다양한 항히스타민제에 대한 교차 과민반응

김영욱 ( Young Uck Kim ),이재천 ( Jae Chun Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2014 Allergy Asthma & Respiratory Disease Vol.2 No.2

Antihistamines (histamine receptor antagonists) are widely prescribed medicines in the treatment of allergic disorders, especially the symptoms of hypersensitivity reactions, mainly blocking the activity of vasoactive amines to their receptors. Drug adverse reactions such as sleepiness and dry mouth are frequently encountered. However, drug hypersensitivity provoking itchy hives by antihistamines were rarely reported. A 41-year-old female patient visited allergy clinic for generalized itchy hives from time to time,\ which had been aggravated 3 months before. Whenever she was exposed to antihistamines for treatment, she felt her hives got immediately full-blown. As a screening, she was tested with various antihistamines on her skin, then skin test-negative antihistamines were orally administered. Finally we failed to choose a safe antihistamine for the treatment of her symptoms. We report a case of drug hypersensitivity to various antihistamines with cross-reactions in a patient with chronic urticaria. (Allergy Asthma Respir Dis 2014;2:134-137)

페로니켈 슬래그 잔골재를 사용한 모르타르의 혼화재료 치환율에 따른 유동성 및 강도특성

김영욱(Kim, Young-Uck),김택수(Kim, Taek-Soo),서동명(Seo, Dong-Myoung),김성진(Kim, Sung-Jin),한지민(Han, Ji-Min),최세진(Choi, Se-Jin) 한국콘크리트학회 2016 한국콘크리트학회 학술대회 논문집 Vol.28 No.1

근이완제에 의한 아나필락시스 1예

김성현 ( Sung Hyun Kim ),이재천 ( Jae Chun Lee ),김수희 ( Su Hee Kim ),김현우 ( Hyun Woo Kim ),김영욱 ( Young Uck Kim ),임영협 ( Young Hyup Lim ),문신항 ( Shin Hang Moon ),문재철 ( Jae Cheol Moon ),허다희 ( Da Hee Heo ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.2

Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing alertness compared with other antispasmodics. Its fatal drug adverse reactions were rarely reported. A 70 year-old female with hives, swollen face, hoarse voice, and near fainting admitted via emergency department. She suffered from the series of the fatal symptoms after administration of the pills, prescribed for her neck pain. Two months before, she had experienced hives on similar medications. At presentation, she revealed hypoxemia and hypotension, and treated with epinephrine, glucocorticoids and antihistamines. Among the medicines she took, eperisone hydrochloride was proven as the causative medicine and others were excluded in oral provocation tests. The positive result in intradermal test with eperisone hydrochloride suggested immediate-type hypersensitivity reaction. We report a case of anaphylaxis to eperisone hydrochloride, one of the widely prescribed medicines in clinical practice, previously without awareness of drug adverse reaction. (Allergy Asthma Respir Dis 2013;1:172-175)

근이완제에 의한 아나필락시스

김성현 ( Sung Hyun Kim ),이재천 ( Jae Chun Lee ),김수희 ( Su Hee Kim ),김현우 ( Hyun Woo Kim ),김영욱 ( Young Uck Kim ),임영협 ( Young Hyup Lim ),문신항 ( Shin Hang Moon ),문재철 ( Jae Cheol Moon ),허다희 ( Da Hee Heo ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.2

Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing alertness compared with other antispasmodics. Its fatal drug adverse reactions were rarely reported. A 70 year-old female with hives, swollen face, hoarse voice, and near fainting admitted via emergency department. She suffered from the series of the fatal symptoms after administration of the pills, prescribed for her neck pain. Two months before, she had experienced hives on similar medications. At presentation, she revealed hypoxemia and hypotension, and treated with epinephrine, glucocorticoids and antihistamines. Among the medicines she took, eperisone hydrochloride was proven as the causative medicine and others were excluded in oral provocation tests. The positive result in intradermal test with eperisone hydrochloride suggested immediate-type hypersensitivity reaction. We report a case of anaphylaxis to eperisone hydrochloride, one of the widely prescribed medicines in clinical practice, previously without awareness of drug adverse reaction. (Allergy Asthma Respir Dis 2013;1:172-175)Allergy Asthma Respir Dis 2013;1:172-175)

홍수방지용 친환경 섬유보강 투수콘크리트 강도 특성 평가

김택수(Kim, Teck-Soo),김영욱(Kim, Young-Uck),서동명(Seo, Dong-Myoung),최세진(Choi, Se-Jin) 한국콘크리트학회 2015 한국콘크리트학회 학술대회 논문집 Vol.2015 No.10

페로니켈 슬래그 잔골재 치환율에 따른 모르타르의 유동성 및 강도특성 평가

서동명(Seo, Dong Myoung),김영욱(Kim, Young Uck),김택수(Kim, Taek Soo),김도빈(Kim, Do Bin),최진훈(Choi, Jin Hoon),최세진(Choi, Se Jin) 한국콘크리트학회 2016 한국콘크리트학회 학술대회 논문집 Vol.28 No.1

비정질 섬유보강 콘크리트의 해양구조물 적용을 위한 강도 및 내부식성 평가

서동명 ( Seo Dong-myoung ),김영욱 ( Kim Young-uck ),김택수 ( Kim Teck-soo ),최세진 ( Choi Se-jin ) 한국구조물진단유지관리공학회 2015 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.19 No.2

증례 : 내분비-대사 ; 고칼륨혈증 주기성 마비로 나타난 무통성 갑상선염 동반 애디슨병 1예

고명주 ( Myeong Ju Koh ),서혜미 ( Hye Mi Seo ),김영욱 ( Young Uck Kim ),김성택 ( Seongteag Kim ),이상아 ( Sang A Lee ),유원상 ( Won Sang Yoo ),김소미 ( So Mi Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.4

고칼륨혈증성 주기성 마비는 매우 드물지만 애디슨병과 연관되어 나타날 수 있는 치명적 합병증이다. 애디슨병은 임상증상이 점진적으로 나타나고 비특이적이어서 진단이 늦어지는 경우가 많아 고칼륨혈증, 저나트륨혈증과 같은 전해질이상, 피부나 점막 등의 색소침착, 과거 결핵력 등을 면밀히 살피는 것이 중요하며 급성 부신기능저하가 발생한 경우에는 반드시 유발인자 유무를 감별해야 하겠다. In cases of hyperkalemia with preserved renal function, the differential diagnoses that should be considered are drug-related disorders, primary tubular disease, and hormonal diseases including primary adrenal insufficiency. Addison`s disease represents a rare disorder characterized by primary adrenal failure, general weakness, poor appetite, nausea, dizziness, and hyperpigmentation. It may also cause fatal adrenal crisis, involving hypotension, loss of consciousness, hyperkalemia, or hyperkalemic periodic paralysis under stressful conditions. We describe herein the case of a 54-year-old Korean male who developed Addison`s disease, due to adrenal tuberculosis, in addition to painless thyroiditis, which led to hyperkalemic periodic paralysis.

흰쥐 뇌에서 렙틴과 콜레시스토키닌의 병합투여로 유도된 Fos 발현

김영욱,유경숙,강호석,정춘희,황태선 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 단기간의 식욕을 억제시키는 물질인 콜레시스토키닌과 장기간의 식욕을 억제시키는 물질인 렙틴이 상승적으로 식욕억제를 시킨다는 보고가 발표되고 있으나 아직까지 작용기전과 부위에 대해서는 명확히 밝혀져 있지 않다. 본 연구에서는 지금까지 렙틴과 콜레시스토키닌이 작용한다고 알려진 뇌의 각 부분에서 렙틴 혹은 콜레시스토키닌 단독 투여시세 비해 렙틴과 콜레시스토키닌 병합투여시 Fos발현이 상승적으로 일어나는 부위를 살펴봄으로써 식욕조절에 있어 렙틴과 콜레시스토키닌이 상승작용을 나타낼 수 있는 부위를 찾아보았다. 방법: Sparague-Dawley계의 수컷 흰 쥐 50마리를 4군으로 나누어 24시간 공복시킨후 1군은 뇌실로 Tris 용액 3μL, 복강으로 식염수 2μL, 2군은 뇌실로 Tris 용액 3μL, 복강으로 콜레시스토키닌 2㎍/㎏, 3군은 뇌실로 렙틴 3㎍, 복강으로 식염수 2μL, 4군은 뇌실로 렙틴 3㎍, 복강으로 콜레시스토키닌 2㎍/㎏을 투여한 후 뇌실곁핵, 시각교차뒤구역, 가쪽시상하부핵, 편도체의 중심핵, 시각로위핵, 활꼴핵, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 배쪽유두체앞핵, 팔곁핵의 위쪽가쪽부위와 바깥가쪽부위, 무릎위핵, 맨아래구역, 맨아래구역이 관찰되는 위치에서 고립로핵의 안쪽부위와 맞교차부위에서 Fos 발현을 관찰하였다. 결과: 1. 렙틴을 뇌실로 투여후 Fos 발현이 증가된 부분은 뇌실곁핵, 시각교차뒤구역, 가쪽시상하부핵, 시각로위핵, 활꼴핵, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 배쪽유두체앞핵, 팔곁핵의 위쪽가쪽부위와 바깥가쪽부위, 무릎위핵, 맨아래구역, 고립로핵의 안쪽부위였다. 2. 콜레시스토키닌 투여 후 Fos 발현 세포의 수가 증가한 부위는 뇌실곁핵, 시각교차뒤구역, 가쪽시상하부핵, 편도체의 중심핵, 시각로위핵, 활꼴핵, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 배쪽유두체앞핵, 팔곁핵의 위쪽가쪽부위와 바깥가쪽부위, 고립로핵의 안쪽부위였다. 3. 콜레스토키닌과 렙틴을 병합투여시 각각 단독투여시 때보다 뇌실곁핵, 시각교차뒤구역, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 팔곁핵의 위쪽가쪽부위, 고립로핵의 안쪽부위에서 Fos 발현이 통계학적으로 의의있게 증가되었다. 결론: 콜레스토키닌과 렙틴을 병합투여시 각각 단독투여시 때보다 뇌실곁핵, 시각교차뒤구역, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 팔곁핵의 위쪽가쪽부위, 고립로핵의 안쪽부위에서 Fos 발현이 통계학적으로 의의있게 증가됨을 통해 식욕조절에 있어 렙틴과 콜레시스토키닌의 상승작용을 매개하는 부위는 뇌실곁핵, 시각교차뒤구역, 배쪽안쪽시상하부핵, 등쪽안쪽시상하부핵, 팔곁핵의 위쪽가쪽부위, 고립로핵의 안쪽부위임을 시사한다. Background: Several studies have reported that cholecystokinin (CCK), a short-term meal related satiety signal, and leptin, long-term signal for controlling feeding behaviour and body weight, act synergistically to inhibit food intake. However the mechanism and neuroanatomical basis for this response remain unclear. To clarify the neuronal mechanism underlying the synergistic interaction between leptin and CCK, we examined the neuron activated by single or combined injection of leptin and CCK in fasted rats using immunohistochemistry for Fos. The expression of Fos can be used to trace neuronal activation pathway. Methods: The rats were divided into 4 groups; Tris solution-saline, Tris solution-CCK, leptin-saline, leptin-CCK. Rats were received a single intracerebroventricular injection of either 3㎕ Tris solution or 3㎕ leptin, and a single intraperitoneal injection of either 2㎕ saline or 2㎕/㎏ sulfated CCK-8. The changes of the Fos expression were investigated in the paraventricular nucleus (Pa), retrochiasmatic area (RCh), lateral hypothalamic nucleus (LH), central nucleus of amygdala (Ce), supraoptic nucleus (SO), arcuate nucleus (Arc), ventromedial hypothalamic nucleus (VMH), dorsomedial hypothalamic nucleus (DM), ventral ptemammillary nucleus (PMV), superior lateral subdivision of parabrachial nucleus (LPBS), external lateral subdivision of parabrachial nucleus (LPBE), supragenual nucleus (SGe), area postema (AP), medial area (SolM) and commissural area (SolC) of nucleus of the solitary tract nuclei. Results: CCK increased the Fos expression in the Pa, RCh, LH, Ce, SO, Arc, VMH, DM, PMV, LPBS, LPBE and SolM. Leptin increased the Fos expression in the Pa, RCh, LH, SO, Arc, VMH, DM, PMV, LPBS, LPBE, SGe, AP and SolM. Injections of leptin and CCK significantly enhanced the Fos expression in the Pa, RCh, VMH, DM, LPBS and SolM compared with those induced by leptin or CCK alone. Conclusion: Our results suggest that the Pa, RCh, VMH, DM, LPBS and SolM may be essential sites mediating the synergistic effect of leptin and CCK regulate food intake (J Kor Soc Endocrinol 17:486∼500, 2002).

흰쥐에서 급성 스트레스 유발 불안반응의 해소에 대한 신경교세포 말초성 벤조다이아제핀 수용체의 매개작용

김영욱,박형배,이종범,김진성,정성덕,하정희,송창진 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적 : 말초성 벤조다이아제핀 수용체가 스트레스로 유발된 불안반응에서의 불안해소작용을 알아보기 위해 흰쥐에 급성 부동화(immobilization) 스트레스를 부하하여 유도된 불안반응에서 뇌조직중의 말초성 벤조다이아제핀 수용체의 매개작용을 검색하고자 본 연구를 시행하였다. 방 법 : 흰쥐에 급성 부동화 스트레스를 가한 후 실험동물의 불안도를 elevated plus maze를 통하여 검정하고 말초성 벤조다이아제핀 수용체의 변화를 수용체 결합반응을 통하여 검색하여 대조군과 비교했고, 말초성 벤조다이아제핀 수용체 효현제 및 길항제의 투여에 의한 실험동물의 불안도의 변화 양상도 동일한 검사를 통하여 검정하였다. 결 과 : 급성 부동화 스트레스에 부하되었던 흰쥐는 불안반응을 나타내었으며, 실험동물에 선택적인 중추성 벤조다이아제핀 수용체 효현제인 clonazepam을 투여하여 스트레스로 인한 불안반응을 감약시킨 후 급성 부동화 스트레스를 가했을 때는 불안반응이 감약되었으며, 후구(olfactory bulb)의 말초성 벤조다이아제핀 수용체의 상향조절도 관찰되지 않았다. 말초성 벤조다이아제핀 수용체 효현제인 Ro5-4864을 투여 후 약한 불안 해소 작용을 나타내었으며, 신경활성 스테로이드의 전구물질인 progesterone을 흰쥐에게 투여한 후 이 실험군의 통로로의 진입율 및 개방통로에서의 체류율은 대조군에 비하여 유의하게 증가되었다. 결 론 : 말초성 벤조다이아제핀 수용체는 급성 스트레스 부하시 야기되는 불안반응에서 내인성 GABA성 신경전달의 조절자로 알려진 신경활성 스테로이드의 합성을 증가시킴으로써 불안반응을 해소하는 기능을 가진다. Objectives : Peripheral benzodiazepine receptor has been suggested to be associated with the relief of anxiety response induced by stresses. This study was designed to observe the anxiolytic activity of peripheral benzodiazepine receptor. Methods : Male Sprague-Dawley rats, weighing 200-250g were forced to suffer an immobilization stress for 2 hours. The level of anxiety by immobilization was performed by an elevated plus maze and was evaluated by the number of [³H]Ro5-4864 binding sites in the olfactory bulb. Results : Saturation experiments followed by scatchard analyses of the results showed that the density of peripheral benzodiazepine receptor increased and the affinity of the peripheral benzodiazepine receptor remained unchanged. It was found that there was no significant change in the cerebral cortex. Pretreatment with clonazepam, a central benzodiazepine receptor agonist, before an immobilization stress abolished the anxious response on the performance of plus maze. In this group, upregulation of peripheral benzodiazepine receptor of olfactory bulb was not observed. Ro5-4864, a peripheral benzodiazepine receptor agonist, elicited an increase of anxiolytic response on the performance of plus maze. Progesterone, a precursor of neuroactive steroid, also increased anxiolytic response on the performance of pius maze. Pretreatment with PK11195, a peripheral benzodiazepine receptor antagonist, abolished the anxiolytic effect of progesterone. Conclusions : From these results, it could be concluded that peripheral benzodiazepine receptor is closely associated with the relief of acute stress induced anxiety response via an increase of synthesis of neuroactive steroid.