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      • SCOPUSKCI등재
      • KCI등재

        Pectin extraction from citron peel: optimization by Box–Behnken response surface design

        Bahare Pasandide,Faramarz Khodaiyan,Zeinab Mousavi,Seyed Saeid Hosseini 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4

        In this study, the effect of acidic extraction conditions (time of 30–90 min, temperature of 75–95 C and pH of 1.5–3) on the yield and degree of esterification (DE) of citron peel pectin was investigated applying Box– Behnken design. The highest production yield of pectin (28.31 ± 0.11%) was achieved at extraction time of 90 min, temperature of 95 C and pH of 1.5, as optimal extraction conditions, which was close to the predicted value (29.87%). Under optimum extraction conditions, the DE and the emulsifying activity were 51.33 and 46.2%, respectively. In addition, the emulsions were 93.9 and 93.5 stable at 4 C, 93.7 and 93.1 at 23 C after 1 and 30 days, respectively. The determination of flow behavior showed that the pectin solutions had a Newtonian behavior at low concentrations (\1.0% w/v), while this behavior was changed to pseudoplastic with increasing concentration.

      • KCI등재

        A Fuzzy Multi-Objective Linear Programming Model

        Bahar Ozyoruk,Nilay Donmez 대한산업공학회 2014 Industrial Engineeering & Management Systems Vol.13 No.3

        Supply chain management is a subject that has an increasing importance due to the developments in the global markets and technology. In this paper, a fuzzy multi-objective linear programming model is developed for the supply chain of a company dealing with procurement, storage, filling, and distribution of liquefied petroleum gas (LPG) in Turkey. The model intends to determine the quantities of LPG to be procured, stored, filled to cylinders, and transported between the plants and demand centers for six planning periods. In this model, which aims to minimize both total costs (sum of procurement, storage, filling, and transportation costs) and total transportation distances, demand quantities of the main demand centers and decision maker’s aspiration levels about objective functions are fuzzy. After comparing the results obtained from the model with those obtained by using different methods, it is concluded that the proposed method can be applied to real world problems practically and it may be used in this type of problems in order to generate an efficient solution.

      • KCI등재

        In-situ Synthesis of SiO2 Nanoparticles on Polyester Fabric as Benign Multi-purpose Catalysts

        Bahare Nozari,Majid Montazer,Mahnaz Mahmoudi Rad 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12

        Here, silica nanoparticles (NPs) as safe multi-purpose catalysts were in situ synthesized on PET fabric to achieve a higher quality fabric. The PET fabric was treated in an aqueous solution of sodium silicate and ammonia at boil for 1 h to insitu synthesis silica NPs along with aminolysis of the fabric. Effect of silica NPs as the multi-purpose catalysts on the fabric were subjected to various analysis such as self-cleaning, hydrophilic, antibacterial and antifungal properties and also thermal resistance. The surface morphology, the crystalline structure and elemental analysis were studied by Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and map and energy dispersive X-ray (EDX) analysis. The optimized treated fabric indicated 4 s for the water to spread and 65 o for contact angle provided higher hydrophilic properties. Silica NPs on the fabric showed thermo-catalytic behavior protecting against yellowing at high temperature (200 oC for 3 h) proved the higher thermal resistance of the treated fabric. Also, the fabric specified good self-cleaning properties through discoloration of methylene blue solution. Further, the treated fabric proposed 100 % anti-bacterial and anti-fungal activities against Staphylococcus aureus, Escherichia coli and Candida albican along with good cell viability. Overall, this research indicates silica NPs as multi-purpose catalysts including photo, bio and thermo-catalyst on the PET fabric using low price materials.

      • KCI등재

        Prostaglandins Inhibit Cytochrome P450 4A Activity and Contribute to Endotoxin-Induced Hypotension in Rats via Nitric Oxide Production

        Bahar Tunctan,Fariborz A. Yaghini,Anne Estes,Kafait U. Malik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

        Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that endotoxemiainduced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure (MAP). By using cyclooxygenase (COX) inhibitor indomethacin, we investigated herein whether prostaglandins, via NO production, inhibit renal CYP 4A1 protein expression and CYP 4A activity and contribute to the endotoxin-induced hypotension. In conscious male Sprague-Dawley rats, endotoxin (10 mg/kg, intraperitoneal (i.p.)) reduced MAP, increased serum nitrite and bicyclo PGE2 levels, renal nitrite production and iNOS protein expression, and decreased renal CYP 4A1 protein expression and CYP 4A activity after 4 h injection. All of the endotoxin-induced changes, except for increase in renal nitrite production, were prevented by indomethacin (5 mg/kg, i.p. 1 h after endotoxin). The effects of indomethacin on the endotoxin-induced decrease in MAP, CYP 4A1 protein expression and CYP 4A activity were minimized by the CYP 4A inhibitor, aminobenzotriazole (50 mg/kg, i.p. 1 h after endotoxin). These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A. Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that endotoxemiainduced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure (MAP). By using cyclooxygenase (COX) inhibitor indomethacin, we investigated herein whether prostaglandins, via NO production, inhibit renal CYP 4A1 protein expression and CYP 4A activity and contribute to the endotoxin-induced hypotension. In conscious male Sprague-Dawley rats, endotoxin (10 mg/kg, intraperitoneal (i.p.)) reduced MAP, increased serum nitrite and bicyclo PGE2 levels, renal nitrite production and iNOS protein expression, and decreased renal CYP 4A1 protein expression and CYP 4A activity after 4 h injection. All of the endotoxin-induced changes, except for increase in renal nitrite production, were prevented by indomethacin (5 mg/kg, i.p. 1 h after endotoxin). The effects of indomethacin on the endotoxin-induced decrease in MAP, CYP 4A1 protein expression and CYP 4A activity were minimized by the CYP 4A inhibitor, aminobenzotriazole (50 mg/kg, i.p. 1 h after endotoxin). These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A.

      • KCI등재

        Some integral curves associated with a timelike Frenet curve in Minkowski 3-space

        Bahar Uyar Duldul 호남수학회 2017 호남수학학술지 Vol.39 No.4

        In this paper, we give some relations related with a spacelike principal-direction curve and a spacelike binormal-direction curve of a timelike Frenet curve. The Darboux-direction curve and the Darboux-rectifying curve of a timelike Frenet curve in Minkowski 3-space $E_1^3$ are introduced and some characterizations related with these associated curves are given. Later we define the spacelike ${\bf V}$-direction curve which is associated with a timelike curve lying on a timelike oriented surface in $E_1^3$ and present some results together with the relationships between the curvatures of this associated curve.

      • KCI등재

        Kinetic study on the leaching of calcined magnesite in gluconic acid solutions

        Bahar Bayrak,Hanifi Sarac,Oral Lac¸in 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.3

        A kinetic study on the leaching of calcinedmagnesite in aqueous gluconic acid solutionswas investigated in batch reactor employing the parameters of particle size, temperature, stirring speed, solid–liquid ratio and acid concentration. A mathematical model was evaluated for the rate increased with decreasing particle size and increasing temperature and initially, the leaching in terms of acid concentration and then fell with increasing concentration. It was found in the study that stirring speed was not effective on leaching rate. The leaching rate decreases as solid–liquid ratio increases. It was shown that the mathematical model for calcined magnesite particle was:1:9041 lnðð1 XBÞ1=3 þ 1:157Þ þ 0:952 lnðð1 XBÞ2=3 1:156ð1 XBÞ1=3 þ 1:338Þ3:298 arctanð0:577ð1:73ð1 XBÞ1=3 1ÞÞ ¼3bkSCA0rBR tDissolution curves were evaluated in order to test shrinking core models for fluid–solid systems. Consequently, it was determined that the leaching rate is controlled by surface chemical reaction. In addition, the fact that dissolution was controlled by the surface chemical reaction was also supported with the relationship between the rate constant and the particle radius. The activation energy of the process was determined to be 32.88 kJ mol1. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

      • KCI등재

        Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin

        Bahar Javid,Narges Panahandeh,Hassan Torabzadeh,Hamid Nazarian,Ardavan Parhizkar,Saeed Asgary 대한치과보존학회 2020 Restorative Dentistry & Endodontics Vol.45 No.1

        Objectives: This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs) through different dentin thicknesses. Materials and Methods: Two-chamber setups were designed to simulate indirect pulp capping (IPC). Human molars were sectioned to obtain 0.1-, 0.3-, and 0.5-mm-thick dentin discs, which were placed between the 2 chambers to simulate an IPC procedure. Then, MTA and CEM were applied on one side of the discs, while hDPSCs were cultured on the other side. After 2 weeks of incubation, the cells were removed, and cell proliferation, morphology, and attachment to the discs were evaluated under scanning electron microscopy (SEM). Energy-dispersive X-ray (EDXA) spectroscopy was performed for elemental analysis. Alkaline phosphatase (ALP) activity was assessed quantitatively. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Results: SEM micrographs revealed elongated cells, collagen fibers, and calcified nucleations in all samples. EDXA verified that the calcified nucleations consisted of calcium phosphate. The largest calcifications were seen in the 0.1-mm-thick dentin subgroups. There was no significant difference in ALP activity across the CEM subgroups; however, ALP activity was significantly lower in the 0.1-mm-thick dentin subgroup than in the other MTA subgroups (p < 0.05). Conclusions: The employed capping biomaterials exerted biological activity on hDPSCs, as shown by cell proliferation, morphology, and attachment and calcific precipitations, through 0.1- to 0.5-mm-thick layers of dentin. In IPC, the bioactivity of these endodontic biomaterials is probably beneficial.

      • KCI등재

        Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity

        Bahar Özcabı,Salih Demirhan,Mesut Akyol,Hatice Öztürkmen Akay,Ayla Güven 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.12

        Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist circumference (WC) (cm) – 58]×triglycerides (mmol/L) in girls; [WC (cm) – 65]×triglycerides (mmol/L) in boys. The minLAP and adjLAP were described (3% and 50% of WC values, respectively) and the total/high-density lipoprotein cholesterol index (TC/HDL-C) was calculated. NAFLD was observed on ultrasound, and patients were divided into 3 groups by steatosis grade (normal, grade 0; mild, grade 1; moderate-severe, grade 2–3). The area under the curve (AUC) and appropriate index cutoff points were calculated by receiver operator characteristic analysis. Results: LAP was positively correlated with puberty stage (rho=0.409; P<0.001), fasting insulin (rho= 0.507; P<0.001), homeostasis model assessment of insulin resistance (rho=0.470; P<0.001), uric acid (rho=0.522; P<0.001), and TC/HDL-C (rho=0.494; P<0.001) and negatively correlated with HDL-C (rho=-3.833; P<0.001). LAP values could be used to diagnose hepatosteatosis (AUC=0.698; P=0.002). The LAP, adjLAP, and minLAP cutoff values were 42.7 (P=0.002), 40.05 (P=0.003), and 53.47 (P= 0.08), respectively. For LAP, the differences between the normal and mild groups (P=0.035) and the normal and moderate-severe groups were statistically significant (P=0.037), whereas the difference between the mild and moderate-severe groups was not (P>0.005). There was a statistically significant difference between the normal and mild groups for adjLAP (P=0.043) but not between the other groups (P>0.005). There was no significant intergroup difference in minLAP (P>0.005). Conclusion: LAP is a powerful and easy tool to predict NAFLD in childhood. If LAP is ≥42.7, NAFLD should be suspected. This is the first study to assess LAP diagnostic accuracy for childhood obesity

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