prompt measures for space regaining have to be started. Especially in the case with early loss of the second deciduous molar, it has been said that there is no suitable appliance for maintaining the space before the eruption of the permanet first molar. In distalizing the upper first molar, headgears have been routinely used, which its resrlt was definitely depended on cooperation of the patients. Nowadays, appliances such as pendulum appliances, K-loop, magnets, which can be used without cooperation of the patients, are introduced. Jones Jig, one of the molar distalizing appliances, was used on the patients who visited department of pediatric dentistry in Seoul National University Dental Hospital complaining of no eruption space for the lower second bicuspid. Either removable splint or lingal arch was used as the anchorage. Jones Jig was favorably used in the lower molar, where vestibule is shallow, and this is a case report on the satisfactory result thereof.

All-in-one 접착제에서 초음파진동이 법랑질과 상아질의 결합강도와 레진침투에 미치는 영향

이범의,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.1

초기의 접착 시스템은 여러 단계의 술식을 필요로 하였으며 술자의 기술과 재료의 성질에 크게 좌우되었으나 최근 산부식, priming, adhesive를 한번에 적용할 수 있는 a11-in-one adhesive system이 등장하였다. 치과에서의 vibration의 이용은 치석의 제거 및 접착제의 점도를 낮추는데 이용되어왔으며 vibration은 접착제의 흐름성을 향상시켜 film thickness를 낮추어 수복물 주위의 미세누출을 줄이는데 도움을 준다. 이에 저자들은 all-in-one adhesive system에서 vibration이 법랑질과 상아질의 접착강도와 레진침투에 미치는 효과를 알아보고자 하였다. 법랑질 시편은 발거 후 실온에서 0.1% thymol 용액에서 보관된 30개의 건전한 사람의 대구치를 무작위로 10개씩 세군으로 나누고 근원심 방향으로 두 부분으로 분리하여 각각은 같은 접착제를 사용하고 초음파진동여부를 다르게 하였고, 아크릴 레진을 이용하여 직경 1-inch의 PVC관에 매몰한 후 협설면이 아크릴봉과 동일한 높이가 되도록 220-, 600-grit 연마지로 순차적으로 연마하였고 군당 10개씩 여섯 군으로 분류하였다. 1군과 2군은 Prompt L-Pop(3M-ESPE, Seefeld, Germany), 3군과 4군은 One-Up Bond F(Tokuyama Corp., Tokyo, Japan). 5군과 6군은 AQ bond(Sun Medical Co., Kyoto, Japan)를 제조사의 지시에 따라 도포하였다. 2군, 4군, 6군은 초음파 치석제거기를 이용하여 치면에 대고 15초간 진동을 가한 후 광중합하였다. 상아질 시편은 치관부 법랑질을 제거한 후 상아질면을 아크릴 봉과 동일한 높이가 되도록 하고 법랑질 시편과 동일하게 처리하였다. 이후 직경 2mm, 높이 3mm의 Teflon mold(Ultradent, U.S.A.)를 이용하여 복합레진을 충전한 후 40초씩 두 번에 나누어 광중합한 후 24시간동안 실온에서 증류수에 보관하였다. 열순환 시행한 후, 만능측정 기(Instron4465)로 전단결합강도를 측정하였으며 Resin tag의 양상을 비교하기 위해 각 군의 시편의 치질을 완전히 용해 시킨 후 표면을 주사전자현미경사진으로 관찰하여 다음과 같은 결과를 얻었다. 1. 법랑질에서 초음파 진동을 가한 군(2,4,6군)은 가하지 않은 군(1,3,5군)에 비해 평균 전단결합강도가 높게 나타났다. 그 차이는 AQ bond 군을 제외하고 통계적으로 유의하였다(p<0.05). 2. 상아질에서 초음파 진동을 가한 군(2,4,6군)은 가하지 않은 군(1,3,5군)에 비해 평균 전단결합강도가 높게 나타났다. 그러나 그 차이는 One-Up Bond F군을 제외하고는 통계적으로 유의한 차이가 없었다. 3. 전자 현미경 관찰에서 초음파 진동을 가한 군에서 더 많은 법랑질의 소실과 상아질에서 resin tag의 길이가 길었고 lateral branch의 수도 많이 관찰되었다. The objective of this study was to apply the vibration technique to reduce the viscosity of bonding adhesives and thereby compare the bond strength and resin penetration in enamel and dentin achieved with those gained using the conventional technique and vibration technique. For enamel specimens, thirty teeth were sectioned mesio-distally. Sectioned two parts were assigned to same adhesive system but different treatment(vibration vs non-vibration) Each specimen was embedded in 1-inch inner diameter PVC pipe with a acrylic resin. The buccal and lingual surfaces were placed so that the tooth and the embedding medium were at the same level. The samples were subsequently polished silicon carbide abrasive papers. Each adhesive system was applied according to its manufacture's instruction. Vibration groups were additionally nitrated for 15 seconds before curing. For dentin specimen, except removing the coronal part and placing occlusal surface at the mold level, the remaining procedures were same as enamel specimen. Resin composite(Z250 3M. U.S.A.) was condensed on to the prepared surface in two increments using a mold kit(Ultradent Inc., U.S.A.) Each increments was light cured for 40 seconds. After 24 hours in tap water at room temperature, the specimens were thermocycled for 1000cycles.. Shear bond strengths were measured with a universal testing machine(Instron 4465, England). To investigate infiltration patterns of adhesive materials, the surface of specimens was examined with scanning electron microscope. The results were as follows : 1. In enamel, the mean values of shear bond strengths in vibration groups(group 2,4,6) were greater than those of non-vibration group(group 1,3,5). The differences were statistically significant except AQ bond group. 2. In dentin, the mean values of shear bond strengths in vibration groups(group 2 4, 6) were greater than those of non-vibration groups(group 1,3,5). But the differences were not statistically significant except One-up Bond F group. 3. The vibration group showed more mineral loss in enamel and longer resin tag and greater number of lateral branches in dentin under SEM examination.

정중과잉치로 인해 회전된 상악 중절치의 치험례

이범의,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

정중과잉치의 원인은 잘 알려지지는 않았지만 dental lamina의 hyperactivity에 의해 발생한다는 가설이 가장 많이 받아들여지고 있다. 이러한 정중과잉치의 병발증으로는 주변 영구절치의 맹출 장애, 만곡 치근, 치근흡수, primordial 혹은 follicular cyst의 형성, 회전, 이환된 부위의 총생 및 비정상적인 정중이개를 일으킬 수 있다. 이러한 이유로 영구전치의 회전이 야기되면 보통 공간의 부족은 적거나 없으며 재발이 흔하므로 과개선이 요구된다. 재발의 방지를 위해서는 조기치료, 과개선, 긴 보정기간, 적절한 접촉면의 형성, 짝힘의 사용, 그리고 수술적인 방법 등이 제안되어왔다. 이에 저자는 정중과잉치로 인하여 심하게 회전된 상악중절치를 주소로 내원한 환아에서 교정적, 외과적 술식을 이용하여 양호한 결과를 얻은 두 증례를 보고하는 바이다. The etiology of mesiodens is unknown but the most widely accepted theory is the hyperactivity of the dental lamina. Complications of mesiodens are delayed or prevented eruption of maxillary central incisors, displacement or rotation of permanent teeth, crowding of affected region, abnormal diastema or permanent space closure, dilaceration or abnormal root development of permanent teeth, primordial or follicular cyst formation, root resorption of adjacent teeth, eruption into nasal cavity. If mesiodens rotate the maxillary central incisors, space deficiency is not common and relapse is very common. So overcorrection is needed. To prevert the rotational relapse, early treatment, overcorrection, long retention period, properly formed proximal surface, use of coupled force, and surgical techniques have been suggested. The authors present two cases, whose chief complain were severely rotated maxillary incisors by mesiodens, treated by orthodontic and surgical technique and showed good results.

백화사설초 메탄올 추출물에 의한 HL-60 細胞 枯死過程에서의 cell cycle 關聯因子의 活性變化 硏究

한세희,이종범,문구,문석재,원진희,박래길,이종덕 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

Objecives: Hedyotis diffusa is used to treat cancer in traditional Korea Medicine. So this study was carried out to examine the expression of cell cycle related genes in HL-60 cells undergoing apoptosis by the methanol extract of Hedyotis diffusa. Methods: 1. HL-60 cells were treated with various concentrations (from 200 to 50㎍/ml)of metnanol extract and H20 extract (200 ㎍/ml) of hedyotis diffusa. After 48 h later, the cells were tested for viability by MTT assay. 2. The HL-60 cells were treated with 200 ㎍/ml of methanol extract for the indicated periods. The whole cell lysates were prepared and analyzed by westem blotting using anti-p53 antibody. 3. The nuclear extract were prepared and analyed by western blotting using anti-p21 antibody, anti-p27 antibody, anti-cyclen A antibody, anti-cylin E antibody and anti-CDK2 antinbody. Results: 1. The methanol extract of Hedyotis diffusa induced the death of HL-60 cells in a dose dependent manner. 2. The methanol extract of Hedyotis diffusa makedly decreased the level of p21/Cipl and cyclin A in a time dependent manner. 3. The methanol extract of Hedyotis diffusa markedly increased tje ;eve; pf p27/Kip and cyclin E in a time dependent mammer. 4.The methanol extract of Hedyotis diffusa markedly did not affect the level of CDK2. Conclusions: These results provide evidence that expression of cell cycle related genes in HL-6- cells undergoing apoptosis by the methanol extract of Hedyotis diffusa mainly results from decreased level of p21/cipl and increased level of p27/Kipl of the cell cycle related genes.

Intentional Replantation에 의한 상악 제 1 소구치 치료의 증례보고

김종범,한세현,정우진,이상훈 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

Intentional replantation of the posterior teeth has been performed as a last resort except extraction when it is impossible to perform the conventional endodontic or surgical endodontic treatment. Many studies have done with the prognosis, and root resorption, of which the responsibility might have been injury of periodontal ligament and remaining periodontal lesion, proved to be major cause of failure. Intentional replantation, however, can exclude anatomic difficulty, risk of nerve injury, and maxillary sinus trauma that surgical access can raise, especially in posterior teeth, and it is reported that success rate is not less than surgical endodontics, independent of replantation of traumatically avulsed teeth. The success of intentional replantation can be evaluated with, clinically, ruduction of pocket depth, pain and mobility(physical mobility), and, radiographically, hard tissue formation, reduction of periapical radiolucency. In this case report, for the maxillary left first bicuspid with dens evaginatus that had periapical lesion, painfulness, mobility and showed no reduction of mobility after even extirpation and a number of irrigation, extraction followed by extraoral root filling with calcium hydroxide and replantation was performed. Based on many studies, it is concluded that hard tissue formation capacity of calcium hydroxide, preceded exterpation before extraction, and careful extraction without injuring periodontal ligament affected successful results of this case.

2단 IMDCT Recursive 구조를 이용한 MPEG-2 AAC 복호화기의 필터뱅크 구현

박세기,강명수,오신범,이채욱 대구대학교 정보통신연구소 2003 情報通信硏究 Vol.2 No.1

MPEG-2 AAC(Advanced Audio Coding)는 높은 압축율과 고음질의 특성을 갖는 멀티채널 오디오 압축 표준으로 알려져 있고, 대우 낮은 비트율에서 방송 음질 수준의 오디오를 제공하기 위해서 고해상도 필터뱅크(high-resolution filter bank), 예측기법(prediction), 허프만 부호화(Huffman coding) 등을 결합하여 사용한다. MPEG-2 AAC 필터뱅크에서 부화화기와 복호화기에서 각각 수행하는 MDCT(Modified Discrete Cosine Transform)/ IMDCT(Inverse MDCT) 연산은 특히 많은 연산을 필요로 한다. 본 논문에서는 MPEG-2 AAC 실시간 복호화 시스템을 하드웨어로 구현시 IMDCT의 연산에 적합한 2단 IMDCT의 Recursive 구조를 제안한다. 그리고 메모리와 연산속도, 하드웨어의 복잡도를 기존에 제안된 알고리듬과 비교하였다. MPEG-2 Advanced Audio Coding(AAC) is the uideb used audio standard and offers the high-quality multi-channel surround audio AAC algonthm combines the coding efficiency of a high-resolution filter bank, prediction techniques, and Huffman coding to achieie the broadcast-qualitv audio at very low data rates The foruard and inperse modified discrete transform(MDCT) are two of the most computational) 1 intensive operation in the MPEG-2 AAC In this paper, we propose the suitable recursive structure at IMDCT process for MPEG-2 AAC real-time decoder, and compared the memory, the computation speed and complexity of hardware with the proposed algonsms

小兒에 있어서의 우식活動性에 對한 硏究

韓世鉉,李範模 大韓小兒齒科學會 1986 大韓小兒齒科學會誌 Vol.13 No.1

This study was performed to evaluate the caries activity with dental plaque of upper right second primary molar by caries activity tester (suntec) and the author compared this caries activity with deft&s index, rate and caries severity. The selected subjects for this study were 97 children (boys 52, girls 45) aged from 3 to 8. According as the swabbed plaque condition was wet or dry, caries activity degree was evaluated in 18 among 97 children. The obtained results were as follows: 1. Caries activity of boys showed slightly higher than that of girls. Deft&s index, rate were also higher in male than in female. 2. According as the caries activity was slightly increased, deft & s index, rate were slightly increased. (P<0.05) 3. According as the caries severity showed increasing tendency, caries activity was also increased. (P<0.05) 4. There was no difference in the caries activity according to wet or dry condition of plaque sample.

혈관내초음파로 평가한 스텐트를 삽입한관동맥의 형태학적 특징

정남식,홍범기,임세중,백성일,이문형,장양수,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice

Lee, Young,Han, Na-Eun,Kim, Wonju,Kim, Jae Gon,Lee, In Bum,Choi, Su Jeong,Chun, Heejung,Seo, Misun,Lee, C. Justin,Koh, Hae-Young,Kim, Joung-Hun,Baik, Ja-Hyun,Bear, Mark F.,Choi, Se-Young,Yoon, Bong-Ju Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.4

The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) ('bridging collaterals') was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.