Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis?

Bahar Bektan Kanat,Gulru Ulugerger Avci,Osman Faruk Bayramlar,Damla Unal,Ozge Sonmez,Ibrahim Murat Bolayirli,Alper Doventas,Deniz Suna Erdincler,Hakan Yavuzer 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.2

Background: Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs). We investigated the use of MMP2/TIMP2 and MMP9/TIMP1 ratios as biomarkers of bone resorption in geriatric osteoporosis and evaluated the relationship between osteoporosis and geriatric syndromes. Methods: This analytical cross-sectional study involved 87 patients (41 with osteoporosis) treated at the geriatric outpatient clinic of a university hospital. The demographic characteristics, comprehensive geriatric assessment scores, laboratory findings, and bone mineral density of the patients were recorded. Serum MMP9, TIMP1, MMP2, and TIMP2 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: We enrolled 41 and 46 patients with and without osteoporosis, respectively. The groups showed no significant differences in MMP2/TIMP2 and MMP9/TIMP1 ratios (p=0.569 and p=0125, respectively). While the basic activities of daily life (BADL) scores in the osteoporosis group were higher than those in the group without osteoporosis, the instrumental activities of daily life (IADL) scores were significantly lower (p=0.001 and p=0.007, respectively). No significant differences were observed in Mini-Nutritional Assessment, Mini-Mental State Examination, and Geriatric Depression Scale scores (p=0.598, p=0.898, and p=0.287, respectively). Conclusion: This is the first study to examine the relationship between osteoporosis and several geriatric syndromes, as well as the relationship between osteoporosis and serum MMP, TIMP values, and MMP/TIMP ratios in geriatric patients. Our results showed that osteoporosis causes dependency in both BADLs and IADLs, and that the MMP2/TIMP2 and MMP9/TIMP1 ratios provided no additional benefit in demonstrating bone resorption in geriatric osteoporosis.

The Effects of Smartphone and Internet Gaming Addiction on Eating Attitudes Among University Students

Bahar Yeş,il Ö,rnek,İ,brahim Gü,ndoğ,muş 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.1

Objective Smartphone addiction is a public health problem increasing with the technologic developments. It particularly affects the university students negatively in terms of psychological, physical, academic achievement and social relations. This study aims to investigate the relation of eating attitudes between smartphone addiction and internet gaming disorder, also the relation of smartphone addiction with obesity.Methods This cross-sectional and prospective study is consisted of 358 volunteer university students. Socio-demographic data form, Short Form of Smartphone Addiction Scale (SF-SAS), Eating Attitude Test (EAT), and internet gaming disorder scale were administered to the participants.Results Mean age of the participants was 22.27±3.10 years and 59.8% (n=214) were female. In terms of the variables “body mass index, body weight, faculty of the student, economic status of the family, and the people they live with together” were significantly different from controls. Also “monthly mobile phone invoice, EAT score, SF-SAS scores” were statistically different. A significant difference was found among “body weight groups” in terms of both EAT score and SF-SAS. According to the linear regression model variables of “gender, smartphone addiction, and school year” were determined as the predictors for EAT.Conclusion Our current study has revealed the relation between smartphone addiction and eating attitudes, and obesity. Smartphone addiction may lead to an increase in body weight, by affecting eating attitudes. Therefore, the effect of eating behavior disorders in the emergence of the smartphone addiction should be considered. Multi-disciplinary solutions are required to prevent this addiction that may increase over time.

통번역 교육에 있어서 지역학의 위치 : 아제르바이잔 언어대학교 한국어 통번역학과를 중심으로

Bahar Aliyeva 국제한국언어문화학회 2021 국제한국언어문화학회 학술대회 Vol.2021 No.05

Prostaglandins Inhibit Cytochrome P450 4A Activity and Contribute to Endotoxin-Induced Hypotension in Rats via Nitric Oxide Production

Bahar Tunctan,Fariborz A. Yaghini,Anne Estes,Kafait U. Malik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that endotoxemiainduced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure (MAP). By using cyclooxygenase (COX) inhibitor indomethacin, we investigated herein whether prostaglandins, via NO production, inhibit renal CYP 4A1 protein expression and CYP 4A activity and contribute to the endotoxin-induced hypotension. In conscious male Sprague-Dawley rats, endotoxin (10 mg/kg, intraperitoneal (i.p.)) reduced MAP, increased serum nitrite and bicyclo PGE2 levels, renal nitrite production and iNOS protein expression, and decreased renal CYP 4A1 protein expression and CYP 4A activity after 4 h injection. All of the endotoxin-induced changes, except for increase in renal nitrite production, were prevented by indomethacin (5 mg/kg, i.p. 1 h after endotoxin). The effects of indomethacin on the endotoxin-induced decrease in MAP, CYP 4A1 protein expression and CYP 4A activity were minimized by the CYP 4A inhibitor, aminobenzotriazole (50 mg/kg, i.p. 1 h after endotoxin). These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A.

Some integral curves associated with a timelike Frenet curve in Minkowski 3-space

Bahar Uyar Duldul 호남수학회 2017 호남수학학술지 Vol.39 No.4

In this paper, we give some relations related with a spacelike principal-direction curve and a spacelike binormal-direction curve of a timelike Frenet curve. The Darboux-direction curve and the Darboux-rectifying curve of a timelike Frenet curve in Minkowski 3-space $E_1^3$ are introduced and some characterizations related with these associated curves are given. Later we define the spacelike ${\bf V}$-direction curve which is associated with a timelike curve lying on a timelike oriented surface in $E_1^3$ and present some results together with the relationships between the curvatures of this associated curve.

Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin

Bahar Javid,Narges Panahandeh,Hassan Torabzadeh,Hamid Nazarian,Ardavan Parhizkar,Saeed Asgary 대한치과보존학회 2020 Restorative Dentistry & Endodontics Vol.45 No.1

Objectives: This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs) through different dentin thicknesses. Materials and Methods: Two-chamber setups were designed to simulate indirect pulp capping (IPC). Human molars were sectioned to obtain 0.1-, 0.3-, and 0.5-mm-thick dentin discs, which were placed between the 2 chambers to simulate an IPC procedure. Then, MTA and CEM were applied on one side of the discs, while hDPSCs were cultured on the other side. After 2 weeks of incubation, the cells were removed, and cell proliferation, morphology, and attachment to the discs were evaluated under scanning electron microscopy (SEM). Energy-dispersive X-ray (EDXA) spectroscopy was performed for elemental analysis. Alkaline phosphatase (ALP) activity was assessed quantitatively. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Results: SEM micrographs revealed elongated cells, collagen fibers, and calcified nucleations in all samples. EDXA verified that the calcified nucleations consisted of calcium phosphate. The largest calcifications were seen in the 0.1-mm-thick dentin subgroups. There was no significant difference in ALP activity across the CEM subgroups; however, ALP activity was significantly lower in the 0.1-mm-thick dentin subgroup than in the other MTA subgroups (p < 0.05). Conclusions: The employed capping biomaterials exerted biological activity on hDPSCs, as shown by cell proliferation, morphology, and attachment and calcific precipitations, through 0.1- to 0.5-mm-thick layers of dentin. In IPC, the bioactivity of these endodontic biomaterials is probably beneficial.

A Fuzzy Multi-Objective Linear Programming Model

Bahar Ozyoruk,Nilay Donmez 대한산업공학회 2014 Industrial Engineeering & Management Systems Vol.13 No.3

Supply chain management is a subject that has an increasing importance due to the developments in the global markets and technology. In this paper, a fuzzy multi-objective linear programming model is developed for the supply chain of a company dealing with procurement, storage, filling, and distribution of liquefied petroleum gas (LPG) in Turkey. The model intends to determine the quantities of LPG to be procured, stored, filled to cylinders, and transported between the plants and demand centers for six planning periods. In this model, which aims to minimize both total costs (sum of procurement, storage, filling, and transportation costs) and total transportation distances, demand quantities of the main demand centers and decision maker’s aspiration levels about objective functions are fuzzy. After comparing the results obtained from the model with those obtained by using different methods, it is concluded that the proposed method can be applied to real world problems practically and it may be used in this type of problems in order to generate an efficient solution.

Kinetic study on the leaching of calcined magnesite in gluconic acid solutions

Bahar Bayrak,Hanifi Sarac,Oral Lac¸in 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.3

A kinetic study on the leaching of calcinedmagnesite in aqueous gluconic acid solutionswas investigated in batch reactor employing the parameters of particle size, temperature, stirring speed, solid–liquid ratio and acid concentration. A mathematical model was evaluated for the rate increased with decreasing particle size and increasing temperature and initially, the leaching in terms of acid concentration and then fell with increasing concentration. It was found in the study that stirring speed was not effective on leaching rate. The leaching rate decreases as solid–liquid ratio increases. It was shown that the mathematical model for calcined magnesite particle was:1:9041 lnðð1 XBÞ1=3 þ 1:157Þ þ 0:952 lnðð1 XBÞ2=3 1:156ð1 XBÞ1=3 þ 1:338Þ3:298 arctanð0:577ð1:73ð1 XBÞ1=3 1ÞÞ ¼3bkSCA0rBR tDissolution curves were evaluated in order to test shrinking core models for fluid–solid systems. Consequently, it was determined that the leaching rate is controlled by surface chemical reaction. In addition, the fact that dissolution was controlled by the surface chemical reaction was also supported with the relationship between the rate constant and the particle radius. The activation energy of the process was determined to be 32.88 kJ mol1. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

ON ADJOINT CURVES OF FRAMED CURVES AND SOME RULED SURFACES

( Bahar Doğan Yazıcı ),( Sıddıka Özkaldı Karakuş ),( Murat Tosun ) 호남수학회 2023 호남수학학술지 Vol.45 No.3

In this study, we introduce the adjoint curves of framed curves. We examine some characterizations of adjoint curve of a framed curve. In addition, we give the conditions for framed curves and adjoint curves to be Bertrand and Mannheim curves. Then, we introduce adjoint curves of Frenet-type framed curves and give ruled surfaces related to adjoint curves. Finally, we create normal and binormal surfaces of the framed adjoint curves and obtain some characterizations of these surfaces and we support by the results with figures.

CLINICAL EXPERIENCE WITH STRESS AND DELAYED THALLIUM-201 QUANTITATIVE SEGMENTAL WASHOUT CURVES (QSWC)

Bahar, R. H.,Hassan, I. M.,Mohamrred, M. M.,Sayed, M. El,Ziada, G.,Simo, G.,Dayem, H. M. Abdel 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1